@mastersthesis{MTMT:31391232, title = {Alterations in Oral Mucosal Microbiota of Patients with Oral Potentially Malignant Disorders [Szájüregi potenciálisan malignus rendellenességekben szenvedő betegek szájnyálkahártya mikrobiótájának változásai]}, url = {https://m2.mtmt.hu/api/publication/31391232}, author = {Decsi, Gábor Sándor}, doi = {10.14232/phd.10420}, publisher = {SZTE}, unique-id = {31391232}, year = {2020}, orcid-numbers = {Decsi, Gábor Sándor/0000-0002-0264-1130} } @misc{MTMT:31013299, title = {A szájüreg potenciálisan malignus elváltozásaival és a szájüregi daganatokkal kapcsolatba hozható fertőző ágensek}, url = {https://m2.mtmt.hu/api/publication/31013299}, author = {Decsi, Gábor Sándor}, unique-id = {31013299}, year = {2019}, orcid-numbers = {Decsi, Gábor Sándor/0000-0002-0264-1130} } @{MTMT:30831606, title = {Az orális mikrobiom változása szájüregi daganatmegelőző elváltozásban szenvedő betegek biopsziás mintáiban}, url = {https://m2.mtmt.hu/api/publication/30831606}, author = {Decsi, Gábor Sándor and Sóki, József and Pap, Bernadett and Dobra, Gabriella and Harmati, Mária and Körmöndi, Sándor Pál and Pankotai, Tibor and Braunitzer, Gábor and Minárovits, János and Sonkodi, István and Zsoldiné Urbán, Edit and Németh, István Balázs and Nagy, Katalin and Buzás, Krisztina}, booktitle = {Szegedi Fogorvosnapok : Magyar Fogpótlástani Társaság XXIII. Kongresszusa : Szegedi Fogorvostalálkozó és Tudományos Konferencia}, unique-id = {30831606}, year = {2019}, pages = {38}, orcid-numbers = {Decsi, Gábor Sándor/0000-0002-0264-1130; Sóki, József/0000-0001-9230-8907; Harmati, Mária/0000-0002-4875-5723; Pankotai, Tibor/0000-0001-9810-5465; Braunitzer, Gábor/0000-0001-8983-5175; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Nagy, Katalin/0000-0001-9383-5952; Buzás, Krisztina/0000-0001-8933-2033} } @article{MTMT:3400563, title = {Chicken or the Egg: Microbial Alterations in Biopsy Samples of Patients with Oral Potentially Malignant Disorders}, url = {https://m2.mtmt.hu/api/publication/3400563}, author = {Decsi, Gábor Sándor and Sóki, József and Pap, Bernadett and Dobra, Gabriella and Harmati, Mária and Körmöndi, Sándor Pál and Pankotai, Tibor and Braunitzer, Gábor and Minárovits, János and Sonkodi, István and Zsoldiné Urbán, Edit and Németh, István Balázs and Nagy, Katalin and Buzás, Krisztina}, doi = {10.1007/s12253-018-0457-x}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {25}, unique-id = {3400563}, issn = {1219-4956}, abstract = {Oral carcinogenesis often leads to the alteration of the microbiota at the site of the tumor, but data are scarce regarding the microbial communities of oral potentially malignant disorders (OPMDs). Punch biopsies were taken from healthy and non-healthy mucosa of OPMD patients to analyze the microbiome using metagenome sequencing. In healthy oral mucosa biopsies the bacterial phyla Firmicutes, Fusobacteria, Proteobacteria, Actinobacteria and Bacteroidetes were detected by Ion Torrent sequencing. The same phyla as well as the phyla Fibrobacteres and Spirochaetes were present in the OPMD biopsies. On the species level, there were 10 bacterial species unique to the healthy tissue and 35 species unique to the OPMD lesions whereas eight species were detected in both samples. We observed that the relative abundance of Streptococcus mitis decreased in the OPMD lesions compared to the uninvolved tissue. In contrast, the relative abundance of Fusobacterium nucleatum, implicated in carcinogenesis, was elevated in OPMD. We detected markedly increased bacterial diversity in the OPMD lesions compared to the healthy oral mucosa. The ratio of S. mitis and F. nucleatum are characteristically altered in the OPMD lesions compared to the healthy mucosa.}, year = {2019}, eissn = {1532-2807}, pages = {1023-1033}, orcid-numbers = {Decsi, Gábor Sándor/0000-0002-0264-1130; Sóki, József/0000-0001-9230-8907; Dobra, Gabriella/0000-0002-2814-7720; Harmati, Mária/0000-0002-4875-5723; Pankotai, Tibor/0000-0001-9810-5465; Braunitzer, Gábor/0000-0001-8983-5175; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Nagy, Katalin/0000-0001-9383-5952; Buzás, Krisztina/0000-0001-8933-2033} } @misc{MTMT:30676408, title = {A szájüreg daganatmegelőző elváltozásainak mikrobiológiai háttere az SZTE-FOK beteganyagának tükrében}, url = {https://m2.mtmt.hu/api/publication/30676408}, author = {Decsi, Gábor Sándor and Buzás, Krisztina}, unique-id = {30676408}, year = {2018}, orcid-numbers = {Decsi, Gábor Sándor/0000-0002-0264-1130; Buzás, Krisztina/0000-0001-8933-2033} } @CONFERENCE{MTMT:30421477, title = {Az orális mikrobiom változása szájüregi daganatmegelőző elváltozásban szenvedő betegek biopsziás mintáiban}, url = {https://m2.mtmt.hu/api/publication/30421477}, author = {Decsi, Gábor Sándor and Sóki, József and Pap, B. and Dobra, Gabriella and Harmati, Mária and Körmöndi, Sándor Pál and Pankotai, Tibor and Braunitzer, Gábor and Minárovits, János and Sonkodi, István and Zsoldiné Urbán, Edit and Németh, I.B. and Nagy, Katalin and Buzás, Krisztina}, booktitle = {Translational interactive hands-on training and conference on epithelial ion transport including two symposia: "Antibacterial and mucolytic therapy in cystic fibrosis" and "Research in oral cavity – from basic science to clinical use"}, unique-id = {30421477}, year = {2018}, pages = {58}, orcid-numbers = {Decsi, Gábor Sándor/0000-0002-0264-1130; Sóki, József/0000-0001-9230-8907; Dobra, Gabriella/0000-0002-2814-7720; Harmati, Mária/0000-0002-4875-5723; Pankotai, Tibor/0000-0001-9810-5465; Braunitzer, Gábor/0000-0001-8983-5175; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Nagy, Katalin/0000-0001-9383-5952; Buzás, Krisztina/0000-0001-8933-2033} } @article{MTMT:30396676, title = {A szegedi Fogászati és Szájsebészeti Klinikán diagnosztizált, az orofacialis régiót érintő jóindulatú daganatok és daganatszerű laesiók klinikopatológiai retrospektív epidemiológiai analízise (1960–2014)}, url = {https://m2.mtmt.hu/api/publication/30396676}, author = {Sonkodi, István and Boda, Krisztina and Decsi, Gábor Sándor and Buzás, Kristóf László and Nagy, Katalin}, doi = {10.1556/650.2018.31164}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {159}, unique-id = {30396676}, issn = {0030-6002}, year = {2018}, eissn = {1788-6120}, pages = {1516-1524}, orcid-numbers = {Boda, Krisztina/0000-0002-9937-0460; Decsi, Gábor Sándor/0000-0002-0264-1130; Nagy, Katalin/0000-0001-9383-5952} } @article{MTMT:3329787, title = {Prevalence and genotypes of human papillomavirus in saliva and tumor samples of head and neck cancer patients in Hungary}, url = {https://m2.mtmt.hu/api/publication/3329787}, author = {Hettmann, Andrea and Nagy-Demcsák, Anett and Bach, Ádám and Decsi, Gábor Sándor and Dencs, Ágnes and Pálinkó, Dóra and Rovó, László and Terhes, Gabriella and Zsoldiné Urbán, Edit and Buzás, Krisztina and Nagy, Katalin and Takács, Mária and Minárovits, János}, doi = {10.1016/j.meegid.2018.01.030}, journal-iso = {INFECT GENET EVOL}, journal = {INFECTION GENETICS AND EVOLUTION}, volume = {59}, unique-id = {3329787}, issn = {1567-1348}, abstract = {Abstract In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hungary, data regarding HPV prevalence in HNSCCs is scarce. We collected biopsy and saliva samples from patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) and tested them for the presence of HPV using the PCR consensus primer set MY09/11 and the GP5+/6+ primer pair. HPV genotypes were assessed by sequencing of the amplified PCR fragments. Oral mucosa and saliva samples from tumor- and OPMD-free individuals were also analysed. HPV was detected in 11 out of 60 HNSCC samples (18%). All of the HPV positive tumors carried HPV type 16. 5 out of the 57 saliva samples collected from HNSCC patients was HPV positive (8.8%); among them, in addition to HPV16, HPV13 was also detected. Tumors located to the oropharynx had the highest HPV positivity rate with 50% (7 out of 14), which was significantly higher than the HPV prevalence in oral mucosa samples collected from controls (0 out of 20; p > 0.001) or in OPMD biopsies (0 out of 21, p > 0.001). 2 out of 57 control saliva samples (3.5%, subtype HPV13 and 11) and 3 out of 39 saliva samples from OPMD patients (7.7%, subtype HPV18, 81 and 10) were HPV positive. Our data suggested that HPV16 infection may contribute, in concert with cigarette smoking, to the development of a subset of head and neck cancers in Hungary. HPV16 infection per se does not account, however, for the high HNSCC incidence rate recorded in this country.}, keywords = {saliva; cigarette smoking; Head and neck cancer; human papillomavirus; Oral potentially malignant disorder}, year = {2018}, eissn = {1567-7257}, pages = {99-106}, orcid-numbers = {Bach, Ádám/0000-0001-9265-1043; Decsi, Gábor Sándor/0000-0002-0264-1130; Rovó, László/0000-0003-1782-1756; Terhes, Gabriella/0000-0002-7301-9672; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Buzás, Krisztina/0000-0001-8933-2033; Nagy, Katalin/0000-0001-9383-5952} } @article{MTMT:3288416, title = {Prevalence of human papillomavirus (HPV) and torque teno virus (TTV) in saliva and tumor biopsy samples of head and neck cancer patients in Hungary}, url = {https://m2.mtmt.hu/api/publication/3288416}, author = {Hettmann, Andrea and Nagy-Demcsák, Anett and Bach, Ádám and Decsi, Gábor Sándor and Dencs, Ágnes and Pálinkó, Dóra and Rovó, László and Terhes, Gabriella and Zsoldiné Urbán, Edit and Nagy, Katalin and Takács, Mária and Minárovits, János}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3288416}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {127-127}, orcid-numbers = {Bach, Ádám/0000-0001-9265-1043; Decsi, Gábor Sándor/0000-0002-0264-1130; Rovó, László/0000-0003-1782-1756; Terhes, Gabriella/0000-0002-7301-9672; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Nagy, Katalin/0000-0001-9383-5952} } @article{MTMT:3170295, title = {Gold nanoparticle-filled biodegradable photopolymer scaffolds induced muscle remodeling: in vitro and in vivo findings}, url = {https://m2.mtmt.hu/api/publication/3170295}, author = {Zsedényi, Ádám Kornél and Farkas, B and Abdelrasoul, GN and Romano, I and Gyukity-Sebestyén, Edina and Nagy, Katalin and Harmati, Mária and Dobra, Gabriella and Körmöndi, Sándor Pál and Decsi, Gábor Sándor and Németh, István Balázs and Diaspro, A and Brandi, F and Beke, S and Buzás, Krisztina}, doi = {10.1016/j.msec.2016.11.124}, journal-iso = {MAT SCI ENG C-MATER}, journal = {MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS}, volume = {72}, unique-id = {3170295}, issn = {0928-4931}, abstract = {Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes. With the help of mask-projection excimer laser stereolithography, 3D hybrid nanoscaffolds were fabricated from biodegradable, photocurable PPF:DEF resin with incorporated gold nanoparticles (Au NPs). The scaffolds were tested in vitro and in vivo in order to find out about their biocompatibility and fitness for our purposes. In vitro, macrophages and mouse autologous adipose stem cells (ASCs) were seeded over the hybrid scaffolds and non-hybrid (with Au NPs) scaffolds for 4 days. The hybrid nanocomposite greater stem cell dispension and stem cell adhesion than PPF scaffolds without Au NPs, but such a difference was not seen in the case of macrophages. In vivo, stem cells, scaffoldings and scaffoldings covered in stem cells were transplanted under the back skin of mice. After 14 days, blood samples were taken and the affected skin area was excised. Cytokine and chemokine profiling did not indicate elevated immunomediators in the sera of experimental animals. Interestingly, the autologous-stem-cell-seeded hybrid nanocomposite scaffold induced muscle tissue regeneration after experimental wound generation in vivo. We could not observe such stem cell-induced tissue regeneration when no scaffolding was used. We conclude that PPF:DEF resin nanoscaffolds with incorporated gold nanoparticles offer a safe and efficient alternative for the enhancement of local tissue remodeling. The results also support the idea that adipose derived stem cells are an optimal cell type for the purposes of regenerative musculoskeletal tissue engineering. © 2016}, keywords = {TISSUE; CELLS; MACROPHAGES; MUSCLE; NANOCOMPOSITES; Stem Cells; stem cell transplantation; Tissue regeneration; Cell Adhesion; Cytology; NANOPARTICLES; GOLD; MAMMALS; Tissue Engineering; biocompatibility; Resins; GOLD NANOPARTICLES; Biodegradable polymers; Gold Alloys; Fiber optic sensors; Excimer lasers; hybrid nanocomposites; Metal Nanoparticles; Scaffolds (biology); Experimental animals; Adipose derived stem cells; Biodegradable photopolymers; Cell engineering; Tissue replacement; Adipose stem cells}, year = {2017}, eissn = {1873-0191}, pages = {625-630}, orcid-numbers = {Gyukity-Sebestyén, Edina/0000-0003-1383-6301; Nagy, Katalin/0000-0001-9383-5952; Harmati, Mária/0000-0002-4875-5723; Dobra, Gabriella/0000-0002-2814-7720; Decsi, Gábor Sándor/0000-0002-0264-1130; Buzás, Krisztina/0000-0001-8933-2033} }