TY - CONF AU - Mardikasari, Sandra Aulia AU - Katona, Gábor AU - Budai-Szűcs, Mária AU - Sipos, Bence AU - Orosz, László AU - Burián, Katalin AU - Rovó, László AU - Pannonhalminé Csóka, Ildikó TI - Development of in situ ionic-sensitive nasal gels of amoxicillin-loaded albumin nanoparticle applying QbD-based optimization for improved local delivery T2 - VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and RegulatoryAffairs, University of Szeged, Faculty of Pharmacy C1 - Szeged PY - 2024 SP - 18 EP - 18 PG - 1 DO - 10.14232/syrptbrs.2024.18 UR - https://m2.mtmt.hu/api/publication/34770795 ID - 34770795 LA - English DB - MTMT ER - TY - CHAP AU - Ashfaq, Rabia AU - Budai-Szűcs, Mária ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Factorial design of injectable chlorhexidine in situ gelling system for the treatment of periodontitis T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 19 EP - 19 PG - 1 DO - 10.14232/syrptbrs.2024.19 UR - https://m2.mtmt.hu/api/publication/34723711 ID - 34723711 LA - English DB - MTMT ER - TY - JOUR AU - Szoleczky, Réka AU - Kovács, Anita AU - Berkó, Szilvia AU - Budai-Szűcs, Mária TI - An Analytical Target Profile for the Development of an In Vitro Release Test Method and Apparatus Selection in the Case of Semisolid Topical Formulations JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 16 PY - 2024 IS - 3 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics16030313 UR - https://m2.mtmt.hu/api/publication/34688545 ID - 34688545 AB - This study focuses on how to define an Analytical Target Profile (ATP) which is intended for use in practice and on facilitating the selection of in vitro release test (IVRT) technology for diclofenac sodium topical hydrogel and cream. The implementation involves incorporating the new draft guidelines of the International Council for Harmonisation (ICH Q14) and USP (United States Pharmacopeia) Chapter 1220. Four IVRT apparatuses were compared (USP Apparatus II with immersion cell, USP Apparatus IV with semisolid adapter, static vertical diffusion cell, and a new, in-house-developed flow-through diffusion cell) with the help of the ATP. Performance characteristics such as accuracy, precision, cumulative amount released at the end of the IVRT experiment, and robustness were investigated. We found that the best apparatus for developing IVRT quality control (QC) tests in both cases was USP II with an immersion cell. All four different IVRT apparatuses were compared with each other and with the data found in the literature. LA - English DB - MTMT ER - TY - JOUR AU - Falusi, Fanni AU - Berkó, Szilvia AU - Budai-Szűcs, Mária AU - Veréb, Zoltán AU - Kovács, Anita TI - Foams Set a New Pace for the Release of Diclofenac Sodium JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 16 PY - 2024 IS - 2 PG - 17 SN - 1999-4923 DO - 10.3390/pharmaceutics16020287 UR - https://m2.mtmt.hu/api/publication/34666840 ID - 34666840 AB - Medicated foams have emerged as promising alternatives to traditional carrier systems in pharmaceutical research. Their rapid and convenient application allows for effective treatment of extensive or hirsute areas, as well as sensitive or inflamed skin surfaces. Foams possess excellent spreading capabilities on the skin, ensuring immediate drug absorption without the need for intense rubbing. Our research focuses on the comparison of physicochemical and biopharmaceutical properties of three drug delivery systems: foam, the foam bulk liquid, and a conventional hydrogel. During the development of the composition, widely used diclofenac sodium was employed. The safety of the formulae was confirmed through an in vitro cytotoxicity assay. Subsequently, the closed Franz diffusion cell was used to determine drug release and permeation in vitro. Ex vivo Raman spectroscopy was employed to investigate the presence of diclofenac sodium in various skin layers. The obtained results of the foam were compared to the bulk liquid and to a conventional hydrogel. In terms of drug release, the foam showed a rapid release, with 80% of diclofenac released within 30 min. In summary, the investigated foam holds promising potential as an alternative to traditional dermal carrier systems, offering faster drug release and permeation. LA - English DB - MTMT ER - TY - CHAP AU - Szalai, Boglárka AU - Jójártné Laczkovich, Orsolya AU - Budai-Szűcs, Mária ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Evaluation of combined thermoresponsive ophthalmic gels T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 22 EP - 22 PG - 1 UR - https://m2.mtmt.hu/api/publication/34561726 ID - 34561726 LA - English DB - MTMT ER - TY - JOUR AU - Csorba, Anita AU - Katona, Gábor AU - Budai-Szűcs, Mária AU - Balogh Weiser, Diána AU - Molnár, P. AU - Maka, Erika AU - Nochta-Kazsoki, Adrienn Katalin AU - Vajna, Márton Antal AU - Zelkó, Romána AU - Nagy, Zoltán Zsolt AU - Balogh, György Tibor TI - A Comparative Pharmacokinetic Study for Cysteamine-Containing Eye Drops as an Orphan Topical Therapy in Cystinosis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25031623 UR - https://m2.mtmt.hu/api/publication/34538437 ID - 34538437 N1 - Department of Ophthalmology, Semmelweis University, Mária Street 39, Budapest, H-1085, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, Szeged, H-6720, Hungary Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Molteam Llc., Mélyfúró Street 4, Budapest, H-1151, Hungary University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, H-1092, Hungary Export Date: 23 February 2024 Correspondence Address: Csorba, A.; Department of Ophthalmology, Mária Street 39, Hungary; email: csorba.anita@semmelweis-univ.hu Correspondence Address: Balogh, G.T.; Department of Pharmaceutical Chemistry, Hőgyes Endre Street 7-9, Hungary; email: balogh.gyorgy.tibor@semmelweis.hu LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Anita AU - Falusi, Fanni AU - Gácsi, Attila AU - Budai-Szűcs, Mária AU - Csányi, Erzsébet AU - Veréb, Zoltán AU - Monostori, Tamás AU - Pannonhalminé Csóka, Ildikó AU - Berkó, Szilvia TI - Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 193 PY - 2024 PG - 15 SN - 0928-0987 DO - 10.1016/j.ejps.2023.106666 UR - https://m2.mtmt.hu/api/publication/34428028 ID - 34428028 N1 - HCEMM-USZ Skin Research Group, Szeged, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Ashfaq, Rabia AU - Rasul, Akhtar AU - Asghar, Sajid AU - Kovács, Anita AU - Berkó, Szilvia AU - Budai-Szűcs, Mária TI - Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 21 PG - 49 SN - 1661-6596 DO - 10.3390/ijms242115764 UR - https://m2.mtmt.hu/api/publication/34397535 ID - 34397535 AB - Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one of the extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability of encapsulated compounds but also provide efficient targeting and reduce the risk of toxicity. Over the last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, and herbs have received more attention due to their remarkable biological and pharmacological health and medical benefits. However, their poor aqueous solubility, compromised stability, insufficient absorption, and accelerated elimination impede research in the nutraceutical sector. Owing to the possibilities offered by various LNPs, their ability to accommodate both hydrophilic and hydrophobic molecules and the availability of various preparation methods suitable for sensitive molecules, loading natural fragile molecules into LNPs offers a promising solution. The primary objective of this work is to explore the synergy between nature and nanotechnology, encompassing a wide range of research aimed at encapsulating natural therapeutic molecules within LNPs. LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Bence AU - Katona, Gábor AU - Szarvas, Flóra Mária AU - Budai-Szűcs, Mária AU - Ambrus, Rita AU - Pannonhalminé Csóka, Ildikó TI - Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 16 PY - 2023 IS - 10 PG - 16 SN - 1424-8247 DO - 10.3390/ph16101447 UR - https://m2.mtmt.hu/api/publication/34192255 ID - 34192255 AB - In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had a proper particle size and drug content after drying with spherical morphology and amorphous structure. After rapid dissolution in water, the polymeric micelles had a particle size around 100–130 nm, in monodisperse size distribution. The high encapsulation efficiency (>80%) and high solubilization (approx. 300-fold increase in thermodynamic solubility) contributed to rapid drug release (>80% in the first 15 min) and fast passive diffusion at simulated nasal conditions. The formulated prototype preparations fulfilled the demands of a low-viscosity, moderately mucoadhesive nasal drug delivery system, which may be capable of increasing the overall bioavailability of drugs administered via the auspicious nasal drug delivery route. LA - English DB - MTMT ER - TY - CONF AU - Ashfaq, Rabia AU - Budai-Szűcs, Mária ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Design of in situ gelling systems containing natural ingredients fortreatment of periodontitis T2 - V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2023 SP - 63 EP - 63 PG - 1 DO - 10.14232/syrptbrs.2023.63 UR - https://m2.mtmt.hu/api/publication/34191180 ID - 34191180 LA - English DB - MTMT ER -