@article{MTMT:34168948,
	title = {Positive Impulsive Control of Tumor Therapy—A Cyber-Medical Approach},
	url = {https://m2.mtmt.hu/api/publication/34168948},
	author = {Kovács, Levente and Ferenci, Tamás and Gombos, Balázs and Füredi, András and Rudas, Imre and Szakács, Gergely and Drexler, Dániel András},
	doi = {10.1109/TSMC.2023.3315637},
	journal-iso = {IIEEE TRANS SYST MAN CYBERN SYST},
	journal = {IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS: SYSTEMS},
	volume = {54},
	unique-id = {34168948},
	issn = {2168-2216},
	year = {2023},
	eissn = {2168-2232},
	pages = {597-608},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800; Ferenci, Tamás/0000-0001-6791-3080; Füredi, András/0000-0002-7883-9901; Rudas, Imre/0000-0002-2067-8578}
}

@article{MTMT:34163799,
	title = {Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells},
	url = {https://m2.mtmt.hu/api/publication/34163799},
	author = {Szebényi, Kornélia and Füredi, András and Bajtai, Eszter and Sama, Sai Nagender and Csiszar, Agnes and Gombos, Balázs and Szabó, Pál Tamás and Grusch, Michael and Szakács, Gergely},
	doi = {10.1016/j.drup.2023.101007},
	journal-iso = {DRUG RESIST UPDATE},
	journal = {DRUG RESISTANCE UPDATES},
	volume = {71},
	unique-id = {34163799},
	issn = {1368-7646},
	year = {2023},
	eissn = {1532-2084},
	orcid-numbers = {Szebényi, Kornélia/0000-0003-1558-8372; Füredi, András/0000-0002-7883-9901; Bajtai, Eszter/0000-0002-5352-7776; Szabó, Pál Tamás/0000-0003-2260-4641}
}

@inproceedings{MTMT:34081684,
	title = {Mathematical modeling of phototoxicity during fluorescent imaging of tumor spheroids},
	url = {https://m2.mtmt.hu/api/publication/34081684},
	author = {Gergics, Borbála and Vajda, Flóra and Puskás, Melánia and Füredi, András and Drexler, Dániel András},
	booktitle = {IEEE 27th International Conference on Intelligent Engineering Systems 2023 (INES 2023)},
	doi = {10.1109/INES59282.2023.10297657},
	unique-id = {34081684},
	year = {2023},
	pages = {291-296},
	orcid-numbers = {Füredi, András/0000-0002-7883-9901}
}

@inproceedings{MTMT:34081565,
	title = {Noise modeling of tumor size measurements from animal experiments for virtual patient generation},
	url = {https://m2.mtmt.hu/api/publication/34081565},
	author = {Puskás, Melánia and Gergics, Borbála and Gombos, Balázs and Füredi, András and Szakács, Gergely and Kovács, Levente and Drexler, Dániel András},
	booktitle = {IEEE 27th International Conference on Intelligent Engineering Systems 2023 (INES 2023)},
	doi = {10.1109/INES59282.2023.10297747},
	unique-id = {34081565},
	year = {2023},
	pages = {53-60},
	orcid-numbers = {Füredi, András/0000-0002-7883-9901; Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:33183423,
	title = {Comparison of Different Clinical Chemotherapeutical Agents' Toxicity and Cell Response on Mesenchymal Stem Cells and Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/33183423},
	author = {Vajda, Flóra and Szepesi, Áron and Várady, György and Sessler, Judit and Kiss, Dániel and Erdei, Zsuzsa and Szebényi, Kornélia and Nemet, Katalin and Szakács, Gergely and Füredi, András},
	doi = {10.3390/cells11192942},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {11},
	unique-id = {33183423},
	abstract = {Mesenchymal stem cells (MSCs) or fibroblasts are one of the most abundant cell types in the tumor microenvironment (TME) exerting various anti- and pro-apoptotic effects during tumorigenesis, invasion, and drug treatment. Despite the recently discovered importance of MSCs in tumor progression and therapy, the response of these cells to chemotherapeutics compared to cancer cells is rarely investigated. A widely accepted view is that these naive MSCs have higher drug tolerance than cancer cells due to a significantly lower proliferation rate. Here, we examine the differences and similarities in the sensitivity of MSCs and cancer cells to nine diverse chemotherapy agents and show that, although MSCs have a slower cell cycle, these cells are still sensitive to various drugs. Surprisingly, MSCs showed similar sensitivity to a panel of compounds, however, suffered fewer DNA double-stranded breaks, did not enter into a senescent state, and was virtually incapable of apoptosis. Our results suggest that MSCs and cancer cells have different cell fates after drug treatment, and this could influence therapy outcome. These findings could help design drug combinations targeting both MSCs and cancer cells in the TME.},
	keywords = {CANCER CELLS; drug tolerance; Mesenchymal Stem Cells; Tumor microenvironment; Chemotherapeutics},
	year = {2022},
	eissn = {2073-4409},
	orcid-numbers = {Várady, György/0000-0003-2012-9680; Szebényi, Kornélia/0000-0003-1558-8372; Füredi, András/0000-0002-7883-9901}
}

@inproceedings{MTMT:33138330,
	title = {Pharmacodynamics modeling based on in vitro 2D cell culture experiments},
	url = {https://m2.mtmt.hu/api/publication/33138330},
	author = {Gergics, Borbála and Gombos, Balázs and Vajda, Flóra and Füredi, András and Gergely, Szakács and Drexler, Dániel András},
	booktitle = {2022 IEEE International Conference on Systems, Man, and Cybernetics (SMC)},
	doi = {10.1109/SMC53654.2022.9945355},
	unique-id = {33138330},
	year = {2022},
	pages = {2409-2414},
	orcid-numbers = {Füredi, András/0000-0002-7883-9901}
}

@{MTMT:33111421,
	title = {NOVEL ANTICANCER THERAPY},
	url = {https://m2.mtmt.hu/api/publication/33111421},
	author = {Mező, Gábor and Hegedüs, Kristóf and Kiss, Krisztina and SZAKÁCS, GERGELY and Füredi, András and VARGA, ZOLTÁN and TÓTH, SZILÁRD and BARTA, GERGŐ and NAGYNÉ, NASZÁLYI LÍVIA and GAÁL, ANIKÓ},
	unique-id = {33111421},
	abstract = {The invention relates to the field of cancer therapy. In particular, a highly effective chemotherapy is provided in the form of liposome-encapsulated 2-deamino-2-pyrrolino-daunorubicin, which has been found to eliminate cancer cells and to support overall survival without causing severe undesired effects in mouse models of different types of cancer.},
	year = {2022},
	orcid-numbers = {Mező, Gábor/0000-0002-7618-7954; Füredi, András/0000-0002-7883-9901}
}

@article{MTMT:33070122,
	title = {P-Glycoprotein Activity at Diagnosis Does Not Predict Therapy Outcome and Survival in Canine B-Cell Lymphoma},
	url = {https://m2.mtmt.hu/api/publication/33070122},
	author = {Dékay, Valéria and Karai, Edina and Füredi, András and Szebényi, Kornélia and Szakács, Gergely and Vajdovich, Péter},
	doi = {10.3390/cancers14163919},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {14},
	unique-id = {33070122},
	abstract = {Various mechanisms are known to be involved in the development of multidrug resistance during cancer treatment. P-glycoprotein (P-gp) decreases the intracellular concentrations of cytotoxic drugs by an energy-dependent efflux mechanism. The aim of this study was to investigate the predictive value of P-gp function based on the evaluation of P-gp activity in tumor cells obtained from canine B-cell lymphoma patients at diagnosis. P-gp function of 79 immunophenotyped canine lymphoma samples was determined by flow cytometry using the Calcein assay. Dogs were treated with either the CHOP or the L-CHOP protocol, a subset of relapsed patients received L-asparaginase and lomustine rescue treatments. Among the 79 dogs, the median overall survival time was 417 days, and the median relapse-free period was 301 days. 47 percent of the samples showed high P-gp activity, which was significantly higher in Stage IV cancer patients compared to Stage II + III and V. Whereas staging was associated with major differences in survival times, we found that the intrinsic P-gp activity of tumor cells measured at diagnosis is not predictive for therapy outcome. Further studies are needed to identify the intrinsic and acquired resistant mechanisms that shape therapy response and survival in B-cell canine lymphoma patients.},
	year = {2022},
	eissn = {2072-6694},
	orcid-numbers = {Karai, Edina/0000-0002-8432-9668; Füredi, András/0000-0002-7883-9901; Szebényi, Kornélia/0000-0003-1558-8372}
}

@inproceedings{MTMT:33060653,
	title = {Tracking parameter changes of an Impulsive Tumor Growth Model},
	url = {https://m2.mtmt.hu/api/publication/33060653},
	author = {Nagy , Erzsébet and Czakó, Bence Géza and Siket, Máté and Gombos, Balázs and Füredi, András and Szakács, Gergely and Kovács, Levente and Drexler, Dániel András},
	booktitle = {IEEE 10th Jubilee International Conference on Computational Cybernetics and Cyber-Medical Systems ICCC 2022},
	doi = {10.1109/ICCC202255925.2022.9922736},
	unique-id = {33060653},
	year = {2022},
	pages = {179-184},
	orcid-numbers = {Füredi, András/0000-0002-7883-9901; Kovács, Levente/0000-0002-3188-0800}
}

@article{MTMT:32838813,
	title = {Experimental Closed-Loop Control of Breast Cancer in Mice},
	url = {https://m2.mtmt.hu/api/publication/32838813},
	author = {Kovács, Levente and Czakó, Bence Géza and Siket, Máté and Ferenci, Tamás and Füredi, András and Gombos, Balázs and Szakács, Gergely and Drexler, Dániel András},
	doi = {10.1155/2022/9348166},
	journal-iso = {COMPLEXITY},
	journal = {COMPLEXITY},
	volume = {2022},
	unique-id = {32838813},
	issn = {1076-2787},
	year = {2022},
	eissn = {1099-0526},
	orcid-numbers = {Kovács, Levente/0000-0002-3188-0800; Ferenci, Tamás/0000-0001-6791-3080; Füredi, András/0000-0002-7883-9901}
}