@article{MTMT:31748109,
	title = {Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation},
	url = {https://m2.mtmt.hu/api/publication/31748109},
	author = {Lorántfy, László and Rutterschmid, Dóra and Örkényi, Róbert Zoltán and Bakonyi, Dávid and Faragó, József and Dargó, Gergő and Könczöl, Árpád},
	doi = {10.1021/acs.oprd.0c00338},
	journal-iso = {ORG PROCESS RES DEV},
	journal = {ORGANIC PROCESS RESEARCH & DEVELOPMENT},
	volume = {24},
	unique-id = {31748109},
	issn = {1083-6160},
	year = {2020},
	eissn = {1520-586X},
	pages = {2676-2688},
	orcid-numbers = {Dargó, Gergő/0000-0002-1141-8379}
}

@article{MTMT:3399624,
	title = {Brief overview of solubility methods: Recent trends in equilibrium solubility measurement and predictive models},
	url = {https://m2.mtmt.hu/api/publication/3399624},
	author = {Könczöl, Árpád and Dargó, Gergő},
	doi = {10.1016/j.ddtec.2018.06.001},
	journal-iso = {DRUG DISCOVERY TODAY: TECHNOLOGIES},
	journal = {DRUG DISCOVERY TODAY: TECHNOLOGIES},
	volume = {27},
	unique-id = {3399624},
	issn = {1740-6749},
	year = {2018},
	pages = {3-10},
	orcid-numbers = {Dargó, Gergő/0000-0002-1141-8379}
}

@article{MTMT:3293443,
	title = {Three newly identified lipophilic flavonoids in Tanacetum parthenium supercritical fluid extract penetrating the Blood-Brain Barrier},
	url = {https://m2.mtmt.hu/api/publication/3293443},
	author = {Végh, Krisztina Emese and Riethmüller, Eszter and Levente, Hosszú and Darcsi, András and Judit, Müller and Alberti, Ágnes and Tóth, Anita and Béni, Szabolcs and Könczöl, Árpád and Balogh, György Tibor and Kéry, Ágnes},
	doi = {10.1016/j.jpba.2017.11.029},
	journal-iso = {J PHARMACEUT BIOMED ANAL},
	journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
	volume = {149},
	unique-id = {3293443},
	issn = {0731-7085},
	year = {2018},
	eissn = {1873-264X},
	pages = {488-493},
	orcid-numbers = {Végh, Krisztina Emese/0000-0002-6565-449X; Riethmüller, Eszter/0000-0002-9719-5427; Darcsi, András/0000-0003-2202-4997; Alberti, Ágnes/0000-0003-3096-4057; Tóth, Anita/0000-0001-7117-898X; Béni, Szabolcs/0000-0001-7056-6825; Balogh, György Tibor/0000-0003-3347-1880; Kéry, Ágnes/0000-0001-6768-5057}
}

@article{MTMT:3189432,
	title = {C8-selective biomimetic transformation of 5,7-dihydroxylated flavonoids by an acid-catalysed phenolic Mannich reaction: Synthesis of flavonoid alkaloids with quercetin and (–)-epicatechin skeletons},
	url = {https://m2.mtmt.hu/api/publication/3189432},
	author = {Ilkei, Viktor and Spaits, A and Prechl, A and Müller, Judit and Könczöl, Árpád and Lévai, S and Riethmüller, Eszter and Szigetvári, Á and Béni, Zoltán and Dékány, M and Martins, Ana and Hunyadi, Attila and Antus, Sándor and Szántay, Csaba (Ifj.) and Balogh, György Tibor and Kalaus, György and Bölcskei, Hedvig and Hazai, László},
	doi = {10.1016/j.tet.2017.01.068},
	journal-iso = {TETRAHEDRON},
	journal = {TETRAHEDRON},
	volume = {73},
	unique-id = {3189432},
	issn = {0040-4020},
	year = {2017},
	eissn = {1464-5416},
	pages = {1503-1510},
	orcid-numbers = {Riethmüller, Eszter/0000-0002-9719-5427; Béni, Zoltán/0000-0002-1275-4155; Hunyadi, Attila/0000-0003-0074-3472; Szántay, Csaba (Ifj.)/0000-0002-1056-1421; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:3135904,
	title = {BBB penetration-targeting physicochemical lead selection: Ecdysteroids as chemo-sensitizers against CNS tumors},
	url = {https://m2.mtmt.hu/api/publication/3135904},
	author = {Müller, Judit and Martins, Ana and Csábi, József and Fenyvesi, Ferenc and Könczöl, Árpád and Hunyadi, Attila and Balogh, György Tibor},
	doi = {10.1016/j.ejps.2016.10.034},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {96},
	unique-id = {3135904},
	issn = {0928-0987},
	abstract = {Abstract The anticancer potential of ecdysteroids, especially their chemo-sensitizing activity has recently gained a substantial scientific interest. A comprehensive physicochemical profiling was performed for a set of natural or semi-synthetic ecdysteroids (N = 37) to identify a lead compound against central nervous system (CNS) tumors. Calculated properties, such as lipophilicity (clogP), topological polar surface area (TPSA), brain-to-plasma ratio (clogBB) along with the measured blood-brain barrier specific in vitro permeability (logPe) were evaluated in parallel. Compounds with the highest CNS-availability predicted (clogBB > 0.0 and logPe > − 6.0) showed moderate to high lipophilicity (clogP = 3.89 − 5.25), relatively low TPSA (94.45 Å2), and shared a common apolar 2,3- and 20,22-diacetonide motif (25, 30–33). These ecdysteroids were selected for testing their capacity to sensitize SH-SY5Y neuroblastoma cells to vincristine. All of the five tested compounds exerted a remarkably strong, dose dependent chemo-sensitizing activity: at 2.5–10.0 μM ecdysteroids increased the cytotoxic activity of vincristine one to three orders of magnitude in (e.g., from IC50 = 39.5 ± 2.9 nM to as low as 0.056 ± 0.03 nM). Moreover, analysis of the combination index (CI) revealed outstanding synergism between ecdysteroids and vincristine (CI50 = 0.072 − 0.444). Thus, based on drug-likeness, physchem character and in vitro CNS activity, compound 25 was proposed as a lead for further in vivo studies.},
	keywords = {CANCER; ecdysteroid; adjuvant; physicochemical profiling; Chemo-sensitization; Lead selection; PAMPA-BBB},
	year = {2017},
	eissn = {1879-0720},
	pages = {571-577},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:3143287,
	title = {Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B},
	url = {https://m2.mtmt.hu/api/publication/3143287},
	author = {Ilkei, Viktor and Spaits, A and Prechl, A and Szigetvári, Á and Béni, Zoltán and Dékány, M and Szántay, Csaba (Ifj.) and Müller, Judit and Könczöl, Árpád and Szappanos, Ádám and Mándi, Attila and Antus, Sándor and Martins, Ana and Hunyadi, Attila and Balogh, György Tibor and Kalaus, György and Bölcskei, Hedvig and Hazai, László and Kurtán, Tibor},
	doi = {10.3762/bjoc.12.247},
	journal-iso = {BEILSTEIN J ORG CHEM},
	journal = {BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY},
	volume = {12},
	unique-id = {3143287},
	issn = {1860-5397},
	abstract = {Starting from racemic naringenin ((±)-1), a mixture of dracocephin A stereoisomers 6-(2”-pyrrolidinone-5”-yl)naringenin (±)-2a–d and its regioisomer, dracocephin B 8-(2”-pyrrolidinone-5”-yl)naringenin (±)-3a–d originally isolated from Dracocephalum rupestre, have been synthesized in a one-pot reaction. The separation of 2a–d and 3a–d was achieved by preparative HPLC. The four stereoisomers of each natural product were separated by analytical chiral HPLC and their absolute configuration was studied by the combination of HPLC–ECD measurements and TDDFT–ECD calculations. The synthesized flavonoid alkaloids were further characterized by physicochemical and in vitro pharmacological studies.},
	year = {2016},
	eissn = {1860-5397},
	pages = {2523-2534},
	orcid-numbers = {Béni, Zoltán/0000-0002-1275-4155; Szántay, Csaba (Ifj.)/0000-0002-1056-1421; Hunyadi, Attila/0000-0003-0074-3472; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:3110098,
	title = {Blood-brain barrier specific permeability assay reveals N-methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba},
	url = {https://m2.mtmt.hu/api/publication/3110098},
	author = {Könczöl, Árpád and Rendes, Kata and Dékány, Miklós and Müller, Judit and Riethmüller, Eszter and Balogh, György Tibor},
	doi = {10.1016/j.jpba.2016.08.032},
	journal-iso = {J PHARMACEUT BIOMED ANAL},
	journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
	volume = {131},
	unique-id = {3110098},
	issn = {0731-7085},
	abstract = {Abstract The linkage between the central nervous system availability and neuropharmacological activity of the constituents of Ginkgo biloba L. extracts (GBE) is still incomplete. In this study, the in vitro blood-brain barrier (BBB) permeability profile of the standardised GBE was investigated by the parallel artificial membrane permeability assay (PAMPA). Biomarkers, such as terpene trilactones, flavonoid aglycones and ginkgotoxin exerted moderate or good BBB-permeability potential (BBB+), while glycosides and biflavones were predicted as unable to pass the BBB. N-methyltyramine (NMT) and N,N-dimethyltyramine or hordenine (Hor) were identified among BBB+ compounds, while subsequent direct HRMS analysis revealed tyramine (Tyr) and N,N,N-trimethyltyramine or candicine (Can) in GBE as trace constituents. Distribution of Tyr, NMT, Hor and Can was determined by a validated ion-exchange mechanism-based liquid chromatography–electrospray ionisation–mass spectrometry (LC-ESI–MS) method in G. biloba samples, such as herbal drugs and dietary supplements. The total content of the four tyramine derivatives in various GBEs ranged from 7.3 up to 6357 μg/g dry extract with NMT and Hor as most abundant ones. Considering the pharmacological activities and the revealed fluctuation in the concentration of the analysed adrenergic protoalkaloids, the presented rapid LC-ESI–MS method is proposed for monitoring of the levels of Tyr, NMT, Hor and Can in G. biloba products.},
	keywords = {Ginkgo biloba; tyramine; LC-MS; PAMPA; blood-brain barrier permeability; Candicine; Hordenine; N-methyltyramine},
	year = {2016},
	eissn = {1873-264X},
	pages = {167-174},
	orcid-numbers = {Riethmüller, Eszter/0000-0002-9719-5427; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:3065548,
	title = {HPLC-DPPH Screening Method for Evaluation of Antioxidant Compounds in Corylus Species},
	url = {https://m2.mtmt.hu/api/publication/3065548},
	author = {Riethmüller, Eszter and Könczöl, Árpád and Bereczki-Szakál, Dorottya and Végh, Krisztina Emese and Balogh, György Tibor and Kéry, Ágnes},
	doi = {10.1177/1934578x1601100522},
	journal-iso = {NAT PROD COMMUN},
	journal = {NATURAL PRODUCT COMMUNICATIONS},
	volume = {11},
	unique-id = {3065548},
	issn = {1934-578X},
	year = {2016},
	eissn = {1555-9475},
	pages = {641-644},
	orcid-numbers = {Riethmüller, Eszter/0000-0002-9719-5427; Bereczki-Szakál, Dorottya/0000-0003-3037-0515; Végh, Krisztina Emese/0000-0002-6565-449X; Balogh, György Tibor/0000-0003-3347-1880; Kéry, Ágnes/0000-0001-6768-5057}
}

@article{MTMT:3030183,
	title = {An unexpected advantage of insectivorism: insect moulting hormones ingested by song birds affect their ticks},
	url = {https://m2.mtmt.hu/api/publication/3030183},
	author = {Hornok, Sándor and Kováts, Dávid and Flaisz, Barbara and Csörgő, Tibor and Könczöl, Árpád and Balogh, György Tibor and Csorba, Attila and Hunyadi, Attila},
	doi = {10.1038/srep23390},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {6},
	unique-id = {3030183},
	issn = {2045-2322},
	year = {2016},
	eissn = {2045-2322},
	orcid-numbers = {Csörgő, Tibor/0000-0002-7060-9853; Balogh, György Tibor/0000-0003-3347-1880; Csorba, Attila/0000-0002-4032-1605; Hunyadi, Attila/0000-0003-0074-3472}
}

@inproceedings{MTMT:3038549,
	title = {N,N-Dimetilanilin β-Deutérium izotópeffektusának mechanisztikus vizsgálata fordított fázisú folyadékkromatográfiával},
	url = {https://m2.mtmt.hu/api/publication/3038549},
	author = {Maszler, P and Kupai, József and Balogh, György Tibor and Könczöl, Árpád},
	booktitle = {XXXVIII. Kémiai Előadói Napok},
	unique-id = {3038549},
	year = {2015},
	pages = {34-38},
	orcid-numbers = {Kupai, József/0000-0002-4212-4517; Balogh, György Tibor/0000-0003-3347-1880}
}