@article{MTMT:34503796, title = {A Comprehensive Study on Lathyrus tuberosus L.: Insights into Phytochemical Composition, Antimicrobial Activity, Antioxidant Capacity, Cytotoxic, and Cell Migration Effects}, url = {https://m2.mtmt.hu/api/publication/34503796}, author = {Jakabfi-Csepregi, Rita and Alberti, Ágnes and Felegyi-Tóth, Csenge Anna and Kőszegi, Tamás and Czigle, Szilvia and Papp, Nóra}, doi = {10.3390/plants13020232}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {13}, unique-id = {34503796}, abstract = {In this study, in vitro antioxidant, antimicrobial, cytotoxic, and cell migration effects of phenolic compounds of Lathyrus tuberosus leaves, known in the Transylvanian ethnomedicine, were investigated. Ultra-high-performance liquid chromatography-tandem mass spectrometry was employed for the analysis of the ethanolic and aqueous extracts. The antimicrobial properties were determined using a conventional microdilution technique. Total antioxidant capacity techniques were used using cell-free methods and cell-based investigations. Cytotoxic effects were conducted on 3T3 mouse fibroblasts and HaCaT human keratinocytes using a multiparametric method, assessing intracellular ATP, total nucleic acid, and protein levels. Cell migration was visualized by phase-contrast microscopy, employing conventional culture inserts to make cell-free areas. Together, 93 polyphenolic and monoterpenoid compounds were characterized, including flavonoid glycosides, lignans, hydroxycinnamic acid, and hydroxybenzoic acid derivatives, as well as iridoids and secoiridoids. The ethanolic extract showed high antioxidant capacity and strong antimicrobial activity against Bacillus subtilis (MIC80 value: 354.37 ± 4.58 µg/mL) and Streptococcus pyogenes (MIC80 value: 488.89 ± 4.75 µg/mL). The abundance of phenolic compounds and the results of biological tests indicate the potential for L. tuberosus to serve as reservoirs of bioactive compounds and to be used in the development of novel nutraceuticals.}, year = {2024}, eissn = {2223-7747}, orcid-numbers = {Alberti, Ágnes/0000-0003-3096-4057; Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Czigle, Szilvia/0000-0002-4634-3311} } @article{MTMT:34720562, title = {Vadgesztenye}, url = {https://m2.mtmt.hu/api/publication/34720562}, author = {Felegyi-Tóth, Csenge Anna and Osztie, Rita and Boldizsár, Imre and Alberti, Ágnes}, journal-iso = {GYÓGYSZERÉSZET}, journal = {GYÓGYSZERÉSZET}, volume = {67}, unique-id = {34720562}, issn = {0017-6036}, year = {2023}, pages = {654-663}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Osztie, Rita/0009-0001-1844-0675; Boldizsár, Imre/0000-0001-7852-8364; Alberti, Ágnes/0000-0003-3096-4057} } @article{MTMT:34122547, title = {Evaluation of the Chemical Stability, Membrane Permeability and Antiproliferative Activity of Cyclic Diarylheptanoids from European Hornbeam (Carpinus betulus L.)}, url = {https://m2.mtmt.hu/api/publication/34122547}, author = {Felegyi-Tóth, Csenge Anna and Heilmann, Tímea and Buda, Eszter and Stipsicz, Bence András and Simon, Alexandra and Boldizsár, Imre and Bősze, Szilvia and Riethmüller, Eszter and Alberti, Ágnes}, doi = {10.3390/ijms241713489}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34122547}, issn = {1661-6596}, abstract = {Four cyclic diarylheptanoids—carpinontriols A (1) and B (2), giffonin X (3) and 3,12,17-trihydroxytricyclo [12.3.1.12,6]nonadeca-1(18),2(19),3,5,14,16-hexaene-8,11-dione (4)—were isolated from Carpinus betulus (Betulaceae). Chemical stability of the isolated diarylheptanoids was evaluated as a function of storage temperature (−15, 5, 22 °C) and time (12 and 23 weeks). The effect of the solvent and the pH (1.2, 6.8, 7.4) on the stability of these diarylheptanoids was also investigated. Compounds 2 and 4 showed good stability both in aqueous and methanolic solutions at all investigated temperatures. Only 2 was stable at all three studied biorelevant pH values. Degradation products of 1 and 3 were formed by the elimination of a water molecule from the parent compounds, as confirmed by ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HR-MS). The permeability of the compounds across biological membranes was evaluated by the parallel artificial membrane permeability assay (PAMPA). Compound 3 possesses a logPe value of −5.92 ± 0.04 in the blood–brain barrier-specific PAMPA-BBB study, indicating that it may be able to cross the blood–brain barrier via passive diffusion. The in vitro antiproliferative activity of the compounds was investigated against five human cancer cell lines, confirming that 1 inhibits cell proliferation in A2058 human metastatic melanoma cells.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Simon, Alexandra/0000-0001-8189-4170; Boldizsár, Imre/0000-0001-7852-8364; Riethmüller, Eszter/0000-0002-9719-5427; Alberti, Ágnes/0000-0003-3096-4057} } @article{MTMT:33692631, title = {Kannabidiol (CBD) alkalmazása a lógyógyászatban 2. rész : Irodalmi összefoglaló}, url = {https://m2.mtmt.hu/api/publication/33692631}, author = {Tokareva, Marina and Wermer, Kata Alina and Cserhalmi, Dániel and Tóth, Luca Anna and Alberti, Ágnes and Wagenhoffer, Zsombor and Korbacska-Kutasi, Orsolya}, doi = {10.56385/magyallorv.2023.03.131-142}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {145}, unique-id = {33692631}, issn = {0025-004X}, abstract = {A szerzők áttekintik a CBD állatgyógyászatban, azon belül a lógyógyászatban való alkalmazásával kapcsolatosan szakirodalmat, kitérve annak hatásmechanizmusára, a farmakokinetikai vizsgálatokra, ill. a főbb lehetséges indikációkra. A korábban más fajokkal kapcsolatban megjelent szakirodalmi adatok alapján az endokannabinoid rendszeren keresztül lehetőség nyílhat a lovak életminőségének javítására fájdalommal, gyulladással járó kórképekben, ill. lovak viselkedészavariban. Lovakban a CBD hatékonyságának bizonyítását célzó tudományos kísérletek elvégzése egyre sürgetőbb, azonban az eddigi tanulmányok alapján további farmakokinetikai vizsgálatok szükségesek.}, year = {2023}, pages = {131-142}, orcid-numbers = {Alberti, Ágnes/0000-0003-3096-4057} } @inproceedings{MTMT:33232303, title = {Mid- and Long-Term Stability Study of Cyclic Diarylheptanoids from Carpinus Betulus}, url = {https://m2.mtmt.hu/api/publication/33232303}, author = {Felegyi-Tóth, Csenge Anna and Heilmann, Tímea and Boldizsár, Imre and Alberti, Ágnes}, booktitle = {33rd International Symposium on Chromatography – ISC 2022}, unique-id = {33232303}, year = {2022}, pages = {91}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Boldizsár, Imre/0000-0001-7852-8364; Alberti, Ágnes/0000-0003-3096-4057} } @CONFERENCE{MTMT:32912120, title = {A Carpinus betulus fenoloidprofiljának és ciklusos diarilheptanoidjainak fitokémiai vizsgálata}, url = {https://m2.mtmt.hu/api/publication/32912120}, author = {Felegyi-Tóth, Csenge Anna and Garádi, Zsófia and Heilmann, Tímea and Buda, Eszter and Simon, Alexandra and Boldizsár, Imre and Alberti, Ágnes}, booktitle = {Fiatal Gyógynövénykutatók Fóruma: a Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának rendezvénye}, doi = {10.14232/fgykf.2022.a1}, unique-id = {32912120}, year = {2022}, pages = {9-9}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Garádi, Zsófia/0000-0002-0152-2746; Simon, Alexandra/0000-0001-8189-4170; Boldizsár, Imre/0000-0001-7852-8364; Alberti, Ágnes/0000-0003-3096-4057} } @article{MTMT:32873552, title = {Membrane Permeability and Aqueous Stability Study of Linear and Cyclic Diarylheptanoids from Corylus maxima}, url = {https://m2.mtmt.hu/api/publication/32873552}, author = {Felegyi-Tóth, Csenge Anna and Tóth, Zsófia and Garádi, Zsófia and Boldizsár, Imre and Nagyné Nedves, Andrea and Simon, Alexandra and Felegyi, Kristóf and Alberti, Ágnes and Riethmüller, Eszter}, doi = {10.3390/pharmaceutics14061250}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32873552}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Garádi, Zsófia/0000-0002-0152-2746; Boldizsár, Imre/0000-0001-7852-8364; Nagyné Nedves, Andrea/0000-0002-7223-993X; Simon, Alexandra/0000-0001-8189-4170; Alberti, Ágnes/0000-0003-3096-4057; Riethmüller, Eszter/0000-0002-9719-5427} } @article{MTMT:32554413, title = {Isolation and quantification of diarylheptanoids from European hornbeam (Carpinus betulus L.) and HPLC-ESI-MS/MS characterization of its antioxidative phenolics}, url = {https://m2.mtmt.hu/api/publication/32554413}, author = {Felegyi-Tóth, Csenge Anna and Garádi, Zsófia and Darcsi, András and Csernák, Orsolya and Boldizsár, Imre and Béni, Szabolcs and Alberti, Ágnes}, doi = {10.1016/j.jpba.2021.114554}, journal-iso = {J PHARMACEUT BIOMED ANAL}, journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS}, volume = {210}, unique-id = {32554413}, issn = {0731-7085}, year = {2022}, eissn = {1873-264X}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Garádi, Zsófia/0000-0002-0152-2746; Darcsi, András/0000-0003-2202-4997; Csernák, Orsolya/0000-0002-9035-4202; Boldizsár, Imre/0000-0001-7852-8364; Béni, Szabolcs/0000-0001-7056-6825; Alberti, Ágnes/0000-0003-3096-4057} } @{MTMT:33851702, title = {Közönséges gyertyán bioaktív vegyületeinek izolálása és szerkezetmeghatározása}, url = {https://m2.mtmt.hu/api/publication/33851702}, author = {Felegyi-Tóth, Csenge Anna and Garádi, Zsófia and Darcsi, András and Boldizsár, Imre and Béni, Szabolcs and Alberti, Ágnes}, booktitle = {10th Jubilee Interdisciplinary Doctoral Conference : Book of Abstracts = 10. Jubileumi Interdiszciplináris Doktorandusz Konferencia : Absztraktkötet}, unique-id = {33851702}, year = {2021}, pages = {219-219}, orcid-numbers = {Felegyi-Tóth, Csenge Anna/0000-0001-6260-465X; Garádi, Zsófia/0000-0002-0152-2746; Darcsi, András/0000-0003-2202-4997; Boldizsár, Imre/0000-0001-7852-8364; Béni, Szabolcs/0000-0001-7056-6825; Alberti, Ágnes/0000-0003-3096-4057} } @article{MTMT:31935889, title = {A pattern-triggered immunity-related phenolic, acetosyringone, boosts rapid inhibition of a diverse set of plant pathogenic bacteria}, url = {https://m2.mtmt.hu/api/publication/31935889}, author = {Szatmári, Ágnes and Móricz, Ágnes and Schwarczinger, Ildikó and Kolozsváriné Nagy, Judit and Alberti, Ágnes and Pogány, Miklós and Bozsó, Zoltán}, doi = {10.1186/s12870-021-02928-4}, journal-iso = {BMC PLANT BIOL}, journal = {BMC PLANT BIOLOGY}, volume = {21}, unique-id = {31935889}, issn = {1471-2229}, year = {2021}, eissn = {1471-2229}, orcid-numbers = {Szatmári, Ágnes/0000-0001-8768-8212; Alberti, Ágnes/0000-0003-3096-4057} }