TY - JOUR AU - Brunner, Szilvia AU - Varga, Dániel AU - Bozó, Renáta AU - Polanek, Róbert AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Molnár, Réka AU - Gémes, Nikolett AU - Szebeni, Gábor AU - Puskás, László AU - Erdélyi, Miklós AU - Hideghéty, Katalin TI - Analysis of Ionizing Radiation Induced DNA Damage by Superresolution dSTORM Microscopy JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 27 PY - 2021 PG - 13 SN - 1219-4956 DO - 10.3389/pore.2021.1609971 UR - https://m2.mtmt.hu/api/publication/32487977 ID - 32487977 N1 - Funding details: Laserlab-Europe Funding details: European Commission, EC Funding details: Horizon 2020, 2017-1.2.1-NKP-2017-00002, 871124, NTP-NFTÖ-20-B-0354 Funding details: European Regional Development Fund, ERDF, GINOP-2.3.6-15-2015-00001 Funding text 1: This work was supported in part by the European Union and co-financed by the European Regional Development Fund through the ELI-ALPS project (GINOP-2.3.6-15-2015-00001), and in part by Horizon 2020, the EU Framework Programme for Research and Innovation under Grant Agreement No. 871124 Laserlab-Europe. The Confocal and superresolution dSTORM experiments and their evaluation were funded by the Hungarian BrainResearch Program (2017-1.2.1-NKP-2017-00002) and the National Young Talent Scholarship programme (NTP-NFTÖ-20-B-0354). LA - English DB - MTMT ER - TY - JOUR AU - Hideghéty, Katalin AU - Tőkés, Tünde AU - Polanek, Róbert AU - Szabó, Emilia Rita TI - Ígéretes sugárkezelési technikák a klinikai bevezetés küszöbén: mikronyaláb- és villanás besugárzás JF - KLINIKAI ONKOLÓGIA J2 - KLINIKAI ONKOLÓGIA VL - 8 PY - 2021 IS - 1 SP - 71 EP - 78 PG - 8 SN - 2064-5058 UR - https://m2.mtmt.hu/api/publication/32013749 ID - 32013749 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Polanek, Róbert AU - Hafiz, Nasr Abdelrahman Mohamed AU - Lécz, Zsolt AU - Papp, Dániel AU - Kamperidis, Christos AU - Brunner, Szilvia AU - Szabó, Emilia Rita AU - Tőkés, Tünde AU - Hideghéty, Katalin TI - 1 kHz laser accelerated electron beam feasible for radiotherapy uses: A PIC–Monte Carlo based study JF - NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT J2 - NUCL INSTRUM METH A VL - 987 PY - 2021 PG - 7 SN - 0168-9002 DO - 10.1016/j.nima.2020.164841 UR - https://m2.mtmt.hu/api/publication/31791845 ID - 31791845 N1 - ELI-ALPS, ELI-HU Non-Profit Ltd. Wolfgang Sandner u. 3, Szeged, H-6728, Hungary National Laboratory on High Power Laser and Physics, SIOM, CAS, Shanghai, 201800, China Department of Plasma and Nuclear Fusion, Nuclear Research Center, Atomic Energy Authority, Abu-Zabal, 13759, Egypt University of Szeged, Faculty of Medicine, Department of Oncotherapy, Korányi fasor 12., Szeged, H-6720, Hungary Cited By :10 Export Date: 15 May 2023 CODEN: NIMAE Correspondence Address: Polanek, R.; ELI-ALPS, Hungary; email: robert.polanek@eli-alps.hu Funding details: Horizon 2020 Framework Programme, H2020 Funding details: College of Arts and Sciences, University of Nebraska-Lincoln, CAS Funding details: European Commission, EC Funding details: Chinese Academy of Sciences, CAS, 181231KYSB20170022 Funding details: Horizon 2020, 654148, 871124 Funding details: European Regional Development Fund, FEDER, GINOP-2.3.6-15-2015-00001 Funding text 1: This work was supported in part by the European Union and co-financed by the European Regional Development Fund through the ELI-ALPS project (GINOP-2.3.6-15-2015-00001), and in part by Horizon 2020, the EU Framework Programme for Research and Innovation under Grant Agreement No. 654148 and No. 871124 Laserlab-Europe. N. A. M. H. acknowledges the President International Fellowship Initiative (PIFI) of the Chinese Academy of Sciences; the International Partnership Program (181231KYSB20170022) of CAS; the Inter-Governmental Science and Technology Cooperation of MOST. Funding text 2: This work was supported in part by the European Union and co-financed by the European Regional Development Fund through the ELI-ALPS project (GINOP-2.3.6-15-2015-00001), and in part by Horizon 2020 , the EU Framework Programme for Research and Innovation under Grant Agreement No. 654148 and No. 871124 Laserlab-Europe. Funding text 3: N. A. M. H. acknowledges the President International Fellowship Initiative (PIFI) of the Chinese Academy of Sciences; the International Partnership Program (181231KYSB20170022) of CAS; the Inter-Governmental Science and Technology Cooperation of MOST. LA - English DB - MTMT ER - TY - JOUR AU - Brunner, Szilvia AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Szabó, Zoltán Imre AU - Reisz, Zita AU - Konczné Gubán, Barbara AU - Szijártó, András Lajos AU - Michael, Brand AU - Stefan, Hans AU - Leonhard, Karsch AU - Elisabeth, Lessmann AU - Jörg, Pawelke AU - Michael, Schürer AU - Elke, Beyreuther AU - Hideghéty, Katalin TI - Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 40 PY - 2020 IS - 11 SP - 6123 EP - 6135 PG - 13 SN - 0250-7005 DO - 10.21873/anticanres.14633 UR - https://m2.mtmt.hu/api/publication/31655754 ID - 31655754 N1 - ELI-ALPS, ELI-HU Non-Profit Ltd., Szeged, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Department of Clinical Neuropathology, King’s College Hospital, London, United Kingdom Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany Helmholtz-Zentrum Dresden–Rossendorf, Dresden, Germany National Center for Tumor Diseases (NCT), Dresden, Germany Department of Oncotherapy, University of Szeged, Szeged, Hungary Export Date: 11 February 2022 CODEN: ANTRD Correspondence Address: Brunner, S.; ELI-ALPS, Wolfgang Sandner Str. 3., Hungary; email: Szilvia.Brunner@elialps.hu LA - English DB - MTMT ER - TY - JOUR AU - Polanek, Róbert AU - Varga, Zoltán AU - Fodor, Emese AU - Brunner, Szilvia AU - Szabó, Emilia Rita AU - Tőkés, Tünde AU - Hideghéty, Katalin TI - Improved FBX chemical dosimeter system with enhanced radiochemical yield for reference dosimetry in radiobiology and radiotherapy research JF - RADIATION PHYSICS AND CHEMISTRY: THE JOURNAL FOR RADIATION PHYSICS RADIATION CHEMISTRY AND RADIATION PROCESSING J2 - RADIAT PHYS CHEM VL - 174 PY - 2020 PG - 8 SN - 0969-806X DO - 10.1016/j.radphyschem.2020.108899 UR - https://m2.mtmt.hu/api/publication/31392882 ID - 31392882 AB - Radiation dosimetry plays important role in the reproducibility of radiobiology experiments, in the replicability of results, as well as in the successful and safe use of radiotherapy procedures. The consistency and accuracy of the applied dosimetry methods pre-define the outcomes of these applications. This paper presents a version of the well-known ferrous sulphate – benzoic acid – xylenol orange (FBX) chemical dosimeter with improved sensitivity, accuracy and precision. Sensitivity is increased due to a slight modification in composition and the preparation procedures. We use stock solutions for the preparation of the dosimeter solution, which consists of 1 mM ferrous sulphate and 16 mM benzoic acid with 0.25 mM xylenol orange added post-irradiation. The nonlinear response to the absorbed dose of this system is eliminated by the increased ferrous sulphate concentration, permitting the calculation of the absorbed dose by a linear relationship between the absorbed dose and the optical absorbance of the solution. The measured chemical yield of our dosimeter is 9.08⋅10−6mol/J for 6 MV photon beams and 6.42⋅10−6mol/J for 250 kVp x-rays. This is a 24% enhancement over the original FBX solution, which permits a finer dose resolution. The accuracy and precision of our method is assured by a well-designed and consistently used practice. A custom designed multipurpose PMMA slab phantom was used for irradiation in reference conditions. This phantom can be used for irradiation in reference conditions of dosimetric solutions, dosimetric films and chemical or biological samples. The combined standard uncertainty of this system is 1.12%, which can be improved by using an appropriate temperature correction factor. Furthermore, a working protocol has been established which allows dosimetry measurements using less than 1 mL dosimetric solutions. LA - English DB - MTMT ER - TY - JOUR AU - Rösch, Thomas F. AU - Szabó, Zoltán Imre AU - Haffa, Daniel AU - Bin, Jianhui AU - Brunner, Szilvia AU - Englbrecht, Franz S. AU - Friedl, Anna A. AU - Gao, Ying AU - Hartmann, Jens AU - Hilz, Peter AU - Kreuzer, Christian AU - Lindner, Florian H. AU - Ostermayr, Tobias M. AU - Polanek, Róbert AU - Speicher, Martin AU - Szabó, Emilia Rita AU - Taray, Derya AU - Tőkés, Tünde AU - Würl, Matthias AU - Parodi, Katia AU - Hideghéty, Katalin AU - Schreiber, Jörg TI - A feasibility study of zebrafish embryo irradiation with laser-accelerated protons JF - REVIEW OF SCIENTIFIC INSTRUMENTS J2 - REV SCI INSTRUM VL - 91 PY - 2020 IS - 6 PG - 8 SN - 0034-6748 DO - 10.1063/5.0008512 UR - https://m2.mtmt.hu/api/publication/31339600 ID - 31339600 N1 - Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-Universität München, Garching bei München, 85748, Germany ELI-ALPS, ELI-HU Non-Profit Ltd., Wolfgang Sandner utca 3., Szeged, H-6728, Hungary Accelerator Technology and Applied Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States Department of Radiation Oncology, University Hospital, LMU München, München, 80337, Germany Oncotherapy Department, University Szeged, Szeged, 6728, Hungary Cited By :7 Export Date: 14 February 2022 CODEN: RSINA Correspondence Address: Rösch, T.F.; Department of Medical Physics, Germany; email: t.roesch@physik.lmu.de LA - English DB - MTMT ER - TY - JOUR AU - Hideghéty, Katalin AU - Brunner, Szilvia AU - Cheesman, Andrew AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Margarone, Daniele AU - Tőkés, Tünde AU - Mogyorósi, Károly TI - 11 Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 39 PY - 2019 IS - 5 SP - 2265 EP - 2276 PG - 12 SN - 0250-7005 DO - 10.21873/anticanres.13343 UR - https://m2.mtmt.hu/api/publication/30732651 ID - 30732651 N1 - University of Szeged, Faculty of Medicine, Department of Oncotherapy, Szeged, Hungary ELI-Beamlines, Institute of Physics of the Czech Academy of Sciences, Prague, Czech Republic ELI-ALPS, ELI-HU NonProfit Ltd, Wolfgang Sandner Str. 3, Szeged, 6728, Hungary Cited By :9 Export Date: 11 May 2022 CODEN: ANTRD Correspondence Address: Brunner, S.; ELI-ALPS, Wolfgang Sandner Str. 3, Hungary; email: Szilvia.Brunner@eli-alps.hu LA - English DB - MTMT ER - TY - JOUR AU - Katona, Melinda AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Brunner, Szilvia AU - Szabó, Zoltán Imre AU - Polanek, Róbert AU - Hideghéty, Katalin AU - Nyúl, László Gábor TI - Automatic Segmentation and Quantitative Analysis of Irradiated Zebrafish Embryos JF - LECTURE NOTES IN COMPUTER SCIENCE J2 - LNCS VL - 10986 PY - 2019 SP - 95 EP - 107 PG - 13 SN - 0302-9743 DO - 10.1007/978-3-030-20805-9_9 UR - https://m2.mtmt.hu/api/publication/30424669 ID - 30424669 N1 - A sorozat rendelkezik IF [és vagy] SJR értékkel, ezért besorolása lehet szakcikk a központi MTMT adminisztrátorokkal történt egyeztetés alapján. (NM, SZTE admin5, 2023.05.08.) AB - Radiotherapy is one of the most common methods to treat different cancer cells in clinical application despite having harmful effects on healthy tissues. Radiobiological experiments are very important to determine the irradiation-caused acute and chronic effects to define the exact consequences of different irradiation sources. Photon irradiation has been used on zebrafish embryos, a very new in vivo and appropriate model system in radiobiology. After irradiation, dose-dependent morphological changes were observable in the embryos. These morphological deteriorations were measured manually by biologist researchers during three weeks, which was an extremely time demanding process (15 minutes per image). The aim of this project was to automate this evaluating process, to save time for researchers and to keep the consistence and accuracy of the evaluation. Hence, an algorithm was developed and used to detect the abnormal development of zebrafish embryos. LA - English DB - MTMT ER - TY - CONF AU - Katona, Melinda AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Brunner, Szilvia AU - Polanek, Róbert AU - Hideghéty, Katalin AU - Nyúl, László Gábor TI - Sugárkezelésen átesett zebrahal embriók automatikus morfológiai elemzése T2 - Képfeldolgozók és Alakfelismerők Társaságának 12. Országos Konferenciája PB - Képfeldolgozók és Alakfelismerők Társasága C1 - Debrecen PY - 2019 PG - 12 UR - https://m2.mtmt.hu/api/publication/30422342 ID - 30422342 AB - A sugárkezelés napjainkban az egyik leggyakoribb módszer a különböző daganatos megbetegedések kezelésében, annak ellenére, hogy sajnos az egészséges szövetekre gyakorolt káros mellékhatásai is ismeretesek. A sugárterápia után bekövetkező rövid és hosszútávú következményeket, valamint a különböző sugárforrások szövetekre, sejtekre kifejtett hatásait sugárbiológiai kísérletekkel vizsgálhatjuk. Az in vivo zebrahal embrió modell egy új állatkísérletes lehetőség a sugárbiológiában. Sugárkezelés után dózisfüggő módon morfológiai elváltozások észlelhetők az embriókban. Ezeket az elváltozásokat eddig manuálisan értékelték a kutatók, ami rendkívül időigényes folyamat volt (8-10 perc/kép), figyelembe véve, hogy a képek száma jellemzően százas vagy ezres nagyságrendű. A projekt célja ennek az értékelésnek az automatizálása volt, mellyel időt és energiát takaríthatunk meg a kutatók számára, ugyanakkor fontos, hogy az értékelés pontos, reprodukálható és megbízható maradjon. Ennek érdekében kifejlesztettünk egy olyan algoritmust, mely segítségével egy automatizált folyamat során történik a károsodott zebrahal embriók morfológiai elváltozásainak meghatározása. LA - Hungarian DB - MTMT ER - TY - GEN AU - V., Kurti AU - Polanek, Róbert AU - Flender, Roland AU - Börzsönyi, Ádám AU - Szabó, Emilia Rita AU - Tőkés, Tünde AU - Z. I., Szabo AU - Hideghéty, Katalin AU - Osvay, Károly TI - Study of ionization effects of femtosecond infrared laser beam filamentation for cancer therapy PY - 2018 UR - https://m2.mtmt.hu/api/publication/32865029 ID - 32865029 LA - English DB - MTMT ER -