TY  - JOUR
AU  - Sántha, Petra
AU  - Veszelka, Szilvia
AU  - Hoyk, Zsófia
AU  - Mészáros, Mária
AU  - Walter, Fruzsina
AU  - Tóth, Andrea
AU  - Kiss, Lóránd
AU  - Kincses, András
AU  - Oláh, Zita
AU  - Seprényi, György
AU  - Rákhely, Gábor
AU  - Dér, András
AU  - Pákáski, Magdolna
AU  - Kálmán, János
AU  - Kittel, Ágnes
AU  - Deli, Mária Anna
TI  - Restraint stress-induced morphological changes at the blood-brain barrier in adult rats
JF  - FRONTIERS IN MOLECULAR NEUROSCIENCE
J2  - FRONT MOL NEUROSCI
VL  - 8
PY  - 2016
PG  - 15
SN  - 1662-5099
DO  - 10.3389/fnmol.2015.00088
UR  - https://m2.mtmt.hu/api/publication/2989762
ID  - 2989762
N1  - These authors have contributed equally to this work: Ágnes Kittel6 and Mária A. Deli.

This study was supported by the European Union and the State of Hungary (grant nos. TÁMOP-4.2.1/B-09/1/KONV-2010-0005, TÁMOP-4.2.2.A-11/1/KONV-2012-0052, “National Excellence Program” A/2-11-1-2012-0001) and the Hungarian Research Fund (OTKA 83667).
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Lénárt, Nikolett
AU  - Walter, Fruzsina
AU  - Bocsik, Alexandra
AU  - Sántha, Petra
AU  - Tóth, Erzsébet Melinda
AU  - Harazin, András
AU  - Tóth, Andrea
AU  - Vizler, Csaba
AU  - Török, Zsolt
AU  - Pilbat, Ana Maria
AU  - Vigh, László
AU  - Puskás, László
AU  - Sántha, Miklós
AU  - Deli, Mária Anna
TI  - Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: effects of oxidized low-density lipoprotein treatment
JF  - FLUIDS AND BARRIERS OF THE CNS
J2  - FLUIDS BARRIERS CNS
VL  - 12
PY  - 2015
PG  - 16
SN  - 2045-8118
DO  - 10.1186/s12987-015-0013-y
UR  - https://m2.mtmt.hu/api/publication/2920970
ID  - 2920970
LA  - English
DB  - MTMT
ER  - 

TY  - THES
AU  - Sántha, Petra
TI  - Stress-induced changes in gene transcriptions and translations related to Alzheimer’s disease
PB  - Szegedi Tudományegyetem (SZTE)
PY  - 2014
SP  - 49
DO  - 10.14232/phd.2358
UR  - https://m2.mtmt.hu/api/publication/2781263
ID  - 2781263
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sándor, Nikolett
AU  - Walter, Fruzsina
AU  - Bocsik, Alexandra
AU  - Sántha, Petra
AU  - Schilling-Tóth, Boglárka
AU  - Léner, Violetta
AU  - Varga, Zoltán
AU  - Kahán, Zsuzsanna
AU  - Deli, Mária Anna
AU  - Sáfrány, Géza
AU  - Hegyesi, Hargita
TI  - Low dose cranial irradiation-induced cerebrovascular damage is reversible in mice
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 9
PY  - 2014
IS  - 11
PG  - 13
SN  - 1932-6203
DO  - 10.1371/journal.pone.0112397
UR  - https://m2.mtmt.hu/api/publication/2773366
ID  - 2773366
N1  - Contributed equally to this work with: Nikolett Sándor, Fruzsina R. Walter
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tóth, Andrea
AU  - Walter, Fruzsina
AU  - Bocsik, Alexandra
AU  - Sántha, Petra
AU  - Veszelka, Szilvia
AU  - Nagy, Lajos István
AU  - Puskás, László
AU  - Couraud, PO
AU  - Takata, F
AU  - Dohgu, S
AU  - Kataoka, Y
AU  - Deli, Mária Anna
TI  - Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 9
PY  - 2014
IS  - 7
PG  - 14
SN  - 1932-6203
DO  - 10.1371/journal.pone.0100152
UR  - https://m2.mtmt.hu/api/publication/2707330
ID  - 2707330
N1  - Cited By :29            
            Export Date: 20 June 2022            
            CODEN: POLNC
AB  - BACKGROUND:

Elevated level of reactive carbonyl species, such as methylglyoxal, triggers carbonyl stress and activates a series of inflammatory responses leading to accelerated vascular damage. Edaravone is the active substance of a Japanese medicine, which aids neurological recovery following acute brain ischemia and subsequent cerebral infarction. Our aim was to test whether edaravone can exert a protective effect on the barrier properties of human brain endothelial cells (hCMEC/D3 cell line) treated with methylglyoxal.
METHODOLOGY:

Cell viability was monitored in real-time by impedance-based cell electronic sensing. The barrier function of the monolayer was characterized by measurement of resistance and flux of permeability markers, and visualized by immunohistochemistry for claudin-5 and β-catenin. Cell morphology was also examined by holographic phase imaging.
PRINCIPAL FINDINGS:

Methylglyoxal exerted a time- and dose-dependent toxicity on cultured human brain endothelial cells: a concentration of 600 µM resulted in about 50% toxicity, significantly reduced the integrity and increased the permeability of the barrier. The cell morphology also changed dramatically: the area of cells decreased, their optical height significantly increased. Edaravone (3 mM) provided a complete protection against the toxic effect of methylglyoxal. Co-administration of edaravone restored cell viability, barrier integrity and functions of brain endothelial cells. Similar protection was obtained by the well-known antiglycating molecule, aminoguanidine, our reference compound.
CONCLUSION:

These results indicate for the first time that edaravone is protective in carbonyl stress induced barrier damage. Our data may contribute to the development of compounds to treat brain endothelial dysfunction in carbonyl stress related diseases.
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Sántha, Petra
AU  - Veszelka, Szilvia
AU  - Kiss, Lóránd
AU  - Walter, Fruzsina
AU  - Oláh, Zita
AU  - Tóth, Andrea
AU  - Bocsik, Alexandra
AU  - Pákáski, Magdolna
AU  - Kálmán, János
AU  - Kittel, Ágnes
AU  - Deli, Mária
TI  - Stressz hatása a vér-agy-gátra: mikroszkópos vizsgálatok patkány agymetszeteken = [Effects of stress on the blood-brain-barrier: microscopic studies on rat brain sections]
T2  - 14. Kolozsvári Biológus Napok : Kolozsvár, 2013. április 12-14. : kivonatfüzet = [14th Biology Days : Cluj-Napoca, 12-14 April 2013 : abstracts]
PB  - Kolozsvári Akadémiai Bizottság
C1  - Kolozsvár
PY  - 2013
SP  - 54
EP  - 54
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/2701829
ID  - 2701829
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Fodor, Eszter
AU  - Pákáski, Magdolna
AU  - Sántha, Petra
AU  - Sántha, Miklós
AU  - Janka, Zoltán
AU  - Kálmán, János
TI  - Immobilizációs stressz hatása a β-aktin citoszkeletonra vad típusú és apoB transzgénikus egér agyban = [The effect of immobilization stress on the β-actin cytoskeleton in wild type and apoB transgenic mice brain]
T2  - 14. Kolozsvári Biológus Napok : Kolozsvár, 2013. április 12-14. : kivonatfüzet = [14th Biology Days : Cluj-Napoca, 12-14 April 2013 : abstracts]
PB  - Kolozsvári Akadémiai Bizottság
C1  - Kolozsvár
PY  - 2013
SP  - 26
EP  - 26
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/2701821
ID  - 2701821
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sántha, Petra
TI  - Életünk a stressz árnyékában
JF  - ÉLET ÉS TUDOMÁNY
J2  - ÉLET ÉS TUDOMÁNY
VL  - 47
PY  - 2013
SP  - 1488
EP  - 1489
PG  - 2
SN  - 0013-6077
UR  - https://m2.mtmt.hu/api/publication/2500898
ID  - 2500898
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sántha, Petra
AU  - Pákáski, Magdolna
AU  - Fodor, Eszter
AU  - Fazekas, OC
AU  - Kálmán, Sára
AU  - Kálmán, János (ifj.)
AU  - Janka, Zoltán
AU  - Szabó, Gyula
AU  - Kálmán, János
TI  - Cytoskeletal Protein Translation and Expression in the Rat Brain Are Stressor-Dependent and Region-Specific
JF  - PLOS ONE
J2  - PLOS ONE
VL  - 8
PY  - 2013
IS  - 10
PG  - 8
SN  - 1932-6203
DO  - 10.1371/journal.pone.0073504
UR  - https://m2.mtmt.hu/api/publication/2437204
ID  - 2437204
AB  - Stress is an integral component of life that can sometimes cause a critical overload, depending on the qualitative and quantitative natures of the stressors. The involvement of actin, the predominant component of dendritic integrity, is a plausible candidate factor in stress-induced neuronal cytoskeletal changes. The major aim of this study was to compare the effects of three different stress conditions on the transcription and translation of actin-related cytoskeletal genes in the rat brain. Male Wistar rats were exposed to one or other of the frequently used models of physical stress, i.e. electric foot shock stress (EFSS), forced swimming stress (FSS), or psychosocial stress (PSS) for periods of 3, 7, 14, or 21 days. The relative mRNA and protein expressions of beta-actin, cofilin and mitogen-activated protein kinase 1 (MAPK-1) were determined by qRT- PCR and western blotting from hippocampus and frontal cortex samples. Stressor-specific alterations in both beta-actin and cofilin expression levels were seen after stress. These alterations were most pronounced in response to EFSS, and exhibited a U-shaped time course. FSS led to a significant beta-actin mRNA expression elevation in the hippocampus and the frontal cortex after 3 and 7 days, respectively, without any subsequent change. PSS did not cause any change in beta-actin or cofilin mRNA or protein expression in the examined brain regions. EFSS, FSS and PSS had no effect on the expression of MAPK-1 mRNA at any tested time point. These findings indicate a very delicate, stress type-dependent regulation of neuronal cytoskeletal components in the rat hippocampus and frontal cortex.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fodor, Eszter Klára
AU  - Sántha, Petra
AU  - Oláh, Zita
AU  - Sántha, Miklós
AU  - Pákáski, Magdolna
AU  - Janka, Zoltán
AU  - Kálmán, János
TI  - Immobilizációs stressz hatása a β-aktin citoszkeletonra apoB transzgénikus egér agyban
JF  - NEUROPSYCHOPHARMACOLOGIA HUNGARICA
J2  - NEUROPSYCHOPHARM HUNG
VL  - 14
PY  - 2012
IS  - Suppl. 1
SP  - 21
EP  - 21
PG  - 1
SN  - 1419-8711
UR  - https://m2.mtmt.hu/api/publication/2701705
ID  - 2701705
LA  - Hungarian
DB  - MTMT
ER  -