@CONFERENCE{MTMT:34770795, title = {Development of in situ ionic-sensitive nasal gels of amoxicillin-loaded albumin nanoparticle applying QbD-based optimization for improved local delivery}, url = {https://m2.mtmt.hu/api/publication/34770795}, author = {Mardikasari, Sandra Aulia and Katona, Gábor and Budai-Szűcs, Mária and Sipos, Bence and Orosz, László and Burián, Katalin and Rovó, László and Pannonhalminé Csóka, Ildikó}, booktitle = {VI. Symposium of Young Researchers on PharmaceuticalTechnology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2024.18}, unique-id = {34770795}, year = {2024}, pages = {18-18}, orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Sipos, Bence/0000-0002-0131-4728; Burián, Katalin/0000-0003-1300-2374; Rovó, László/0000-0003-1782-1756; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @{MTMT:34723711, title = {Factorial design of injectable chlorhexidine in situ gelling system for the treatment of periodontitis}, url = {https://m2.mtmt.hu/api/publication/34723711}, author = {Ashfaq, Rabia and Budai-Szűcs, Mária}, booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2024.19}, unique-id = {34723711}, year = {2024}, pages = {19-19}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} } @article{MTMT:34688545, title = {An Analytical Target Profile for the Development of an In Vitro Release Test Method and Apparatus Selection in the Case of Semisolid Topical Formulations}, url = {https://m2.mtmt.hu/api/publication/34688545}, author = {Szoleczky, Réka and Kovács, Anita and Berkó, Szilvia and Budai-Szűcs, Mária}, doi = {10.3390/pharmaceutics16030313}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {16}, unique-id = {34688545}, issn = {1999-4923}, abstract = {This study focuses on how to define an Analytical Target Profile (ATP) which is intended for use in practice and on facilitating the selection of in vitro release test (IVRT) technology for diclofenac sodium topical hydrogel and cream. The implementation involves incorporating the new draft guidelines of the International Council for Harmonisation (ICH Q14) and USP (United States Pharmacopeia) Chapter 1220. Four IVRT apparatuses were compared (USP Apparatus II with immersion cell, USP Apparatus IV with semisolid adapter, static vertical diffusion cell, and a new, in-house-developed flow-through diffusion cell) with the help of the ATP. Performance characteristics such as accuracy, precision, cumulative amount released at the end of the IVRT experiment, and robustness were investigated. We found that the best apparatus for developing IVRT quality control (QC) tests in both cases was USP II with an immersion cell. All four different IVRT apparatuses were compared with each other and with the data found in the literature.}, year = {2024}, eissn = {1999-4923}, orcid-numbers = {Kovács, Anita/0000-0001-5593-1329; Berkó, Szilvia/0000-0002-3842-8876; Budai-Szűcs, Mária/0000-0001-5187-5702} } @article{MTMT:34666840, title = {Foams Set a New Pace for the Release of Diclofenac Sodium}, url = {https://m2.mtmt.hu/api/publication/34666840}, author = {Falusi, Fanni and Berkó, Szilvia and Budai-Szűcs, Mária and Veréb, Zoltán and Kovács, Anita}, doi = {10.3390/pharmaceutics16020287}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {16}, unique-id = {34666840}, issn = {1999-4923}, abstract = {Medicated foams have emerged as promising alternatives to traditional carrier systems in pharmaceutical research. Their rapid and convenient application allows for effective treatment of extensive or hirsute areas, as well as sensitive or inflamed skin surfaces. Foams possess excellent spreading capabilities on the skin, ensuring immediate drug absorption without the need for intense rubbing. Our research focuses on the comparison of physicochemical and biopharmaceutical properties of three drug delivery systems: foam, the foam bulk liquid, and a conventional hydrogel. During the development of the composition, widely used diclofenac sodium was employed. The safety of the formulae was confirmed through an in vitro cytotoxicity assay. Subsequently, the closed Franz diffusion cell was used to determine drug release and permeation in vitro. Ex vivo Raman spectroscopy was employed to investigate the presence of diclofenac sodium in various skin layers. The obtained results of the foam were compared to the bulk liquid and to a conventional hydrogel. In terms of drug release, the foam showed a rapid release, with 80% of diclofenac released within 30 min. In summary, the investigated foam holds promising potential as an alternative to traditional dermal carrier systems, offering faster drug release and permeation.}, year = {2024}, eissn = {1999-4923}, orcid-numbers = {Falusi, Fanni/0009-0002-4769-5500; Berkó, Szilvia/0000-0002-3842-8876; Budai-Szűcs, Mária/0000-0001-5187-5702; Veréb, Zoltán/0000-0002-9518-2155; Kovács, Anita/0000-0001-5593-1329} } @{MTMT:34561726, title = {Evaluation of combined thermoresponsive ophthalmic gels}, url = {https://m2.mtmt.hu/api/publication/34561726}, author = {Szalai, Boglárka and Jójártné Laczkovich, Orsolya and Budai-Szűcs, Mária}, booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, unique-id = {34561726}, year = {2024}, pages = {22-22}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} } @article{MTMT:34538437, title = {A Comparative Pharmacokinetic Study for Cysteamine-Containing Eye Drops as an Orphan Topical Therapy in Cystinosis}, url = {https://m2.mtmt.hu/api/publication/34538437}, author = {Csorba, Anita and Katona, Gábor and Budai-Szűcs, Mária and Balogh Weiser, Diána and Molnár, P. and Maka, Erika and Nochta-Kazsoki, Adrienn Katalin and Vajna, Márton Antal and Zelkó, Romána and Nagy, Zoltán Zsolt and Balogh, György Tibor}, doi = {10.3390/ijms25031623}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34538437}, issn = {1661-6596}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Csorba, Anita/0000-0002-3256-9440; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Balogh Weiser, Diána/0000-0002-9957-1203; Maka, Erika/0000-0002-3631-3506; Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Vajna, Márton Antal/0000-0001-5280-7533; Zelkó, Romána/0000-0002-5419-9137; Nagy, Zoltán Zsolt/0000-0002-7330-0464; Balogh, György Tibor/0000-0003-3347-1880} } @article{MTMT:34428028, title = {Formulation and investigation of hydrogels containing an increased level of diclofenac sodium using risk assessment tools}, url = {https://m2.mtmt.hu/api/publication/34428028}, author = {Kovács, Anita and Falusi, Fanni and Gácsi, Attila and Budai-Szűcs, Mária and Csányi, Erzsébet and Veréb, Zoltán and Monostori, Tamás and Pannonhalminé Csóka, Ildikó and Berkó, Szilvia}, doi = {10.1016/j.ejps.2023.106666}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {193}, unique-id = {34428028}, issn = {0928-0987}, year = {2024}, eissn = {1879-0720}, orcid-numbers = {Kovács, Anita/0000-0001-5593-1329; Falusi, Fanni/0009-0002-4769-5500; Budai-Szűcs, Mária/0000-0001-5187-5702; Csányi, Erzsébet/0000-0002-3010-1959; Veréb, Zoltán/0000-0002-9518-2155; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Berkó, Szilvia/0000-0002-3842-8876} } @article{MTMT:34397535, title = {Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals}, url = {https://m2.mtmt.hu/api/publication/34397535}, author = {Ashfaq, Rabia and Rasul, Akhtar and Asghar, Sajid and Kovács, Anita and Berkó, Szilvia and Budai-Szűcs, Mária}, doi = {10.3390/ijms242115764}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34397535}, issn = {1661-6596}, abstract = {Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one of the extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability of encapsulated compounds but also provide efficient targeting and reduce the risk of toxicity. Over the last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, and herbs have received more attention due to their remarkable biological and pharmacological health and medical benefits. However, their poor aqueous solubility, compromised stability, insufficient absorption, and accelerated elimination impede research in the nutraceutical sector. Owing to the possibilities offered by various LNPs, their ability to accommodate both hydrophilic and hydrophobic molecules and the availability of various preparation methods suitable for sensitive molecules, loading natural fragile molecules into LNPs offers a promising solution. The primary objective of this work is to explore the synergy between nature and nanotechnology, encompassing a wide range of research aimed at encapsulating natural therapeutic molecules within LNPs.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Rasul, Akhtar/0000-0002-9321-0087; Asghar, Sajid/0000-0002-9184-9098; Kovács, Anita/0000-0001-5593-1329; Berkó, Szilvia/0000-0002-3842-8876; Budai-Szűcs, Mária/0000-0001-5187-5702} } @article{MTMT:34192255, title = {Development of Vinpocetine-Loaded Nasal Polymeric Micelles via Nano-Spray-Drying}, url = {https://m2.mtmt.hu/api/publication/34192255}, author = {Sipos, Bence and Katona, Gábor and Szarvas, Flóra Mária and Budai-Szűcs, Mária and Ambrus, Rita and Pannonhalminé Csóka, Ildikó}, doi = {10.3390/ph16101447}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {16}, unique-id = {34192255}, abstract = {In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles were developed via nano-spray-drying. Three different mucoadhesive excipients were applied in the studies, namely chitosan, hyaluronic acid and hydroxypropyl methylcellulose. In all cases, the formulations had a proper particle size and drug content after drying with spherical morphology and amorphous structure. After rapid dissolution in water, the polymeric micelles had a particle size around 100–130 nm, in monodisperse size distribution. The high encapsulation efficiency (>80%) and high solubilization (approx. 300-fold increase in thermodynamic solubility) contributed to rapid drug release (>80% in the first 15 min) and fast passive diffusion at simulated nasal conditions. The formulated prototype preparations fulfilled the demands of a low-viscosity, moderately mucoadhesive nasal drug delivery system, which may be capable of increasing the overall bioavailability of drugs administered via the auspicious nasal drug delivery route.}, year = {2023}, eissn = {1424-8247}, orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @CONFERENCE{MTMT:34191180, title = {Design of in situ gelling systems containing natural ingredients fortreatment of periodontitis}, url = {https://m2.mtmt.hu/api/publication/34191180}, author = {Ashfaq, Rabia and Budai-Szűcs, Mária}, booktitle = {V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2023.63}, unique-id = {34191180}, year = {2023}, pages = {63-63}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} }