@article{MTMT:34572686,
	title = {Effects of H2S-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts},
	url = {https://m2.mtmt.hu/api/publication/34572686},
	author = {Tánczos, Bence and Vass, Virág and Szabó, Erzsébet and Lovas, Miklós and Kattoub, Rasha Ghanem and Bakai-Bereczki, Ilona and Borbás, Anikó and Herczegh, Pál and Tósaki, Árpád},
	doi = {10.1016/j.ejps.2024.106721},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {195},
	unique-id = {34572686},
	issn = {0928-0987},
	year = {2024},
	eissn = {1879-0720},
	pages = {106721},
	orcid-numbers = {Bakai-Bereczki, Ilona/0000-0003-4601-7257; Borbás, Anikó/0000-0001-8462-4547}
}

@article{MTMT:34427826,
	title = {Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase},
	url = {https://m2.mtmt.hu/api/publication/34427826},
	author = {Lőrincz, Eszter Boglárka and Herczeg, Mihály and Houser, Josef and Rievajová, Martina and Kuki, Ákos and Malinovská, Lenka and Naesens, Lieve and Wimmerová, Michaela and Borbás, Anikó and Herczegh, Pál and Bakai-Bereczki, Ilona},
	doi = {10.3390/ijms242417268},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34427826},
	issn = {1661-6596},
	abstract = {In the shadow of SARS-CoV-2, influenza seems to be an innocent virus, although new zoonotic influenza viruses evolved by mutations may lead to severe pandemics. According to WHO, there is an urgent need for better antiviral drugs. Blocking viral hemagglutinin with multivalent N-acetylneuraminic acid derivatives is a promising approach to prevent influenza infection. Moreover, dual inhibition of both hemagglutinin and neuraminidase may result in a more powerful effect. Since both viral glycoproteins can bind to neuraminic acid, we have prepared three series of amphiphilic self-assembling 2-thio-neuraminic acid derivatives constituting aggregates in aqueous medium to take advantage of their multivalent effect. One of the series was prepared by the azide-alkyne click reaction, and the other two by the thio-click reaction to yield neuraminic acid derivatives containing lipophilic tails of different sizes and an enzymatically stable thioglycosidic bond. Two of the three bis-octyl derivatives produced proved to be active against influenza viruses, while all three octyl derivatives bound to hemagglutinin and neuraminidase from H1N1 and H3N2 influenza types.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Houser, Josef/0000-0003-4504-3891; Naesens, Lieve/0000-0001-9742-9302; Wimmerová, Michaela/0000-0002-7108-4198; Borbás, Anikó/0000-0001-8462-4547; Bakai-Bereczki, Ilona/0000-0003-4601-7257}
}

@article{MTMT:34316518,
	title = {Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives},
	url = {https://m2.mtmt.hu/api/publication/34316518},
	author = {Lőrincz, Eszter Boglárka and Tóth, Gergely and Spolárics, Júlia and Herczeg, Mihály and Hodek, Jan and Zupkó, István and Minorics, Renáta and Ádám, Dorottya and Oláh, Attila and Zouboulis, Christos C. and Weber, Jan and Nagy, Lajos and Ostorházi, Eszter and Bácskay, Ildikó and Borbás, Anikó and Herczegh, Pál and Bakai-Bereczki, Ilona},
	doi = {10.1038/s41598-023-45565-7},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34316518},
	issn = {2045-2322},
	abstract = {(−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral bioavailability is moderate, which is unfavorable for medicinal use. Therefore, there is a great need for appropriate chemical modifications to improve their physicochemical and biological properties. In this study, Mannich-type reaction was used for the synthetic modification of CBD and CBG for the first time, and thus fifteen new cannabinoid derivatives containing one or two tertiary amino groups were prepared. Thereafter the antiviral, antiproliferative and antibacterial properties of the derivatives and their effects on certain skin cells were investigated. Some modified CBD derivatives showed remarkable antiviral activity against SARS-CoV-2 without cytotoxic effect, while synthetic modifications on CBG resulted in a significant increase in antiproliferative activity in some cases compared to the parent compound.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Oláh, Attila/0000-0003-4122-5639; Ostorházi, Eszter/0000-0002-9459-7316; Borbás, Anikó/0000-0001-8462-4547; Bakai-Bereczki, Ilona/0000-0003-4601-7257}
}

@article{MTMT:34125145,
	title = {Pharmacological Evaluation of Newly Synthesized Cannabidiol Derivates on H9c2 Cells},
	url = {https://m2.mtmt.hu/api/publication/34125145},
	author = {Szőke, Kitti and Kajtár, Richárd and Gyöngyösi, Alexandra and Czompa, Attila and Fésüs, Adina and Lőrincz, Eszter Boglárka and Petróczi, Ferenc Dániel and Herczegh, Pál and Bak, István and Borbás, Anikó and Bakai-Bereczki, Ilona and Lekli, István},
	doi = {10.3390/antiox12091714},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34125145},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Fésüs, Adina/0000-0002-6351-7715; Borbás, Anikó/0000-0001-8462-4547; Bakai-Bereczki, Ilona/0000-0003-4601-7257}
}

@article{MTMT:34081319,
	title = {In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues},
	url = {https://m2.mtmt.hu/api/publication/34081319},
	author = {Bege, Miklós and Singh, Vigyasa and Sharma, Neha and Debreczeni, Nóra and Bakai-Bereczki, Ilona and Nam, Poo and Herczegh, Pál and Rathi, Brijesh and Singh, Shailja and Borbás, Anikó},
	doi = {10.1038/s41598-023-39541-4},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34081319},
	issn = {2045-2322},
	abstract = {Drug-resistant Plasmodium falciparum ( Pf ) infections are a major burden on the population and the healthcare system. The establishment of Pf resistance to most existing antimalarial therapies has complicated the problem, and the emergence of resistance to artemisinin derivatives is even more concerning. It is increasingly difficult to cure malaria patients due to the limited availability of effective antimalarial drugs, resulting in an urgent need for more efficacious and affordable treatments to eradicate this disease. Herein, new nucleoside analogues including morpholino-nucleoside hybrids and thio-substituted nucleoside derivatives were prepared and evaluated for in vitro and in vivo antiparasitic activity that led a few hits especially nucleoside-thiopyranoside conjugates, which are highly effective against Pf 3D7 and Pf RKL-9 strains in submicromolar concentration. One adenosine derivative and four pyrimidine nucleoside analogues significantly reduced the parasite burden in mouse models infected with Plasmodium berghei ANKA. Importantly, no significant hemolysis and cytotoxicity towards human cell line (RAW) was observed for the hits, suggesting their safety profile. Preliminary research suggested that these thiosugar-nucleoside conjugates could be used to accelerate the antimalarial drug development pipeline and thus deserve further investigation.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Bakai-Bereczki, Ilona/0000-0003-4601-7257; Borbás, Anikó/0000-0001-8462-4547}
}

@article{MTMT:33768628,
	title = {Reperfusion-induced injury and the effects of the dithioacetate type hydrogen sulfide donor ibuprofen derivative, BM-88, in isolated rat hearts},
	url = {https://m2.mtmt.hu/api/publication/33768628},
	author = {Vass, Virág and Szabó, Erzsébet and Bakai-Bereczki, Ilona and Debreczeni, Nóra and Borbás, Anikó and Herczegh, Pál and Tósaki, Árpád},
	doi = {10.1016/j.ejps.2023.106449},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {185},
	unique-id = {33768628},
	issn = {0928-0987},
	year = {2023},
	eissn = {1879-0720},
	orcid-numbers = {Bakai-Bereczki, Ilona/0000-0003-4601-7257; Borbás, Anikó/0000-0001-8462-4547}
}

@article{MTMT:33657380,
	title = {Triaza-tricyclanos – synthesis of a new class of tricyclic nucleoside analogues by stereoselective cascade cyclocondensation},
	url = {https://m2.mtmt.hu/api/publication/33657380},
	author = {Bege, Miklós and Herczeg, Mihály and Bakai-Bereczki, Ilona and Debreczeni, Nóra and Bényei, Attila Csaba and Herczegh, Pál and Borbás, Anikó},
	doi = {10.1039/D3OB00154G},
	journal-iso = {ORG BIOMOL CHEM},
	journal = {ORGANIC & BIOMOLECULAR CHEMISTRY},
	volume = {21},
	unique-id = {33657380},
	issn = {1477-0520},
	abstract = {Conformationally constrained tricyclic morpholino-nucleosides containing three new chirality centers were prepared with full stereoselectivity, through two consecutive hemiaminal-imidazolidine cascade reactions.},
	year = {2023},
	eissn = {1477-0539},
	pages = {2213-2219},
	orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Bakai-Bereczki, Ilona/0000-0003-4601-7257; Borbás, Anikó/0000-0001-8462-4547}
}

@article{MTMT:33297309,
	title = {N‐Fluoroalkylated Morpholinos – a New Class of Nucleoside Analogues},
	url = {https://m2.mtmt.hu/api/publication/33297309},
	author = {Debreczeni, Nóra and Hotzi, Judit and Bege, Miklós and Lovas, Miklós and Mező, Erika and Bakai-Bereczki, Ilona and Herczegh, Pál and Kiss, Loránd and Borbás, Anikó},
	doi = {10.1002/chem.202203248},
	journal-iso = {CHEM-EUR J},
	journal = {CHEMISTRY-A EUROPEAN JOURNAL},
	volume = {29},
	unique-id = {33297309},
	issn = {0947-6539},
	year = {2023},
	eissn = {1521-3765},
	orcid-numbers = {Mező, Erika/0000-0002-8329-6745; Bakai-Bereczki, Ilona/0000-0003-4601-7257; Herczegh, Pál/0000-0003-4265-5518; Kiss, Loránd/0000-0003-2346-9816; Borbás, Anikó/0000-0001-8462-4547}
}

@article{MTMT:33702177,
	title = {Glikopeptid antibiotikumok újragondolva - antivirális terápiás lehetőségek},
	url = {https://m2.mtmt.hu/api/publication/33702177},
	author = {Bakai-Bereczki, Ilona},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {66},
	unique-id = {33702177},
	issn = {0017-6036},
	year = {2022},
	pages = {1-5},
	orcid-numbers = {Bakai-Bereczki, Ilona/0000-0003-4601-7257}
}

@article{MTMT:33299485,
	title = {Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in Gram-positive and Gram-negative bacteria in synergy with teicoplanin in vitro},
	url = {https://m2.mtmt.hu/api/publication/33299485},
	author = {Szűcs, Zsolt and Bakai-Bereczki, Ilona and Fenyvesi, Ferenc and Herczegh, Pál and Ostorházi, Eszter and Borbás, Anikó},
	doi = {10.1038/s41598-022-24807-0},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {33299485},
	issn = {2045-2322},
	abstract = {Gram-negative bacteria possess intrinsic resistance to glycopeptide antibiotics so these important antibacterial medications are only suitable for the treatment of Gram-positive bacterial infections. At the same time, polymyxins are peptide antibiotics, structurally related to glycopeptides, with remarkable activity against Gram-negative bacteria. With the aim of breaking the intrinsic resistance of Gram-negative bacteria against glycopeptides, a polycationic vancomycin aglycone derivative carrying an n -decanoyl side chain and five aminoethyl groups, which resembles the structure of polymyxins, was prepared. Although the compound by itself was not active against the Gram-negative bacteria tested, it synergized with teicoplanin against Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii , and it was able to potentiate vancomycin against these Gram-negative strains. Moreover, it proved to be active against vancomycin- and teicoplanin-resistant Gram-positive bacteria.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Bakai-Bereczki, Ilona/0000-0003-4601-7257; Ostorházi, Eszter/0000-0002-9459-7316; Borbás, Anikó/0000-0001-8462-4547}
}