@book{MTMT:34433118, title = {Szerves kémia szemináriumok I.}, url = {https://m2.mtmt.hu/api/publication/34433118}, isbn = {9786155722301}, author = {Balogh, Balázs and Bogdán, Dóra and Czompa, Andrea and Deme, Ruth and Dunkel, Petra and Kaleta, Zoltán and Varró, Nikolett and Krajsovszky, Gábor and Mándity, István and Pollák, Patrik}, publisher = {Semmelweis Egyetem}, unique-id = {34433118}, year = {2023}, orcid-numbers = {Balogh, Balázs/0000-0001-7282-7283; Bogdán, Dóra/0000-0003-4455-8914; Czompa, Andrea/0000-0001-8442-8554; Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Kaleta, Zoltán/0000-0003-2350-5100; Varró, Nikolett/0000-0003-4161-9021; Krajsovszky, Gábor/0000-0002-3224-4566; Mándity, István/0000-0003-2865-6143} } @book{MTMT:34315226, title = {Organic chemistry test questions. Semmelweis University, Faculty of Pharmaceutical Sciences, Department of Organic Chemistry}, url = {https://m2.mtmt.hu/api/publication/34315226}, isbn = {9786155722295}, author = {Balogh, Balázs and Bogdán, Dóra and Czompa, Andrea and Deme, Ruth and Dunkel, Petra and Ivánczi, Márton and Kárpáti, Levente and Krajsovszky, Gábor and Mándity, István and Tétényi, Péter}, publisher = {Semmelweis Kiadó és Multimédia Stúdió}, unique-id = {34315226}, year = {2023}, orcid-numbers = {Balogh, Balázs/0000-0001-7282-7283; Bogdán, Dóra/0000-0003-4455-8914; Czompa, Andrea/0000-0001-8442-8554; Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Kárpáti, Levente/0000-0002-9091-3027; Krajsovszky, Gábor/0000-0002-3224-4566; Mándity, István/0000-0003-2865-6143} } @book{MTMT:34186753, title = {Szerves kémia tesztfeladatok}, url = {https://m2.mtmt.hu/api/publication/34186753}, isbn = {9786155722288}, author = {Balogh, Balázs and Bogdán, Dóra and Czompa, Andrea and Deme, Ruth and Dunkel, Petra and Ivánczi, Márton and Kárpáti, Levente and Krajsovszky, Gábor and Mándity, István and Tétényi, Péter}, publisher = {Semmelweis Egyetem}, unique-id = {34186753}, year = {2023}, orcid-numbers = {Balogh, Balázs/0000-0001-7282-7283; Bogdán, Dóra/0000-0003-4455-8914; Czompa, Andrea/0000-0001-8442-8554; Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Krajsovszky, Gábor/0000-0002-3224-4566; Mándity, István/0000-0003-2865-6143} } @article{MTMT:32187933, title = {A comprehensive study of the Ca2+ ion binding of fluorescently labelled BAPTA analogues}, url = {https://m2.mtmt.hu/api/publication/32187933}, author = {Csomos, Attila and Kontra, Bence and Jancsó, Attila and Galbács, Gábor and Deme, Ruth and Kele, Zoltán and Rózsa J., Balázs and Kovács, Ervin and Mucsi, Zoltán}, doi = {10.1002/ejoc.202100948}, journal-iso = {EUR J ORG CHEM}, journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, volume = {2021}, unique-id = {32187933}, issn = {1434-193X}, abstract = {Since its development, the ionophore BAPTA (1,2?bis(2?aminophenoxy)-ethane?N,N,N?,N??tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as ?linker?). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the length of the linker, the number of O atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca 2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.}, keywords = {Calcium ChelatesDensity functional calculationsDyesFluorescent probes}, year = {2021}, eissn = {1099-0690}, pages = {5248-5261}, orcid-numbers = {Kontra, Bence/0000-0001-8293-3637; Jancsó, Attila/0000-0003-2362-0758; Galbács, Gábor/0000-0002-1799-5329; Deme, Ruth/0000-0002-0798-6912; Kele, Zoltán/0000-0002-4401-0302; Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847} } @article{MTMT:31927621, title = {Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin}, url = {https://m2.mtmt.hu/api/publication/31927621}, author = {Fliszár-Nyúl, Eszter and Faisal, Anna Zelma and Mohos, Violetta Karolin and Derdák, Diána and Lemli, Beáta and Kálai, Tamás and Pápayné Sár, Cecília and Zsidó, Balázs Zoltán and Hetényi, Csaba and Horváth, Ádám István and Helyes, Zsuzsanna and Deme, Ruth and Bogdán, Dóra and Czompa, Andrea and Mátyus, Péter and Poór, Miklós}, doi = {10.1016/j.molliq.2021.115945}, journal-iso = {J MOL LIQ}, journal = {JOURNAL OF MOLECULAR LIQUIDS}, volume = {333}, unique-id = {31927621}, issn = {0167-7322}, year = {2021}, eissn = {1873-3166}, orcid-numbers = {Fliszár-Nyúl, Eszter/0000-0003-0923-0059; Mohos, Violetta Karolin/0000-0001-6248-060X; Lemli, Beáta/0000-0001-8903-1337; Deme, Ruth/0000-0002-0798-6912; Bogdán, Dóra/0000-0003-4455-8914; Czompa, Andrea/0000-0001-8442-8554; Mátyus, Péter/0000-0003-3963-9445} } @article{MTMT:31328319, title = {Simple route to new oxadiazaboroles and oxadiazoles via amidoximes}, url = {https://m2.mtmt.hu/api/publication/31328319}, author = {Pilipecz, Mihály and Varga, Tamás Róbert and Krall, Peter and Vincze, Zoltán and Mucsi, Zoltán and Deme, Ruth and Szabó, Pál Tamás and Nemes, Péter}, doi = {10.1080/00397911.2020.1755439}, journal-iso = {SYNTHETIC COMMUN}, journal = {SYNTHETIC COMMUNICATIONS}, volume = {50}, unique-id = {31328319}, issn = {0039-7911}, abstract = {The novel push-pull alkene, the 2-(nitro-nitrosomethylene)-pyrrolidine with numerous aliphatic or aromatic amines as nucleophiles afforded amidoximes. Various substituted oxadiazaborole and oxadiazole derivatives were prepared starting from these amidoximes, widening the synthetic applicability of the push-pull alkenes. Acylation of the amidoximes was also examined. The mechanism of the amidoxime formation was investigated by computational methods.}, keywords = {CYCLIZATION; pyrimidines; Computational methods; aromaticity; Oxadiazoles; Nitroenamines; AMIDOXIMES}, year = {2020}, eissn = {1532-2432}, pages = {1712-1723}, orcid-numbers = {Varga, Tamás Róbert/0000-0003-2123-9435; Mucsi, Zoltán/0000-0003-3224-8847; Deme, Ruth/0000-0002-0798-6912; Szabó, Pál Tamás/0000-0003-2260-4641} } @article{MTMT:30810156, title = {Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes}, url = {https://m2.mtmt.hu/api/publication/30810156}, author = {Jakab, Géza and Bogdán, Dóra and Mazák, Károly and Deme, Ruth and Mucsi, Zoltán and Mándity, István and Noszál, Béla and Kállai-Szabó, Nikolett and Antal, István}, doi = {10.1208/s12249-019-1525-6}, journal-iso = {AAPS PHARMSCITECH}, journal = {AAPS PHARMSCITECH}, volume = {20}, unique-id = {30810156}, issn = {1530-9932}, year = {2019}, eissn = {1530-9932}, orcid-numbers = {Jakab, Géza/0000-0002-8103-774X; Bogdán, Dóra/0000-0003-4455-8914; Mazák, Károly/0000-0002-9682-4826; Deme, Ruth/0000-0002-0798-6912; Mucsi, Zoltán/0000-0003-3224-8847; Mándity, István/0000-0003-2865-6143; Noszál, Béla/0000-0003-3898-3084; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Antal, István/0000-0002-5434-201X} } @article{MTMT:30734521, title = {Galls of European Fraxinus trees as new and abundant sources of valuable phenylethanoid and coumarin glycosides}, url = {https://m2.mtmt.hu/api/publication/30734521}, author = {Zürn, Moritz and Tóth, Gergő and Mazákné Kraszni, Márta and Sólyomváry, Anna and Mucsi, Zoltán and Deme, Ruth and Rózsa J., Balázs and Fodor, Blanka and Perlné Molnár, Ibolya and Horváti, Kata and Bősze, Szilvia and Pályi, B. and Kis, Z. and Béni, Szabolcs and Noszál, Béla and Boldizsár, Imre}, doi = {10.1016/j.indcrop.2019.111517}, journal-iso = {IND CROP PROD}, journal = {INDUSTRIAL CROPS AND PRODUCTS}, volume = {139}, unique-id = {30734521}, issn = {0926-6690}, year = {2019}, eissn = {1872-633X}, orcid-numbers = {Zürn, Moritz/0000-0002-3539-034X; Tóth, Gergő/0000-0001-5341-319X; Mazákné Kraszni, Márta/0000-0003-4364-9486; Sólyomváry, Anna/0000-0002-6903-540X; Mucsi, Zoltán/0000-0003-3224-8847; Deme, Ruth/0000-0002-0798-6912; Fodor, Blanka/0000-0003-2222-9546; Perlné Molnár, Ibolya/0000-0002-4965-3980; Horváti, Kata/0000-0003-4092-6011; Béni, Szabolcs/0000-0001-7056-6825; Noszál, Béla/0000-0003-3898-3084; Boldizsár, Imre/0000-0001-7852-8364} } @article{MTMT:3367882, title = {Equilibrium, structural and antibacterial characterization of moxifloxacin-β-cyclodextrin complex}, url = {https://m2.mtmt.hu/api/publication/3367882}, author = {Szabó, Zoltán-István and Deme, Ruth and Mucsi, Zoltán and Rusu, Aura and Mare, Anca Delia and Fiser, Béla and Toma, Felicia and Sipos, Emese and Tóth, Gergő}, doi = {10.1016/j.molstruc.2018.04.045}, journal-iso = {J MOL STRUCT}, journal = {JOURNAL OF MOLECULAR STRUCTURE}, volume = {1166}, unique-id = {3367882}, issn = {0022-2860}, abstract = {Moxifloxacin (MOX), a novel fourth-generation fluoroquinolone antibacterial was characterized in terms of β-cyclodextrin (β-CD) complexation in order to improve its antibacterial activity. The inclusion complexation has been examined with a wide variety of state-of-the-art analytical techniques, such as nuclear magnetic resonance spectroscopy (NMR), affinity capillary electrophoresis (ACE), mass spectrometry (MS), infrared spectroscopy (IR) and differential scanning calorimetry (DSC). The stoichiometry of the complex was investigated by two different techniques. NMR Job plot method indicated 1:1 stoichiometry in liquid state, however MS study revealed that a complex with 2:1 (MOX:β-CD) stoichiometry can also be formed in gas phase. The stability constants were determined by 1H NMR titration and ACE at different pH values, where MOX exists predominantly in monocationic, neutral and monoanionic form, respectively, indicating that the neutral macrospecies forms the most stable complex with the host (logK = 2.51 ± 0.03). Geometric aspects of the inclusion complex were assessed by 2D ROESY NMR and proved that the tricyclic moiety of guest can enter the host cavity. To understand the interaction of different protonation forms of MOX with β-CD at atomic level molecular modeling studies were also performed. Solid state complexation in 1:1 M ratio was carried out by lyophilization and investigated by DSC and IR, which also confirmed the inclusion complex formation in solid state. The antibacterial activity of the complex was tested against Gram-negative and Gram-positive bacteria by determination of minimum inhibitory concentrations, which revealed that supramolecular interactions do not affect significantly the antibacterial activity of the drug.}, keywords = {NMR; cyclodextrin; antibacterial activity; Fluoroquinolone; moxifloxacin; inclusion complex}, year = {2018}, eissn = {1872-8014}, pages = {228-236}, orcid-numbers = {Deme, Ruth/0000-0002-0798-6912; Mucsi, Zoltán/0000-0003-3224-8847; Fiser, Béla/0000-0003-0603-4626; Tóth, Gergő/0000-0001-5341-319X} } @mastersthesis{MTMT:3268122, title = {Diastereoselective synthesis of novel tetrahydroquinoline derivatives via tert-amino effect}, url = {https://m2.mtmt.hu/api/publication/3268122}, author = {Deme, Ruth}, doi = {10.14753/SE.2017.2264}, publisher = {Semmelweis Egyetem}, unique-id = {3268122}, year = {2017}, orcid-numbers = {Deme, Ruth/0000-0002-0798-6912} }