@article{MTMT:34718775,
	title = {Finding Maximum Tolerated Dose in Phase I Oncology Clinical Trials with Bayesian Methods},
	url = {https://m2.mtmt.hu/api/publication/34718775},
	author = {Sápi, Johanna},
	journal-iso = {ACTA POLYTECH HUNG},
	journal = {ACTA POLYTECHNICA HUNGARICA},
	volume = {21},
	unique-id = {34718775},
	issn = {1785-8860},
	year = {2024},
	eissn = {1785-8860},
	pages = {129-145}
}

@article{MTMT:32127306,
	title = {Nodular fasciitis: a comprehensive, time-correlated investigation of 17 cases},
	url = {https://m2.mtmt.hu/api/publication/32127306},
	author = {Sápi, Zoltán and Lippai, Zoltán and Papp, Gergő and Hegyi, Lajos and Sápi, Johanna and Dezső, Katalin and Szuhai, Károly},
	doi = {10.1038/s41379-021-00883-x},
	journal-iso = {MODERN PATHOL},
	journal = {MODERN PATHOLOGY},
	volume = {34},
	unique-id = {32127306},
	issn = {0893-3952},
	year = {2021},
	eissn = {1530-0285},
	pages = {2192-2199},
	orcid-numbers = {Lippai, Zoltán/0000-0001-9064-2493; Papp, Gergő/0000-0001-5840-2369; Dezső, Katalin/0000-0002-4856-0483; Szuhai, Károly/0000-0002-1228-4245}
}

@article{MTMT:31546506,
	title = {H∞ control of nonlinear systems with positive input with application to antiangiogenic therapy},
	url = {https://m2.mtmt.hu/api/publication/31546506},
	author = {Drexler, Dániel András and Sápi, Johanna and Kovács, Levente},
	doi = {10.1016/j.ifacol.2018.11.096},
	journal-iso = {IFACOL},
	journal = {IFAC PAPERSONLINE},
	volume = {51},
	unique-id = {31546506},
	issn = {2405-8971},
	abstract = {There are many systems in practice that can have only positive (nonnegative) input, typical examples for such systems are physiological systems. Moreover, the parameters of these systems are usually not known exactly or may vary over time, thus application of robust controllers represents a reasonable possibility. Most model-based controller design methods are developed for systems that can (or must) have negative and positive inputs as well, thus a dynamical extension is given here to the original system that ensures that the input of the original system is positive but the extended system can have negative input as well. The current paper investigates a robust control design method with positive input for an automatic therapy possibility in the case of antiangiogenic targeted molecular therapy using a recently published tumor growth model based on mice experiments. The extended system is transformed into an integrator series that is further modified using state-feedback to prepare the system for H-infinity norm-based controller synthesis. The simulations demonstrate the robustness of the controller and the positivity of the input. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.},
	keywords = {Robust control; output feedback control; Positive systems; Decision support and control; Biomedical system modeling and simulation},
	year = {2018},
	eissn = {2405-8963},
	pages = {146-151},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:27606372,
	title = {Optimal PID Based Computed Torque Control of Tumor Growth Models},
	url = {https://m2.mtmt.hu/api/publication/27606372},
	author = {Czakó, Bence Géza and Sápi, Johanna and Kovács, Levente},
	doi = {10.1016/j.ifacol.2018.06.109},
	journal-iso = {IFACOL},
	journal = {IFAC PAPERSONLINE},
	volume = {51},
	unique-id = {27606372},
	issn = {2405-8971},
	year = {2018},
	eissn = {2405-8963},
	pages = {900-905},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:3407974,
	title = {The oncomir face of microRNA-206: A permanent miR-206 transfection study.},
	url = {https://m2.mtmt.hu/api/publication/3407974},
	author = {Mihály, Dóra and Papp, Gergő and Mervai, Zsolt and Reszegi, Andrea and Tátrai, Péter and Szalóki, Gábor and Sápi, Johanna and Sápi, Zoltán},
	doi = {10.1177/1535370218795406},
	journal-iso = {EXP BIOL MED},
	journal = {EXPERIMENTAL BIOLOGY AND MEDICINE},
	volume = {243},
	unique-id = {3407974},
	issn = {1535-3702},
	abstract = {MiR-206 is a remarkable miRNA because it functions as a suppressor miRNA in rhabdomyosarcoma while at the same time, as previously showed, it can act as an oncomiRNA in SMARCB1 immunonegative soft tissue sarcomas. The aim of this study was to investigate the effect of miR-206 on its several target genes in various human tumorous and normal cell lines. In the current work, we created miR-206-overexpressing cell lines (HT-1080, Caco2, iASC, and SS-iASC) using permanent transfection. mRNA expression of the target genes of miR-206 (SMARCB1, ACTL6A, CCND1, POLA1, NOTCH3, MET, and G6PD) and SMARCB1 protein expression were examined with quantitative real-time polymerase chain reaction, immunoblotting, immunocytochemistry, and flow cytometry. MiRNA inhibition was used to validate our results. We found a diverse silencing effect of miR-206 on its target genes. While an overall tendency of downregulation was noted, expression profiles of individual cell lines showed large variability. Only CCND1 and MET were consistently downregulated. MiR-206 had an antiproliferative effect on a normal human fibroblast cell line. A strong silencing effect of SMARCB1 in miR-206 transfected SS-iASC was most likely caused by the synergic influence of the SS18-SSX1 fusion protein and miR-206. In the same cell line, a moderate decrease of SMARCB1 protein expression could be observed with immunocytochemistry and flow cytometry. In the most comprehensive analysis of miR-206 effects so far, a modest but significant downregulation of miR-206 targets on the mRNA level was confirmed across all cell lines. However, the variability of the effect shows that the action of this miRNA is largely cell context-dependent. Our results also support the conception that the oncomiR effect of miR-206 on SMARCB1 plays an important but not exclusive role in SMARCB1 immunonegative soft tissue sarcomas so it can be considered important in planning the targeted therapy of these tumors in the future. Impact statement Mir-206 is a very unique microRNA because it can act as a suppressor miRNA or as an oncomiRNA depending on the tumor tissue. In SMARCB1 negative soft tissue sarcomas miR-206 is overexpressed, so thus in epithelioid and synovial sarcomas it functions as an oncomiRNA. MiR-206 has diverse silencing effects on its target genes. We found that the action of miR-206 is largely cell context dependent. The oncomiR role of miR-206 is crucial but not exclusive in SMARCB1 negative soft tissue sarcomas and miR-206 has an antiproliferative effect on a normal human fibroblast cell line. Expressions of miR-206 targets observed in tumors can only be reproduced in the corresponding tumorous cell lines. This is the first study which examined the permanent effect of miR-206 on its target genes in normal, tumor, and genetically engineered cell lines.},
	year = {2018},
	eissn = {1535-3699},
	pages = {1014-1023},
	orcid-numbers = {Mihály, Dóra/0000-0003-3690-7723; Papp, Gergő/0000-0001-5840-2369; Reszegi, Andrea/0000-0001-6902-7883; Tátrai, Péter/0000-0001-9726-1992}
}

@inproceedings{MTMT:3407348,
	title = {Model-based simulation and comparison of open-loop and closed-loop combined therapies for tumor treatment},
	url = {https://m2.mtmt.hu/api/publication/3407348},
	author = {Csercsik, Dávid and Sápi, Johanna and Kovács, Levente},
	booktitle = {Proceedings of the 2018 IEEE Conference on Control Technology and Applications},
	doi = {10.1109/CCTA.2018.8511526},
	unique-id = {3407348},
	abstract = {Targeted molecular therapies opened new ways and increased the efficiency of cancer therapies. Antiangiogenic therapy focuses against the growth of tumor by blocking the blood vessel formation of it. Its control engineering perspective has been presented several times, but its key point represents modeling the tumor growth. The purpose of our research is to go beyond the already published minimalistic approach and set up a bi-compartmental (vasculature-dependent tumor growth and angiogenesis) model. The aim of the current paper is to extend our recently published dynamical bicompartmetal model to include the effect of not only for antiangiogenic, but also cytotoxic drugs as well as input. We compare the effect of the two different inputs on the model dynamics in the context of final tumor volume, which can be used as a measure of therapy effectiveness. According to the model prediction, the combination of drugs is more efficient compared to either monotherapy. Furthermore, we compare an optimized open-loop protocol with a very simple intuitive feedback therapy solution.},
	year = {2018},
	pages = {1383-1388},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}

@inproceedings{MTMT:3320070,
	title = {Bi-compartmental modelling of tumor and supporting vasculature growth dynamics for cancer treatment optimization purpose},
	url = {https://m2.mtmt.hu/api/publication/3320070},
	author = {Csercsik, Dávid and Sápi, Johanna and Tamás, Gönczy and Kovács, Levente},
	booktitle = {2017 IEEE 56th Annual Conference on Decision and Control, CDC 2017},
	doi = {10.1109/CDC.2017.8264353},
	unique-id = {3320070},
	year = {2018},
	pages = {4698-4702},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:27348698,
	title = {Optimal discrete time control of antiangiogenic tumor therapy},
	url = {https://m2.mtmt.hu/api/publication/27348698},
	author = {Drexler, Dániel András and Sápi, Johanna and Kovács, Levente},
	doi = {10.1016/j.ifacol.2017.08.2337},
	journal-iso = {IFACOL},
	journal = {IFAC PAPERSONLINE},
	volume = {50},
	unique-id = {27348698},
	issn = {2405-8971},
	year = {2017},
	eissn = {2405-8963},
	pages = {13504-13509},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:3309515,
	title = {Modeling of Tumor Growth Incorporating the Effects of Necrosis and the Effect of Bevacizumab},
	url = {https://m2.mtmt.hu/api/publication/3309515},
	author = {Drexler, Dániel András and Sápi, Johanna and Kovács, Levente},
	doi = {10.1155/2017/5985031},
	journal-iso = {COMPLEXITY},
	journal = {COMPLEXITY},
	volume = {2017},
	unique-id = {3309515},
	issn = {1076-2787},
	year = {2017},
	eissn = {1099-0526},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:3307426,
	title = {A bicompartmental dynamic tumor growth model},
	url = {https://m2.mtmt.hu/api/publication/3307426},
	author = {Csercsik, Dávid and Sápi, Johanna and Kovács, Levente},
	doi = {10.1016/j.ifacol.2017.08.2119},
	journal-iso = {IFACOL},
	journal = {IFAC PAPERSONLINE},
	volume = {50},
	unique-id = {3307426},
	issn = {2405-8971},
	year = {2017},
	eissn = {2405-8963},
	pages = {12216-12221},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800}
}