TY - THES AU - Decsi, Gábor Sándor TI - Alterations in Oral Mucosal Microbiota of Patients with Oral Potentially Malignant Disorders [Szájüregi potenciálisan malignus rendellenességekben szenvedő betegek szájnyálkahártya mikrobiótájának változásai] PB - Szegedi Tudományegyetem (SZTE) PY - 2020 SP - 94 DO - 10.14232/phd.10420 UR - https://m2.mtmt.hu/api/publication/31391232 ID - 31391232 LA - English DB - MTMT ER - TY - GEN AU - Decsi, Gábor Sándor TI - A szájüreg potenciálisan malignus elváltozásaival és a szájüregi daganatokkal kapcsolatba hozható fertőző ágensek PY - 2019 UR - https://m2.mtmt.hu/api/publication/31013299 ID - 31013299 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Decsi, Gábor Sándor AU - Sóki, József AU - Pap, Bernadett AU - Dobra, Gabriella AU - Harmati, Mária AU - Körmöndi, Sándor Pál AU - Pankotai, Tibor AU - Braunitzer, Gábor AU - Minárovits, János AU - Sonkodi, István AU - Zsoldiné Urbán, Edit AU - Németh, István Balázs AU - Nagy, Katalin AU - Buzás, Krisztina TI - Az orális mikrobiom változása szájüregi daganatmegelőző elváltozásban szenvedő betegek biopsziás mintáiban T2 - Szegedi Fogorvosnapok : Magyar Fogpótlástani Társaság XXIII. Kongresszusa : Szegedi Fogorvostalálkozó és Tudományos Konferencia PB - Expert Event Hungary Kft. CY - Algyő SN - 9786150055886 PY - 2019 SP - 38 UR - https://m2.mtmt.hu/api/publication/30831606 ID - 30831606 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Decsi, Gábor Sándor AU - Sóki, József AU - Pap, Bernadett AU - Dobra, Gabriella AU - Harmati, Mária AU - Körmöndi, Sándor Pál AU - Pankotai, Tibor AU - Braunitzer, Gábor AU - Minárovits, János AU - Sonkodi, István AU - Zsoldiné Urbán, Edit AU - Németh, István Balázs AU - Nagy, Katalin AU - Buzás, Krisztina TI - Chicken or the Egg: Microbial Alterations in Biopsy Samples of Patients with Oral Potentially Malignant Disorders JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 25 PY - 2019 IS - 3 SP - 1023 EP - 1033 PG - 11 SN - 1219-4956 DO - 10.1007/s12253-018-0457-x UR - https://m2.mtmt.hu/api/publication/3400563 ID - 3400563 N1 - Faculty of Dentistry, Department of Oral Surgery, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Albert Szent-Gyorgyi Clinical Centre, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Albert Szent-Gyorgyi Clinical Centre, Department of Traumatology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Biochemistry and Molecular Biology, University of Szeged, Kozep fasor 52, Szeged, H-6726, Hungary dicomLAB Ltd., Pulz u. 46/b, Szeged, H-6724, Hungary Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Cited By :1 Export Date: 5 September 2019 CODEN: POREF Correspondence Address: Buzas, K.; Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Hungary; email: kr.buzas@gmail.com Funding details: Magyar Tudományos Akadémia, MTA, GINOP 2.3.2-15-2016-00011 Funding details: 11493, GINOP-2.3.2-15-2016-00015 Funding text 1: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. Faculty of Dentistry, Department of Oral Surgery, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Albert Szent-Gyorgyi Clinical Centre, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Albert Szent-Gyorgyi Clinical Centre, Department of Traumatology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Biochemistry and Molecular Biology, University of Szeged, Kozep fasor 52, Szeged, H-6726, Hungary dicomLAB Ltd., Pulz u. 46/b, Szeged, H-6724, Hungary Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Cited By :1 Export Date: 6 November 2019 CODEN: POREF Correspondence Address: Buzas, K.; Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Hungary; email: kr.buzas@gmail.com Funding details: Magyar Tudományos Akadémia, MTA, GINOP 2.3.2-15-2016-00011 Funding details: 11493, GINOP-2.3.2-15-2016-00015 Funding text 1: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, János Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. Faculty of Dentistry, Department of Oral Surgery, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Albert Szent-Gyorgyi Clinical Centre, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Albert Szent-Gyorgyi Clinical Centre, Department of Traumatology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Biochemistry and Molecular Biology, University of Szeged, Kozep fasor 52, Szeged, H-6726, Hungary dicomLAB Ltd., Pulz u. 46/b, Szeged, H-6724, Hungary Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Cited By :2 Export Date: 14 January 2020 CODEN: POREF Correspondence Address: Buzas, K.; Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Hungary; email: kr.buzas@gmail.com Chemicals/CAS: DNA, Bacterial Funding details: Magyar Tudományos Akadémia, MTA, GINOP 2.3.2-15-2016-00011 Funding details: 11493, GINOP-2.3.2-15-2016-00015 Funding text 1: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, János Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. Funding Agency and Grant Number: National Research, Development and Innovation Fund of Hungary under the NKFI-6-K funding scheme [11493]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; [GINOP-2.3.2-15-2016-00015]; [GINOP 2.3.2-15-2016-00011] Funding text: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. Faculty of Dentistry, Department of Oral Surgery, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Albert Szent-Gyorgyi Clinical Centre, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Albert Szent-Gyorgyi Clinical Centre, Department of Traumatology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Biochemistry and Molecular Biology, University of Szeged, Kozep fasor 52, Szeged, H-6726, Hungary dicomLAB Ltd., Pulz u. 46/b, Szeged, H-6724, Hungary Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Cited By :2 Export Date: 7 March 2020 CODEN: POREF Correspondence Address: Buzas, K.; Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Hungary; email: kr.buzas@gmail.com Chemicals/CAS: DNA, Bacterial Funding details: Magyar Tudományos Akadémia, MTA, GINOP 2.3.2-15-2016-00011 Funding details: 11493, GINOP-2.3.2-15-2016-00015 Funding text 1: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, János Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. Faculty of Dentistry, Department of Oral Surgery, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Albert Szent-Gyorgyi Clinical Centre, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Albert Szent-Gyorgyi Clinical Centre, Department of Traumatology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Biochemistry and Molecular Biology, University of Szeged, Kozep fasor 52, Szeged, H-6726, Hungary dicomLAB Ltd., Pulz u. 46/b, Szeged, H-6724, Hungary Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Cited By :5 Export Date: 19 September 2020 CODEN: POREF Correspondence Address: Buzas, K.; Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Hungary; email: kr.buzas@gmail.com Chemicals/CAS: DNA, Bacterial Funding details: Magyar Tudományos Akadémia, MTA, GINOP 2.3.2-15-2016-00011 Funding details: 11493, GINOP-2.3.2-15-2016-00015, NKFI-6-K Funding text 1: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, János Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. Faculty of Dentistry, Department of Oral Surgery, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Albert Szent-Gyorgyi Clinical Centre, Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Albert Szent-Gyorgyi Clinical Centre, Department of Traumatology, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Biochemistry and Molecular Biology, University of Szeged, Kozep fasor 52, Szeged, H-6726, Hungary dicomLAB Ltd., Pulz u. 46/b, Szeged, H-6724, Hungary Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, University of Szeged, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Cited By :6 Export Date: 14 March 2021 CODEN: POREF Correspondence Address: Buzas, K.; Biological Research Centre, Temesvari krt. 62, Hungary; email: kr.buzas@gmail.com Chemicals/CAS: DNA, Bacterial Funding details: 11493, GINOP-2.3.2-15-2016-00015, NKFI-6-K Funding details: Magyar Tudományos Akadémia, MTA, GINOP 2.3.2-15-2016-00011 Funding text 1: This work was in part supported by the National Research, Development and Innovation Fund of Hungary, financed under the NKFI-6-K funding scheme (11493 project), GINOP-2.3.2-15-2016-00015, János Bolyai Research Scholarship of the Hungarian Academy of Sciences and GINOP 2.3.2-15-2016-00011. AB - Oral carcinogenesis often leads to the alteration of the microbiota at the site of the tumor, but data are scarce regarding the microbial communities of oral potentially malignant disorders (OPMDs). Punch biopsies were taken from healthy and non-healthy mucosa of OPMD patients to analyze the microbiome using metagenome sequencing. In healthy oral mucosa biopsies the bacterial phyla Firmicutes, Fusobacteria, Proteobacteria, Actinobacteria and Bacteroidetes were detected by Ion Torrent sequencing. The same phyla as well as the phyla Fibrobacteres and Spirochaetes were present in the OPMD biopsies. On the species level, there were 10 bacterial species unique to the healthy tissue and 35 species unique to the OPMD lesions whereas eight species were detected in both samples. We observed that the relative abundance of Streptococcus mitis decreased in the OPMD lesions compared to the uninvolved tissue. In contrast, the relative abundance of Fusobacterium nucleatum, implicated in carcinogenesis, was elevated in OPMD. We detected markedly increased bacterial diversity in the OPMD lesions compared to the healthy oral mucosa. The ratio of S. mitis and F. nucleatum are characteristically altered in the OPMD lesions compared to the healthy mucosa. LA - English DB - MTMT ER - TY - GEN AU - Decsi, Gábor Sándor AU - Buzás, Krisztina TI - A szájüreg daganatmegelőző elváltozásainak mikrobiológiai háttere az SZTE-FOK beteganyagának tükrében PY - 2018 UR - https://m2.mtmt.hu/api/publication/30676408 ID - 30676408 LA - Hungarian DB - MTMT ER - TY - CONF AU - Decsi, Gábor Sándor AU - Sóki, József AU - Pap, B. AU - Dobra, Gabriella AU - Harmati, Mária AU - Körmöndi, Sándor Pál AU - Pankotai, Tibor AU - Braunitzer, Gábor AU - Minárovits, János AU - Sonkodi, István AU - Zsoldiné Urbán, Edit AU - Németh, I.B. AU - Nagy, Katalin AU - Buzás, Krisztina TI - Az orális mikrobiom változása szájüregi daganatmegelőző elváltozásban szenvedő betegek biopsziás mintáiban T2 - Translational interactive hands-on training and conference on epithelial ion transport including two symposia: "Antibacterial and mucolytic therapy in cystic fibrosis" and "Research in oral cavity – from basic science to clinical use" PY - 2018 SP - 58 UR - https://m2.mtmt.hu/api/publication/30421477 ID - 30421477 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sonkodi, István AU - Boda, Krisztina AU - Decsi, Gábor Sándor AU - Buzás, Kristóf László AU - Nagy, Katalin TI - A szegedi Fogászati és Szájsebészeti Klinikán diagnosztizált, az orofacialis régiót érintő jóindulatú daganatok és daganatszerű laesiók klinikopatológiai retrospektív epidemiológiai analízise (1960–2014) JF - ORVOSI HETILAP J2 - ORV HETIL VL - 159 PY - 2018 IS - 37 SP - 1516 EP - 1524 PG - 9 SN - 0030-6002 DO - 10.1556/650.2018.31164 UR - https://m2.mtmt.hu/api/publication/30396676 ID - 30396676 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hettmann, Andrea AU - Nagy-Demcsák, Anett AU - Bach, Ádám AU - Decsi, Gábor Sándor AU - Dencs, Ágnes AU - Pálinkó, Dóra AU - Rovó, László AU - Terhes, Gabriella AU - Zsoldiné Urbán, Edit AU - Buzás, Krisztina AU - Nagy, Katalin AU - Takács, Mária AU - Minárovits, János TI - Prevalence and genotypes of human papillomavirus in saliva and tumor samples of head and neck cancer patients in Hungary JF - INFECTION GENETICS AND EVOLUTION J2 - INFECT GENET EVOL VL - 59 PY - 2018 SP - 99 EP - 106 PG - 8 SN - 1567-1348 DO - 10.1016/j.meegid.2018.01.030 UR - https://m2.mtmt.hu/api/publication/3329787 ID - 3329787 N1 - Megjegyzés-27366097 N1 Funding details: i4i, Invention for Innovation Programme N1 Funding details: Ministry of Economy N1 Funding details: SIBS, CAS, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences N1 Funding details: STRIDE Center, Southeastern Transportation Research, Innovation, Development and Education Center N1 Funding details: ERDF, European Regional Development Fund N1 Funding text: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Division of Virology, National Public Health Institute, Budapest, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary Export Date: 9 January 2019 CODEN: IGENC Correspondence Address: Minarovits, J.; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Hungary; email: minarovits.janos@stoma.szote.u-szeged.hu Funding details: Ministry of Economy Funding details: European Regional Development Fund, FEDER Funding text 1: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Division of Virology, National Public Health Institute, Budapest, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary Cited By :1 Export Date: 26 August 2019 CODEN: IGENC Correspondence Address: Minarovits, J.; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Hungary; email: minarovits.janos@stoma.szote.u-szeged.hu Funding details: Hungary Funding details: Ministry of Economy Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund Funding details: Office of Research, Innovation and Economic Development, California State Polytechnic University, Pomona Funding text 1: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Division of Virology, National Public Health Institute, Budapest, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary Cited By :1 Export Date: 14 January 2020 CODEN: IGENC Correspondence Address: Minarovits, J.; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Hungary; email: minarovits.janos@stoma.szote.u-szeged.hu Funding details: Hungary Funding details: Ministry of Economy Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund Funding details: Office of Research, Innovation and Economic Development, California State Polytechnic University, Pomona Funding text 1: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Funding Agency and Grant Number: European Regional Development Fund of the European UnionEuropean Union (EU); [GINOP-2.3.2-15-2016-00011] Funding text: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. AB - Abstract In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hungary, data regarding HPV prevalence in HNSCCs is scarce. We collected biopsy and saliva samples from patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) and tested them for the presence of HPV using the PCR consensus primer set MY09/11 and the GP5+/6+ primer pair. HPV genotypes were assessed by sequencing of the amplified PCR fragments. Oral mucosa and saliva samples from tumor- and OPMD-free individuals were also analysed. HPV was detected in 11 out of 60 HNSCC samples (18%). All of the HPV positive tumors carried HPV type 16. 5 out of the 57 saliva samples collected from HNSCC patients was HPV positive (8.8%); among them, in addition to HPV16, HPV13 was also detected. Tumors located to the oropharynx had the highest HPV positivity rate with 50% (7 out of 14), which was significantly higher than the HPV prevalence in oral mucosa samples collected from controls (0 out of 20; p > 0.001) or in OPMD biopsies (0 out of 21, p > 0.001). 2 out of 57 control saliva samples (3.5%, subtype HPV13 and 11) and 3 out of 39 saliva samples from OPMD patients (7.7%, subtype HPV18, 81 and 10) were HPV positive. Our data suggested that HPV16 infection may contribute, in concert with cigarette smoking, to the development of a subset of head and neck cancers in Hungary. HPV16 infection per se does not account, however, for the high HNSCC incidence rate recorded in this country. LA - English DB - MTMT ER - TY - JOUR AU - Hettmann, Andrea AU - Nagy-Demcsák, Anett AU - Bach, Ádám AU - Decsi, Gábor Sándor AU - Dencs, Ágnes AU - Pálinkó, Dóra AU - Rovó, László AU - Terhes, Gabriella AU - Zsoldiné Urbán, Edit AU - Nagy, Katalin AU - Takács, Mária AU - Minárovits, János TI - Prevalence of human papillomavirus (HPV) and torque teno virus (TTV) in saliva and tumor biopsy samples of head and neck cancer patients in Hungary JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl. 1 SP - 127 EP - 127 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3288416 ID - 3288416 LA - English DB - MTMT ER - TY - JOUR AU - Zsedényi, Ádám Kornél AU - Farkas, B AU - Abdelrasoul, GN AU - Romano, I AU - Gyukity-Sebestyén, Edina AU - Nagy, Katalin AU - Harmati, Mária AU - Dobra, Gabriella AU - Körmöndi, Sándor Pál AU - Decsi, Gábor Sándor AU - Németh, István Balázs AU - Diaspro, A AU - Brandi, F AU - Beke, S AU - Buzás, Krisztina TI - Gold nanoparticle-filled biodegradable photopolymer scaffolds induced muscle remodeling: in vitro and in vivo findings JF - MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS J2 - MAT SCI ENG C-MATER VL - 72 PY - 2017 SP - 625 EP - 630 PG - 6 SN - 0928-4931 DO - 10.1016/j.msec.2016.11.124 UR - https://m2.mtmt.hu/api/publication/3170295 ID - 3170295 N1 - N1 Funding details: 112493, OTKA, Országos Tudományos Kutatási Alapprogramok Megjegyzés-26443945 N1 Funding details: 112493, OTKA, Országos Tudományos Kutatási Alapprogramok N1 Funding text: This research was funded by Hungarian Scientific Research Fund (OTKA K) 112493 and GINOP-2.3.2-15-2016-00001. University of Szeged, Faculty of Dentistry, Tisza Lajos krt. 64, Szeged, H-6720, Hungary Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, Genova, 16163, Italy Hungarian Academy of Sciences, Biological Research Centre, Temesvari krt. 62, Szeged, H-67268, Hungary University of Szeged, Department of Traumatology, Semmelweis utca 6, Szeged, H-6720, Hungary University of Szeged, Department of Dermatology and Allergology, Koranyi fasor 6, Szeged, H-6720, Hungary Istituto Nazionale di Ottica (INO-CNR), Via Moruzzi 1, Pisa, 56124, Italy Biological Research Centre Institute of Biochemistry, Temesvari krt. 62, Szeged, H-6726, Hungary Cited By :3 Export Date: 14 January 2020 Correspondence Address: Buzas, K.; University of Szeged, Faculty of Dentistry, Tisza Lajos krt. 64, Hungary; email: kr.buzas@gmail.com Chemicals/CAS: gold, 7440-57-5; Biocompatible Materials; Chemokines; Cytokines; Gold; Polymers Funding details: Országos Tudományos Kutatási Alapprogramok, OTKA Funding details: Országos Tudományos Kutatási Alapprogramok, OTKA, K, K) 112493, GINOP-2.3.2-15-2016-00001 Funding text 1: This research was funded by Hungarian Scientific Research Fund (OTKA K) 112493 and GINOP-2.3.2-15-2016-00001. AB - Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes. With the help of mask-projection excimer laser stereolithography, 3D hybrid nanoscaffolds were fabricated from biodegradable, photocurable PPF:DEF resin with incorporated gold nanoparticles (Au NPs). The scaffolds were tested in vitro and in vivo in order to find out about their biocompatibility and fitness for our purposes. In vitro, macrophages and mouse autologous adipose stem cells (ASCs) were seeded over the hybrid scaffolds and non-hybrid (with Au NPs) scaffolds for 4 days. The hybrid nanocomposite greater stem cell dispension and stem cell adhesion than PPF scaffolds without Au NPs, but such a difference was not seen in the case of macrophages. In vivo, stem cells, scaffoldings and scaffoldings covered in stem cells were transplanted under the back skin of mice. After 14 days, blood samples were taken and the affected skin area was excised. Cytokine and chemokine profiling did not indicate elevated immunomediators in the sera of experimental animals. Interestingly, the autologous-stem-cell-seeded hybrid nanocomposite scaffold induced muscle tissue regeneration after experimental wound generation in vivo. We could not observe such stem cell-induced tissue regeneration when no scaffolding was used. We conclude that PPF:DEF resin nanoscaffolds with incorporated gold nanoparticles offer a safe and efficient alternative for the enhancement of local tissue remodeling. The results also support the idea that adipose derived stem cells are an optimal cell type for the purposes of regenerative musculoskeletal tissue engineering. © 2016 LA - English DB - MTMT ER -