@article{MTMT:32493048,
	title = {Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization},
	url = {https://m2.mtmt.hu/api/publication/32493048},
	author = {Nath Bhaumik, Kaushik and Hetényi, Anasztázia and Olajos, Gábor and Martins, Ana and Spohn, Réka and Németh, Lukács and Jójárt, Balázs and Szili, Petra and Dunai, Anett and Jangir, Pramod Kumar and Daruka, Lejla and Földesi, Imre and Kata, Diána and Pál, Csaba and Martinek, Tamás},
	doi = {10.1039/D1ME00118C},
	journal-iso = {MOL SYST DES ENG},
	journal = {MOLECULAR SYSTEMS DESIGN & ENGINEERING},
	volume = {7},
	unique-id = {32493048},
	issn = {2058-9689},
	abstract = {The negative membrane potential of bacterial cells influences crucial cellular processes. Inspired by the molecular scaffold of the antimicrobial peptide PGLa, we have developed antimicrobial foldamers with a computer-guided design strategy. The novel PGLa analogues induce sustained membrane hyperpolarization. When co-administered as an adjuvant, the resulting compounds - PGLb1 and PGLb2 - have substantially reduced the level of antibiotic resistance of multi-drug resistant Escherichia coli, Klebsiella pneumoniae and Shigella flexneri clinical isolates. The observed antibiotic potentiation was mediated by hyperpolarization of the bacterial membrane caused by the alteration of cellular ion transport. Specifically, PGLb1 and PGLb2 are selective ionophores that enhance the Goldman-Hodgkin-Katz potential across the bacterial membrane. These findings indicate that manipulating bacterial membrane electrophysiology could be a valuable tool to overcome antimicrobial resistance.},
	year = {2022},
	eissn = {2058-9689},
	pages = {21-33},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Olajos, Gábor/0000-0002-2479-4891; Jangir, Pramod Kumar/0000-0001-8330-0655; Földesi, Imre/0000-0002-3329-8136; Kata, Diána/0000-0002-4432-9380; Martinek, Tamás/0000-0003-3168-8066}
}

@CONFERENCE{MTMT:31192702,
	title = {Natural product inspired chemical approaches against MDR cancer},
	url = {https://m2.mtmt.hu/api/publication/31192702},
	author = {Fási, Laura and Vágvölgyi, Máté and Latif, Ahmed Dhahir and Issaadi, Halima Meriem and Zoofishan, Zoofishan and Zupkó, István and Spengler, Gabriella and Martins, Ana and Hunyadi, Attila},
	booktitle = {New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours},
	unique-id = {31192702},
	year = {2019},
	pages = {12-13},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Zupkó, István/0000-0003-3243-5300; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:31038930,
	title = {Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action},
	url = {https://m2.mtmt.hu/api/publication/31038930},
	author = {Kintses, Bálint and Jangir, Pramod Kumar and Fekete, Gergely and Számel, Mónika and Méhi, Orsolya Katinka and Spohn, Réka and Daruka, Lejla and Martins, Ana and Hosseinnia, A. and Gagarinova, A. and Kim, S. and Phanse, S. and Csörgő, Bálint and Györkei, Ádám and Ari, Eszter and Lázár, Viktória and Nagy, István and Babu, M. and Pál, Csaba and Papp, Balázs},
	doi = {10.1038/s41467-019-13618-z},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {10},
	unique-id = {31038930},
	issn = {2041-1723},
	year = {2019},
	eissn = {2041-1723},
	orcid-numbers = {Jangir, Pramod Kumar/0000-0001-8330-0655; Méhi, Orsolya Katinka/0009-0004-7918-913X; Csörgő, Bálint/0000-0003-0397-6845; Ari, Eszter/0000-0001-7774-1067}
}

@article{MTMT:30865039,
	title = {Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance},
	url = {https://m2.mtmt.hu/api/publication/30865039},
	author = {Spohn, Réka and Daruka, Lejla and Lázár, Viktória and Martins, Ana and Vidovics, Fanni and Grézal, Gábor and Méhi, Orsolya Katinka and Kintses, Bálint and Számel, Mónika and Jangir, Pramod Kumar and Csörgő, Bálint and Györkei, Ádám and Bódi, Zoltán and Faragó, Anikó and Bodai, László and Földesi, Imre and Kata, Diána and Maróti, Gergely and Pap, Bernadett and Wirth, Roland and Papp, Balázs and Pál, Csaba},
	doi = {10.1038/s41467-019-12364-6},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {10},
	unique-id = {30865039},
	issn = {2041-1723},
	abstract = {Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. Here we systematically study the evolution of resistance to 14 chemically diverse AMPs and 12 antibiotics in Escherichia coli. Our work indicates that evolution of resistance against certain AMPs, such as tachyplesin II and cecropin P1, is limited. Resistance level provided by point mutations and gene amplification is very low and antibiotic-resistant bacteria display no cross-resistance to these AMPs. Moreover, genomic fragments derived from a wide range of soil bacteria confer no detectable resistance against these AMPs when introduced into native host bacteria on plasmids. We have found that simple physicochemical features dictate bacterial propensity to evolve resistance against AMPs. Our work could serve as a promising source for the development of new AMP-based therapeutics less prone to resistance, a feature necessary to avoid any possible interference with our innate immune system.},
	year = {2019},
	eissn = {2041-1723},
	orcid-numbers = {Grézal, Gábor/0000-0003-1685-4791; Méhi, Orsolya Katinka/0009-0004-7918-913X; Jangir, Pramod Kumar/0000-0001-8330-0655; Csörgő, Bálint/0000-0003-0397-6845; Bodai, László/0000-0001-8411-626X; Földesi, Imre/0000-0002-3329-8136; Kata, Diána/0000-0002-4432-9380; Maróti, Gergely/0000-0002-3705-0461; Wirth, Roland/0000-0002-2383-2323}
}

@article{MTMT:30380633,
	title = {Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging},
	url = {https://m2.mtmt.hu/api/publication/30380633},
	author = {Fási, Laura and Di Meo, Florent and Kuo, Ching-Ying and Stojkovic Buric, Sonja and Martins, Ana and Kúsz, Norbert and Béni, Zoltán and Dékány, Miklós and Balogh, György Tibor and Pesic, Milica and Wang, Hui-Chun and Trouillas, Patrick and Hunyadi, Attila},
	doi = {10.1021/acs.jmedchem.8b01994},
	journal-iso = {J MED CHEM},
	journal = {JOURNAL OF MEDICINAL CHEMISTRY},
	volume = {62},
	unique-id = {30380633},
	issn = {0022-2623},
	abstract = {Cancer cells generally possess higher levels of reactive oxygen species than normal cells, and this can serve as a possible therapeutic target. In this proof-of-concept study, an antioxidant-inspired drug discovery strategy was evaluated using a hydroxycinnamic acid derivative. The processing of oxidized mixtures of p-coumaric acid methyl ester (pcm) revealed a new antitumor lead, graviquinone. Graviquinone bypassed ABCB1-mediated resistance, induced DNA damage in lung carcinoma cells but exerted DNA protective activity in normal keratinocytes, and modulated DNA damage response in MCF-7 cells. The cytotoxic effect of pcm in MCF-7 cells was potentiated under H2O2-induced oxidative stress, and the formation of graviquinone was confirmed by Fenton's reaction on pcm. In silico density functional theory calculations suggested graviquinone as a kinetic product of pcm-scavenging (OH)-O-center dot radicals. Our results demonstrate the pharmacological value of an in situ-formed, oxidative stress-related metabolite of an antioxidant. This might be of particular importance for designing new strategies for antioxidant-based drug discovery.},
	year = {2019},
	eissn = {1520-4804},
	pages = {1657-1668},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Béni, Zoltán/0000-0002-1275-4155; Balogh, György Tibor/0000-0003-3347-1880; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:3378998,
	title = {Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides},
	url = {https://m2.mtmt.hu/api/publication/3378998},
	author = {Lázár, Viktória and Martins, Ana and Spohn, Réka and Daruka, Lejla and Grézal, Gábor and Fekete, Gergely and Számel, Mónika and Jangir, Pramod Kumar and Kintses, Bálint and Csörgő, Bálint and Nyerges, Ákos and Györkei, Ádám and Kincses, András and Dér, András and Walter, Fruzsina and Deli, Mária Anna and Zsoldiné Urbán, Edit and Hegedüs, Zsófia and Olajos, Gábor and Méhi, Orsolya Katinka and Bálint, Balázs and Nagy, István and Martinek, Tamás and Papp, Balázs and Pál, Csaba},
	doi = {10.1038/s41564-018-0164-0},
	journal-iso = {NAT MICROBIOL},
	journal = {NATURE MICROBIOLOGY},
	volume = {3},
	unique-id = {3378998},
	issn = {2058-5276},
	abstract = {Antimicrobial peptides are promising alternative antimicrobial agents. However, little is known about whether resistance to small-molecule antibiotics leads to cross-resistance (decreased sensitivity) or collateral sensitivity (increased sensitivity) to antimicrobial peptides. We systematically addressed this question by studying the susceptibilities of a comprehensive set of 60 antibiotic-resistant Escherichia coli strains towards 24 antimicrobial peptides. Strikingly, antibiotic-resistant bacteria show a high frequency of collateral sensitivity to antimicrobial peptides, whereas cross-resistance is relatively rare. We identify clinically relevant multidrug-resistance mutations that increase bacterial sensitivity to antimicrobial peptides. Collateral sensitivity in multidrug-resistant bacteria arises partly through regulatory changes shaping the lipopolysaccharide composition of the bacterial outer membrane. These advances allow the identification of antimicrobial peptide-antibiotic combinations that enhance antibiotic activity against multidrug-resistant bacteria and slow down de novo evolution of resistance. In particular, when co-administered as an adjuvant, the antimicrobial peptide glycine-leucine-amide caused up to 30-fold decrease in the antibiotic resistance level of resistant bacteria. Our work provides guidelines for the development of efficient peptide-based therapies of antibiotic-resistant infections.},
	year = {2018},
	eissn = {2058-5276},
	pages = {718-731},
	orcid-numbers = {Grézal, Gábor/0000-0003-1685-4791; Jangir, Pramod Kumar/0000-0001-8330-0655; Csörgő, Bálint/0000-0003-0397-6845; Nyerges, Ákos/0000-0002-1581-490X; Walter, Fruzsina/0000-0001-8145-2823; Deli, Mária Anna/0000-0001-6084-6524; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Hegedüs, Zsófia/0000-0002-5546-8167; Olajos, Gábor/0000-0002-2479-4891; Méhi, Orsolya Katinka/0009-0004-7918-913X; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:3370143,
	title = {Discovery of Novel Enhancers of Isoniazid Toxicity in Mycobacterium tuberculosis},
	url = {https://m2.mtmt.hu/api/publication/3370143},
	author = {Lentz, F and Reiling, N and Martins, Ana and Molnár, József and Hilgeroth, A},
	doi = {10.3390/molecules23040825},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {23},
	unique-id = {3370143},
	issn = {1420-3049},
	abstract = {The number of effective first-line antibiotics for the treatment of Mycobacterium tuberculosis infection is strongly limited to a few drugs. Due to emerging resistance against those drugs, second- and third-line antibiotics have been established in therapy with certain problems and also increasing mycobacterial resistance. An alternative to such novel drugs or combined therapeutic regimes which may reduce resistance development is finding enhancers of mycobacterial drug effectiveness, especially enhancers that counteract causative resistance mechanisms. Such enhancers may reduce the extracellular drug efflux mediated by bacterial efflux pumps and thus enhance the intracellular drug toxicity. We developed novel 1,4-dihydropyridines (DHPs) as potential efflux pump inhibitors with some determined P-gp affinities. The influence on the antituberculotic drug toxicity has been investigated for three prominent antituberculotic drugs. Exclusive and selective toxicity enhancing effects have been detected for isoniazid (INH) which could be related to certain substituent effects of the 1,4-DHPs. So, structure-dependent activities have been found. Thus, promising enhancers could be identified and a suggested efflux pump inhibition is discussed.},
	year = {2018},
	eissn = {1420-3049}
}

@article{MTMT:3302693,
	title = {Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam},
	url = {https://m2.mtmt.hu/api/publication/3302693},
	author = {Vágvölgyi, Máté and Martins, Ana and Kulmány, Ágnes Erika and Zupkó, István and Gáti, Tamás and Simon, András and Tóth, Gábor and Hunyadi, Attila},
	doi = {10.1016/j.ejmech.2017.12.032},
	journal-iso = {EUR J MED CHEM},
	journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},
	volume = {144},
	unique-id = {3302693},
	issn = {0223-5234},
	year = {2018},
	eissn = {1768-3254},
	pages = {730-739},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Kulmány, Ágnes Erika/0000-0003-3243-5300; Zupkó, István/0000-0003-3243-5300; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:3287862,
	title = {Preparation and chemo-sensitizing activity of nitrogen-containing ecdysteroid derivatives: 6-oximes, oxime ethers, and a lactam},
	url = {https://m2.mtmt.hu/api/publication/3287862},
	author = {Vágvölgyi, Máté and Martins, Ana and Kulmány, Ágnes Erika and Zupkó, István and Tóth, Gábor and Hunyadi, Attila},
	doi = {10.1055/s-0037-1608147},
	journal-iso = {PLANTA MEDICA INT OPEN},
	journal = {PLANTA MEDICA INTERNATIONAL OPEN},
	volume = {4},
	unique-id = {3287862},
	year = {2017},
	eissn = {2509-6656},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Kulmány, Ágnes Erika/0000-0003-3243-5300; Zupkó, István/0000-0003-3243-5300; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:3253009,
	title = {New cyclic 2,3-sulfite ester derivatives of poststerone – Discriminating diastereomers and probing spatial proximities by NMR and DFT calculations},
	url = {https://m2.mtmt.hu/api/publication/3253009},
	author = {Balázs, Attila and Hunyadi, Attila and Csábi, József and Tillekeratne, LMV and Martins, Ana and Tóth, Gábor},
	doi = {10.1002/mrc.4641},
	journal-iso = {MAGN RESON CHEM},
	journal = {MAGNETIC RESONANCE IN CHEMISTRY},
	volume = {55},
	unique-id = {3253009},
	issn = {0749-1581},
	year = {2017},
	eissn = {1097-458X},
	pages = {1102-1107},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472}
}