TY - CHAP AU - Gamiel, Alaa AU - Bartos, Csilla AU - Ambrus, Rita ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Effect of drying process on the physico-chemical properties of oxicam drugs T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 56 PG - 1 DO - 10.14232/syrptbrs.2024.56 UR - https://m2.mtmt.hu/api/publication/34598593 ID - 34598593 LA - English DB - MTMT ER - TY - JOUR AU - Alshweiat, Areen AU - Varga, Patrícia Orsolya AU - Pannonhalminé Csóka, Ildikó AU - Motzwickler-Németh, Anett AU - Bartos, Csilla AU - Ambrus, Rita TI - Preparation and Characterization of Smartcrystals for Dissolution Enhancement of Poorly Water - Soluble Niflumic Acid JF - FARMACIA (BUCHAREST) J2 - FARMACIA VL - 71 PY - 2023 IS - 3 SP - 501 EP - 510 PG - 10 SN - 0014-8237 DO - 10.31925/farmacia.2023.3.7 UR - https://m2.mtmt.hu/api/publication/34066497 ID - 34066497 N1 - Department of pharmaceutics and pharmaceutical technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, 13133, Jordan Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Export Date: 20 September 2023 CODEN: FRMBA Correspondence Address: Ambrus, R.; Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u. 6, Hungary; email: ambrus.rita@szte.hu LA - English DB - MTMT ER - TY - CHAP AU - Varga, Patrícia Orsolya AU - Bartos, Csilla AU - Ambrus, Rita ED - Hajdú, Péter TI - Meloxikám-kálium tartalmú nazális porok stabilitásvizsgálata T2 - XXVI. Tavaszi Szél Konferencia 2023 : Absztrakt kötet PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786156457233 PY - 2023 SP - 359 EP - 359 PG - 1 UR - https://m2.mtmt.hu/api/publication/34066446 ID - 34066446 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Mirankó, Mirella AU - Tóth, Judit AU - Bartos, Csilla AU - Ambrus, Rita AU - Feczkó, Tivadar TI - Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics15020317 UR - https://m2.mtmt.hu/api/publication/33573245 ID - 33573245 AB - Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form composite powders for nasal administration. The product was composed of hydroxypropyl methylcellulose polymer, including LC as a zwitterion, after neutralization by NaOH, and XRD investigations verified its amorphous state. This and a sulfobutylated-beta-cyclodextrin sodium salt-containing sample showed crystal peaks due to NaCl content as products of the neutralization reaction in the solutions before drying. The average particle size of the spherical microparticles was between 2.42 and 3.44 µm, except for those containing a polyvinyl alcohol excipient, which were characterized by a medium diameter of 29.80 µm. The drug was completely and immediately liberated from all the samples at pH 5.6 and 32 °C; i.e., the carriers did not change the good dissolution behavior of LC. A permeability test was carried out by dipping the synthetic cellulose ester membrane in isopropyl myristate using modified horizontal diffusion cells. The spray-dried powder with β-cyclodextrin showed the highest permeability (188.37 µg/cm2/h), as this additive was the least hydrophilic. Products prepared with other cyclodextrins (randomly methylated-beta-cyclodextrin, sulfobutylated-beta-cyclodextrin sodium salt and (hydroxypropyl)-beta-cyclodextrin) showed similar or slightly higher penetration abilities than LC. Other polymer excipients resulted in lower penetration of the active agent than the pure LC. LA - English DB - MTMT ER - TY - JOUR AU - Csicsák, Dóra AU - Szolláth, Rita Mariann AU - Kádár, Szabina AU - Ambrus, Rita AU - Bartos, Csilla AU - Bertalanné Balogh, Emese AU - Antal, István AU - Köteles, István AU - Tőzsér, Petra AU - Bárdos, Vivien AU - Horváth, Péter AU - Borbás, Enikő AU - Takácsné Novák, Krisztina AU - Sinkó, B. AU - Völgyi, Gergely TI - The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 1 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics15010278 UR - https://m2.mtmt.hu/api/publication/33562140 ID - 33562140 LA - English DB - MTMT ER - TY - CONF AU - Varga, Patrícia Orsolya AU - Alshweiat, Areen AU - Pannonhalminé Csóka, Ildikó AU - Révész, Piroska AU - Bartos, Csilla AU - Ambrus, Rita TI - Nifluminsav nanokristályok előállítása és vizsgálata T2 - Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2022: A Magyar Gyógyszerésztudományi Társaság Gyógyszeripari Szervezetének és Gyógyszertechnológiai Szakosztályának Konferenciája PY - 2022 UR - https://m2.mtmt.hu/api/publication/33231423 ID - 33231423 N1 - [poszter] LA - Hungarian DB - MTMT ER - TY - CHAP AU - Varga, Patrícia Orsolya AU - Bartos, Csilla AU - Ambrus, Rita ED - Aleš, Obreza ED - Rok, Dreu ED - Alenka, Zvonar Pobirk ED - Barbara, Sterle Zorec TI - Investigation Of Meloxicam Potassium Containing Nanoparticles For Intranasal Administration T2 - 9th BBBB International Conference on Pharmaceutical Sciences - Pharma Sciences of Tomorrow: Book of Abstracts PB - Univerza v Ljubljani CY - Ljubljana SN - 9789619423042 PY - 2022 SP - 247 EP - 248 PG - 2 UR - https://m2.mtmt.hu/api/publication/33231285 ID - 33231285 LA - English DB - MTMT ER - TY - CHAP AU - Varga, Patrícia Orsolya AU - Ambrus, Rita AU - Révész, Piroska AU - Kókai, Dávid AU - Burián, Katalin AU - Bella, Zsolt AU - Fenyvesi, Ferenc AU - Bartos, Csilla ED - Uhljar, Luca Éva ED - Sipos, Bence TI - Preparation and investigation of meloxicam potassium containing cyclodextrin nanoparticles intended for nasal application T2 - IV. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science : book of abstracts PB - University of Szeged CY - Szeged PY - 2022 SP - 32 EP - 32 PG - 1 DO - 10.14232/syrptbrs.2022.32 UR - https://m2.mtmt.hu/api/publication/32868295 ID - 32868295 LA - English DB - MTMT ER - TY - JOUR AU - Ambrus, Rita AU - Alshweiat, Areen AU - Révész, Piroska AU - Bartos, Csilla AU - Pannonhalminé Csóka, Ildikó TI - Smartcrystals for Efficient Dissolution of Poorly Water-Soluble Meloxicam JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics14020245 UR - https://m2.mtmt.hu/api/publication/32613774 ID - 32613774 LA - English DB - MTMT ER - TY - CONF AU - Varga, Patrícia Orsolya AU - Ambrus, Rita AU - Bartos, Csilla TI - Nazális bevitel céljából előállított meloxikám-kálium tartalmú nanoszférák vizsgálata T2 - MKE Kristályosítási és Gyógyszerformulálási Szakosztály 13. Kerekasztal Konferenciája PY - 2021 SP - 24 EP - 25 PG - 2 UR - https://m2.mtmt.hu/api/publication/32900458 ID - 32900458 LA - Hungarian DB - MTMT ER -