@article{MTMT:32487977, title = {Analysis of Ionizing Radiation Induced DNA Damage by Superresolution dSTORM Microscopy}, url = {https://m2.mtmt.hu/api/publication/32487977}, author = {Brunner, Szilvia and Varga, Dániel and Bozó, Renáta and Polanek, Róbert and Tőkés, Tünde and Szabó, Emilia Rita and Molnár, Réka and Gémes, Nikolett and Szebeni, Gábor and Puskás, László and Erdélyi, Miklós and Hideghéty, Katalin}, doi = {10.3389/pore.2021.1609971}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {27}, unique-id = {32487977}, issn = {1219-4956}, year = {2021}, eissn = {1532-2807}, orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Bozó, Renáta/0000-0003-4242-2474; Polanek, Róbert/0000-0003-3645-8331; Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Molnár, Réka/0000-0002-3128-825X; Szebeni, Gábor/0000-0002-6998-5632; Erdélyi, Miklós/0000-0002-9501-5752; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:32013749, title = {Ígéretes sugárkezelési technikák a klinikai bevezetés küszöbén: mikronyaláb- és villanás besugárzás}, url = {https://m2.mtmt.hu/api/publication/32013749}, author = {Hideghéty, Katalin and Tőkés, Tünde and Polanek, Róbert and Szabó, Emilia Rita}, journal-iso = {KLINIKAI ONKOLÓGIA}, journal = {KLINIKAI ONKOLÓGIA}, volume = {8}, unique-id = {32013749}, issn = {2064-5058}, year = {2021}, pages = {71-78}, orcid-numbers = {Hideghéty, Katalin/0000-0001-7080-2365; Tőkés, Tünde/0000-0002-0587-7886; Polanek, Róbert/0000-0003-3645-8331; Szabó, Emilia Rita/0000-0003-3611-2066} } @article{MTMT:31791845, title = {1 kHz laser accelerated electron beam feasible for radiotherapy uses: A PIC–Monte Carlo based study}, url = {https://m2.mtmt.hu/api/publication/31791845}, author = {Polanek, Róbert and Hafiz, Nasr Abdelrahman Mohamed and Lécz, Zsolt and Papp, Dániel and Kamperidis, Christos and Brunner, Szilvia and Szabó, Emilia Rita and Tőkés, Tünde and Hideghéty, Katalin}, doi = {10.1016/j.nima.2020.164841}, journal-iso = {NUCL INSTRUM METH A}, journal = {NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT}, volume = {987}, unique-id = {31791845}, issn = {0168-9002}, year = {2021}, eissn = {1872-9576}, orcid-numbers = {Polanek, Róbert/0000-0003-3645-8331; Hafiz, Nasr Abdelrahman Mohamed/0000-0002-6597-571X; Lécz, Zsolt/0000-0001-5968-8012; Papp, Dániel/0000-0002-7954-3686; Kamperidis, Christos/0000-0002-0360-7671; Szabó, Emilia Rita/0000-0003-3611-2066; Tőkés, Tünde/0000-0002-0587-7886; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:31655754, title = {Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model}, url = {https://m2.mtmt.hu/api/publication/31655754}, author = {Brunner, Szilvia and Tőkés, Tünde and Szabó, Emilia Rita and Polanek, Róbert and Szabó, Zoltán Imre and Reisz, Zita and Konczné Gubán, Barbara and Szijártó, András Lajos and Michael, Brand and Stefan, Hans and Leonhard, Karsch and Elisabeth, Lessmann and Jörg, Pawelke and Michael, Schürer and Elke, Beyreuther and Hideghéty, Katalin}, doi = {10.21873/anticanres.14633}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {40}, unique-id = {31655754}, issn = {0250-7005}, year = {2020}, eissn = {1791-7530}, pages = {6123-6135}, orcid-numbers = {Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Szabó, Zoltán Imre/0000-0001-8278-8038; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:31392882, title = {Improved FBX chemical dosimeter system with enhanced radiochemical yield for reference dosimetry in radiobiology and radiotherapy research}, url = {https://m2.mtmt.hu/api/publication/31392882}, author = {Polanek, Róbert and Varga, Zoltán and Fodor, Emese and Brunner, Szilvia and Szabó, Emilia Rita and Tőkés, Tünde and Hideghéty, Katalin}, doi = {10.1016/j.radphyschem.2020.108899}, journal-iso = {RADIAT PHYS CHEM}, journal = {RADIATION PHYSICS AND CHEMISTRY: THE JOURNAL FOR RADIATION PHYSICS RADIATION CHEMISTRY AND RADIATION PROCESSING}, volume = {174}, unique-id = {31392882}, issn = {0969-806X}, abstract = {Radiation dosimetry plays important role in the reproducibility of radiobiology experiments, in the replicability of results, as well as in the successful and safe use of radiotherapy procedures. The consistency and accuracy of the applied dosimetry methods pre-define the outcomes of these applications. This paper presents a version of the well-known ferrous sulphate – benzoic acid – xylenol orange (FBX) chemical dosimeter with improved sensitivity, accuracy and precision. Sensitivity is increased due to a slight modification in composition and the preparation procedures. We use stock solutions for the preparation of the dosimeter solution, which consists of 1 mM ferrous sulphate and 16 mM benzoic acid with 0.25 mM xylenol orange added post-irradiation. The nonlinear response to the absorbed dose of this system is eliminated by the increased ferrous sulphate concentration, permitting the calculation of the absorbed dose by a linear relationship between the absorbed dose and the optical absorbance of the solution. The measured chemical yield of our dosimeter is 9.08⋅10−6mol/J for 6 MV photon beams and 6.42⋅10−6mol/J for 250 kVp x-rays. This is a 24% enhancement over the original FBX solution, which permits a finer dose resolution. The accuracy and precision of our method is assured by a well-designed and consistently used practice. A custom designed multipurpose PMMA slab phantom was used for irradiation in reference conditions. This phantom can be used for irradiation in reference conditions of dosimetric solutions, dosimetric films and chemical or biological samples. The combined standard uncertainty of this system is 1.12%, which can be improved by using an appropriate temperature correction factor. Furthermore, a working protocol has been established which allows dosimetry measurements using less than 1 mL dosimetric solutions.}, keywords = {FBX chemical dosimeter; PMMA slab Phantom; Enhanced radiochemical yield; Reference dosimetry}, year = {2020}, eissn = {1879-0895}, orcid-numbers = {Polanek, Róbert/0000-0003-3645-8331; Varga, Zoltán/0000-0001-8537-6282; Szabó, Emilia Rita/0000-0003-3611-2066; Tőkés, Tünde/0000-0002-0587-7886; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:31339600, title = {A feasibility study of zebrafish embryo irradiation with laser-accelerated protons}, url = {https://m2.mtmt.hu/api/publication/31339600}, author = {Rösch, Thomas F. and Szabó, Zoltán Imre and Haffa, Daniel and Bin, Jianhui and Brunner, Szilvia and Englbrecht, Franz S. and Friedl, Anna A. and Gao, Ying and Hartmann, Jens and Hilz, Peter and Kreuzer, Christian and Lindner, Florian H. and Ostermayr, Tobias M. and Polanek, Róbert and Speicher, Martin and Szabó, Emilia Rita and Taray, Derya and Tőkés, Tünde and Würl, Matthias and Parodi, Katia and Hideghéty, Katalin and Schreiber, Jörg}, doi = {10.1063/5.0008512}, journal-iso = {REV SCI INSTRUM}, journal = {REVIEW OF SCIENTIFIC INSTRUMENTS}, volume = {91}, unique-id = {31339600}, issn = {0034-6748}, year = {2020}, eissn = {1089-7623}, orcid-numbers = {Szabó, Zoltán Imre/0000-0001-8278-8038; Polanek, Róbert/0000-0003-3645-8331; Szabó, Emilia Rita/0000-0003-3611-2066; Tőkés, Tünde/0000-0002-0587-7886; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:30732651, title = {11 Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy}, url = {https://m2.mtmt.hu/api/publication/30732651}, author = {Hideghéty, Katalin and Brunner, Szilvia and Cheesman, Andrew and Szabó, Emilia Rita and Polanek, Róbert and Margarone, Daniele and Tőkés, Tünde and Mogyorósi, Károly}, doi = {10.21873/anticanres.13343}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {39}, unique-id = {30732651}, issn = {0250-7005}, year = {2019}, eissn = {1791-7530}, pages = {2265-2276}, orcid-numbers = {Hideghéty, Katalin/0000-0001-7080-2365; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Tőkés, Tünde/0000-0002-0587-7886} } @article{MTMT:30424669, title = {Automatic Segmentation and Quantitative Analysis of Irradiated Zebrafish Embryos}, url = {https://m2.mtmt.hu/api/publication/30424669}, author = {Katona, Melinda and Tőkés, Tünde and Szabó, Emilia Rita and Brunner, Szilvia and Szabó, Zoltán Imre and Polanek, Róbert and Hideghéty, Katalin and Nyúl, László Gábor}, doi = {10.1007/978-3-030-20805-9_9}, journal-iso = {LNCS}, journal = {LECTURE NOTES IN COMPUTER SCIENCE}, volume = {10986}, unique-id = {30424669}, issn = {0302-9743}, abstract = {Radiotherapy is one of the most common methods to treat different cancer cells in clinical application despite having harmful effects on healthy tissues. Radiobiological experiments are very important to determine the irradiation-caused acute and chronic effects to define the exact consequences of different irradiation sources. Photon irradiation has been used on zebrafish embryos, a very new in vivo and appropriate model system in radiobiology. After irradiation, dose-dependent morphological changes were observable in the embryos. These morphological deteriorations were measured manually by biologist researchers during three weeks, which was an extremely time demanding process (15 minutes per image). The aim of this project was to automate this evaluating process, to save time for researchers and to keep the consistence and accuracy of the evaluation. Hence, an algorithm was developed and used to detect the abnormal development of zebrafish embryos.}, year = {2019}, eissn = {1611-3349}, pages = {95-107}, orcid-numbers = {Katona, Melinda/0000-0001-8236-0955; Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Szabó, Zoltán Imre/0000-0001-8278-8038; Polanek, Róbert/0000-0003-3645-8331; Hideghéty, Katalin/0000-0001-7080-2365; Nyúl, László Gábor/0000-0002-3826-543X} } @CONFERENCE{MTMT:30422342, title = {Sugárkezelésen átesett zebrahal embriók automatikus morfológiai elemzése}, url = {https://m2.mtmt.hu/api/publication/30422342}, author = {Katona, Melinda and Tőkés, Tünde and Szabó, Emilia Rita and Brunner, Szilvia and Polanek, Róbert and Hideghéty, Katalin and Nyúl, László Gábor}, booktitle = {Képfeldolgozók és Alakfelismerők Társaságának 12. Országos Konferenciája}, unique-id = {30422342}, abstract = {A sugárkezelés napjainkban az egyik leggyakoribb módszer a különböző daganatos megbetegedések kezelésében, annak ellenére, hogy sajnos az egészséges szövetekre gyakorolt káros mellékhatásai is ismeretesek. A sugárterápia után bekövetkező rövid és hosszútávú következményeket, valamint a különböző sugárforrások szövetekre, sejtekre kifejtett hatásait sugárbiológiai kísérletekkel vizsgálhatjuk. Az in vivo zebrahal embrió modell egy új állatkísérletes lehetőség a sugárbiológiában. Sugárkezelés után dózisfüggő módon morfológiai elváltozások észlelhetők az embriókban. Ezeket az elváltozásokat eddig manuálisan értékelték a kutatók, ami rendkívül időigényes folyamat volt (8-10 perc/kép), figyelembe véve, hogy a képek száma jellemzően százas vagy ezres nagyságrendű. A projekt célja ennek az értékelésnek az automatizálása volt, mellyel időt és energiát takaríthatunk meg a kutatók számára, ugyanakkor fontos, hogy az értékelés pontos, reprodukálható és megbízható maradjon. Ennek érdekében kifejlesztettünk egy olyan algoritmust, mely segítségével egy automatizált folyamat során történik a károsodott zebrahal embriók morfológiai elváltozásainak meghatározása.}, year = {2019}, orcid-numbers = {Katona, Melinda/0000-0001-8236-0955; Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Hideghéty, Katalin/0000-0001-7080-2365; Nyúl, László Gábor/0000-0002-3826-543X} } @misc{MTMT:32865029, title = {Study of ionization effects of femtosecond infrared laser beam filamentation for cancer therapy}, url = {https://m2.mtmt.hu/api/publication/32865029}, author = {V., Kurti and Polanek, Róbert and Flender, Roland and Börzsönyi, Ádám and Szabó, Emilia Rita and Tőkés, Tünde and Z. I., Szabo and Hideghéty, Katalin and Osvay, Károly}, unique-id = {32865029}, year = {2018}, orcid-numbers = {Polanek, Róbert/0000-0003-3645-8331; Flender, Roland/0000-0001-6970-0716; Szabó, Emilia Rita/0000-0003-3611-2066; Tőkés, Tünde/0000-0002-0587-7886; Hideghéty, Katalin/0000-0001-7080-2365; Osvay, Károly/0000-0002-3468-8312} }