TY - JOUR AU - Merkel, Keresztély Géza AU - Szöllősi, Dávid AU - Horváth, Ildikó AU - Jezsó, Bálint AU - Baranyai, Zsolt AU - Szigeti, Krisztián AU - Varga, Zoltán AU - Hegedüs, Imre AU - Padmanabhan, P. AU - Gulyás, B. AU - Bergmann, Ralf Konrad AU - Máthé, Domokos TI - Radiolabeling of Platelets with 99mTc-HYNIC-Duramycin for In Vivo Imaging Studies JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 23 PG - 11 SN - 1661-6596 DO - 10.3390/ijms242317119 UR - https://m2.mtmt.hu/api/publication/34443931 ID - 34443931 LA - English DB - MTMT ER - TY - JOUR AU - Ragó, Zsuzsanna AU - Tóth, Barbara AU - Szalenko-Tőkés, Ágnes AU - Bella, Zsolt AU - Dembrovszky, Fanni AU - Borbásné Farkas, Kornélia AU - Kiss, Szabolcs AU - Hegyi, Péter AU - Matuz, Mária AU - Crul-Tóth, Noémi AU - Hegedüs, Imre AU - Máthé, Domokos AU - Csupor, Dezső TI - Results of a systematic review and meta-analysis of early studies on ivermectin in SARS-CoV-2 infection. JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 45 PY - 2023 IS - 4 SP - 2179 EP - 2193 PG - 15 SN - 2509-2715 DO - 10.1007/s11357-023-00756-y UR - https://m2.mtmt.hu/api/publication/33695397 ID - 33695397 AB - Ivermectin, an antiparasitic drug, has been repurposed for COVID-19 treatment during the SARS-CoV-2 pandemic. Although its antiviral efficacy was confirmed early in vitro and in preclinical studies, its clinical efficacy remained ambiguous. Our purpose was to assess the efficacy of ivermectin in terms of time to viral clearance based on the meta-analysis of available clinical trials at the closing date of the data search period, one year after the start of the pandemic. This meta-analysis was reported by following the PRISMA guidelines and by using the PICO format for formulating the question. The study protocol was registered on PROSPERO. Embase, MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), bioRvix, and medRvix were searched for human studies of patients receiving ivermectin therapy with control groups. No language or publication status restrictions were applied. The search ended on 1/31/2021 exactly one year after WHO declared the public health emergency on novel coronavirus. The meta-analysis of three trials involving 382 patients revealed that the mean time to viral clearance was 5.74 days shorter in case of ivermectin treatment compared to the control groups [WMD = -5.74, 95% CI (-11.1, -0.39), p = 0.036]. Ivermectin has significantly reduced the time to viral clearance in mild to moderate COVID-19 diseases compared to control groups. However, more eligible studies are needed for analysis to increase the quality of evidence of ivermectin use in COVID-19. LA - English DB - MTMT ER - TY - CONF AU - Hajdrik, Polett AU - Szöllősi, Dávid AU - Hegedüs, Imre AU - Varga, Z. AU - Szigeti, Krisztián AU - Horváth, I. AU - Kovács, N. AU - Máthé, Domokos AU - Bergmann, Ralf Konrad ED - Kovács, Tibor ED - Tóth-Bodrogi, Edit ED - Bátor, Gergő ED - Réka, Nagy TI - Radiolabeling of different microorganisms using the medically relevant radioisotopes Lu-177 and Cu-64 T2 - Book of Abstracts (VIII. Terrestrial Radioisotopes in Environment International Conference on Environmental Protection) PY - 2022 SP - 1 UR - https://m2.mtmt.hu/api/publication/33266469 ID - 33266469 LA - English DB - MTMT ER - TY - GEN AU - Hegedüs, Imre AU - Pázmány, Rita AU - Voniatis, Constantinos AU - Máthé, Domokos AU - Kellermayer, Miklós AU - Jedlovszky-Hajdú, Angéla TI - Structure and nanomechanics of electrospun nanofibers PY - 2022 UR - https://m2.mtmt.hu/api/publication/33266406 ID - 33266406 LA - English DB - MTMT ER - TY - CONF AU - Hegedüs, Imre AU - Pázmány, Rita AU - Voniatis, Constantinos AU - Máthé, Domokos AU - Kellermayer, Miklós AU - Jedlovszky-Hajdú, Angéla TI - Nanomechanical characterization of single electrospun nanofibers T2 - Semmelweis symposium 2022 PY - 2022 SP - 1 UR - https://m2.mtmt.hu/api/publication/33260272 ID - 33260272 LA - English DB - MTMT ER - TY - GEN AU - Hegedüs, Imre AU - Kitti, Andreidesz AU - József, L. Szentpéteri AU - Zoltán, Kaleta AU - László, Szabó AU - Szigeti, Krisztián AU - Balázs, Gulyás AU - Parasuraman, Padmanabhan AU - Ferenc, Budan AU - Domokos, Máthé TI - Molecular Components of Grape Seeds and Grape Marc PY - 2022 UR - https://m2.mtmt.hu/api/publication/33193633 ID - 33193633 LA - English DB - MTMT ER - TY - JOUR AU - Hegedüs, Imre AU - Andreidesz, Kitti AU - Szentpéteri, József László (Joe Petersburger) AU - Kaleta, Zoltán AU - Szabó, László AU - Szigeti, Krisztián AU - Gulyás, Balázs AU - Padmanabhan, Parasuraman AU - Budán, Ferenc Csaba AU - Máthé, Domokos TI - The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 19 PG - 34 SN - 1661-6596 DO - 10.3390/ijms231911165 UR - https://m2.mtmt.hu/api/publication/33107211 ID - 33107211 N1 - * Megosztott szerzőség AB - Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or their byproducts. The molecular pathways and cellular signaling cascades involved in the effects of these polyphenol molecules are also presented in this review, which summarizes currently available in vitro and in vivo experimental literature data on their biological activities mostly in easily accessible tabular form. New molecules for different therapeutic purposes can also be synthesized based on existing polyphenol compound classes available in high quantities in grape, wine, and grape marc. Therefore an overview of these molecular structures is provided. Novel possibilities as dendrimer nanobioconjugates are reviewed, too. Currently available in vitro and in vivo experimental literature data on polyphenol biological activities are presented in easily accessible tabular form. The scope of the review details the antidiabetic, anticarcinogenic, antiviral, vasoprotective, and neuroprotective roles of grape-origin flavonoids. The novelty of the study lies in the description of the processing of agricultural by-products (grape seeds and skins) of industrial relevance, and the detailed description of the molecular mechanisms of action. In addition, the review of the clinical therapeutic applications of polyphenols is unique as no summary study has yet been done. LA - English DB - MTMT ER - TY - GEN AU - Andreidesz, Kitti AU - Szabó, László AU - Molnár, Richárd AU - Tomesz, András AU - Daragó, Richárd AU - Deutsch, Árpád AU - Varjas, Tímea AU - Ritter, Zsombor AU - Szentpéteri, József László (Joe Petersburger) AU - Máthé, Domokos AU - Hegedüs, Imre AU - Sík, Attila AU - Kiss, István AU - Budán, Ferenc Csaba TI - A transz-zsírsavak súlyosbítják a line-1 retrotanszpozon DNS hipometilációt DMBA környezeti karcinogén modellben PY - 2022 UR - https://m2.mtmt.hu/api/publication/32900564 ID - 32900564 N1 - Poszter LA - Hungarian DB - MTMT ER - TY - GEN AU - Budán, Ferenc Csaba AU - Szabó, László AU - Molnár, Richárd AU - Tomesz, András AU - Varjas, Tímea AU - Ritter, Zsombor AU - Szentpéteri, József László (Joe Petersburger) AU - Máthé, Domokos AU - Hegedüs, Imre AU - Sík, Attila AU - Kiss, István AU - Andreidesz, Kitti TI - Az extraszűz olíva olaj csökkenti a karcinogén DMBA l1-RTP DNS hipometiláló hatását PY - 2022 UR - https://m2.mtmt.hu/api/publication/32900534 ID - 32900534 N1 - Poszter LA - Hungarian DB - MTMT ER - TY - GEN AU - Hegedüs, Imre AU - Pázmány, Rita AU - Voniatis, Constantinos AU - Kellermayer, Miklós AU - Máthé, Domokos AU - Jedlovszky-Hajdú, Angéla TI - Elektrosztatikus szálképzéssel előállított polimer szálak atomerő mikroszkópos vizsgálata PY - 2022 UR - https://m2.mtmt.hu/api/publication/32900508 ID - 32900508 LA - Hungarian DB - MTMT ER -