@article{MTMT:34724664, title = {PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion}, url = {https://m2.mtmt.hu/api/publication/34724664}, author = {Laczkó-Dobos, Hajnalka and Bhattacharjee, Arindam and Maddali, Asha Kiran and Kincses, András and Abuammar, Hussein and Sebőkné Nagy, Krisztina and Páli, Tibor and Dér, András and Hegedűs, Tamás and Csordás, Gábor and Juhász, Gábor}, doi = {10.1080/15548627.2024.2322493}, journal-iso = {AUTOPHAGY}, journal = {AUTOPHAGY}, volume = {0}, unique-id = {34724664}, issn = {1554-8627}, year = {2024}, eissn = {1554-8635}, pages = {0}, orcid-numbers = {Páli, Tibor/0000-0003-1649-1097; Hegedűs, Tamás/0000-0002-0331-9629; Csordás, Gábor/0000-0001-6871-6839; Juhász, Gábor/0000-0001-8548-8874} } @article{MTMT:34673907, title = {Lab-on-a-chip models of the blood-brain barrier: evolution, problems, perspectives}, url = {https://m2.mtmt.hu/api/publication/34673907}, author = {Deli, Mária Anna and Porkoláb, Gergő and Kincses, András and Mészáros, Mária and Szecskó, Anikó and Kocsis, Anna and Vigh, Judit Piroska and Valkai, Sándor and Veszelka, Szilvia and Walter, Fruzsina and Dér, András}, doi = {10.1039/d3lc00996c}, journal-iso = {LAB CHIP}, journal = {LAB ON A CHIP}, unique-id = {34673907}, issn = {1473-0197}, year = {2024}, eissn = {1473-0189}, orcid-numbers = {Deli, Mária Anna/0000-0001-6084-6524; Valkai, Sándor/0000-0001-8479-8141; Walter, Fruzsina/0000-0001-8145-2823} } @article{MTMT:34153921, title = {Spin-Label Electron Paramagnetic Resonance Spectroscopy Reveals Effects of Wastewater Filter Membrane Coated with Titanium Dioxide Nanoparticles on Bovine Serum Albumin}, url = {https://m2.mtmt.hu/api/publication/34153921}, author = {Sebőkné Nagy, Krisztina and Kóta, Zoltán and Kincses, András and Fazekas, Ákos Ferenc and Dér, András and László, Zsuzsanna and Páli, Tibor}, doi = {10.3390/molecules28196750}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34153921}, issn = {1420-3049}, abstract = {The accumulation of proteins in filter membranes limits the efficiency of filtering technologies for cleaning wastewater. Efforts are ongoing to coat commercial filters with different materials (such as titanium dioxide, TiO2) to reduce the fouling of the membrane. Beyond monitoring the desired effect of the retention of biomolecules, it is necessary to understand what the biophysical changes are in water-soluble proteins caused by their interaction with the new coated filter membranes, an aspect that has received little attention so far. Using spin-label electron paramagnetic resonance (EPR), aided with native fluorescence spectroscopy and dynamic light scattering (DLS), here, we report the changes in the structure and dynamics of bovine serum albumin (BSA) exposed to TiO2 (P25) nanoparticles or passing through commercial polyvinylidene fluoride (PVDF) membranes coated with the same nanoparticles. We have found that the filtering process and prolonged exposure to TiO2 nanoparticles had significant effects on different regions of BSA, and denaturation of the protein was not observed, neither with the TiO2 nanoparticles nor when passing through the TiO2-coated filter membranes.}, year = {2023}, eissn = {1420-3049}, pages = {0-17}, orcid-numbers = {Kóta, Zoltán/0000-0003-2420-8773; László, Zsuzsanna/0000-0001-8130-7482; Páli, Tibor/0000-0003-1649-1097} } @article{MTMT:33688148, title = {The Use of Sensors in Blood-Brain Barrier-on-a-Chip Devices: Current Practice and Future Directions}, url = {https://m2.mtmt.hu/api/publication/33688148}, author = {Kincses, András and Vigh, Judit Piroska and Petrovszki, Dániel and Valkai, Sándor and Kocsis, Anna and Walter, Fruzsina and Lin, Hung-Yin and Jan, Jeng-Shiung and Deli, Mária Anna and Dér, András}, doi = {10.3390/bios13030357}, journal-iso = {BIOSENSORS-BASEL}, journal = {BIOSENSORS}, volume = {13}, unique-id = {33688148}, abstract = {The application of lab-on-a-chip technologies in in vitro cell culturing swiftly resulted in improved models of human organs compared to static culture insert-based ones. These chip devices provide controlled cell culture environments to mimic physiological functions and properties. Models of the blood-brain barrier (BBB) especially profited from this advanced technological approach. The BBB represents the tightest endothelial barrier within the vasculature with high electric resistance and low passive permeability, providing a controlled interface between the circulation and the brain. The multi-cell type dynamic BBB-on-chip models are in demand in several fields as alternatives to expensive animal studies or static culture inserts methods. Their combination with integrated biosensors provides real-time and noninvasive monitoring of the integrity of the BBB and of the presence and concentration of agents contributing to the physiological and metabolic functions and pathologies. In this review, we describe built-in sensors to characterize BBB models via quasi-direct current and electrical impedance measurements, as well as the different types of biosensors for the detection of metabolites, drugs, or toxic agents. We also give an outlook on the future of the field, with potential combinations of existing methods and possible improvements of current techniques.}, year = {2023}, eissn = {2079-6374}, orcid-numbers = {Valkai, Sándor/0000-0001-8479-8141; Walter, Fruzsina/0000-0001-8145-2823; Jan, Jeng-Shiung/0000-0002-8379-404X; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:33688118, title = {Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia}, url = {https://m2.mtmt.hu/api/publication/33688118}, author = {Barabási, Beáta and Barna, Lilla and Santa Maria, Anaraquel and Harazin, András and Molnár, Réka and Kincses, András and Vigh, Judit Piroska and Dukay, Brigitta and Sántha, Miklós and Tóth, Erzsébet Melinda and Walter, Fruzsina and Deli, Mária Anna and Hoyk, Zsófia}, doi = {10.1186/s12987-023-00418-3}, journal-iso = {FLUIDS BARRIERS CNS}, journal = {FLUIDS AND BARRIERS OF THE CNS}, volume = {20}, unique-id = {33688118}, issn = {2045-8118}, year = {2023}, eissn = {2045-8118}, orcid-numbers = {Santa Maria, Anaraquel/0000-0003-3505-5477; Harazin, András/0000-0002-0904-5606; Molnár, Réka/0000-0002-3128-825X; Walter, Fruzsina/0000-0001-8145-2823; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:32667372, title = {Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells}, url = {https://m2.mtmt.hu/api/publication/32667372}, author = {Walter, Fruzsina and Harazin, András and Tóth, Andrea and Veszelka, Szilvia and Santa Maria, Anaraquel and Barna, Lilla and Kincses, András and Biczo, G and Balla, Zsolt and Kui, Balázs and Maléth, József and Cervenak, László and Tubak, Vilmos and Kittel, Ágnes and Rakonczay, Zoltán and Deli, Mária Anna}, doi = {10.1186/s12987-022-00308-0}, journal-iso = {FLUIDS BARRIERS CNS}, journal = {FLUIDS AND BARRIERS OF THE CNS}, volume = {19}, unique-id = {32667372}, issn = {2045-8118}, year = {2022}, eissn = {2045-8118}, orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Harazin, András/0000-0002-0904-5606; Santa Maria, Anaraquel/0000-0003-3505-5477; Maléth, József/0000-0001-5768-3090; Cervenak, László/0000-0003-0166-8697; Tubak, Vilmos/0000-0002-6141-3920; Rakonczay, Zoltán/0000-0002-1499-3416; Deli, Mária Anna/0000-0001-6084-6524} } @misc{MTMT:33017577, title = {Special Issue "Versatile Organ-on-a-Chip Devices"}, url = {https://m2.mtmt.hu/api/publication/33017577}, editor = {Dér, András and Valkai, Sándor and Walter, Fruzsina and Kincses, András}, unique-id = {33017577}, year = {2021}, orcid-numbers = {Valkai, Sándor/0000-0001-8479-8141; Walter, Fruzsina/0000-0001-8145-2823} } @mastersthesis{MTMT:32868162, title = {Lab-on-a-chip tool for the investigation of biological barriers [Csiplaboratóriumi eszköz biológiai gátak modellezésére]}, url = {https://m2.mtmt.hu/api/publication/32868162}, author = {Kincses, András}, doi = {10.14232/phd.11024}, publisher = {SZTE}, unique-id = {32868162}, year = {2021} } @article{MTMT:32077894, title = {Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods}, url = {https://m2.mtmt.hu/api/publication/32077894}, author = {Vigh, Judit Piroska and Kincses, András and Ozgür, Burak and Walter, Fruzsina and Santa Maria, Anaraquel and Valkai, Sándor and Vastag, Monika and Neuhaus, Winfried and Brodin, Birger and Dér, András and Deli, Mária Anna}, doi = {10.3390/mi12060685}, journal-iso = {MICROMACHINES-BASEL}, journal = {MICROMACHINES}, volume = {12}, unique-id = {32077894}, year = {2021}, eissn = {2072-666X}, orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Santa Maria, Anaraquel/0000-0003-3505-5477; Valkai, Sándor/0000-0001-8479-8141; Neuhaus, Winfried/0000-0002-6552-7183; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:32008069, title = {Breast adenocarcinoma-derived exosomes lower first-contact de-adhesion strength of adenocarcinoma cells to brain endothelial layer}, url = {https://m2.mtmt.hu/api/publication/32008069}, author = {Fazakas, Csilla and Kozma, Mihály and Molnár, Kinga and Kincses, András and Dér, András and Fejér, Adrienn and Horváth, Barnabás and Wilhelm, Imola Mária and Krizbai, István Adorján and Végh, Attila Gergely}, doi = {10.1016/j.colsurfb.2021.111810}, journal-iso = {COLLOID SURFACE B}, journal = {COLLOIDS AND SURFACES B: BIOINTERFACES}, volume = {204}, unique-id = {32008069}, issn = {0927-7765}, year = {2021}, eissn = {1873-4367}, orcid-numbers = {Fazakas, Csilla/0000-0001-7822-5881; Wilhelm, Imola Mária/0000-0003-2366-7337; Végh, Attila Gergely/0000-0003-0524-0946} }