@article{MTMT:34538603, title = {P421 The faecal biomarker LDN-051 is a novel tool for monitoring disease activity and therapeutic response in Inflammatory Bowel Diseases}, url = {https://m2.mtmt.hu/api/publication/34538603}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Pallagi, Petra and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad212.0551}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34538603}, issn = {1873-9946}, year = {2024}, eissn = {1876-4479}, pages = {i869-i869}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Pallagi, Petra/0000-0001-8906-0840; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34538600, title = {P072 LDN-071, a novel first-in-class amino acid-based PAI-1 inhibitor, significantly reduces the severity of experimental colitis in mice}, url = {https://m2.mtmt.hu/api/publication/34538600}, author = {Jójárt, Boldizsár and Csákány-Papp, Noémi and Laub, H and Vasas, Béla and Barta, B and Szabó, Viktória and Bagyánszki, Mária and Mándity, I and Heltovics, G and Pallagi, Petra and Maléth, József}, doi = {10.1093/ecco-jcc/jjad212.0202}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34538600}, issn = {1873-9946}, year = {2024}, eissn = {1876-4479}, pages = {i342-i342}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Csákány-Papp, Noémi/0000-0002-3614-2698; Szabó, Viktória/0000-0001-6547-9102; Bagyánszki, Mária/0000-0003-3533-9461; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34482233, title = {Reduction of intracellular oxidative stress with copper incorporated layered double hydroxide}, url = {https://m2.mtmt.hu/api/publication/34482233}, author = {Szerlauth, Adél and Madácsy, Tamara and Samu, Gergely Ferenc and Bíró, Péter and Erdélyi, Miklós and Varga, Gábor and Xu, Zhi Ping and Maléth, József and Szilágyi, István}, doi = {10.1039/D3CC05762C}, journal-iso = {CHEM COMMUN}, journal = {CHEMICAL COMMUNICATIONS}, volume = {60}, unique-id = {34482233}, issn = {1359-7345}, abstract = {Biocompatible Cu(II)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase and catalase-like activity in chemical assays, while proved as...}, year = {2024}, eissn = {1364-548X}, pages = {1325-1328}, orcid-numbers = {Madácsy, Tamara/0000-0001-5598-9723; Samu, Gergely Ferenc/0000-0002-3239-9154; Erdélyi, Miklós/0000-0002-9501-5752; Varga, Gábor/0000-0002-7131-1629; Maléth, József/0000-0001-5768-3090; Szilágyi, István/0000-0001-7289-0979} } @article{MTMT:34167015, title = {Plasminogen activator inhibitor 1 is a novel faecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases}, url = {https://m2.mtmt.hu/api/publication/34167015}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Pallagi, Petra and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad160}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34167015}, issn = {1873-9946}, abstract = {Crohn's disease and ulcerative colitis require lifelong treatment and patient monitoring. Current biomarkers have several limitations, therefore, there is an unmet need to identify novel biomarkers in inflammatory bowel disease (IBD). Previously, the role of plasminogen activator inhibitor 1 (PAI-1) was established in the pathogenesis of IBD and suggested as a potential biomarker. Therefore, we aimed to comprehensively analyze the selectivity of PAI-1 in IBD, its correlation with the disease activity, and its potential to predict therapeutic response.Blood, colon biopsy, organoid cultures (OC), and faecal samples were used from active and inactive IBD patients and control subjects. Serpin E1 gene expressions and PAI-1 protein levels and localization in serum, biopsy, and fecal samples were evaluated by qRT-PCR, ELISA, and immunostaining, respectively.The study population comprised 132 IBD patients (56 CD and 76 UC) and 40 non-IBD patients. We demonstrated that the serum, mucosal, and faecal PAI-1 concentration is elevated in IBD patients, showing clinical and endoscopic activity. In responders (decrease of eMayo≥3 in UC; or SES-CD>50% in CD), the initial PAI-1 level decreased significantly upon successful therapy. OCs derived from active IBD patients produced higher concentrations of PAI-1 than the controls, suggesting that epithelial cells could be a source of PAI-1. Moreover, faecal PAI-1 selectively increases in active IBD but not other organic gastrointestinal diseases.The serum, mucosal, and faecal PAI-1 concentration correlates with the disease activity and therapeutic response in IBD, suggesting that PAI-1 could be utilized as a novel non-invasive, disease-specific faecal biomarker in the patient follow-up.}, keywords = {Inflammatory bowel disease; PAI-1; faecal marker}, year = {2024}, eissn = {1876-4479}, pages = {392-405}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Pallagi, Petra/0000-0001-8906-0840; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @misc{MTMT:34714725, title = {Intercellular communication between epithelial and stromal cells in ex vivo co-cultures}, url = {https://m2.mtmt.hu/api/publication/34714725}, author = {Kúthy-Sutus, Enikő and Kiss, Aletta Kata and Pallagi, Petra and Maléth, József}, unique-id = {34714725}, year = {2023}, orcid-numbers = {Kúthy-Sutus, Enikő/0000-0002-1398-4120; Kiss, Aletta Kata/0000-0001-6404-1555; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @misc{MTMT:34687647, title = {Orai1 calcium channel inhibition prevents progression of chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34687647}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, Ferhan and Jee, Shyam and Tiszlavicz, László and Stauderman, Kenneth and Hebbar, Sudarshan and Pallagi, Petra and Maléth, József}, unique-id = {34687647}, year = {2023}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34687430, title = {ORAI1 CALCIUM CHANNEL INHIBITION PREVENTS PROGRESSION OF RECURRENT ACUTE AND CHRONIC PANCREATITIS}, url = {https://m2.mtmt.hu/api/publication/34687430}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, AK and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, M and Bódi, N and Ayaydin, F and Jee, S and Tiszlavicz, L and Stauderman, K and Hebbar, S and Pallagi, Petra and Maléth, József}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {34687430}, issn = {2050-6406}, year = {2023}, eissn = {2050-6414}, pages = {66-66}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34687367, title = {PLASMINOGEN ACTIVATOR INHIBITOR 1 A POTENTIAL NEW THERAPEUTIC TARGET IN THE TREATMENT OF CHRONIC PANCREATITIS}, url = {https://m2.mtmt.hu/api/publication/34687367}, author = {Molnár, Tamás and Szabó, Viktória and Jójárt, Boldizsár and Csákány-Papp, Noémi and Pallagi, Petra and Maléth, József}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {34687367}, issn = {2050-6406}, year = {2023}, eissn = {2050-6414}, pages = {463-463}, orcid-numbers = {Molnár, Tamás/0000-0002-4913-7599; Szabó, Viktória/0000-0001-6547-9102; Jójárt, Boldizsár/0000-0002-2764-3925; Csákány-Papp, Noémi/0000-0002-3614-2698; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @misc{MTMT:34672053, title = {The inhibition of Orai1 calcium channel reduces the progression of chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34672053}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, Ferhan and Shyam, Jee and Tiszlavicz, László and Stauderman, Kenneth and Hebbar, Sudarshan and Pallagi, Petra and Maléth, József}, unique-id = {34672053}, year = {2023}, pages = {1}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Bagyánszki, Mária/0000-0003-3533-9461; Bódi, Nikolett/0000-0002-9774-1387; Tiszlavicz, László/0000-0003-1134-6587; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @CONFERENCE{MTMT:34657516, title = {TAVT-135, a novel chloride ion transporter for the pan-genotypic treatment of cystic fibrosis: electrophysiological and mucus-hydration properties}, url = {https://m2.mtmt.hu/api/publication/34657516}, author = {Ilagan, Roger and Gentzsch, Martina and Maléth, József and L., Quinney Nancy and Szabó, Viktória and Zákány, Florina and Basa-Dénes, Orsolya and Molnár, László and Mándity, István}, booktitle = {18th ECFS Basic Science Conference}, unique-id = {34657516}, year = {2023}, pages = {69}, orcid-numbers = {Maléth, József/0000-0001-5768-3090; Szabó, Viktória/0000-0001-6547-9102; Molnár, László/0000-0003-4535-7292; Mándity, István/0000-0003-2865-6143} }