TY - GEN AU - Halász, László AU - Balint, VARKUTI AU - Gabriella, MIKLOS AU - Saman, HAGH GOOIE AU - Tóth, Emília AU - Max, HASSELBERGER AU - Gijs, VAN ELSWIJK AU - Erőss, Loránd TI - Sensory-substitution-based perception interface using spinal cord stimulation applied for hearing aid PY - 2023 UR - https://m2.mtmt.hu/api/publication/34125060 ID - 34125060 LA - English DB - MTMT ER - TY - JOUR AU - Fabó, Dániel AU - Bokodi, Virág AU - Szabó, Johanna Petra AU - Tóth, Emília AU - Salami, Pariya AU - Keller, Corey J AU - Hajnal, Boglárka Zsófia AU - Thesen, Thomas AU - Devinsky, Orrin AU - Doyle, Werner AU - Mehta, Ashesh AU - Madsen, Joseph AU - Eskandar, Emad AU - Erőss, Loránd AU - Ulbert, István AU - Halgren, Eric AU - Cash, Sydney S TI - The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 17 SN - 2045-2322 DO - 10.1038/s41598-022-22497-2 UR - https://m2.mtmt.hu/api/publication/34019088 ID - 34019088 N1 - Epilepsy Unit, Department of Neurology, National Institute of Mental Health, Neurology and Neurosurgery, Amerikai Út 57. 1145, Budapest, Hungary Roska Tamás Doctoral School of Sciences and Technologies, Budapest, Hungary János Szentágothai Doctoral School of Neurosciences, Budapest, Hungary Department of Neurology, University of Texas, McGovern Medical School, Houston, TX, United States Epilepsy Division, Department of Neurology, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, United States VA Palo Alto Health Care System, Palo Alto, CA, United States Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY, United States Department of Biomedical Sciences, College of Medicine, University of Houston, Houston, TX, United States Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell and Feinstein Institute for Medical Research, Manhasset, NY, United States The Children’s Hospital, Boston, MA, United States Massachusetts General Hospital Neurosurgery Research, Boston, MA, United States Department of Functional Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary Institute of Psychology, Eötvös Loránd Research Network, Budapest, Hungary Department of Radiology, Neurosciences and Psychiatry, University of California, San Diego, San Diego, CA, United States Export Date: 30 October 2023 Correspondence Address: Fabo, D.; Epilepsy Unit, Amerikai Út 57. 1145, Hungary; email: fabo@oiti.hu Correspondence Address: Cash, S.S.; Epilepsy Division, United States; email: scash@mgh.harvard.edu AB - Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. We recorded potential gradients with laminar multielectrode arrays (LME) for current source density (CSD) and multi-unit activity (MUA) analysis of interictal epileptiform discharges IEDs and HFOs in the neocortex and mesial temporal lobe of focal epilepsy patients. IEDs were observed in 20/29, while ripples only in 9/29 patients. Ripples were all detected within the seizure onset zone (SOZ). Compared to hippocampal HFOs, neocortical ripples proved to be longer, lower in frequency and amplitude, and presented non-uniform cycles. A subset of ripples (≈ 50%) co-occurred with IEDs, while IEDs were shown to contain variable high-frequency activity, even below HFO detection threshold. The limit between slow and fast ripples was defined at 150 Hz, while IEDs' high frequency components form clusters separated at 185 Hz. CSD analysis of IEDs and ripples revealed an alternating sink-source pair in the supragranular cortical layers, although fast ripple CSD appeared lower and engaged a wider cortical domain than slow ripples MUA analysis suggested a possible role of infragranularly located neural populations in ripple and IED generation. Laminar distribution of peak frequencies derived from HFOs and IEDs, respectively, showed that supragranular layers were dominated by slower (< 150 Hz) components. Our findings suggest that cortical slow ripples are generated primarily in upper layers while fast ripples and associated MUA in deeper layers. The dissociation of macro- and microdomains suggests that microelectrode recordings may be more selective for SOZ-linked ripples. We found a complex interplay between neural activity in the neocortical laminae during ripple and IED formation. We observed a potential leading role of cortical neurons in deeper layers, suggesting a refined utilization of LMEs in SOZ localization. LA - English DB - MTMT ER - TY - JOUR AU - Hajnal, Boglárka Zsófia AU - Entz, László AU - Tóth, Emília AU - Wittner, Lucia AU - Ulbert, István AU - Erőss, Loránd AU - Fabó, Dániel TI - A humán agykéreg elektromos ingerlésével kiváltott válaszok alatti lokális hálózati és egysejt-szintű aktivitásváltozásainak vizsgálata JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 18 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/33075628 ID - 33075628 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hajnal, Boglárka Zsófia AU - Entz, László AU - Tóth, Emília AU - Ulbert, István AU - Erőss, Loránd AU - Fabó, Dániel TI - Local neuronal network and single unit changes evoked by single and paired pulse cortical stimulation in humans JF - EPILEPSIA J2 - EPILEPSIA VL - 62 PY - 2021 IS - Suppl. 3 SP - 264 EP - 265 PG - 2 SN - 0013-9580 UR - https://m2.mtmt.hu/api/publication/32548110 ID - 32548110 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Emília AU - Bokodi, Virág AU - Somogyvári, Zoltán AU - Maglóczky, Zsófia AU - Wittner, Lucia AU - Ulbert, István AU - Erőss, Loránd AU - Fabó, Dániel TI - Laminar distribution of electrically evoked hippocampal short latency ripple activity highlights the importance of the subiculum in vivo in human epilepsy, an intraoperative study JF - EPILEPSY RESEARCH J2 - EPILEPSY RES VL - 169 PY - 2021 PG - 9 SN - 0920-1211 DO - 10.1016/j.eplepsyres.2020.106509 UR - https://m2.mtmt.hu/api/publication/31794996 ID - 31794996 LA - English DB - MTMT ER - TY - JOUR AU - Hajnal, Boglárka Zsófia AU - Entz, László AU - Tóth, Emília AU - Ulbert, István AU - Fabó, Dániel AU - Erőss, Loránd TI - The neocortical neural correlates of electrically evoked cortical potentials in humans JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 130 PY - 2019 IS - 7 SP - e97 SN - 1388-2457 DO - 10.1016/j.clinph.2019.04.550 UR - https://m2.mtmt.hu/api/publication/32055138 ID - 32055138 LA - English DB - MTMT ER - TY - CHAP AU - Nánási, Tibor AU - File, Bálint AU - Tóth, Emília AU - Entz, László AU - Ulbert, István AU - Fabó, Dániel AU - Erőss, Loránd TI - Synergism of spectral and coupling modalities in epileptic focus localization from iEEG recordings T2 - 6th International Workshop on Pattern Recognition in Neuroimaging, PRNI 2016 PB - IEEE CY - Seattle (WA) SN - 9781467365307 T3 - PRNI 2016 - 6th International Workshop on Pattern Recognition in Neuroimaging PY - 2016 SP - 113 EP - 116 PG - 4 DO - 10.1109/PRNI.2016.7552354 UR - https://m2.mtmt.hu/api/publication/30401320 ID - 30401320 N1 - WoS:hiba:000387080100029 2020-12-05 11:05 befoglaló egyiknél nincsenek szerzők, befoglaló cím nem egyezik LA - English DB - MTMT ER - TY - THES AU - Tóth, Emília TI - Development of multimodal diagnostic tools for epilepsy patients implanted with intracranial micro- and macroelectrodes PB - Pázmány Péter Katolikus Egyetem (PPKE) PY - 2016 SP - 112 DO - 10.15774/PPKE.ITK.2016.004 UR - https://m2.mtmt.hu/api/publication/3094852 ID - 3094852 LA - English DB - MTMT ER - TY - CONF AU - Bokodi, Virág AU - Tóth, Emília AU - Somogyvári, Zoltán AU - Maglóczky, Zsófia AU - Erőss, Loránd AU - Ulbert, István AU - Fabó, Dániel TI - High frequency oscillations in the human hippocampal formation using single pulse cortical electrical stimulation [poster] T2 - IBRO Workshop 2016 PY - 2016 PG - 1 UR - https://m2.mtmt.hu/api/publication/3015752 ID - 3015752 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Emília AU - Fabó, Dániel AU - Entz, László AU - Ulbert, István AU - Erőss, Loránd TI - Intracranial neuronal ensemble recordings and analysis in epilepsy. JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 260 PY - 2016 IS - SI SP - 261 EP - 269 PG - 9 SN - 0165-0270 DO - 10.1016/j.jneumeth.2015.09.028 UR - https://m2.mtmt.hu/api/publication/3015678 ID - 3015678 N1 - Funding Agency and Grant Number: Hungarian Government - National Research Development and Innovation Office [OTKA PD101754, KTIA NAP 13-1-2013-0001] Funding text: This work was supported by Hungarian Government - National Research Development and Innovation Office (OTKA PD101754, KTIA NAP 13-1-2013-0001). AB - Pathological neuronal firing was demonstrated 50 years ago as the hallmark of epileptically transformed cortex with the use of implanted microelectrodes. Since then, microelectrodes remained only experimental tools in humans to detect unitary neuronal activity to reveal physiological and pathological brain functions. This recording technique has evolved substantially in the past few decades; however, based on recent human data implying their usefulness as diagnostic tools, we expect a substantial increase in the development of microelectrodes in the near future. Here, we review the technological background and history of microelectrode array development for human examinations in epilepsy, including discussions on of wire-based and microelectrode arrays fabricated using micro-electro-mechanical system (MEMS) techniques and novel future techniques to record neuronal ensemble. We give an overview of clinical and surgical considerations, and try to provide a list of probes on the market with their availability for human recording. Then finally, we briefly review the literature on modulation of single neuron for the treatment of epilepsy, and highlight the current topics under examination that can be background for the future development. LA - English DB - MTMT ER -