TY - CONF AU - Vadovics, Máté AU - Igaz, Nóra AU - Veres, Éva AU - Szücs, Balázs AU - Alföldi, Róbert AU - Nagy, Lajos István AU - Puskás, László AU - Csontné Kiricsi, Mónika AU - Gácser, Attila TI - Az orális candidiasis szájüregi laphámsejtes karcinóma progressziójára gyakorolt hatásának vizsgálata T2 - Immunológiai szemle. XII. évf. 3. szám. PY - 2020 SP - 18 UR - https://m2.mtmt.hu/api/publication/32616020 ID - 32616020 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Balog, József Ágoston AU - Hackler, László AU - Kovács, Anita Kármen AU - Neuperger, Patricia AU - Alföldi, Róbert AU - Nagy, Lajos István AU - Puskás, László AU - Szebeni, Gábor TI - Single Cell Mass Cytometry Revealed the Immunomodulatory Effect of Cisplatin Via Downregulation of Splenic CD44+, IL-17A+ MDSCs and Promotion of Circulating IFN-γ+ Myeloid Cells in the 4T1 Metastatic Breast Cancer Model. JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 1 SN - 1661-6596 DO - 10.3390/ijms21010170 UR - https://m2.mtmt.hu/api/publication/31143380 ID - 31143380 N1 - Laboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary School in Biology, University of Szeged, Szeged, H6726, Hungary AstridBio Technologies Ltd., Also kikötő sor 11/D, Szeged, H6726, Hungary Avidin Ltd., Also kikötő sor 11/D, Szeged, H6726, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Export Date: 30 January 2020 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu Laboratory of Functional Genomics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary School in Biology, University of Szeged, Szeged, H6726, Hungary AstridBio Technologies Ltd., Also kikötő sor 11/D, Szeged, H6726, Hungary Avidin Ltd., Also kikötő sor 11/D, Szeged, H6726, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Cited By :3 Export Date: 10 February 2021 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu AB - The treatment of metastatic breast cancer remained a challenge despite the recent breakthrough in the immunotherapy regimens. Here, we addressed the multidimensional immunophenotyping of 4T1 metastatic breast cancer by the state-of-the-art single cell mass cytometry (CyTOF). We determined the dose and time dependent cytotoxicity of cisplatin on 4T1 cells by the xCelligence real-time electronic sensing assay. Cisplatin treatment reduced tumor growth, number of lung metastasis, and the splenomegaly of 4T1 tumor bearing mice. We showed that cisplatin inhibited the tumor stroma formation, the polarization of carcinoma-associated fibroblasts by the diminished proteolytic activity of fibroblast activating protein. The CyTOF analysis revealed the emergence of CD11b+/Gr-1+/CD44+ or CD11b+/Gr-1+/IL-17A+ myeloid-derived suppressor cells (MDSCs) and the absence of B220+ or CD62L+ B-cells, the CD62L+/CD4+ and CD62L+/CD8+ T-cells in the spleen of advanced cancer. We could show the immunomodulatory effect of cisplatin via the suppression of splenic MDSCs and via the promotion of peripheral IFN-γ+ myeloid cells. Our data could support the use of low dose chemotherapy with cisplatin as an immunomodulatory agent for metastatic triple negative breast cancer. LA - English DB - MTMT ER - TY - CONF AU - Vadovics, Máté AU - Igaz, Nóra AU - Veres, Éva AU - Alföldi, Róbert AU - Nagy, Lajos István AU - Puskás, László AU - Csontné Kiricsi, Mónika AU - Gácser, Attila TI - Candida and oral squamous cell carcinoma T2 - Immunológiai szemle. XI. évf. 3. szám. PY - 2019 SP - 38 UR - https://m2.mtmt.hu/api/publication/32614080 ID - 32614080 LA - English DB - MTMT ER - TY - CONF AU - Vadovics, Máté AU - Igaz, Nóra AU - Veres, Éva AU - Adamecz, Dóra Izabella AU - Alföldi, Róbert AU - Nagy, Lajos István AU - Puskás, László AU - Vágvölgyi, Csaba AU - Csontné Kiricsi, Mónika AU - Gácser, Attila TI - The effects of Candida cells on oral squamous cell carcinoma cell lines. T2 - HFP2019: Molecular Mechanisms of Host–Pathogen Interactions and Virulence in Human Fungal Pathogens PY - 2019 SP - P80B UR - https://m2.mtmt.hu/api/publication/32614027 ID - 32614027 LA - English DB - MTMT ER - TY - CONF AU - Vadovics, Máté AU - Igaz, Nóra AU - Veres, Éva AU - Adamecz, Dóra Izabella AU - Alföldi, Róbert AU - Nagy, Lajos István AU - Puskás, László AU - Vágvölgyi, Csaba AU - Csontné Kiricsi, Mónika AU - Gácser, Attila TI - The Effects of Fungal Cells on the Metastatic Activity of Oral Squamous Cell Carcinoma Cell Lines. T2 - Gordon Research Conference, Immunology of Fungal Infections, Mechanisms of Fungal Immunopathology PY - 2019 SP - PP40 UR - https://m2.mtmt.hu/api/publication/32611589 ID - 32611589 LA - English DB - MTMT ER - TY - CONF AU - Vadovics, Máté AU - Igaz, Nóra AU - Veres, Éva AU - Alföldi, Róbert AU - Nagy, Lajos István AU - Puskás, László AU - Vágvölgyi, Csaba AU - Csontné Kiricsi, Mónika AU - Gácser, Attila TI - The impact of Candida albicans and Candida parapsilosis on oral squamous cell carcinoma. T2 - Acta Microbiologica et Immunologica Hungarica Volume 66 Supplement 1 PB - Akadémiai Kiadó C1 - Budapest T3 - Acta Microbiologia et Immunologica Hungarica Supplement, ISSN 1217-8950 ; 66/1. PY - 2019 SP - 207 EP - 207 PG - 1 UR - https://m2.mtmt.hu/api/publication/32608820 ID - 32608820 LA - English DB - MTMT ER - TY - JOUR AU - Gyuris, Márió AU - Hackler, László AU - Nagy, Lajos István AU - Alföldi, Róbert AU - Rédei, Eszter AU - Marton, Annamária AU - Vellai, Tibor AU - Faragó, Nóra AU - Ózsvári, Béla AU - Hetényi, Anasztázia AU - Tóth, Gábor K AU - Sipos, Péter AU - Kanizsai, Iván AU - Puskás, László TI - Mannich Curcuminoids as Potent Anticancer Agents JF - ARCHIV DER PHARMAZIE J2 - ARCH PHARM VL - 350 PY - 2017 IS - 7 PG - 22 SN - 0365-6233 DO - 10.1002/ardp.201700005 UR - https://m2.mtmt.hu/api/publication/3229024 ID - 3229024 N1 - Funding Agency and Grant Number: [GOP-1.1.1-11-2011-0003]\n Funding text: This work was supported by the following grant: GOP-1.1.1-11-2011-0003.\n AB - A series of novel curcuminoids were synthesised for the first time via a Mannich-3CR/organocatalysed Claisen–Schmidt condensation sequence. Structure–activity relationship (SAR) studies were performed by applying viability assays and holographic microscopic imaging to these curcumin analogues for anti-proliferative activity against A549 and H1975 lung adenocarcinoma cells. The TNFα-induced NF-κB inhibition and autophagy induction effects correlated strongly with the cytotoxic potential of the analogues. Significant inhibition of tumour growth was observed when the most potent analogue 44 was added in liposomes at one-sixth of the maximally tolerated dose in the A549 xenograft model. The novel spectrum of activity of these Mannich curcuminoids warrants further preclinical investigations. LA - English DB - MTMT ER - TY - JOUR AU - Szebeni, Gábor AU - Vizler, Csaba AU - Nagy, Lajos István AU - Kitajka, Klára AU - Puskás, László TI - Pro-Tumoral Inflammatory Myeloid Cells as Emerging Therapeutic Targets JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 17 PY - 2016 IS - 11 PG - 28 SN - 1661-6596 DO - 10.3390/ijms17111958 UR - https://m2.mtmt.hu/api/publication/3157888 ID - 3157888 N1 - Avidin Ltd, Also kikoto sor 11/D, Szeged, H-6726, Hungary Synaptogenex Ltd, Őzsuta utca 20995/1, Budapest, H-1037, Hungary Department of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Temesvari krt. 62, Szeged, H-6726, Hungary Cited By :19 Export Date: 21 January 2021 Correspondence Address: Szebeni, G.J.; Avidin Ltd, Also kikoto sor 11/D, Hungary; email: g.szebeni@avidinbiotech.com AB - Since the observation of Virchow, it has long been known that the tumor microenvironment constitutes the soil for the infiltration of inflammatory cells and for the release of inflammatory mediators. Under certain circumstances, inflammation remains unresolved and promotes cancer development. Here, we review some of these indisputable experimental and clinical evidences of cancer related smouldering inflammation. The most common myeloid infiltrate in solid tumors is composed of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). These cells promote tumor growth by several mechanisms, including their inherent immunosuppressive activity, promotion of neoangiogenesis, mediation of epithelial-mesenchymal transition and alteration of cellular metabolism. The pro-tumoral functions of TAMs and MDSCs are further enhanced by their cross-talk offering a myriad of potential anti-cancer therapeutic targets. We highlight these main pro-tumoral mechanisms of myeloid cells and give a general overview of their phenotypical and functional diversity, offering examples of possible therapeutic targets. Pharmacological targeting of inflammatory cells and molecular mediators may result in therapies improving patient condition and prognosis. Here, we review experimental and clinical findings on cancer-related inflammation with a major focus on creating an inventory of current small molecule-based therapeutic interventions targeting cancer-related inflammatory cells: TAMs and MDSCs. LA - English DB - MTMT ER - TY - THES AU - Nagy, Lajos István TI - Talidomid analógok hatásának vizsgálata jelölésmentes szűrőrendszeren és a hepatocelluláris karcinóma egér modelljén PB - Szegedi Tudományegyetem (SZTE) PY - 2016 SP - 89 DO - 10.14232/phd.2839 UR - https://m2.mtmt.hu/api/publication/3106118 ID - 3106118 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Talapka, Petra AU - Magyariné, Berkó Anikó AU - Nagy, Lajos István AU - Chandrakumar, Lalitha AU - Bagyánszki, Mária AU - Puskás, László AU - Fekete, É AU - Bódi, Nikolett TI - Structural and molecular features of intestinal strictures in rats with Crohn's-like disease JF - WORLD JOURNAL OF GASTROENTEROLOGY J2 - WORLD J LGASTROENTEROL VL - 22 ET - 0 PY - 2016 IS - 22 SP - 5154 EP - 5164 PG - 11 SN - 1007-9327 DO - 10.3748/wjg.v22.i22.5154 UR - https://m2.mtmt.hu/api/publication/3080203 ID - 3080203 N1 - Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences and Informatics, University of Szeged, Szeged, H-6726, Hungary Avidin Ltd., Szeged, H-6726, Hungary Cited By :8 Export Date: 21 February 2023 CODEN: WJGAF Correspondence Address: Bagyánszki, M.; Department of Physiology, Közép fasor 52, Hungary; email: bmarcsi@bio.u-szeged.hu Chemicals/CAS: caspase 9, 180189-96-2; gelatinase B, 146480-36-6; sodium chloride, 7647-14-5, 23724-87-0, 49658-21-1; tissue inhibitor of metalloproteinase 1, 140208-24-8; trinitrobenzenesulfonic acid, 16655-63-3, 2508-19-2; Matrix Metalloproteinase 9; Mmp9 protein, rat; RNA, Messenger; Tgfb2 protein, rat; Tgfb3 protein, rat; Tissue Inhibitor of Metalloproteinase-1; tissue inhibitor of metalloproteinase-1 protein, rat; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Trinitrobenzenesulfonic Acid Funding details: Hungarian Scientific Research Fund, OTKA, OTKA PD 108309 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Supported by Hungarian Scientific Research Fund, No. OTKA PD 108309 to Bódi N; and the János Bolyai Research Scholarship Funding text 2: Supported by Hungarian Scientific Research Fund, No. OTKA PD 108309 to B?di N; and the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences to Bagy?nszki M. LA - English DB - MTMT ER -