@article{MTMT:34443931, title = {Radiolabeling of Platelets with 99mTc-HYNIC-Duramycin for In Vivo Imaging Studies}, url = {https://m2.mtmt.hu/api/publication/34443931}, author = {Merkel, Keresztély Géza and Szöllősi, Dávid and Horváth, Ildikó and Jezsó, Bálint and Baranyai, Zsolt and Szigeti, Krisztián and Varga, Zoltán and Hegedüs, Imre and Padmanabhan, P. and Gulyás, B. and Bergmann, Ralf Konrad and Máthé, Domokos}, doi = {10.3390/ijms242317119}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34443931}, issn = {1661-6596}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Szöllősi, Dávid/0000-0002-3363-3862; Jezsó, Bálint/0000-0002-1306-4797; Varga, Zoltán/0000-0002-5741-2669; Hegedüs, Imre/0000-0002-1438-3511} } @article{MTMT:33695397, title = {Results of a systematic review and meta-analysis of early studies on ivermectin in SARS-CoV-2 infection.}, url = {https://m2.mtmt.hu/api/publication/33695397}, author = {Ragó, Zsuzsanna and Tóth, Barbara and Szalenko-Tőkés, Ágnes and Bella, Zsolt and Dembrovszky, Fanni and Borbásné Farkas, Kornélia and Kiss, Szabolcs and Hegyi, Péter and Matuz, Mária and Crul-Tóth, Noémi and Hegedüs, Imre and Máthé, Domokos and Csupor, Dezső}, doi = {10.1007/s11357-023-00756-y}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {45}, unique-id = {33695397}, issn = {2509-2715}, abstract = {Ivermectin, an antiparasitic drug, has been repurposed for COVID-19 treatment during the SARS-CoV-2 pandemic. Although its antiviral efficacy was confirmed early in vitro and in preclinical studies, its clinical efficacy remained ambiguous. Our purpose was to assess the efficacy of ivermectin in terms of time to viral clearance based on the meta-analysis of available clinical trials at the closing date of the data search period, one year after the start of the pandemic. This meta-analysis was reported by following the PRISMA guidelines and by using the PICO format for formulating the question. The study protocol was registered on PROSPERO. Embase, MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), bioRvix, and medRvix were searched for human studies of patients receiving ivermectin therapy with control groups. No language or publication status restrictions were applied. The search ended on 1/31/2021 exactly one year after WHO declared the public health emergency on novel coronavirus. The meta-analysis of three trials involving 382 patients revealed that the mean time to viral clearance was 5.74 days shorter in case of ivermectin treatment compared to the control groups [WMD = -5.74, 95% CI (-11.1, -0.39), p = 0.036]. Ivermectin has significantly reduced the time to viral clearance in mild to moderate COVID-19 diseases compared to control groups. However, more eligible studies are needed for analysis to increase the quality of evidence of ivermectin use in COVID-19.}, keywords = {Meta-analysis; systematic review; ivermectin; COVID-19; SARS-CoV-2}, year = {2023}, eissn = {2509-2723}, pages = {2179-2193}, orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Dembrovszky, Fanni/0000-0001-6953-3591; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Matuz, Mária/0000-0002-7877-2399; Hegedüs, Imre/0000-0002-1438-3511; Csupor, Dezső/0000-0002-4088-3333} } @CONFERENCE{MTMT:33266469, title = {Radiolabeling of different microorganisms using the medically relevant radioisotopes Lu-177 and Cu-64}, url = {https://m2.mtmt.hu/api/publication/33266469}, author = {Hajdrik, Polett and Szöllősi, Dávid and Hegedüs, Imre and Varga, Z. and Szigeti, Krisztián and Horváth, I. and Kovács, N. and Máthé, Domokos and Bergmann, Ralf Konrad}, booktitle = {Book of Abstracts (VIII. Terrestrial Radioisotopes in Environment International Conference on Environmental Protection)}, unique-id = {33266469}, year = {2022}, pages = {1}, orcid-numbers = {Hajdrik, Polett/0000-0002-5452-4892; Szöllősi, Dávid/0000-0002-3363-3862; Hegedüs, Imre/0000-0002-1438-3511} } @misc{MTMT:33266406, title = {Structure and nanomechanics of electrospun nanofibers}, url = {https://m2.mtmt.hu/api/publication/33266406}, author = {Hegedüs, Imre and Pázmány, Rita and Voniatis, Constantinos and Máthé, Domokos and Kellermayer, Miklós and Jedlovszky-Hajdú, Angéla}, unique-id = {33266406}, year = {2022}, orcid-numbers = {Hegedüs, Imre/0000-0002-1438-3511; Kellermayer, Miklós/0000-0002-5553-6553; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X} } @CONFERENCE{MTMT:33260272, title = {Nanomechanical characterization of single electrospun nanofibers}, url = {https://m2.mtmt.hu/api/publication/33260272}, author = {Hegedüs, Imre and Pázmány, Rita and Voniatis, Constantinos and Máthé, Domokos and Kellermayer, Miklós and Jedlovszky-Hajdú, Angéla}, booktitle = {Semmelweis symposium 2022}, unique-id = {33260272}, year = {2022}, pages = {1}, orcid-numbers = {Hegedüs, Imre/0000-0002-1438-3511; Kellermayer, Miklós/0000-0002-5553-6553; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X} } @misc{MTMT:33193633, title = {Molecular Components of Grape Seeds and Grape Marc}, url = {https://m2.mtmt.hu/api/publication/33193633}, author = {Hegedüs, Imre and Kitti, Andreidesz and József, L. Szentpéteri and Zoltán, Kaleta and László, Szabó and Szigeti, Krisztián and Balázs, Gulyás and Parasuraman, Padmanabhan and Ferenc, Budan and Domokos, Máthé}, unique-id = {33193633}, year = {2022}, orcid-numbers = {Hegedüs, Imre/0000-0002-1438-3511} } @article{MTMT:33107211, title = {The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc}, url = {https://m2.mtmt.hu/api/publication/33107211}, author = {Hegedüs, Imre and Andreidesz, Kitti and Szentpéteri, József László (Joe Petersburger) and Kaleta, Zoltán and Szabó, László and Szigeti, Krisztián and Gulyás, Balázs and Padmanabhan, Parasuraman and Budán, Ferenc Csaba and Máthé, Domokos}, doi = {10.3390/ijms231911165}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33107211}, issn = {1661-6596}, abstract = {Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or their byproducts. The molecular pathways and cellular signaling cascades involved in the effects of these polyphenol molecules are also presented in this review, which summarizes currently available in vitro and in vivo experimental literature data on their biological activities mostly in easily accessible tabular form. New molecules for different therapeutic purposes can also be synthesized based on existing polyphenol compound classes available in high quantities in grape, wine, and grape marc. Therefore an overview of these molecular structures is provided. Novel possibilities as dendrimer nanobioconjugates are reviewed, too. Currently available in vitro and in vivo experimental literature data on polyphenol biological activities are presented in easily accessible tabular form. The scope of the review details the antidiabetic, anticarcinogenic, antiviral, vasoprotective, and neuroprotective roles of grape-origin flavonoids. The novelty of the study lies in the description of the processing of agricultural by-products (grape seeds and skins) of industrial relevance, and the detailed description of the molecular mechanisms of action. In addition, the review of the clinical therapeutic applications of polyphenols is unique as no summary study has yet been done.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Hegedüs, Imre/0000-0002-1438-3511; Kaleta, Zoltán/0000-0003-2350-5100} } @misc{MTMT:32900564, title = {A transz-zsírsavak súlyosbítják a line-1 retrotanszpozon DNS hipometilációt DMBA környezeti karcinogén modellben}, url = {https://m2.mtmt.hu/api/publication/32900564}, author = {Andreidesz, Kitti and Szabó, László and Molnár, Richárd and Tomesz, András and Daragó, Richárd and Deutsch, Árpád and Varjas, Tímea and Ritter, Zsombor and Szentpéteri, József László (Joe Petersburger) and Máthé, Domokos and Hegedüs, Imre and Sík, Attila and Kiss, István and Budán, Ferenc Csaba}, unique-id = {32900564}, year = {2022}, orcid-numbers = {Varjas, Tímea/0000-0002-4950-0669; Hegedüs, Imre/0000-0002-1438-3511} } @misc{MTMT:32900534, title = {Az extraszűz olíva olaj csökkenti a karcinogén DMBA l1-RTP DNS hipometiláló hatását}, url = {https://m2.mtmt.hu/api/publication/32900534}, author = {Budán, Ferenc Csaba and Szabó, László and Molnár, Richárd and Tomesz, András and Varjas, Tímea and Ritter, Zsombor and Szentpéteri, József László (Joe Petersburger) and Máthé, Domokos and Hegedüs, Imre and Sík, Attila and Kiss, István and Andreidesz, Kitti}, unique-id = {32900534}, year = {2022}, orcid-numbers = {Varjas, Tímea/0000-0002-4950-0669; Hegedüs, Imre/0000-0002-1438-3511} } @misc{MTMT:32900508, title = {Elektrosztatikus szálképzéssel előállított polimer szálak atomerő mikroszkópos vizsgálata}, url = {https://m2.mtmt.hu/api/publication/32900508}, author = {Hegedüs, Imre and Pázmány, Rita and Voniatis, Constantinos and Kellermayer, Miklós and Máthé, Domokos and Jedlovszky-Hajdú, Angéla}, unique-id = {32900508}, year = {2022}, orcid-numbers = {Hegedüs, Imre/0000-0002-1438-3511; Kellermayer, Miklós/0000-0002-5553-6553; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X} }