TY  - JOUR
AU  - Torma, Ferenc Gergely
AU  - Kerepesi, Csaba
AU  - Jókai, Mátyás
AU  - Bábszky, Gergely
AU  - Koltai, Erika
AU  - Ligeti, Balázs
AU  - Kalcsevszki, Regina
AU  - McGreevy, Kristen M.
AU  - Horvath, Steve
AU  - Radák, Zsolt
TI  - Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness
JF  - AGING CELL
J2  - AGING CELL
VL  - 23
PY  - 2024
IS  - 4
PG  - 12
SN  - 1474-9718
DO  - 10.1111/acel.14101
UR  - https://m2.mtmt.hu/api/publication/34693196
ID  - 34693196
N1  - Funding Agency and Grant Number: European Union; National Research, Development and Innovation Office, Hungary; National Excellence Program [126823]; National Science and Research Found [OTKA142192, TKP2021-EGA-37]; Hungarian University Sport Science, Innovation and Technology Ministry, Hungary [2021-28]; National Academy of Science, Hungary;  [RRF-2.3.1-21-2022-00004];  [OTKA146113]
            Funding text: CK was supported by the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory, and the National Excellence Program (OTKA146113) of the National Research, Development and Innovation Office, Hungary. ZR acknowledges support from the National Excellence Program (126823) National Science and Research Found (OTKA142192) and Scientific Excellence Program TKP2021-EGA-37 at the Hungarian University Sport Science, Innovation and Technology Ministry, Hungary, as well as Post-Covid 2021-28 grant by National Academy of Science, Hungary. We thank to Szilvia Farkas (Semmelweis University, Hungary) for the valuable discussions.
AB  - Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Plesz, Szonja Bianka
AU  - Adlan, Leatitia Gabriella
AU  - Büki, Alexandra
AU  - Horváth, Gyöngyi
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán Sándor
AU  - Kékesi, Gabriella
TI  - Exploring the gut-brain connection: How does microbiome composition relate to cognitive behavior in Wisket model rats?
T2  - 7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet
PY  - 2024
SP  - 86
UR  - https://m2.mtmt.hu/api/publication/34577105
ID  - 34577105
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Adlan, Leatitia Gabriella
AU  - Plesz, Szonja Bianka
AU  - Büki, Alexandra
AU  - Horváth, Gyöngyi
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán Sándor
AU  - Kékesi, Gabriella
TI  - The Firmicutes/Bacteroidetes ratio in the triple-hit Wisket model rats of schizophrenia
T2  - International Neuroscience Conference, Pécs 2024
PY  - 2024
SP  - 74
UR  - https://m2.mtmt.hu/api/publication/34577022
ID  - 34577022
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Plesz, Szonja Bianka
AU  - Adlan, Leatitia Gabriella
AU  - Büki, Alexandra
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán Sándor
AU  - Kékesi, Gabriella
TI  - Is gut dysbiosis associated with the motivational deficit observed in Wisket animals?
T2  - International Neuroscience Conference, Pécs 2024
PY  - 2024
SP  - 73
UR  - https://m2.mtmt.hu/api/publication/34576951
ID  - 34576951
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ligeti, Balázs
AU  - Szepesi-Nagy, István
AU  - Bodnár, Babett
AU  - Ligeti-Nagy, Noémi
AU  - Juhász, János
TI  - ProkBERT family: genomic language models for microbiome applications
JF  - FRONTIERS IN MICROBIOLOGY
J2  - FRONT MICROBIOL
VL  - 14
PY  - 2024
PG  - 19
SN  - 1664-302X
DO  - 10.3389/fmicb.2023.1331233
UR  - https://m2.mtmt.hu/api/publication/34548692
ID  - 34548692
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Plesz, Szonja Bianka
AU  - Adlan, Leatitia Gabriella
AU  - Büki, Alexandra
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán Sándor
AU  - Horváth, Gyöngyi
AU  - Kékesi, Gabriella
TI  - A Lactobacillaceae baktériumok előfordulása a szkizofrénia Wisket állatmodelljének mikrobiomjában
T2  - A XI. Eötvözet Konferencián elhangzó előadások rövid összefoglalója
PY  - 2023
SP  - 24
EP  - 24
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/34577063
ID  - 34577063
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Plesz, Szonja Bianka
AU  - Adlan, Leatitia Gabriella
AU  - Büki, Alexandra
AU  - Horváth, Gyöngyi
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán
AU  - Kékesi, Gabriella
TI  - DECREASED LACTOBACILLACEAE ABUNDANCE IN THE GUT MICROBIOTA OF A ‘THREE-HIT’ SCHIZOPHRENIA RAT MODEL (WISKET)
JF  - IBRO NEUROSCIENCE REPORTS
J2  - IBRO NEUROSCI REP
VL  - 15
PY  - 2023
SP  - S630
SN  - 2667-2421
DO  - 10.1016/j.ibneur.2023.08.1256
UR  - https://m2.mtmt.hu/api/publication/34407638
ID  - 34407638
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Adlan, Leatitia Gabriella
AU  - Plesz, Szonja Bianka
AU  - Büki, Alexandra
AU  - Horváth, Gyöngyi
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán
AU  - Kékesi, Gabriella
TI  - GUT MICROBIAL ABUNDANCE IN THE SCHIZOPHRENIA-LIKE WISKET RAT MODEL
JF  - IBRO NEUROSCIENCE REPORTS
J2  - IBRO NEUROSCI REP
VL  - 15
PY  - 2023
SP  - S522
SN  - 2667-2421
DO  - 10.1016/j.ibneur.2023.08.1027
UR  - https://m2.mtmt.hu/api/publication/34407635
ID  - 34407635
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Kékesi, Gabriella
AU  - Plesz, Szonja Bianka
AU  - Adlan, Leatitia Gabriella
AU  - Horváth, Gyöngyi
AU  - Szűcs, Kálmán Ferenc
AU  - Gáspár, Róbert
AU  - Ligeti, Balázs
AU  - Zádori, Zoltán Sándor
TI  - GUT MICROBIOME COMPOSITION AND GASTROINTESTINAL ACTIVITY IN THE WISKET RAT MODEL OF SCHIZOPHRENIA
T2  - FAMÉ 2023
PY  - 2023
SP  - 124
EP  - 124
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/34152373
ID  - 34152373
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Haghighi, Arezoo
AU  - Tóth, András S.
AU  - Lázár, Bernadette
AU  - László, Szilvia B.
AU  - Hutka, Barbara
AU  - Al-Khrasani, Mahmoud
AU  - Ágg, Bence
AU  - Ligeti, Balázs
AU  - Makra, Nóra
AU  - Ostorházi, Eszter
AU  - Szabó, Dóra
AU  - Gyires, Klára
AU  - Zádori, Zoltán Sándor
TI  - THE EFFECT OF CONVENTIONAL NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND SELECTIVE COX-2 INHIBITORS ON GUT MICROBIOTA COMPOSITION
T2  - FAMÉ 2023
PY  - 2023
SP  - 125
EP  - 125
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/34148279
ID  - 34148279
LA  - English
DB  - MTMT
ER  -