TY - JOUR AU - Szőllősi, Gergő József AU - Minh, Nguyen Chau AU - Santoso, Cornelia Melinda Adi AU - Zsuga, Judit AU - Nagy, Attila Csaba AU - Kardos, László TI - An Exploratory Assessment of Factors with Which Influenza Vaccine Uptake Is Associated in Hungarian Adults 65 Years Old and Older: Findings from European Health Interview Surveys JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 19 PY - 2022 IS - 12 SN - 1661-7827 DO - 10.3390/ijerph19127545 UR - https://m2.mtmt.hu/api/publication/33572509 ID - 33572509 AB - Influenza vaccination is an imperative public health task for elderly people due to a higher risk of developing more severe complications. The main aim of our study was to determine the influencing factors of being vaccinated against influenza among subjects aged 65 and above. Data were from the Hungarian implementations of the European Health Interview Survey 2009, 2014 and 2019 studies with a final sample size of 3355. A multivariate logistic regression model with interactions was used to identify the possible factors associated with vaccination. Approximately 32% of the participants were vaccinated for the most recent influenza season. The most important factors were identified that contributed to influenza vaccination among individuals, which were the following: educational attainment, having a partner, the annual frequency of specialist and doctor visits, and having comorbidities. Respondents who thought that they could do a lot for their health had higher odds of being immunized. Being obese seemed to be a risk factor. According to our findings, the current influenza vaccination coverage was considered as low in Hungary; hence, the implementation of minor reformulations in the field of health policy is suggested. LA - English DB - MTMT ER - TY - JOUR AU - Viczján, Gábor AU - Szilagyi, Anna AU - Takács, Barbara AU - Ovari, Ignac AU - Szekeres, Réka Mária AU - Tarjányi, Vera AU - Erdei, Tamas AU - Teleki, Vanda AU - Zsuga, Judit AU - Szilvássy, Zoltán AU - Juhász, Béla AU - Varga, Balázs AU - Gesztelyi, Rudolf TI - The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 13 PY - 2022 SN - 1663-9812 DO - 10.3389/fphar.2022.1043275 UR - https://m2.mtmt.hu/api/publication/33538911 ID - 33538911 AB - Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects. The aim of this study was to explore the effect that CBD exerts on the adenosinergic system of paced left atria isolated from obese type Zucker Diabetic Fatty (ZDF) rats, maintained on diabetogenic rat chow, received 60 mg/kg/day CBD or vehicle via gavage for 4 weeks. We found that N6-cyclopentyladenosine (CPA), a relatively stable and poorly transported A1 adenosine receptor agonist, elicited a significantly weaker response in the CBD-treated group than in the vehicle-treated one. In contrast, adenosine, a quickly metabolized and transported adenosine receptor agonist, evoked a significantly stronger response in the CBD-treated group than in the vehicle-treated counterpart (excepting its highest concentrations). These results can be explained only with the adenosine transport inhibitory property of CBD (and not with its adenosine receptor agonist activity). If all the effects of CBD are attributed to the interstitial adenosine accumulation caused by CBD in the myocardium, then a significantly increased adenosinergic activation can be assumed during the long-term oral CBD treatment, suggesting a considerably enhanced adenosinergic protection in the heart. Considering that our results may have been influenced by A1 adenosine receptor downregulation due to the chronic interstitial adenosine accumulation, an adenosinergic activation smaller than it seemed cannot be excluded, but it was above the CBD-naïve level in every case. Additionally, this is the first study offering functional evidence about the adenosine transport inhibitory action of CBD in the myocardium. LA - English DB - MTMT ER - TY - BOOK AU - Bányai, Gábor AU - Bíró, Klára AU - Borbély, Ágnes AU - Legoza, József AU - Nagy, Attila Csaba AU - Papp, Csaba Sándor AU - Szőllősi, Gergő József AU - Zsuga, Judit ED - Zsuga, Judit TI - Debrecen Megyei Jogú Város egészségterve 2021 PB - Debreceni Egyetem Népegészségügyi Kar CY - Debrecen PY - 2021 SP - 206 SN - 9789634903932 UR - https://m2.mtmt.hu/api/publication/33287173 ID - 33287173 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Santoso, Cornelia Melinda Adi AU - Ketti, Fera AU - Bramantoro, Taufan AU - Zsuga, Judit AU - Nagy, Attila Csaba TI - Association between Oral Hygiene and Metabolic Syndrome: A Systematic Review and Meta-Analysis JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 10 PY - 2021 IS - 13 SP - 2873 PG - 16 SN - 2077-0383 DO - 10.3390/jcm10132873 UR - https://m2.mtmt.hu/api/publication/32502987 ID - 32502987 AB - Emerging evidence has linked poor oral hygiene to metabolic syndrome (MetS), but previously, no summary of evidence has been conducted on the topic. This systematic review and meta-analysis aims to evaluate the associations of oral hygiene status and care with MetS. A systematic search of the PubMed and Web of Science databases from inception to 17 March 2021, and examination of reference lists was conducted to identify eligible observational studies. A random-effects model was applied to pool the effects of oral hygiene status and care on MetS. Thirteen studies met the inclusion criteria and had sufficient methodological quality. Good oral hygiene status (OR = 0.30 (0.13–0.66); I2 = 91%), frequent tooth brushing (OR = 0.68 (0.58–0.80); I2 = 89%), and frequent interdental cleaning (OR = 0.89 (0.81–0.99); I2 = 27%) were associated with a lower risk of MetS. Only one study examined the association between dental visits and MetS (OR = 1.10 (0.77–1.55)). Our findings suggested that there might be inverse associations of oral hygiene status, tooth-brushing frequency, and interdental cleaning with MetS. However, substantial heterogeneity for tooth-brushing frequency and inconsistent results for oral hygiene status in subgroup analyses were observed. There was insufficient evidence for the association between dental visits and MetS. Further longitudinal studies are needed to investigate these associations. LA - English DB - MTMT ER - TY - JOUR AU - Nguyen, Chau Minh AU - Santoso, Cornelia Melinda Adi AU - Vu, Duyen Thi Huong AU - Szőllősi, Gergő József AU - Bata, Róbert AU - Zsuga, Judit AU - Nagy, Attila Csaba TI - Awareness Related to Cardiometabolic Diseases: A Cross-Sectional Study in Southern Vietnam JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 18 PY - 2021 IS - 19 PG - 8 SN - 1661-7827 DO - 10.3390/ijerph181910209 UR - https://m2.mtmt.hu/api/publication/32490620 ID - 32490620 AB - Background: the prevalence of cardiometabolic diseases (CMDs), such as type 2 diabetes mellitus (T2DM) and hypertension, is increasing rapidly in developing countries. This study aims to assess the awareness of CMD among a selected population in Vietnam. Method: a cross-sectional random sample of 402 Vietnamese citizens in two districts (Thu Duc and 12th district) in Ho Chi Minh City were interviewed. Data on knowledge, attitude, and preventive behavior (KAB) of the two conditions were collected through an interview-based questionnaire. Results: the mean (± SD) age was 47.75 (± 15.61) years, and around 60.2% were female. Multiple logistic regression was performed to explore the association of sociodemographic factors, disease status, and awareness of the CMD. Females showed better awareness than males (OR = 3.89 (1.28–11.78)), and those with T2DM and hypertension had a significantly better awareness (OR = 8.33 (2.44–28.37)) than those without CMD. Conclusion: the awareness of CMD in our sample was poor. An extensive effort to increase awareness of CMD prevention is needed. Future studies and interventions can be developed more efficiently by targeting the right population. LA - English DB - MTMT ER - TY - JOUR AU - Viczján, Gábor AU - Erdei, Tamás Dániel AU - Óvári, Ignác AU - Lampé, Nóra AU - Szekeres, Réka Mária AU - Bombicz, Mariann AU - Takács, Barbara AU - Szilágyi, Anna AU - Zsuga, Judit AU - Szilvássy, Zoltán AU - Juhász, Béla AU - Gesztelyi, Rudolf TI - A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A1 Adenosine Receptor Antagonist So Far JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 18 PG - 21 SN - 1661-6596 DO - 10.3390/ijms22189831 UR - https://m2.mtmt.hu/api/publication/32193722 ID - 32193722 AB - In previous studies using isolated, paced guinea pig left atria, we observed that FSCPX, known as a selective A(1) adenosine receptor antagonist, paradoxically increased the direct negative inotropic response to A(1) adenosine receptor agonists (determined using concentration/effect (E/c) curves) if NBTI, a nucleoside transport inhibitor, was present. Based on mathematical modeling, we hypothesized that FSCPX blunted the cardiac interstitial adenosine accumulation in response to nucleoside transport blockade, probably by inhibiting CD39 and/or CD73, which are the two main enzymes of the interstitial adenosine production in the heart. The goal of the present study was to test this hypothesis. In vitro CD39 and CD73 inhibitor assays were carried out; furthermore, E/c curves were constructed in isolated, paced rat and guinea pig left atria using adenosine, CHA and CPA (two A(1) adenosine receptor agonists), FSCPX, NBTI and NBMPR (two nucleoside transport inhibitors), and PSB-12379 (a CD73 inhibitor), measuring the contractile force. We found that FSCPX did not show any inhibitory effect during the in vitro enzyme assays. However, we successfully reproduced the paradox effect of FSCPX in the rat model, mimicked the "paradox" effect of FSCPX with PSB-12379, and demonstrated the lipophilia of FSCPX, which could explain the negative outcome of inhibitor assays with CD39 and CD73 dissolved in a water-based solution. Taken together, these three pieces of indirect evidence are strong enough to indicate that FSCPX possesses an additional action besides the A(1) adenosine receptor antagonism, which action may be the inhibition of an ectonucleotidase. Incidentally, we found that POM-1 inhibited CD73, in addition to CD39. LA - English DB - MTMT ER - TY - JOUR AU - Tele-Héri, Brigitta AU - Dobos, Karoly AU - Kolozsváriné Harsányi, Szilvia AU - Pálinkás, Judit AU - Fenyosi, Fanni AU - Gesztelyi, Rudolf AU - More, Csaba E. AU - Zsuga, Judit TI - Vestibular Stimulation May Drive Multisensory Processing: Principles for Targeted Sensorimotor Therapy (TSMT) JF - BRAIN SCIENCES J2 - BRAIN SCI VL - 11 PY - 2021 IS - 8 PG - 13 SN - 2076-3425 DO - 10.3390/brainsci11081111 UR - https://m2.mtmt.hu/api/publication/32162175 ID - 32162175 AB - At birth, the vestibular system is fully mature, whilst higher order sensory processing is yet to develop in the full‐term neonate. The current paper lays out a theoretical framework to ac-count for the role vestibular stimulation may have driving multisensory and sensorimotor integra-tion. Accordingly, vestibular stimulation, by activating the parieto‐insular vestibular cortex, and/or the posterior parietal cortex may provide the cortical input for multisensory neurons in the superior colliculus that is needed for multisensory processing. Furthermore, we propose that motor devel-opment, by inducing change of reference frames, may shape the receptive field of multisensory neurons. This, by leading to lack of spatial contingency between formally contingent stimuli, may cause degradation of prior motor responses. Additionally, we offer a testable hypothesis explaining the beneficial effect of sensory integration therapies regarding attentional processes. Key concepts of a sensorimotor integration therapy (e.g., targeted sensorimotor therapy (TSMT)) are also put into a neurological context. TSMT utilizes specific tools and instruments. It is administered in 8‐weeks long successive treatment regimens, each gradually increasing vestibular and postural stimulation, so sensory‐motor integration is facilitated, and muscle strength is increased. Empirically TSMT is indicated for various diseases. Theoretical foundations of this sensorimotor therapy are discussed. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. LA - English DB - MTMT ER - TY - JOUR AU - Kolozsvári, László Róbert AU - Bérczes, Tamás AU - Hajdu, András AU - Gesztelyi, Rudolf AU - Tiba, Attila AU - Varga, Imre AU - Al-Tammemi, Ala'a B. AU - Szőllősi, Gergő József AU - Kolozsváriné Harsányi, Szilvia AU - Garbóczy, Szabolcs AU - Zsuga, Judit TI - Predicting the epidemic curve of the coronavirus (SARS-CoV-2) disease (COVID-19) using artificial intelligence: An application on the first and second waves JF - INFORMATICS IN MEDICINE UNLOCKED J2 - INFORM MED UNLOCKED VL - 25 PY - 2021 PG - 13 SN - 2352-9148 DO - 10.1016/j.imu.2021.100691 UR - https://m2.mtmt.hu/api/publication/32151549 ID - 32151549 LA - English DB - MTMT ER - TY - JOUR AU - Papp, Csaba Sándor AU - Kolozsváriné Harsányi, Szilvia AU - Gesztelyi, Rudolf AU - Emri, Miklós AU - Zsuga, Judit TI - Assessment of patient flow and optimized use of lean thinking transformation from the perspective of graph theory and spectral graph theory: A case study JF - TECHNOLOGY AND HEALTH CARE J2 - TECHNOL HEALTH CARE VL - 29 PY - 2021 IS - 2 SP - 199 EP - 211 PG - 13 SN - 0928-7329 DO - 10.3233/THC-191782 UR - https://m2.mtmt.hu/api/publication/31358392 ID - 31358392 LA - English DB - MTMT ER - TY - JOUR AU - Szűcs, Gabriella AU - Szekanecz, Zoltán AU - Aszalós, Zsuzsanna AU - Gesztelyi, Rudolf AU - Zsuga, Judit AU - Szodoray, Peter AU - Kemény-Beke, Ádám TI - A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis JF - OCULAR IMMUNOLOGY AND INFLAMMATION J2 - OCUL IMMUNOL INFLAMM VL - 29 PY - 2021 IS - 1 SP - 81 EP - 89 PG - 9 SN - 0927-3948 DO - 10.1080/09273948.2019.1657467 UR - https://m2.mtmt.hu/api/publication/30836484 ID - 30836484 LA - English DB - MTMT ER -