@article{MTMT:34391940, title = {Endocrine side effects of immune-checkpoint inhibitors in patients with malignant melanoma}, url = {https://m2.mtmt.hu/api/publication/34391940}, author = {Erdei, Annamária and Enikő, Ménes and Emri, Gabriella}, journal-iso = {ENDOCR ABSTR}, journal = {ENDOCRINE ABSTRACTS}, volume = {90}, unique-id = {34391940}, issn = {1470-3947}, year = {2023}, eissn = {1479-6848}, pages = {EP678} } @article{MTMT:34391921, title = {Kezelés nélkül javuló acromegalia a pandémia alatt}, url = {https://m2.mtmt.hu/api/publication/34391921}, author = {Dániel, Eszter and Nagy, B. Edit and Nagy, Endre and Erdei, Annamária}, journal-iso = {METABOLIZMUS}, journal = {METABOLIZMUS}, volume = {21}, unique-id = {34391921}, issn = {1589-7311}, year = {2023}, pages = {86-89} } @article{MTMT:34280731, title = {A felnőttkori növekedésihormon-hiány szív- és érrendszeri szövődményei}, url = {https://m2.mtmt.hu/api/publication/34280731}, author = {Ratku, Balázs and Sebestyén, Veronika and Szelesné Árokszállási, Andrea and Erdei, Annamária and Berta, Eszter and Szabó, Zoltán and Bodor, Miklós and Nagy, Endre and Somodi, Sándor}, doi = {10.1556/650.2023.32890}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {164}, unique-id = {34280731}, issn = {0030-6002}, abstract = {A növekedési hormon–inzulinszerű növekedési faktor-1 (GH–IGF-1-) tengely jelentős szerepet tölt be a cardiovascularis rendszer fiziológiás működésének fenntartásában. Az elmúlt évtizedek kutatási eredményei alapján a GH–IGF-1-tengely részt vesz a perifériás ellenállás szabályozásában, és hozzájárul a normális szívizomtömeg és balkamra-funkció megtartásához. A GH–IGF-1-tengely érfalprotektív funkciói az atherosclerosis ellenében hatnak. Ellentétben a gyermekkori GH-hiánnyal, amelynél a betegség egyértelmű biológiai következménye a gyermek növekedésbeli visszamaradása, a felnőttkori növekedésihormon-hiánynak (adult growth hormone deficiency – AGHD) nincsenek specifikus tünetei. Az AGHD klinikai megjelenését a cardiovascularis rizikótényezők halmozódása jellemzi, amely miatt a klinikai kép leginkább a metabolicus szindrómához hasonlítható. Újabb kutatások AGHD esetében a tradicionális rizikótényezők mellett krónikus kisfokú gyulladás, prothromboticus állapot és oxidatív stressz jelenlétére is rámutattak, amelyek szintén közrejátszhatnak a fokozott kardiometabolikus rizikó kialakulásában. A tartós GH-szubsztitúció AGHD-betegek esetében a lipidprofil jelentős javulását eredményezi, és kedvező hatással van a testösszetételre, a szívizomtömegre, az endothelfunkcióra, valamint az újonnan felismert, nem tradicionális rizikótényezőkre is. A betegséggel összefüggő fokozott mortalitás a mai felfogás szerint multikauzális, és nem vezethető vissza csupán a GH hiányára. A kedvezőtlen mortalitásért az etiológia, az alkalmazott kezelés és az egyéb hypophysishormon-hiányok kezelésének nehézsége is felelős lehet. Mindazonáltal hypopituitarismus esetében optimális, a GH-pótlást is magában foglaló hormonszubsztitúcióval az átlagpopulációéhoz közelítő mortalitás érhető el. Orv Hetil. 2023; 164(41): 1616–1627.}, year = {2023}, eissn = {1788-6120}, pages = {1616-1627}, orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300} } @article{MTMT:33578444, title = {Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy}, url = {https://m2.mtmt.hu/api/publication/33578444}, author = {Galgóczi, Erika and Katkó, Mónika and Papp, Fruzsina Réka and Csiki, Róbert and Bak-Csiha, Sára and Erdei, Annamária and Bodor, Miklós and Ujhelyi, Bernadett and Steiber, Zita and Győry, Ferenc and Nagy, Endre}, doi = {10.3390/molecules28010015}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {33578444}, issn = {1420-3049}, abstract = {Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment. Here we show that hydrocortisone (HC), prednisolone (P), methylprednisolone (MP), and dexamethasone (DEX) inhibit the hyaluronan (HA) production of orbital (OF) and dermal (DF) fibroblasts. HA production of GO OFs (n = 4), NON-GO OFs (n = 4) and DFs (n = 4) was measured by ELISA. mRNA expression of enzymes of HA metabolism and fibroblast proliferation was examined by RT-PCR and BrdU incorporation, respectively. After 24 h of GC treatment (1µM) HA production decreased by an average of 67.9 ± 3.11% (p < 0.0001) in all cell cultures. HAS2, HAS3 and HYAL1 expression in OFs also decreased (p = 0.009, p = 0.0005 and p = 0.015, respectively). Ten ng/mL PDGF-BB increased HA production and fibroblast proliferation in all cell lines (p < 0.0001); GC treatment remained effective and reduced HA production under PDGF-BB-stimulated conditions (p < 0.0001). MP and DEX reduced (p < 0.001, p = 0.002, respectively) PDGF-BB-induced HAS2 expression in OFs. MP and DEX treatment decreased PDGF-BB stimulated HAS3 expression (p = 0.035 and p = 0.029, respectively). None of the GCs tested reduced the PDGF-BB stimulated proliferation rate. Our results confirm that GCs directly reduce the HA production of OFs, which may contribute to the beneficial effect of GCs in GO.}, year = {2023}, eissn = {1420-3049} } @article{MTMT:33594906, title = {Alcohol consumption affects the late endocrine consequences of mild traumatic brain injury.}, url = {https://m2.mtmt.hu/api/publication/33594906}, author = {Frendl, István and Erdei, Annamária and Zsíros, Noémi and Katkó, Mónika and Galgóczi, Erika and Nemeti, Zoltan and Bhattoa Harjit, Pál and Kappelmayer, János and Posta, János and Turchányi, Béla and Urbán, Ferenc and Nagy, Endre}, journal-iso = {NEUROENDOCRINOL LETT}, journal = {NEUROENDOCRINOLOGY LETTERS}, volume = {43}, unique-id = {33594906}, issn = {0172-780X}, abstract = {Currently there are no widely applied methods which could identify, at the time of head trauma, those mild traumatic brain injury (mTBI) patients who later develop pituitary dysfunction. The effect of alcohol consumption on post-TBI endocrine dysfunction is unclear.Five hundred and eight TBI patients, 406 of them with mTBI, were studied. Sixty-one patients (46 males, 15 females) were available for follow-up. Admission serum samples were evaluated for S100B protein and markers of alcohol consumption: ethanol level for day-of-injury intake and carbohydrate deficient transferrin (CDT) level for regular alcohol consumption. Regular alcohol consumption was defined as CDT > 1.5%, including both social and heavy drinkers. Admission and one-year follow-up samples were evaluated for pituitary dysfunction.Newly developed pituitary hormone deficiency was found in 16% of mTBI patients. When cohorts developing and not developing late pituitary dysfunction were compared, 30% and 69% of patients were regular alcohol consumers, respectively (p = 0.02). Neither S100B level nor day-of-injury alcohol consumption was predictive of late pituitary dysfunction.The findings of this preliminary study suggest that regular alcohol consumption may protect against the late endocrine consequences of mTBI. Alcohol intake during the weeks preceding mTBI may identify patients at higher risk for late pituitary dysfunction.}, year = {2022}, eissn = {2354-4716}, pages = {239-245}, orcid-numbers = {Bhattoa Harjit, Pál/0000-0002-4909-0065} } @article{MTMT:33211389, title = {The effect of glucocorticoids on hyaluronan production of orbital fibroblasts}, url = {https://m2.mtmt.hu/api/publication/33211389}, author = {Galgóczi, Erika and Katko, Monika and Erdei, Annamária and Bodor, Miklós and Ujhelyi, Bernadett and Steiber, Zita and Győry, Ferenc and Nagy, Endre}, doi = {10.1530/endoabs.84.PS2-07-64}, journal-iso = {ENDOCR ABSTR}, journal = {ENDOCRINE ABSTRACTS}, volume = {84}, unique-id = {33211389}, issn = {1470-3947}, year = {2022}, eissn = {1479-6848} } @article{MTMT:33211370, title = {Cessation of GH secretion in acromegaly without medical or surgical intervetion :$bCovid-postponed surgery was escaped}, url = {https://m2.mtmt.hu/api/publication/33211370}, author = {Erdei, Annamária and Daniel, Eszter and Gazdag, Annamária and Griger, Mihály and Nagy, Edit B. and Nagy, Endre}, journal-iso = {ENDOCR ABSTR}, journal = {ENDOCRINE ABSTRACTS}, volume = {81}, unique-id = {33211370}, issn = {1470-3947}, year = {2022}, eissn = {1479-6848} } @article{MTMT:33211224, title = {G4-immunglobulinnal társult endokrin betegségek}, url = {https://m2.mtmt.hu/api/publication/33211224}, author = {Erdei, Annamária}, doi = {10.1556/650.2022.32527}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {163}, unique-id = {33211224}, issn = {0030-6002}, year = {2022}, eissn = {1788-6120}, pages = {1175-1180} } @article{MTMT:33032320, title = {Non-surgical orbital decompression using diuresis in dysthyroid optic neuropathy: a case report}, url = {https://m2.mtmt.hu/api/publication/33032320}, author = {Erdei, Annamária and Gazdag, Annamária and Ujhelyi, Bernadett and Nagy, Edit B and Berényi, Ervin László and Berta, Eszter and Steiber, Zita and Barna, Sándor Kristóf and Mezősi, Emese and Bodor, Miklós and Nagy, Endre}, doi = {10.1530/ETJ-22-0078}, journal-iso = {EUR THYROID J}, journal = {EUROPEAN THYROID JOURNAL}, volume = {11}, unique-id = {33032320}, issn = {2235-0640}, abstract = {Dysthyroid optic neuropathy (DON) is a rare, severe form of thyroid eye disease, in which decreased visual acuity is accompanied by characteristic MRI findings. The treatment of DON has always been a challenge.In a patient in whom visual acuity deteriorated on the left eye, mannitol 20% 200 ml followed by furosemide 40 mg 6 hours later, administered daily, were initiated on the day of admission. Visual function by ophthalmology methods, and orbital compartment volumes and water content by MRI were followed. Intravenous diuretics resulted in immediate therapeutic response. Visual acuity improved from 20/50 to 20/25 after two days of treatment. MRI revealed decreasing water content of both the muscle and connective tissue compartments without any volume changes. Subsequently, corticosteroids and orbital irradiation were started. Orbital decompression surgery was not required.Edematous swelling of orbital tissues is an established contributor of local pressure increase in thyroid eye disease. Diuretics reduce orbital pressure and, if confirmed by others, may be useful additions to the standard of care in sight threatening DON.}, year = {2022}, eissn = {2235-0802}, orcid-numbers = {Mezősi, Emese/0000-0001-9367-3877} } @article{MTMT:32866680, title = {Different Effects of Cigarette Smoke, Heated Tobacco Product and E-Cigarette Vapour on Orbital Fibroblasts in Graves’ Orbitopathy; a Study by Real Time Cell Electronic Sensing}, url = {https://m2.mtmt.hu/api/publication/32866680}, author = {Aranyosi, János and Galgóczi, Erika and Erdei, Annamária and Katkó, Mónika and Fodor, Mariann and Ujhelyi, Zoltán and Bácskay, Ildikó and Nagy, Endre and Ujhelyi, Bernadett}, doi = {10.3390/molecules27093001}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {27}, unique-id = {32866680}, issn = {1420-3049}, year = {2022}, eissn = {1420-3049} }