TY - BOOK AU - Balogh, Balázs AU - Bogdán, Dóra AU - Czompa, Andrea AU - Deme, Ruth AU - Dunkel, Petra AU - Kaleta, Zoltán AU - Varró, Nikolett AU - Krajsovszky, Gábor AU - Mándity, István AU - Pollák, Patrik TI - Szerves kémia szemináriumok I. PB - Semmelweis Egyetem CY - Budapest PY - 2023 SN - 9786155722301 UR - https://m2.mtmt.hu/api/publication/34433118 ID - 34433118 LA - Hungarian DB - MTMT ER - TY - BOOK AU - Balogh, Balázs AU - Bogdán, Dóra AU - Czompa, Andrea AU - Deme, Ruth AU - Dunkel, Petra AU - Ivánczi, Márton AU - Kárpáti, Levente AU - Krajsovszky, Gábor AU - Mándity, István AU - Tétényi, Péter TI - Organic chemistry test questions. Semmelweis University, Faculty of Pharmaceutical Sciences, Department of Organic Chemistry PB - Semmelweis Kiadó CY - Budapest PY - 2023 SN - 9786155722295 UR - https://m2.mtmt.hu/api/publication/34315226 ID - 34315226 LA - English DB - MTMT ER - TY - BOOK AU - Balogh, Balázs AU - Bogdán, Dóra AU - Czompa, Andrea AU - Deme, Ruth AU - Dunkel, Petra AU - Ivánczi, Márton AU - Kárpáti, Levente AU - Krajsovszky, Gábor AU - Mándity, István AU - Tétényi, Péter TI - Szerves kémia tesztfeladatok PB - Semmelweis Egyetem CY - Budapest PY - 2023 SN - 9786155722288 UR - https://m2.mtmt.hu/api/publication/34186753 ID - 34186753 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csomos, Attila AU - Kontra, Bence AU - Jancsó, Attila AU - Galbács, Gábor AU - Deme, Ruth AU - Kele, Zoltán AU - Rózsa J., Balázs AU - Kovács, Ervin AU - Mucsi, Zoltán TI - A comprehensive study of the Ca2+ ion binding of fluorescently labelled BAPTA analogues JF - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY J2 - EUR J ORG CHEM VL - 2021 PY - 2021 IS - 37 SP - 5248 EP - 5261 PG - 17 SN - 1434-193X DO - 10.1002/ejoc.202100948 UR - https://m2.mtmt.hu/api/publication/32187933 ID - 32187933 AB - Since its development, the ionophore BAPTA (1,2?bis(2?aminophenoxy)-ethane?N,N,N?,N??tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as ?linker?). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the length of the linker, the number of O atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca 2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications. LA - English DB - MTMT ER - TY - JOUR AU - Fliszár-Nyúl, Eszter AU - Faisal, Anna Zelma AU - Mohos, Violetta Karolin AU - Derdák, Diána AU - Lemli, Beáta AU - Kálai, Tamás AU - Pápayné Sár, Cecília AU - Zsidó, Balázs Zoltán AU - Hetényi, Csaba AU - Horváth, Ádám István AU - Helyes, Zsuzsanna AU - Deme, Ruth AU - Bogdán, Dóra AU - Czompa, Andrea AU - Mátyus, Péter AU - Poór, Miklós TI - Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin JF - JOURNAL OF MOLECULAR LIQUIDS J2 - J MOL LIQ VL - 333 PY - 2021 PG - 10 SN - 0167-7322 DO - 10.1016/j.molliq.2021.115945 UR - https://m2.mtmt.hu/api/publication/31927621 ID - 31927621 N1 - Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs, H-7624, Hungary Institute of Organic and Medicinal Chemistry, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Green Chemistry Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs, H-7624, Hungary Department of General and Physical Chemistry, Faculty of Sciences, University of Pécs, Ifjúság 6, Pécs, H-7624, Hungary Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary Molecular Pharmacology Research Group & Centre for Neuroscience, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, Pécs, H-7624, Hungary PharmInVivo Ltd., Szondi György u. 10, Pécs, H-7629, Hungary Algonist Gmbh, 1030 Karl-Farkas-Gasse 22, Wien, Austria Department of Organic Chemistry, Faculty of Pharmacy, Semmelweis University, Hőgyes u. 7, Budapest, H-1092, Hungary Institute of Digital Health Sciences, Semmelweis University, Faculty of Health and Public Services, Ferenc tér 15, Budapest, H-1094, Hungary E-Group Ict Software Zrt, Kacsa u. 11, Budapest, H-1027, Hungary Cited By :10 Export Date: 31 August 2023 CODEN: JMLID Correspondence Address: Poór, M.; Department of Pharmacology, Szigeti út 12, Hungary; email: poor.miklos@pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Pilipecz, Mihály AU - Varga, Tamás Róbert AU - Krall, Peter AU - Vincze, Zoltán AU - Mucsi, Zoltán AU - Deme, Ruth AU - Szabó, Pál Tamás AU - Nemes, Péter TI - Simple route to new oxadiazaboroles and oxadiazoles via amidoximes JF - SYNTHETIC COMMUNICATIONS J2 - SYNTHETIC COMMUN VL - 50 PY - 2020 IS - 11 SP - 1712 EP - 1723 PG - 12 SN - 0039-7911 DO - 10.1080/00397911.2020.1755439 UR - https://m2.mtmt.hu/api/publication/31328319 ID - 31328319 AB - The novel push-pull alkene, the 2-(nitro-nitrosomethylene)-pyrrolidine with numerous aliphatic or aromatic amines as nucleophiles afforded amidoximes. Various substituted oxadiazaborole and oxadiazole derivatives were prepared starting from these amidoximes, widening the synthetic applicability of the push-pull alkenes. Acylation of the amidoximes was also examined. The mechanism of the amidoxime formation was investigated by computational methods. LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Géza AU - Bogdán, Dóra AU - Mazák, Károly AU - Deme, Ruth AU - Mucsi, Zoltán AU - Mándity, István AU - Noszál, Béla AU - Kállai-Szabó, Nikolett AU - Antal, István TI - Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 20 PY - 2019 IS - 8 PG - 12 SN - 1530-9932 DO - 10.1208/s12249-019-1525-6 UR - https://m2.mtmt.hu/api/publication/30810156 ID - 30810156 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary Department of Organic Chemistry, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2., Budapest, 1117, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary Femtonics Ltd., Tűzoltó Street 59, Budapest, 1094, Hungary Cited By :6 Export Date: 18 February 2021 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7-9, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary Department of Organic Chemistry, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2., Budapest, 1117, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary Femtonics Ltd., Tűzoltó Street 59, Budapest, 1094, Hungary Cited By :8 Export Date: 28 April 2021 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7-9, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu Funding Agency and Grant Number: Semmelweis University (SE) Funding text: Open access funding provided by Semmelweis University (SE). Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary Department of Organic Chemistry, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2., Budapest, 1117, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. Street 7-9, Budapest, 1092, Hungary Femtonics Ltd., Tűzoltó Street 59, Budapest, 1094, Hungary Cited By :10 Export Date: 15 August 2021 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7-9, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Zürn, Moritz AU - Tóth, Gergő AU - Mazákné Kraszni, Márta AU - Sólyomváry, Anna AU - Mucsi, Zoltán AU - Deme, Ruth AU - Rózsa J., Balázs AU - Fodor, Blanka AU - Perlné Molnár, Ibolya AU - Horváti, Kata AU - Bősze, Szilvia AU - Pályi, B. AU - Kis, Z. AU - Béni, Szabolcs AU - Noszál, Béla AU - Boldizsár, Imre TI - Galls of European Fraxinus trees as new and abundant sources of valuable phenylethanoid and coumarin glycosides JF - INDUSTRIAL CROPS AND PRODUCTS J2 - IND CROP PROD VL - 139 PY - 2019 PG - 9 SN - 0926-6690 DO - 10.1016/j.indcrop.2019.111517 UR - https://m2.mtmt.hu/api/publication/30734521 ID - 30734521 N1 - Department of Plant Anatomy, Institute of Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, 1117, Hungary Eötvös Loránd University, Institutional Excellence Program, Natural Bioactive Compounds Group, Pázmány Péter sétány 1/C, Budapest, 1117, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre u. 9, Budapest, 1092, Hungary Department of Pharmacognosy, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary Femtonics Ltd, Tűzoltó u. 59, Budapest, 1094, Hungary Department of Organic Chemistry, Semmelweis University, Hőgyes Endre u. 7, Budapest, 1092, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, Budapest, 1083, Hungary Department of Analytical Chemistry, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest, 1117, Hungary MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University, Hungarian Academy of Sciences, Budapest, Hungary National Public Health Center, Albert Flórián út 2-6, Budapest, 1097, Hungary Cited By :7 Export Date: 28 April 2023 CODEN: ICRDE Correspondence Address: Boldizsár, I.; Department of Plant Anatomy, Pázmány Péter sétány 1/C, Hungary; email: boldizsarimi@gmail.com Funding details: ÚNKP‐18‐4‐SE‐121 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Emberi Eroforrások Minisztériuma, EMMI, 1783-3/2018/FEKUTSRAT, STIA-18-KF, STIA-M-17 Funding details: National Research, Development and Innovation Office, 115431, KFI_16-1-2016-0177, NVKP_16-1-2016-0043, OTKA 124077, VEKOP-2.3.2-16-2017-00014, VEKOP-2.3.3-15-2017-00020 Funding text 1: This work was supported by the National Research, Development and Innovation Office, Hungary (grants: VEKOP-2.3.3-15-2017-00020 , VEKOP-2.3.2-16-2017-00014 , OTKA 115431 , OTKA 124077 , KFI_16-1-2016-0177 , NVKP_16-1-2016-0043 ), by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (to I. Boldizsár, S. Béni, K. Horváti and G. Tóth), by the Bolyai+New National Excellence Program (grant number: ÚNKP‐18‐4‐SE‐121 ) of the Ministry of Human Capacities (S. Béni) and by the Semmelweis Innovation Found STIA-M-17 and STIA-18-KF (to G. Tóth). This work was completed in the ELTE Institutional Excellence Program (1783-3/2018/FEKUTSRAT) supported by the Hungarian Ministry of Human Capacities. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Zoltán-István AU - Deme, Ruth AU - Mucsi, Zoltán AU - Rusu, Aura AU - Mare, Anca Delia AU - Fiser, Béla AU - Toma, Felicia AU - Sipos, Emese AU - Tóth, Gergő TI - Equilibrium, structural and antibacterial characterization of moxifloxacin-β-cyclodextrin complex JF - JOURNAL OF MOLECULAR STRUCTURE J2 - J MOL STRUCT VL - 1166 PY - 2018 SP - 228 EP - 236 PG - 9 SN - 0022-2860 DO - 10.1016/j.molstruc.2018.04.045 UR - https://m2.mtmt.hu/api/publication/3367882 ID - 3367882 N1 - Department of Drugs Industry and Pharmaceutical Management, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Femtonics Ltd., Tűzoltó u. 59, Budapest, H-1094, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Computational Molecular Design Research Group, Institute of Chemistry, University of Miskolc, Miskolc, Hungary Ferenc Rákóczi II. Transcarpathian Hungarian Institute, Beregszász, Transcarpathia, Ukraine Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary Cited By :16 Export Date: 11 July 2021 CODEN: JMOSB Correspondence Address: Tóth, G.; Department of Pharmaceutical Chemistry, Hőgyes E. u. 9, Hungary; email: toth.gergo@pharma.semmelweis-univ.hu Funding Agency and Grant Number: New National Excellence Program of the Ministry of Human Capacity [UNKP-17-4]; Semmelweis University School of PhD. studies Funding text: The financial support from UNKP-17-4 New National Excellence Program of the Ministry of Human Capacity is highly appreciated. The research was supported by the Semmelweis University School of PhD. studies. Department of Drugs Industry and Pharmaceutical Management, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Femtonics Ltd., Tűzoltó u. 59, Budapest, H-1094, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Computational Molecular Design Research Group, Institute of Chemistry, University of Miskolc, Miskolc, Hungary Ferenc Rákóczi II. Transcarpathian Hungarian Institute, Beregszász, Transcarpathia, Ukraine Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary Cited By :16 Export Date: 21 July 2021 CODEN: JMOSB Correspondence Address: Tóth, G.; Department of Pharmaceutical Chemistry, Hőgyes E. u. 9, Hungary; email: toth.gergo@pharma.semmelweis-univ.hu Department of Drugs Industry and Pharmaceutical Management, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Femtonics Ltd., Tűzoltó u. 59, Budapest, H-1094, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Computational Molecular Design Research Group, Institute of Chemistry, University of Miskolc, Miskolc, Hungary Ferenc Rákóczi II. Transcarpathian Hungarian Institute, Beregszász, Transcarpathia, Ukraine Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary Cited By :16 Export Date: 14 August 2021 CODEN: JMOSB Correspondence Address: Tóth, G.; Department of Pharmaceutical Chemistry, Hőgyes E. u. 9, Hungary; email: toth.gergo@pharma.semmelweis-univ.hu Department of Drugs Industry and Pharmaceutical Management, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Femtonics Ltd., Tűzoltó u. 59, Budapest, H-1094, Hungary Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Tîrgu, Mureș, Romania Computational Molecular Design Research Group, Institute of Chemistry, University of Miskolc, Miskolc, Hungary Ferenc Rákóczi II. Transcarpathian Hungarian Institute, Beregszász, Transcarpathia, Ukraine Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary Cited By :16 Export Date: 15 August 2021 CODEN: JMOSB Correspondence Address: Tóth, G.; Department of Pharmaceutical Chemistry, Hőgyes E. u. 9, Hungary; email: toth.gergo@pharma.semmelweis-univ.hu AB - Moxifloxacin (MOX), a novel fourth-generation fluoroquinolone antibacterial was characterized in terms of β-cyclodextrin (β-CD) complexation in order to improve its antibacterial activity. The inclusion complexation has been examined with a wide variety of state-of-the-art analytical techniques, such as nuclear magnetic resonance spectroscopy (NMR), affinity capillary electrophoresis (ACE), mass spectrometry (MS), infrared spectroscopy (IR) and differential scanning calorimetry (DSC). The stoichiometry of the complex was investigated by two different techniques. NMR Job plot method indicated 1:1 stoichiometry in liquid state, however MS study revealed that a complex with 2:1 (MOX:β-CD) stoichiometry can also be formed in gas phase. The stability constants were determined by 1H NMR titration and ACE at different pH values, where MOX exists predominantly in monocationic, neutral and monoanionic form, respectively, indicating that the neutral macrospecies forms the most stable complex with the host (logK = 2.51 ± 0.03). Geometric aspects of the inclusion complex were assessed by 2D ROESY NMR and proved that the tricyclic moiety of guest can enter the host cavity. To understand the interaction of different protonation forms of MOX with β-CD at atomic level molecular modeling studies were also performed. Solid state complexation in 1:1 M ratio was carried out by lyophilization and investigated by DSC and IR, which also confirmed the inclusion complex formation in solid state. The antibacterial activity of the complex was tested against Gram-negative and Gram-positive bacteria by determination of minimum inhibitory concentrations, which revealed that supramolecular interactions do not affect significantly the antibacterial activity of the drug. LA - English DB - MTMT ER - TY - THES AU - Deme, Ruth TI - Diastereoselective synthesis of novel tetrahydroquinoline derivatives via tert-amino effect PB - Semmelweis Egyetem PY - 2017 DO - 10.14753/SE.2017.2264 UR - https://m2.mtmt.hu/api/publication/3268122 ID - 3268122 LA - English DB - MTMT ER -