TY - JOUR AU - Hangyási, Dávid Botond AU - Körtvélyessy, Győző AU - Blaskovic, Marko AU - Rider, Patrick AU - Rogge, Svenja AU - Siber, Stjepan AU - Kacarevic, Zeljka Peric AU - Candrlic, Marija TI - Regeneration of Intrabony Defects Using a Novel Magnesium Membrane JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 59 PY - 2023 IS - 11 PG - 10 SN - 1010-660X DO - 10.3390/medicina59112018 UR - https://m2.mtmt.hu/api/publication/34476284 ID - 34476284 N1 - Department of Periodontology, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Department of Oral Surgery, Faculty of Dental Medicine Rijeka, University of Rijeka, Krešimirova 40/42, Rijeka, 51 000, Croatia Botiss Biomaterials GmbH, Zossen, 15806, Germany Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, Osijek, 31 000, Croatia Department of Anatomy, Histology, Embryology, Pathologic Anatomy and Pathologic Histology, J.J. Strossmayer University of Osijek, Crkvena 21, Osijek, 31 000, Croatia Export Date: 12 January 2024 Correspondence Address: Kačarević, Ž.P.; Botiss Biomaterials GmbHGermany Correspondence Address: Čandrlić, M.; Department of Dental Medicine, Crkvena 21, Croatia; email: siberstjepan@yahoo.com Chemicals/CAS: magnesium, 7439-95-4; Magnesium; Membranes, Artificial AB - Background and Objectives: Due to their specific morphology, the regeneration of intrabony defects (IBDs) represents one of the greatest challenges for clinicians. Based on the specific properties of a magnesium membrane, a new approach for the surgical treatment of IBD was developed. The surgical procedure was described using a series of three cases. Materials and Methods: The patients were healthy individuals suffering from a severe form of periodontitis associated with IBD. Based on radiographic examination, the patients had interproximal bone loss of at least 4 mm. Due to its good mechanical properties, it was easy to cut and shape the magnesium membrane into three different shapes to treat the specific morphology of each IBD. In accordance with the principles of guided bone regeneration, a bovine xenograft was used to fill the IBD in all cases. Results: After a healing period of 4 to 6 months, successful bone regeneration was confirmed using radiological analysis. The periodontal probing depth (PPD) after healing showed a reduction of 1.66 +/- 0.29 mm. Conclusions: Overall, the use of the different shapes of the magnesium membrane in the treatment of IBD resulted in a satisfactory functional and esthetic outcome. LA - English DB - MTMT ER - TY - JOUR AU - Blašković, M. AU - Blašković, D. AU - Hangyási, Dávid Botond AU - Peloza, O.C. AU - Tomas, M. AU - Čandrlić, M. AU - Rider, P. AU - Mang, B. AU - Kačarević, Ž.P. AU - Trajkovski, B. TI - Evaluation between Biodegradable Magnesium Metal GBR Membrane and Bovine Graft with or without Hyaluronate JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 13 PY - 2023 IS - 8 PG - 13 SN - 2077-0375 DO - 10.3390/membranes13080691 UR - https://m2.mtmt.hu/api/publication/34124966 ID - 34124966 N1 - Department of Oral Surgery, Faculty of Dental Medicine Rijeka, University of Rijeka, Krešimirova 40/42, Rijeka, 51000, Croatia Dental Clinic Dr. Blašković, Linićeva ulica 16, Rijeka, 51000, Croatia Department of Periodontology, Semmelweis University, Budapest, 1052, Hungary Department of Anatomy, Faculty of Medicine, University of Rijeka, Braće Branchetta 20/1, Rijeka, 51000, Croatia Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Crkvena 21, Osijek, 31000, Croatia Botiss Biomaterials, Ullsteinstrasse 108, Berlin, 12109, Germany Department of Anatomy, Embriology, Pathology and Pathohistology, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Crkvena 21, Osijek, 31000, Croatia Faculty of Dentistry, Kuwait University, Safat, 13110, Kuwait Export Date: 22 September 2023 Correspondence Address: Kačarević, Ž.P.; Department of Anatomy, Crkvena 21, Croatia Correspondence Address: Trajkovski, B.; Faculty of Dentistry, Kuwait; email: biobranko@gmail.com AB - Bone substitutes and barrier membranes are widely used in dental regeneration procedures. New materials are constantly being developed to provide the most optimal surgical outcomes. One of these developments is the addition of hyaluronate (HA) to the bovine bone graft, which has beneficial wound healing and handling properties. However, an acidic environment that is potentially produced by the HA is known to increase the degradation of magnesium metal. The aim of this study was to evaluate the potential risk for the addition of HA to the bovine bone graft on the degradation rate and hence the efficacy of a new biodegradable magnesium metal GBR membrane. pH and conductivity measurements were made in vitro for samples placed in phosphate-buffered solutions. These in vitro tests showed that the combination of the bovine graft with HA resulted in an alkaline environment for the concentrations that were used. The combination was also tested in a clinical setting. The use of the magnesium metal membrane in combination with the tested grafting materials achieved successful treatment in these patients and no adverse effects were observed in vivo for regenerative treatments with or without HA. Magnesium based biodegradable GBR membranes can be safely used in combination with bovine graft with or without hyaluronate. © 2023 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Blašković, M. AU - Butorac, Prpić I. AU - Blašković, D. AU - Rider, P. AU - Tomas, M. AU - Čandrlić, S. AU - Hangyási, Dávid Botond AU - Čandrlić, M. AU - Perić, Kačarević Ž. TI - Guided Bone Regeneration Using a Novel Magnesium Membrane: A Literature Review and a Report of Two Cases in Humans JF - JOURNAL OF FUNCTIONAL BIOMATERIALS J2 - J FUNCT BIOMATER VL - 14 PY - 2023 IS - 6 PG - 18 SN - 2079-4983 DO - 10.3390/jfb14060307 UR - https://m2.mtmt.hu/api/publication/34067364 ID - 34067364 N1 - Department of Oral Surgery, Faculty of Dental Medicine Rijeka, University of Rijeka, Krešimirova 40/42, Rijeka, 51 000, Croatia Dental Clinic Blašković, Linićeva ulica 16, Rijeka, 51 000, Croatia Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, Strossmayer University of Osijek, Crkvena 21, J.J, Osijek, 31 000, Croatia Botiss Biomaterials GmbH, Zossen, 15806, Germany Department of Interdisciplinary Areas, Faculty of Dental Medicine and Health Osijek, Strossmayer University of Osijek, Crkvena 21, J.J, Osijek, 31 000, Croatia Department of Periodontology, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Department of Anatomy, Histology, Embriology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, Osijek, 31 000, Croatia Export Date: 18 July 2023 Correspondence Address: Čandrlić, M.; Department of Dental Medicine, Crkvena 21, J.J, Croatia Correspondence Address: Perić Kačarević, Ž.; Botiss Biomaterials GmbHGermany LA - English DB - MTMT ER - TY - JOUR AU - Körtvélyessy, Győző AU - Hangyási, Dávid Botond AU - Tarjányi, Tamás AU - Tóth, Zsolt AU - Matusovits, Danica AU - Pelsőczi-Kovács, István AU - Baráth, Zoltán Lajos TI - Static and dynamic compression load tests of conically connected, screw fixed dental abutment – implant assemblies JF - ANALECTA TECHNICA SZEGEDINENSIA J2 - REV FAC ENG ANALECTA TECH SZEGED VL - 17 PY - 2023 IS - 3 SP - 1 EP - 12 PG - 12 SN - 1788-6392 DO - 10.14232/analecta.2023.3.1-12 UR - https://m2.mtmt.hu/api/publication/34028905 ID - 34028905 N1 - Nem állapítható meg egyértelműen a levelező szerzőség.(SE, SZTE admin5, 2023.06.30.) LA - English DB - MTMT ER - TY - JOUR AU - Körtvélyessy, Győző AU - Szabó, Árpád László AU - Pelsőczi-Kovács, István AU - Tarjányi, Tamás AU - Tóth, Zsolt AU - Kárpáti, Krisztina AU - Matusovits, Danica AU - Hangyási, Dávid Botond AU - Baráth, Zoltán Lajos TI - Different Conical Angle Connection of Implant and Abutment Behavior: A Static and Dynamic Load Test and Finite Element Analysis Study JF - MATERIALS J2 - MATERIALS VL - 16 PY - 2023 IS - 5 PG - 19 SN - 1996-1944 DO - 10.3390/ma16051988 UR - https://m2.mtmt.hu/api/publication/33680532 ID - 33680532 N1 - Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Department of Prosthodontics, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Department of Medical Physics and Informatics, Albert Szent-Györgyi Medical School, Faculty of Science and Informatics, University of Szeged, Korányi fasor 9, Szeged, H-6720, Hungary Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Department of Periodontology, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66, Szeged, H-6720, Hungary Export Date: 9 May 2023 Correspondence Address: Baráth, Z.; Department of Prosthodontics, Tisza Lajos krt. 64-66, Hungary; email: barath.zoltan@stoma.szote.u-szeged.hu Funding details: Szegedi Tudományegyetem, SZTE Funding text 1: The authors are thankful for the support of Botond Veres, and the Study Group for Dental Research Methodology and Health Sciences, University of Szeged. AB - Dental implants are artificial dental roots anchoring prosthetic restorations to replace natural teeth. Dental implant systems may have different tapered conical connections. Our research focused on the mechanical examination of implant–superstructure connections. Thirty-five samples with 5 different cone angles (24°, 35°, 55°, 75°, and 90°) were tested for static and dynamic loads, carried out by a mechanical fatigue testing machine. Fixing screws were fixed with a torque of 35 Ncm before measurements. For static loading, samples were loaded with a force of 500 N in 20 s. For dynamic loading, the samples were loaded for 15,000 cycles with a force of 250 ± 150 N. In both cases, the compression resulting from load and reverse torque was examined. At the highest compression load of the static tests, a significant difference (p = 0.021) was found for each cone angle group. Following dynamic loading, significant differences (p < 0.001) for the reverse torques of the fixing screw were also shown. Static and dynamic results showed a similar trend: under the same loading conditions, changing the cone angle—which determines the relationship between the implant and the abutment—had led to significant differences in the loosening of the fixing screw. In conclusion, the greater the angle of the implant–superstructure connection, the smaller the screw loosening due to loading, which may have considerable effects on the long-term, safe operation of the dental prosthesis. LA - English DB - MTMT ER - TY - JOUR AU - Rider, P. AU - Kačarević, Ž.P. AU - Elad, A. AU - Rothamel, D. AU - Sauer, G. AU - Bornert, F. AU - Windisch, Péter AU - Hangyási, Dávid Botond AU - Molnár, Bálint AU - Hesse, B. AU - Assad, M. AU - Witte, F. TI - Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs JF - MATERIALS J2 - MATERIALS VL - 15 PY - 2022 IS - 12 PG - 11 SN - 1996-1944 DO - 10.3390/ma15124111 UR - https://m2.mtmt.hu/api/publication/32995603 ID - 32995603 N1 - Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité–Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, Berlin, 14197, Germany Botiss Biomaterials AG, Ullsteinstrasse 108, Berlin, 12109, Germany Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, Osijek, 31000, Croatia CMF Surgery, Johannes BLA Hospital, Mönchengladbach, 41239, Germany Faculté de Chirurgie Dentaire de Strasbourg, Université de Strasbourg, 8 Rue Sainte-Elisabeth, Strasbourg, 67000, France Department of Periodontology, Semmelweis University, Budapest, 1769, Hungary Xploraytion GmbH, Bismarkstrasse 11, Berlin, 10625, Germany Medical Device Preclinical Services, Charles River Laboratories, 1635 Lionel-Bertrand Blvd., Boisbriand, QC J7H 1N8, Canada Cited By :1 Export Date: 19 July 2022 Correspondence Address: Witte, F.; Department of Prosthodontics, Aßmannshauser Straße 4–6, Germany; email: frank.witte@charite.de LA - English DB - MTMT ER - TY - JOUR AU - Rider, P. AU - Kačarević, Ž.P. AU - Elad, A. AU - Rothamel, D. AU - Sauer, G. AU - Bornert, F. AU - Windisch, Péter AU - Hangyási, Dávid Botond AU - Molnár, Bálint AU - Hesse, B. AU - Witte, F. TI - Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs JF - MATERIALS J2 - MATERIALS VL - 15 PY - 2022 IS - 9 PG - 16 SN - 1996-1944 DO - 10.3390/ma15093106 UR - https://m2.mtmt.hu/api/publication/32827927 ID - 32827927 N1 - Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité—Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, Berlin, 14197, Germany Botiss Biomaterials AG, Ullsteinstrasse 108, Berlin, 12109, Germany Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, Osijek, 31000, Croatia CMF Surgery, Johannes BLA Hospital, Mönchengladbach, 41239, Germany Faculté de Chirurgie Dentaire de Strasbourg, Université de Strasbourg, 8 rue Sainte-Elisabeth, Strasbourg, 67000, France Department of Periodontology, Semmelweis University, Budapest, 1769, Hungary Xploraytion GmbH, Bismarkstrasse 11, Berlin, 10625, Germany Export Date: 22 January 2023 Correspondence Address: Witte, F.; Department of Prosthodontics, Aßmannshauser Straße 4–6, Germany; email: frank.witte@charite.de LA - English DB - MTMT ER - TY - JOUR AU - Rider, Patrick AU - Kačarević, Željka Perić AU - Elad, Akiva AU - Tadic, Drazen AU - Rothamel, Daniel AU - Sauer, Gerrit AU - Bornert, Fabien AU - Windisch, Péter AU - Hangyási, Dávid Botond AU - Molnár, Bálint AU - Bortel, Emely AU - Hesse, Bernhard AU - Witte, Frank TI - Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery JF - BIOACTIVE MATERIALS J2 - BIOACT MATER VL - 14 PY - 2022 SP - 152 EP - 168 PG - 17 SN - 2452-199X DO - 10.1016/j.bioactmat.2021.11.018 UR - https://m2.mtmt.hu/api/publication/32529185 ID - 32529185 AB - Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. LA - English DB - MTMT ER - TY - JOUR AU - Kačarević, Željka Perić AU - Rider, Patrick AU - Elad, Akiva AU - Tadic, Drazen AU - Rothamel, Daniel AU - Sauer, Gerrit AU - Bornert, Fabien AU - Windisch, Péter AU - Hangyási, Dávid Botond AU - Molnár, Bálint AU - Kämmerer, Till AU - Hesse, Bernhard AU - Bortel, Emely AU - Bartosch, Marco AU - Witte, Frank TI - Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration JF - BIOACTIVE MATERIALS J2 - BIOACT MATER VL - 14 PY - 2022 SP - 15 EP - 30 PG - 16 SN - 2452-199X DO - 10.1016/j.bioactmat.2021.10.036 UR - https://m2.mtmt.hu/api/publication/32529182 ID - 32529182 AB - An ideal fixation system for guided bone (GBR) regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation, complete resorption when no longer needed, complete replacement by bone, as well as be biocompatible and have a good clinical manageability. For the first time, a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these criteria. Adequate mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable device. Results demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of degradation. Biocompatibility of the magnesium fixation screw was demonstrated in several in vitro and in vivo tests. Degradation of the magnesium screw was investigated in in vitro and in vivo tests, where it was found that the screw is resorbed slowly and completely after 52 weeks, providing adequate fixation in the early critical healing phase. Overall, the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration (GBR) surgeries. LA - English DB - MTMT ER - TY - GEN AU - Hangyási, Dávid Botond AU - Körtvélyessy, Győző TI - Galaxis Periimplanticum Útikalauz Fogorvosoknak, avagy “A Szelíd és az Agresszív” - eredmények és gyakorlati tapasztalatok PY - 2021 UR - https://m2.mtmt.hu/api/publication/32605280 ID - 32605280 LA - Hungarian DB - MTMT ER -