TY - JOUR AU - Vilimi, Zsófia AU - Pápay, Zsófia Edit AU - Basa, Bálint AU - Orekhova, Xeniya AU - Kállai-Szabó, Nikolett AU - Antal, István TI - Microfluidic Rheology: An Innovative Method for Viscosity Measurement of Gels and Various Pharmaceuticals JF - GELS (BASEL) J2 - GELS-BASEL VL - 10 PY - 2024 IS - 7 PG - 14 SN - 2310-2861 DO - 10.3390/gels10070464 UR - https://m2.mtmt.hu/api/publication/35149948 ID - 35149948 N1 - Export Date: 8 October 2024 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7-9, Hungary; email: antal.istvan@semmelweis.hu AB - Measuring the viscosity of pharmaceutical dosage forms is a crucial process. Viscosity provides information about the stability of the composition, the release rate of the drug, bioavailability, and, in the case of injectable drug formulations, even the force required for injection. However, measuring viscosity is a complex task with numerous challenges, especially for non-Newtonian materials, which include most pharmaceutical formulations, such as gels. Selecting the appropriate shear rate is critical. Since viscosity in many systems is highly temperature-dependent, stable temperature control is necessary during the measurement. Using microfluidics technology, it is now possible to perform rheological characterization and conduct fast and accurate measurements. Small sample volumes (even below 500 µL) are required, and viscosity determination can be carried out over a wide range of shear rates. Nevertheless, the pharmaceutical application of viscometers operating on the principle of microfluidics is not yet widespread. In our work, we compare the results of measurements taken with a microfluidic chip-based viscometer on different pharmaceutical forms (gels, solution) with those obtained using a traditional rotational viscometer, evaluating the relative advantages and disadvantages of the different methods. The microfluidics-based method enables time- and sample-efficient viscosity analysis of the examined pharmaceutical forms. LA - English DB - MTMT ER - TY - JOUR AU - Vilimi, Zsófia AU - Király, Márton AU - Barna, Ádám Tibor AU - Pápay, Zsófia Edit AU - Budai, Lívia AU - Ludányi, Krisztina AU - Kállai-Szabó, Nikolett AU - Antal, István TI - Formulation of Emulgels Containing Clotrimazole for the Treatment of Vaginal Candidiasis JF - GELS (BASEL) J2 - GELS-BASEL VL - 10 PY - 2024 IS - 11 PG - 14 SN - 2310-2861 DO - 10.3390/gels10110730 UR - https://m2.mtmt.hu/api/publication/35531327 ID - 35531327 N1 - Department of Pharmaceutics, Semmelweis University, Budapest, 1092, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, 1085, Hungary Cited By :1 Export Date: 5 February 2025 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hungary; email: antal.istvan@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Pápay, Zsófia Edit AU - Vilimi, Zsófia AU - Antal, István TI - Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity JF - GELS (BASEL) J2 - GELS-BASEL VL - 9 PY - 2023 IS - 6 PG - 20 SN - 2310-2861 DO - 10.3390/gels9060469 UR - https://m2.mtmt.hu/api/publication/34009564 ID - 34009564 AB - Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine. LA - English DB - MTMT ER - TY - JOUR AU - Budai, Lívia AU - Budai, Marianna AU - Pápay, Zsófia Edit AU - Szalkai, Petra AU - Niczinger, Noémi AU - Kijima, S. AU - Sugibayashi, K. AU - Antal, István AU - Kállai-Szabó, Nikolett TI - Viscoelasticity of Liposomal Dispersions JF - NANOMATERIALS J2 - NANOMATERIALS-BASEL VL - 13 PY - 2023 IS - 16 PG - 14 SN - 2079-4991 DO - 10.3390/nano13162340 UR - https://m2.mtmt.hu/api/publication/34096011 ID - 34096011 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, Budapest, 1092, Hungary Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Saitama, Sakado, 350-0295, Japan Export Date: 21 November 2023 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: antal.istvan@semmelweis.hu Correspondence Address: Kállai-Szabó, N.; Department of Pharmaceutics, Hőgyes Str. 7, Hungary; email: kallai.nikolett@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Pápay, Zsófia Edit AU - MAGRAMANE, Sabrina AU - Király, Márton AU - Szalkai, Petra AU - Ludányi, Krisztina AU - Horváth, Péter AU - Antal, István TI - Optimization and Development of Albumin–Biopolymer Bioconjugates with Solubility-Improving Properties JF - BIOMEDICINES J2 - BIOMEDICINES VL - 9 PY - 2021 IS - 7 PG - 21 SN - 2227-9059 DO - 10.3390/biomedicines9070737 UR - https://m2.mtmt.hu/api/publication/32083266 ID - 32083266 LA - English DB - MTMT ER - TY - JOUR AU - MAGRAMANE, Sabrina AU - Pápay, Zsófia Edit AU - Kovács, Anna AU - Zelkó, Romána AU - Antal, István TI - Formulation of Apigenin-Loaded Liposomes for Pulmonary Delivery JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 268 EP - 268 PG - 1 SN - 0001-6659 DO - 10.33892/aph.2021.91.268-269 UR - https://m2.mtmt.hu/api/publication/32496154 ID - 32496154 N1 - Poster-53 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Szalkai, Petra AU - Pápay, Zsófia Edit AU - Budai, Lívia AU - Sárády-Kesztyűs, Ágnes AU - Antal, István TI - Rheological Studies of Hydrogels and Liposomal Dispersions: Factors Influencing the Viscoelastic Properties JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 320 EP - 321 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/32496688 ID - 32496688 N1 - P-78 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - MAGRAMANE, Sabrina AU - Pápay, Zsófia Edit AU - Turbucz, Béla AU - Antal, István TI - Formulation and Characterization of Pulmonary Drug Delivery Systems JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 89 PY - 2019 IS - 2 SP - 63 EP - 83 PG - 21 SN - 0001-6659 DO - 10.33892/aph.2019.89.63-83 UR - https://m2.mtmt.hu/api/publication/30802791 ID - 30802791 LA - English DB - MTMT ER - TY - CONF AU - Pápay, Zsófia Edit AU - Szerőczei, Debóra AU - Király, Márton AU - Ludányi, Krisztina AU - Antal, István TI - Humán szérum albumin glikokonjugátumok előállítása biopolimerekkel és vizsgálataik T2 - Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2019 PY - 2019 SP - PO23 UR - https://m2.mtmt.hu/api/publication/31176388 ID - 31176388 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lengyel, Miléna AU - Bertalanné Balogh, Emese AU - Szerőczei, Debóra AU - Dobó-Nagy, Csaba AU - Pápay, Zsófia Edit AU - Stommer, V AU - Klebovich, Imre AU - Antal, István TI - Study on process parameters and optimization of microencapsulation based on phase separation JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 122 PY - 2018 SP - 273 EP - 280 PG - 8 SN - 0928-0987 DO - 10.1016/j.ejps.2018.07.015 UR - https://m2.mtmt.hu/api/publication/3400122 ID - 3400122 AB - As surfactants are capable of influencing the droplet formation, our study primarily aims the investigation of the effect of a nonionic surfactant e.g. Polysorbate 80 on the formation of microspheres on the course of vibrating nozzle method with coacervation. The experiments also concern the impact of the different process parameters (e.g. vibration frequency, feed rate and voltage) on the shape and size distribution of microspheres characterized by laser diffraction size determination completed with particle image analysis. The calcium-alginate microspheres were processed using freeze-drying to ensure solid state with better drug carrier capability. Addition of isomalt was advantageous in the formation of freeze-dried microspheres at low alginate concentration, which was explained by micro-CT analysis of the constructed particle structure. The internal three-dimensional network of calcium alginate demonstrated a more cancellous architecture ameliorating the roundness of microparticles. LA - English DB - MTMT ER -