@article{MTMT:32494653, title = {Az mFOLFIRINOX a pankreaszkarcinóma kezelésében: a valós klinikai gyakorlat eredményei}, url = {https://m2.mtmt.hu/api/publication/32494653}, author = {Torday, László and Varga, Eszter and Nagy‐László, Roland and Tóth, Dávid and Uhercsák, Gabriella and Pepó, Judit and Maráz, Anikó and Sántha, Dóra and Csenki, Melinda and Nikolényi, Alíz and Dobi, Ágnes and Valicsek, Erzsébet and Szilágyi, Éva and Farkas, Gyula Jr. and Vasas, Béla and Szepes, Zoltán and Tiszlavicz, László and Lázár, György ifj and Oláh, Judit Magdolna}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {65}, unique-id = {32494653}, issn = {0025-0244}, year = {2021}, eissn = {2060-0399}, pages = {57-57}, orcid-numbers = {Torday, László/0000-0002-2911-5499; Tóth, Dávid/0000-0002-1076-3031; Maráz, Anikó/0000-0002-2018-8413; Farkas, Gyula Jr./0000-0003-4054-0864; Szepes, Zoltán/0000-0002-9466-8719; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978} } @article{MTMT:32494623, title = {A perioperatív FLOT a reszekábilis gyomor/GEJ tumorok kezelésében: a valós klinikai gyakorlat eredményei}, url = {https://m2.mtmt.hu/api/publication/32494623}, author = {Torday, László and Tigyi, Dóra and Nagy‐László, Roland and Tóth, Dávid and Uhercsák, Gabriella and Pepó, Judit and Maráz, Anikó and Sántha, Dóra and Csenki, Melinda and Dobi, Ágnes and Valicsek, Erzsébet and Szilágyi, Éva and Vasas, Béla and Erdős, Márton and Paszt, Attila and Szepes, Zoltán and Tiszlavicz, László and Lázár, György ifj and Oláh, Judit Magdolna}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {65}, unique-id = {32494623}, issn = {0025-0244}, year = {2021}, eissn = {2060-0399}, pages = {57-57}, orcid-numbers = {Torday, László/0000-0002-2911-5499; Tóth, Dávid/0000-0002-1076-3031; Maráz, Anikó/0000-0002-2018-8413; Paszt, Attila/0000-0002-1637-8652; Szepes, Zoltán/0000-0002-9466-8719; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978} } @article{MTMT:32490905, title = {A férfi emlőrák más, mint a női? − 15 év tapasztalata}, url = {https://m2.mtmt.hu/api/publication/32490905}, author = {Kelemen, Gyöngyi and Hetényi, A and Dobi, Ágnes and Uhercsák, Gabriella and Sántha, Dóra and Valicsek, Erzsébet and Kószó, Renáta Lilla and Vörös, András and Oláh-Németh, O and Hamar, Sándor and Lázár, György ifj and Simonka, Zsolt and Paszt, Attila and Ormándi, K and Hoffmann, C and Telek, A and Kahán, Zsuzsanna and Oláh, Judit Magdolna and Nikolényi, Alíz}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {65}, unique-id = {32490905}, issn = {0025-0244}, year = {2021}, eissn = {2060-0399}, pages = {27-27}, orcid-numbers = {Kószó, Renáta Lilla/0000-0002-1958-7839; Vörös, András/0000-0001-6837-0567; Lázár, György ifj/0000-0001-7155-2978; Simonka, Zsolt/0000-0002-3490-226X; Paszt, Attila/0000-0002-1637-8652; Kahán, Zsuzsanna/0000-0002-5021-8775} } @article{MTMT:32101773, title = {BC-Monitor: Towards a Routinely Accessible Circulating Tumor DNA-Based Tool for Real-Time Monitoring Breast Cancer Progression and Treatment Effectiveness}, url = {https://m2.mtmt.hu/api/publication/32101773}, author = {Priskin, Katalin and Pólya, Sára and Pintér, Lajos and Jaksa, Gábor and Csányi, Bernadett and Enyedi, Márton Zsolt and Sági-Zsigmond, Eszter and Sükösd, Farkas and Oláh, Orsolya and Kelemen, Gyöngyi and Nikolényi, Alíz and Uhercsák, Gabriella and Sántha, Dóra and Dobi, Ágnes and Szilágyi, Éva and Valicsek, Erzsébet and Torday, László and Tóth, Rozália and Kahán, Zsuzsanna and Haracska, Lajos}, doi = {10.3390/cancers13143489}, journal-iso = {CANCERS}, journal = {CANCERS}, volume = {13}, unique-id = {32101773}, year = {2021}, eissn = {2072-6694}, orcid-numbers = {Oláh, Orsolya/0000-0002-5731-4030; Torday, László/0000-0002-2911-5499; Kahán, Zsuzsanna/0000-0002-5021-8775} } @article{MTMT:32475393, title = {Örökletes BRCA-status vizsgálata emlőrákos betegek rutin onkológiai ellátásában: első tapasztalataink}, url = {https://m2.mtmt.hu/api/publication/32475393}, author = {Nikolényi, Alíz and Uhercsák, Gabriella and Valicsek, Erzsébet and Dobi, Ágnes and Torday, László and Sántha, Dóra and Horváth, Emese and Egyedi, Márton and Haracska, Lajos and Kahán, Zsuzsanna}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {63}, unique-id = {32475393}, issn = {0025-0244}, year = {2019}, eissn = {2060-0399}, pages = {53}, orcid-numbers = {Torday, László/0000-0002-2911-5499; Kahán, Zsuzsanna/0000-0002-5021-8775} } @article{MTMT:30938381, title = {Keringő tumor DNS vizsgálat neoadjuváns kezelésben részesülő, illetve metasztatikus emlőrákos betegnél – kezdeti tapasztalataink}, url = {https://m2.mtmt.hu/api/publication/30938381}, author = {Kelemen, Gyöngyi and Tóth, R and Kószó, Renáta Lilla and Nikolényi, Alíz and Uhercsák, Gabriella and Sántha, Dóra and Valicsek, Erzsébet and Szilágyi, Éva and Torday, László and Pepó, J and Dobi, Ágnes and Priskin, Katalin and Pintér, Lajos and Pólya, Sára Erzsébet and Haracska, Lajos and Sükösd, Farkas and Kahán, Zsuzsanna}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {63}, unique-id = {30938381}, issn = {0025-0244}, year = {2019}, eissn = {2060-0399}, pages = {33-33}, orcid-numbers = {Kószó, Renáta Lilla/0000-0002-1958-7839; Torday, László/0000-0002-2911-5499; Kahán, Zsuzsanna/0000-0002-5021-8775} } @CONFERENCE{MTMT:30837594, title = {Örökletes BRCA status vizsgálat emlőrákos betegek rutin onkológiai ellátásában: első tapasztalataink}, url = {https://m2.mtmt.hu/api/publication/30837594}, author = {Nikolényi, Alíz and Uhercsák, Gabriella and Valicsek, Erzsébet and Dobi, Ágnes and Torday, László and Sántha, Dóra and Horváth, Emese and Egyedi, Márton and Haracska, Lajos and Kahán, Zsuzsanna}, booktitle = {VIII. Szegedi Emlőrák Szimpózium}, unique-id = {30837594}, year = {2019}, pages = {48-49}, orcid-numbers = {Torday, László/0000-0002-2911-5499; Kahán, Zsuzsanna/0000-0002-5021-8775} } @CONFERENCE{MTMT:30801735, title = {Keringő tumor DNS vizsgálat neoadjuváns kezelésben részesülő, illetve metasztatikus emlőrákos betegeknél – kezdeti tapasztalataink}, url = {https://m2.mtmt.hu/api/publication/30801735}, author = {Kelemen, Gyöngyi and Tóth, Rozália and Kószó, Renáta Lilla and Nikolényi, Alíz and Uhercsák, Gabriella and Sántha, Dóra and Valicsek, Erzsébet and Szilágyi, Éva and Torday, László and Pepó, Judit and Dobi, Ágnes and Priskin, Katalin and Pintér, Lajos and Pólya, Sára Erzsébet and Haracska, Lajos and Sükösd, Farkas and Kahán, Zsuzsanna}, booktitle = {VIII. Szegedi Emlőrák Szimpózium}, unique-id = {30801735}, year = {2019}, pages = {47-48}, orcid-numbers = {Kószó, Renáta Lilla/0000-0002-1958-7839; Torday, László/0000-0002-2911-5499; Kahán, Zsuzsanna/0000-0002-5021-8775} } @article{MTMT:3422494, title = {Clinical benefit of fulvestrant monotherapy in the multimodal treatment of hormone receptor and HER2 positive advanced breast cancer. a case series}, url = {https://m2.mtmt.hu/api/publication/3422494}, author = {Rusz, Orsolya and Kószó, Renáta Lilla and Dobi, Ágnes and Csenki, Melinda and Valicsek, Erzsébet and Nikolényi, Alíz and Uhercsák, Gabriella and Cserháti, Adrienn and Kahán, Zsuzsanna}, doi = {10.2147/OTT.S170736}, journal-iso = {ONCOTARGETS THER}, journal = {ONCOTARGETS AND THERAPY}, volume = {11}, unique-id = {3422494}, issn = {1178-6930}, year = {2018}, eissn = {1178-6930}, pages = {5459-5463}, orcid-numbers = {Rusz, Orsolya/0000-0001-5726-4072; Kószó, Renáta Lilla/0000-0002-1958-7839; Kahán, Zsuzsanna/0000-0002-5021-8775} } @article{MTMT:3341845, title = {Loss of CDX2 gene expression is associated with DNA repair proteins and is a crucial member of the Wnt signaling pathway in liver metastasis of colorectal cancer}, url = {https://m2.mtmt.hu/api/publication/3341845}, author = {Tóth, Csaba and Sükösd, Farkas and Valicsek, Erzsébet and Herpel, E and Schirmacher, P and Tiszlavicz, László}, doi = {10.3892/ol.2018.7756}, journal-iso = {ONCOL LETT}, journal = {ONCOLOGY LETTERS}, volume = {15}, unique-id = {3341845}, issn = {1792-1074}, abstract = {Caudal type homeobox 2 (CDX2) has been well-established as a diagnostic marker for colorectal cancer (CRC); however, less is known about its regulation, particularly its potential interactions with the DNA repair proteins, adenomatous polyposis coli (APC) and beta-catenin, in a non-transcriptional manner. In the present study, the protein expression of CDX2 was analyzed, depending on the expression of the DNA repair proteins, mismatch repair (MMR), O6-methylguanine DNA methyltransferase (MGMT) and excision repair cross-complementing 1 (ERCC1), and its importance in Wnt signaling was also determined. A total of 101 liver metastases were punched into tissue microarray (TMA) blocks and serial sections were cut for immunohistochemistry. For each protein, an immunoreactive score was generated according to literature data and the scores were fitted to TMA. Subsequently, statistical analysis was performed to compare the levels of expression with each other and with clinical data. CDX2 loss of expression was observed in 38.5% of the CRC liver metastasis cases. A statistically significant association between CDX2 and each of the investigated MMRs was observed: MutL Homolog 1 (P<0.01), MutS protein Homolog (MSH) 2 (P<0.01), MSH6 (P<0.01), and postmeiotic segregation increased 2 (P=0.040). Furthermore, loss of MGMT and ERCC1 was also associated with CDX2 loss (P=0.039 and P<0.01, respectively). In addition, CDX2 and ERCC1 were inversely associated with metastatic tumor size (P=0.038 and P=0.027, respectively). Sustained CDX2 expression was associated with a higher expression of cytoplasmic/membranous beta-catenin and with nuclear APC expression (P=0.042 and P<0.01, respectively). In conclusion, CDX2 loss of expression was not a rare event in liver metastasis of CRC and the results suggested that CDX2 may be involved in mechanisms resulting in the loss of DNA repair protein expression, and in turn methylation; however, its exact function in this context remains to be elucidated.}, year = {2018}, eissn = {1792-1082}, pages = {3586-3593}, orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587} }