@article{MTMT:34744438,
	title = {The triumvirate of effective and rapid synthesis, analysis, and artificial intelligence to explore the structure-property relationship of copolymers},
	url = {https://m2.mtmt.hu/api/publication/34744438},
	author = {Nagy, Tibor and Róth, Gergő and Kuki, Ákos and Pardi-Tóth, Veronika Csilla and Nyul, Dávid and Kyzy, Zuura Kaldybek and Palacios, Isaac Alexander Iglesias and Benedek, Máté and Nagy, Lajos and Zsuga, Miklós and Kéki, Sándor},
	doi = {10.1016/j.giant.2024.100248},
	journal-iso = {GIANT},
	journal = {GIANT},
	volume = {17},
	unique-id = {34744438},
	issn = {2666-5425},
	abstract = {Understanding the structure-property relationship is of paramount importance for tailoring copolymers for specific applications. Poly(N-acryloylmorpholine)-block-poly(N-isopropylacrylamide) (PNAM-b-PNIPAM) diblock copolymers were synthesized by reversible addition?fragmentation chain transfer (RAFT) polymerization with varying Mn and composition, providing the basis for deducing structure-property relationships. The chemical structure of the copolymers was analyzed by mass spectrometry (MS). A novel and efficient mass spectrum processing methodology was developed for the detailed analysis of polymers/copolymers that greatly expands the upper mass limit of the time-of-flight (TOF) analyzers in the linear mode up to 20,000 Da. Our method "makes visible" the mass peaks of the individual copolymer species and their isotopologues providing effective and fast automatized analysis. The self-assembly property of the thermoresponsive PNAM-b-PNIPAM diblocks in aqueous solutions was investigated by dynamic light scattering (DLS) experiments, and quantified by determining the incipient temperature of the phase transition. For rapid evaluation, an artificial neural network (ANN) was created to explore the hidden relationships between the structural information obtained by our novel mass analysis method and the properties as well as to predict the self-assembly behavior of the copolymers.},
	keywords = {COPOLYMERS; Artificial intelligence; MALDI-TOF MS; Structure-property relation},
	year = {2024},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X}
}

@article{MTMT:34720754,
	title = {Optimization of Extraction Conditions to Synthesize Green Carbon Nanodots from Maillard Reaction},
	url = {https://m2.mtmt.hu/api/publication/34720754},
	author = {Nguyen Huu Huong, Duyen and Muthu, Arjun and El-Ramady, Hassan and Daróczi, Lajos and Nagy, Lajos and Kéki, Sándor and Béni, Áron and Csarnovics, István and Prokisch, József},
	doi = {10.1039/D4MA00037D},
	journal-iso = {MATER ADV},
	journal = {MATERIALS ADVANCES},
	unique-id = {34720754},
	abstract = {Carbon nanodots (CNDs) are a class of nanoparticles with unique optical properties with broad applications in various fields. However, synthesizing CNDs with high fluorescence intensity and small size using green...},
	year = {2024},
	eissn = {2633-5409},
	orcid-numbers = {Nguyen Huu Huong, Duyen/0000-0002-8450-2272}
}

@CONFERENCE{MTMT:34274180,
	title = {Alifás diizocianátok és butan-1-ol reakcióinak kinetikai vizsgálata =$bKinetic study of the reactions between aliphatic diisocyanates and butan-1-ol},
	url = {https://m2.mtmt.hu/api/publication/34274180},
	author = {Vadkerti, Bence and Lakatos, Csilla and Üneri, Haymana Serra and Rágyanszki, Anita and Farkas, Ödön and Juhász, Anett and Zsuga, Miklós and Kéki, Sándor and Nagy, Lajos},
	booktitle = {XXIX. Nemzetközi Vegyészkonferencia / 29th International Conference on Chemistry},
	unique-id = {34274180},
	year = {2023},
	pages = {61},
	orcid-numbers = {Farkas, Ödön/0000-0002-4217-0150}
}

@CONFERENCE{MTMT:34272050,
	title = {Anyagba integrált adatok dekódolása DART-MS ionforrással},
	url = {https://m2.mtmt.hu/api/publication/34272050},
	author = {Pardi-Tóth, Veronika Csilla and Nagy, Tibor and Kordován, Marcell Árpád and Róth, Gergő and Nagy, Lajos and Kuki, Ákos and Zsuga, Miklós and Kéki, Sándor},
	booktitle = {XXIX. Nemzetközi Vegyészkonferencia / 29th International Conference on Chemistry},
	unique-id = {34272050},
	abstract = {A molekuláris adattárolás a hagyományos információtároló rendszerekkel azonos szerepet is képes lehet betölteni akár már napjainkban is. A tárolni kívánt információ bináris kódra történő átalakítása által a 0 illetve 1 értékek a kismolekulák hiányát vagy jelenlétét jelezik. Kutatómunkánk során olyan molekulacsoportot szintetizáltunk, amely illékonysága és termikus stabilitása révén alkalmas a kódolást követően DART-MS ionforrással történő visszaolvasásra. Habár a komponensek hasonló szerkezetűek voltak, a tömegcsúcsok intenzitásában mégis jelentős különbségek adódtak az eltérő ionizációs hatásfokok miatt. A tárolt kód hibás visszaolvasásának elkerülése érdekében a koncentrációkat úgy állítottuk be, hogy minden vegyületre hasonló intenzitást kapjunk. Az intenzitásarányok beállítását követően többféle platformon is megvalósítottuk az információ tárolását és hibamentes visszaolvasását.},
	year = {2023},
	pages = {58},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X}
}

@CONFERENCE{MTMT:34271518,
	title = {7Li-NMR relaxációs módszerek alkalmazása lítium-levegő akkumulátorok határfelületeinek vizsgálatára},
	url = {https://m2.mtmt.hu/api/publication/34271518},
	author = {Nyul, Dávid and Nagy, Lajos and Kuki, Ákos and Nagy, Tibor and Bányai, István and Zsuga, Miklós and Kéki, Sándor},
	booktitle = {XXIX. Nemzetközi Vegyészkonferencia / 29th International Conference on Chemistry},
	unique-id = {34271518},
	abstract = {A modern kor egyik legégetőbb problémája a megtermelt energia tárolása, hiszen megfelelő
		tárolókapacitás nélkül nem képzelhető el olyan elektromos hálózat, ami tisztán megújuló
		energiaforrásokkal üzemel. A különböző kémiájú akkumulátorok közt a lítium-ion alapú cellák
		kimagaslóan nagy fajlagos és volumetrikus energiasűrűséggel rendelkeznek. A legnagyobb
		energiasűrűséggel a lítium-levegő akkumulátor rendelkezik. Az NMR spektroszkópia egy igen gyorsan fejlődő és sokoldalú szerkezetvizsgáló és képalkotó
		módszercsalád. Szilárd fázisú NMR technikákkal már vizsgálták az elektródanyagok és az alkálifémek
		kölcsönhatását, például porózus szénben interkalált nátrium vagy grafitban interkalált lítium
		viselkedését. A szilárd fázisú módszereknek viszont nagy hátránya, hogy nem tudják ezeket a
		rendszereket valós körülmények közt vizsgálni. A folyadék fázisú NMR módszerek közvetlen
		információt nem képesek szolgáltatni egy szilárd anyagról, de a felület és a folyadék fázis közti
		kölcsönhatások vizsgálatával értékes többletinformációt nyerhetünk az adott rendszerről. Minden alkálifémnek van NMR aktív izotópja és ezek az izotópok kivétel nélkül kvadrupólusmagok. A kvadrupólus csatolás megjelenése oldat fázisban nem lehetséges, hiszen az alkálifém ionok
		gyors mozgása és rotációja miatt a kvadrupólus kölcsönhatások kiátlagolódnak. Ha az alkálifém-ion egy
		lassan mozgó részecskéhez vagy egy felülethez kötődik, akkor a rotációja eléggé lelassul ahhoz, hogy
		kvadrupólus relaxáció is megfigyelhető legyen. A kvadrupólus vagy többkvantum (MQ) relaxációs
		útvonalak detektálása MQ szűrők segítségével vagy TQTPPI (triplakvantum időarányos fázistolás)
		szekvencia segítségével történhet.},
	year = {2023},
	pages = {59-60},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X; Bányai, István/0000-0002-6260-9175}
}

@CONFERENCE{MTMT:34267869,
	title = {3D nyomtatással készült Li-levegő cellák tanulmányozása különböző szerves oldószerrel készült elektrolitok jelenlétében},
	url = {https://m2.mtmt.hu/api/publication/34267869},
	author = {Nagy, Lajos and Hayamana, Serra Üneri and Kordován, Marcell Árpád and Nagy, Tibor and Kuki, Ákos and Nyul, Dávid and Pál, Petra and Zsuga, Miklós and Kéki, Sándor},
	booktitle = {XXIX. Nemzetközi Vegyészkonferencia / 29th International Conference on Chemistry},
	unique-id = {34267869},
	year = {2023},
	pages = {53},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X}
}

@CONFERENCE{MTMT:34267400,
	title = {Fém-levegő akkumulátorok formatervezése és 3D nyomtatása},
	url = {https://m2.mtmt.hu/api/publication/34267400},
	author = {Kordován, Marcell Árpád and Nagy, Tibor and Nagy, Lajos and Kuki, Ákos and Üneri, Haymana Serra and Róth, Gergő and Zsuga, Miklós and Kéki, Sándor},
	booktitle = {XXIX. Nemzetközi Vegyészkonferencia / 29th International Conference on Chemistry},
	unique-id = {34267400},
	year = {2023},
	pages = {49},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X}
}

@article{MTMT:34218802,
	title = {Molecular data storage using direct analysis in real time (DART) ionization mass spectrometry for decoding},
	url = {https://m2.mtmt.hu/api/publication/34218802},
	author = {Pardi-Tóth, Veronika Csilla and Kuki, Ákos and Kordován, Marcell Árpád and Róth, Gergő and Nagy, Lajos and Zsuga, Miklós and Nagy, Tibor and Kéki, Sándor},
	doi = {10.1038/s41598-023-43658-x},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34218802},
	issn = {2045-2322},
	abstract = {Molecular data storage is becoming a viable alternative to traditional information storage systems.
		Here, we propose a method where the presence or absence of a given molecule in a mixture of
		compounds represents a bit of information. As a novel approach, direct analysis in real time (DART)
		ionization mass spectrometry is used to recover and decode the information stored at the molecular
		level. Nicotinic acid derivatives were synthesized and used as the ‘bit compounds’. Their volatility and
		ease of ionization make these molecules especially suitable for DART-MS detection. The application
		of DART-MS as a method with an ambient ionization technique, enables the re-reading of digital
		chemical codes embedded in the material of ordinary objects. Our method is designed to store and
		read back short pieces of digital information, up to several hundred bits. These codes can have the
		function of barcodes or QR codes, as shown in our proof-of-principle applications. First, modelling
		a QR code as a link to our university’s website, three solutions were prepared, each representing 22
		bits. Proceeding further, the bit compounds were incorporated into a polymer matrix that is suitable
		for 3D printing, and a toy ship was created with a hidden barcode. In addition, decoding software
		was developed to process the DART-MS spectra. The nicotinic acid components representing the bits
		dominated the DART-MS spectra and error-free decoding was achieved.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X}
}

@article{MTMT:34204372,
	title = {One-pot green synthesis and characterization of novel furan-based oligoesters},
	url = {https://m2.mtmt.hu/api/publication/34204372},
	author = {Bîtcan, Ioan and Pellis, Alessandro and Petrovici, Andreea and Dreavă, Diana-Maria and Păușescu, Iulia and Peter, Francisc and Nagy, Lajos and Kéki, Sándor and Gardossi, Lucia and Todea, Anamaria},
	doi = {10.1016/j.scp.2023.101229},
	journal-iso = {SUSTAIN CHEM PHARM},
	journal = {SUSTAINABLE CHEMISTRY AND PHARMACY},
	volume = {35},
	unique-id = {34204372},
	issn = {2352-5541},
	abstract = {he synthesis of bio-based poly(5-hydroxymethyl-2-furancarboxylate-co-ricinoleate) was investigated either from ricinoleic acid and 5-hydroxymethyl-2-furancarboxylic acid or directly from castor oil by green biocatalytic pathways. The reactions were carried out using commercially available native and immobilized hydrolases. The reactions were performed either in the absence of solvent or in different organic solvents or ionic liquids at various molar ratios and temperatures up to 80 °C. The lipase from Pseudomonas stutzeri showed the highest catalytic efficiency at 50 °C in t-butanol. To increase the sustainability of the process, in the next step, an original “one-pot” system consisting of two consecutive reactions catalyzed by the same enzyme was developed. Ricinoleic acid, obtained by in-situ hydrolysis of castor oil, was used together with 5-hydroxymethyl-2-furancarboxylic acid as raw material for the oligoester synthesis at 100 mbar pressure in a solventless reaction system, yielding a product with average molecular weight of about 5800 gmol-1, in optimized conditions. The insertion of 5-hydroxymethyl-2-furancarboxylic acid units into the ricinoleic acid estolide backbone was demonstrated by MALDI-TOF MS and 2D NMR analysis.},
	year = {2023},
	eissn = {2352-5541},
	orcid-numbers = {Peter, Francisc/0000-0001-7248-2641}
}

@article{MTMT:34112909,
	title = {Biocatalytic synthesis of new polyesteramides from ε-caprolactam and hydroxy acids: Structural characterization, biodegradability, and suitability as drug nanocarriers},
	url = {https://m2.mtmt.hu/api/publication/34112909},
	author = {Benea, Ioana Cristina and Kántor, Izolda and Todea, Anamaria and Pellis, Alessandro and Bîtcan, Ioan and Nagy, Lajos and Kéki, Sándor and Dreavă, Diana Maria and Péter, Francisc and Feczkó, Tivadar},
	doi = {10.1016/j.reactfunctpolym.2023.105702},
	journal-iso = {REACT FUNCT POLYM},
	journal = {REACTIVE & FUNCTIONAL POLYMERS},
	volume = {191},
	unique-id = {34112909},
	issn = {1381-5148},
	abstract = {The synthesis of polyesters and polyamides by enzyme-catalyzed processes in vitro was developed in the last decades as a green alternative to obtain biodegradable synthetic polymers with various applications, such as nanoparticle-sized carriers for drug delivery. Polyesteramides were much less studied in this respect, although having the presumable advantage of increased mechanical and thermic resistance brought by the amide moieties. In this work, polyesteramides were synthesized for the first time employing as raw materials epsilon-caprolactam and a hydroxy acid. L-malic, 3-hydroxybutyric, 12-hydroxystearic and 16-hydroxyhexadecanoic acid, respectively, were investigated as co-monomers in solventless or organic medium, using the immobilized lipase Novozyme 435 as catalyst. The short chain hydroxy acids holding secondary hydroxyl groups yielded oligomers with average degree of polymerization no higher than 4, while in the case of the long-chain 12-hydroxystearic acid this value increased to 7. The best results were achieved by using 16-hydroxyhexadecanoic acid in 2:1 M excess at 80. C, yielding a product with 75% copolymer content and average molecular weight higher than 3000 Da. The emulsion-solvent evaporation method allowed the efficient production of nanoparticles based on this copolymer, with sizes around 230 nm, used for the encapsulation of a model bioactive compound, the anticancer drug sorafenib. Production yields of >70% and encapsulation efficiencies of around 60% are very promising for further development of this approach.},
	keywords = {BIOCATALYSIS; Polymer nanoparticle; Polyesteramide},
	year = {2023},
	eissn = {1873-166X}
}