TY - JOUR AU - Vedelek, Viktor AU - Petra, Bicskei AU - Mariann, Tábi AU - Biróné Lajkó, Noémi AU - Csaba, Ékes AU - Bereczki, Kristóf AU - Zsófia, Meixner-Csáti AU - Sinka, Rita AU - Vágvölgyi, Anna AU - Zádori, János TI - Endometrium development patterns and BMI groups among in vitro fertilization patients; prognostic aspects JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1379109 UR - https://m2.mtmt.hu/api/publication/34772955 ID - 34772955 LA - English DB - MTMT ER - TY - JOUR AU - Vedelek, Viktor AU - Jankovics, Ferenc AU - Zádori, János AU - Sinka, Rita TI - Mitochondrial Differentiation during Spermatogenesis: Lessons from Drosophila melanogaster JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 7 PG - 25 SN - 1661-6596 DO - 10.3390/ijms25073980 UR - https://m2.mtmt.hu/api/publication/34772438 ID - 34772438 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office Funding text: No Statement Available AB - Numerous diseases can arise as a consequence of mitochondrial malfunction. Hence, there is a significant focus on studying the role of mitochondria in cancer, ageing, neurodegenerative diseases, and the field of developmental biology. Mitochondria could exist as discrete organelles in the cell; however, they have the ability to fuse, resulting in the formation of interconnected reticular structures. The dynamic changes between these forms correlate with mitochondrial function and mitochondrial health, and consequently, there is a significant scientific interest in uncovering the specific molecular constituents that govern these transitions. Moreover, the specialized mitochondria display a wide array of variable morphologies in their cristae formations. These inner mitochondrial structures are closely associated with the specific functions performed by the mitochondria. In multiple cases, the presence of mitochondrial dysfunction has been linked to male sterility, as it has been observed to cause a range of abnormal spermatogenesis and sperm phenotypes in different species. This review aims to elucidate the dynamic alterations and functions of mitochondria in germ cell development during the spermatogenesis of Drosophila melanogaster. LA - English DB - MTMT ER - TY - JOUR AU - Datki, Zsolt László AU - Darula, Zsuzsanna AU - Vedelek, Viktor AU - Hunyadi-Gulyás Éva, Csilla AU - Dingmann, Brian J. AU - Vedelek, Balázs AU - Kalman, Janos AU - Urban, Peter AU - Gyenesei, Attila AU - Galik-Olah, Zita AU - Gálik, Bence AU - Sinka, Rita TI - Biofilm formation initiating rotifer-specific biopolymer and its predicted components JF - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES J2 - INT J BIOL MACROMOL VL - 253 PY - 2023 IS - Part 5 PG - 14 SN - 0141-8130 DO - 10.1016/j.ijbiomac.2023.127157 UR - https://m2.mtmt.hu/api/publication/34334193 ID - 34334193 N1 - Megosztott szerzőség AB - The rotifer-specific biopolymer, namely Rotimer, is a recently discovered group of the biomolecule family. Rotimer has an active role in the biofilm formation initiated by rotifers (e.g., Euchlanis dilatata or Adineta vaga) or in the female-male sexual interaction of monogononts. To understand the Ca2+- and polarity-dependent formation of this multifunctional viscoelastic material, it is essential to explore its molecular composition. The investigation of the rotifer-enhanced biofilm and Rotimer-inductor conglomerate (RIC) formation yielded several protein candidates to predict the Rotimer-specific main components. The exudate of E. dilatata males was primarily applied from different biopolimer-containing samples (biofilm or RIC). The advantage of males over females lies in their degenerated digestive system and simple anatomy. Thus, their exudate is less contaminated with food and endosymbiont elements. The sequenced and annotated genome and transcriptome of this species opened the way for identifying Rotimer proteins by mass spectrometry. The predicted rotifer-biopolymer forming components are SCO-spondins and 14-3-3 protein. The characteristics of Rotimer are similar to Reissner's fiber, which is found in the central nervous system of vertebrates and is mainly formed from SCO-spondins. This molecular information serves as a starting point for its interdisciplinary investigation and application in biotechnology, biomedicine, or neurodegeneration-related drug development. LA - English DB - MTMT ER - TY - JOUR AU - Vedelek, Viktor AU - Vedelek, Balázs AU - Lőrincz, Péter AU - Juhász, Gábor AU - Sinka, Rita TI - A comparative analysis of fruit fly and human glutamate dehydrogenases in Drosophila melanogaster sperm development JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 11 PY - 2023 PG - 16 SN - 2296-634X DO - 10.3389/fcell.2023.1281487 UR - https://m2.mtmt.hu/api/publication/34239207 ID - 34239207 N1 - Funding Agency and Grant Number: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by NKFIH (PD137914 to VV, K132155 to RS, and FK138851 to PL), National Research, Development, and Innovation Offi [PD137914, K132155, FK138851]; NKFIH [2022-2.1.1-NL-2022-00008, EKA 2022/045-P101-2, LP 2022-13/2022]; National Research, Development, and Innovation Office of Hungary (Biotechnology National Laboratory) Funding text: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by NKFIH (PD137914 to VV, K132155 to RS, and FK138851 to PL), National Research, Development, and Innovation Office of Hungary (Biotechnology National Laboratory 2022-2.1.1-NL-2022-00008 to GJ), and Eotvos Lorand University Excellence Fund (EKA 2022/045-P101-2), MTA-t (LP 2022-13/2022) to PL.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by NKFIH (PD137914 to VV, K132155 to RS, and FK138851 to PL), National Research, Development, and Innovation Office of Hungary (Biotechnology National Laboratory 2022-2.1.1-NL-2022-00008 to GJ), and Eotvos Lorand University Excellence Fund (EKA 2022/045-P101-2), MTA-t (LP 2022-13/2022) to PL. AB - Glutamate dehydrogenases are enzymes that take part in both amino acid and energy metabolism. Their role is clear in many biological processes, from neuronal function to cancer development. The putative testis-specific Drosophila glutamate dehydrogenase, Bb8, is required for male fertility and the development of mitochondrial derivatives in spermatids. Testis-specific genes are less conserved and could gain new functions, thus raising a question whether Bb8 has retained its original enzymatic activity. We show that while Bb8 displays glutamate dehydrogenase activity, there are significant functional differences between the housekeeping Gdh and the testis-specific Bb8. Both human GLUD1 and GLUD2 can rescue the bb8 ms mutant phenotype, with superior performance by GLUD2. We also tested the role of three conserved amino acids observed in both Bb8 and GLUD2 in Gdh mutants, which showed their importance in the glutamate dehydrogenase function. The findings of our study indicate that Drosophila Bb8 and human GLUD2 could be novel examples of convergent molecular evolution. Furthermore, we investigated the importance of glutamate levels in mitochondrial homeostasis during spermatogenesis by ectopic expression of the mitochondrial glutamate transporter Aralar1, which caused mitochondrial abnormalities in fly spermatids. The data presented in our study offer evidence supporting the significant involvement of glutamate metabolism in sperm development. LA - English DB - MTMT ER - TY - CHAP AU - Vedelek, Viktor AU - Gábor, Juhász AU - Lőrincz, Péter AU - Sinka, Rita ED - László, Buday ED - Miklós, Erdélyi ED - Beáta, Lontay ED - József, Mihály ED - Sinka, Rita ED - László, Virág ED - Gergely, Szakáts ED - Attila, Varga TI - Mitochondrial dynamics and metabolic remodelling in Drosophila spermatogenesis T2 - Hungarian Molecular Life Sciences 2021 PB - Diamond Congress Kft. CY - Eger SN - 9786155270673 PY - 2021 SP - 161 UR - https://m2.mtmt.hu/api/publication/32529946 ID - 32529946 LA - English DB - MTMT ER - TY - CHAP AU - Elham, Alzyoud AU - Vedelek, Viktor AU - Zsuzsanna, Réthi-Nagy AU - Zoltán, Lipinszki AU - Sinka, Rita ED - László, Buday ED - Miklós, Erdélyi ED - Beáta, Lontay ED - József, Mihály ED - Sinka, Rita ED - László, Virág ED - Gergely, Szakáts ED - Attila, Varga TI - Microtubule organizing centers contain testis-specific γ-TuRC proteins in spermatids of Drosophila T2 - Hungarian Molecular Life Sciences 2021 PB - Diamond Congress Kft. CY - Eger SN - 9786155270673 PY - 2021 SP - 34 UR - https://m2.mtmt.hu/api/publication/32529454 ID - 32529454 LA - English DB - MTMT ER - TY - JOUR AU - Alzyoud, Elham AU - Vedelek, Viktor AU - Réthi-Nagy, Zsuzsánna AU - Lipinszki, Zoltán AU - Sinka, Rita TI - Microtubule Organizing Centers Contain Testis-Specific γ-TuRC Proteins in Spermatids of Drosophila JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 9 PY - 2021 PG - 11 SN - 2296-634X DO - 10.3389/fcell.2021.727264 UR - https://m2.mtmt.hu/api/publication/32264137 ID - 32264137 LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Katalin AU - Tasi, Zsolt AU - Vedelek, Viktor AU - Vágvölgyi, Csaba AU - Sinka, Rita AU - Gácser, Attila TI - Deciphering of Candida parapsilosis induced immune response in Drosophila melanogaster JF - VIRULENCE J2 - VIRULENCE VL - 12 PY - 2021 IS - 1 SP - 2571 EP - 2582 PG - 12 SN - 2150-5594 DO - 10.1080/21505594.2021.1980989 UR - https://m2.mtmt.hu/api/publication/32246048 ID - 32246048 N1 - Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Genetics, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary HCEMM-USZ, Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary MTA-SZTE Lendület Mycobiome Research Group, University of Szeged, Szeged, Hungary Export Date: 19 January 2022 Correspondence Address: Gácser, A.; HCEMM-USZ, Hungary; email: gacsera@bio.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Vedelek, Viktor AU - Kovács, Attila Lajos AU - Juhász, Gábor AU - Alzyoud, Elham AU - Sinka, Rita TI - The tumor suppressor archipelago E3 ligase is required for spermatid differentiation in Drosophila testis JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 9 SN - 2045-2322 DO - 10.1038/s41598-021-87656-3 UR - https://m2.mtmt.hu/api/publication/31976016 ID - 31976016 N1 - Department of Genetics, University of Szeged, Szeged, Hungary Department of Anatomy, Cell and Developmental Biology, Eötvös Lóránd University of Science, Budapest, Hungary Export Date: 10 May 2021 Correspondence Address: Vedelek, V.; Department of Genetics, Hungary; email: ugu@veta.hu Correspondence Address: Sinka, R.; Department of Genetics, Hungary; email: rsinka@bio.u-szeged.hu Department of Genetics, University of Szeged, Szeged, Hungary Department of Anatomy, Cell and Developmental Biology, Eötvös Lóránd University of Science, Budapest, Hungary Export Date: 11 May 2021 Correspondence Address: Vedelek, V.; Department of Genetics, Hungary; email: ugu@veta.hu Correspondence Address: Sinka, R.; Department of Genetics, Hungary; email: rsinka@bio.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Bajusz, Csaba AU - Kristó, Ildikó AU - Abonyi, Csilla AU - Venit, Tomáš AU - Vedelek, Viktor AU - Lukácsovich, Tamás AU - Farkas, Attila AU - Borkúti, Péter AU - Kovács, Zoltán AU - Bajusz, Izabella AU - Marton, Annamária AU - Vizler, Csaba AU - Lipinszki, Zoltán AU - Sinka, Rita AU - Percipalle, Piergiorgio AU - Vilmos, Péter TI - The nuclear activity of the actin‐binding Moesin protein is necessary for gene expression in Drosophila JF - FEBS JOURNAL J2 - FEBS J VL - 288 PY - 2021 IS - 16 SP - 4812 EP - 4832 PG - 21 SN - 1742-464X DO - 10.1111/febs.15779 UR - https://m2.mtmt.hu/api/publication/31909117 ID - 31909117 N1 - Eötvös Loránd Research Network (ELKH), Biological Research Centre, Szeged, Hungary Doctoral School of Biology, University of Szeged, Hungary Department of Genetics, University of Szeged, Hungary Doctoral School of Multidisciplinary Medical Science, University of Szeged, Hungary Lendület Laboratory of Cell Cycle Regulation, ELKH, Biological Research Centre, Szeged, Hungary LA - English DB - MTMT ER -