@article{MTMT:34687262,
	title = {Preparation, characterization and in vitro evaluation of the antimicrobial and antitumor activity of MnOx nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/34687262},
	author = {Rónavári, Andrea and Ochirkhuyag, Altantuya and Igaz, Nóra and Szerencsés, Bettina and Ballai, Gergő and Huliák, Ildikó and Bocz, Csenge and Kovács, Ákos and Pfeiffer, Ilona and Csontné Kiricsi, Mónika and Kónya, Zoltán},
	doi = {10.1016/j.colsurfa.2024.133528},
	journal-iso = {COLLOID SURFACE A},
	journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS},
	volume = {688},
	unique-id = {34687262},
	issn = {0927-7757},
	year = {2024},
	eissn = {1873-4359},
	orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Ochirkhuyag, Altantuya/0000-0001-6495-7360; Igaz, Nóra/0000-0003-1580-4397; Pfeiffer, Ilona/0000-0003-0680-7596; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Kónya, Zoltán/0000-0002-9406-8596}
}

@misc{MTMT:34205216,
	title = {A Magyar Tudományos Akadémia Analítikai és Környezetkémiai Bizottságának 11. Környezetkémiai Szimpóziuma. (2023)},
	url = {https://m2.mtmt.hu/api/publication/34205216},
	isbn = {9789633069547},
	editor = {Kónya, Zoltán and Csontné Kiricsi, Mónika},
	unique-id = {34205216},
	year = {2023},
	orcid-numbers = {Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@CONFERENCE{MTMT:34154600,
	title = {The possible modulatory effects of metal nanoparticles on macrophage polarization in co-culture},
	url = {https://m2.mtmt.hu/api/publication/34154600},
	author = {Adamecz, Dóra Izabella and Petra, Bicskei and Árva, Hédi and Igaz, Nóra and Veres, Éva and Rónavári, Andrea and Gácser, Attila and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	booktitle = {Abstracts for the 47th FEBS Congress},
	unique-id = {34154600},
	year = {2023},
	orcid-numbers = {Adamecz, Dóra Izabella/0000-0002-1883-9600; Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@CONFERENCE{MTMT:34154565,
	title = {Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors},
	url = {https://m2.mtmt.hu/api/publication/34154565},
	author = {Igaz, Nóra and Szőke, Krisztina and Bocz, Csenge and Kovács, Dávid and Rónavári, Andrea and Szabó, Emilia Rita and Polanek, Róbert and Buhala, Andrea and Vizler, Csaba and Tiszlavicz, László and Rázga, Zsolt and Hideghéty, Katalin and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	booktitle = {FAMÉ 2023},
	unique-id = {34154565},
	year = {2023},
	pages = {75-76},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hideghéty, Katalin/0000-0001-7080-2365; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:34147665,
	title = {Medicinal Chemistry‐driven Approach to Novel 2‐Substituted Benzoxazole – Estradiol Chimeras: Synthesis, Anticancer Activity and Early ADME Profile},
	url = {https://m2.mtmt.hu/api/publication/34147665},
	author = {Kovács, Ferenc and Huliák, Ildikó and Árva, Hédi and Csontné Kiricsi, Mónika and Erdős, Dóra and Kocsis, Marianna and Takács, Gergely and Balogh, György Tibor and Nagyné Frank, Éva},
	doi = {10.1002/cmdc.202300352},
	journal-iso = {CHEMMEDCHEM},
	journal = {CHEMMEDCHEM},
	volume = {18},
	unique-id = {34147665},
	issn = {1860-7179},
	abstract = {The efficient synthesis of novel estradiol‐based A‐ring‐fused oxazole derivatives, which can be considered as benzoxazole‐steroid domain‐integrated hybrids containing a common benzene structural motif, is described. The target compounds were prepared from steroidal 2‐aminophenol precursors by heterocycle formation or functional group interconversion (FGI) strategies. According to 2D projection‐based t‐distributed stochastic neighbor embedding (t‐SNE), the novel molecules were proved to represent a new chemical space among steroid drugs. They were characterized based on critical physicochemical parameters using in silico and experimental data. The performance of the compounds to inhibit cell proliferation was tested on four human cancer cell lines and non‐cancerous cells. Further examinations were performed to reveal IC50 and lipophilic ligand efficiency (LLE) values, cancer cell selectivity, and apoptosis‐triggering features. Pharmacological tests and LLE metric revealed that some derivatives, especially the 2‐(4‐ethylpiperazin‐1‐yl)oxazole derivative exhibit strong anticancer activity and trigger the apoptosis of cancer cells with relatively low promiscuity risk similarly to the structurally most closely‐related and intensively studied anticancer agent, 2‐methoxy‐estradiol.},
	year = {2023},
	eissn = {1860-7187},
	orcid-numbers = {Csontné Kiricsi, Mónika/0000-0002-8416-2052; Balogh, György Tibor/0000-0003-3347-1880; Nagyné Frank, Éva/0000-0002-1332-0551}
}

@article{MTMT:34070423,
	title = {P-01.1-10 Semi-synthetic dihydrotestosterone derivatives modulate inherent multidrug resistance and sensitize colon cancer cells to chemotherapy},
	url = {https://m2.mtmt.hu/api/publication/34070423},
	author = {Nagy, Ferenc István and Gopisetty, Mohana Krishna and Huliák, Ildikó and Nagyné Frank, Éva and Csontné Kiricsi, Mónika},
	doi = {10.1002/2211-5463.13646},
	journal-iso = {FEBS OPEN BIO},
	journal = {FEBS OPEN BIO},
	volume = {13},
	unique-id = {34070423},
	issn = {2211-5463},
	year = {2023},
	eissn = {2211-5463},
	pages = {66-66},
	orcid-numbers = {Gopisetty, Mohana Krishna/0000-0002-4310-3478; Nagyné Frank, Éva/0000-0002-1332-0551; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:34067381,
	title = {Phase-separated ribosome-nascent chain complexes in genotoxic stress response},
	url = {https://m2.mtmt.hu/api/publication/34067381},
	author = {Szatmári, Orsolya and Nagy-Mikó, Bence and Györkei, Ádám and Varga, Dániel and H. Kovács, Bálint Barna and Igaz, Nóra and Bognár, Bence and Rázga, Zsolt and Nagy, Gábor and Zsindely, Nóra and Bodai, László and Papp, Balázs and Erdélyi, Miklós and Csontné Kiricsi, Mónika and Blastyák, András and Collart, Martine A and Boros, Imre Miklós and Villanyi, Zoltan},
	doi = {10.1261/rna.079755.123},
	journal-iso = {RNA},
	journal = {RNA-A PUBLICATION OF THE RNA SOCIETY},
	volume = {29},
	unique-id = {34067381},
	issn = {1355-8382},
	abstract = {Assemblysomes are EDTA- and RNase-resistant ribonucleoprotein (RNP) complexes of paused ribosomes with protruding nascent polypeptide chains. They have been described in yeast and human cells for the proteasome subunit Rpt1, and the disordered N-terminal part of the nascent chain was found to be indispensable for the accumulation of the Rpt1-RNP into assemblysomes. Motivated by this, to find other assemblysome-associated RNPs we used bioinformatics to rank subunits of Saccharomyces cerevisiae protein complexes according to their N-terminal disorder propensity. The results revealed that gene products involved in DNA repair are enriched among the top candidates. The Sgs1 DNA helicase was chosen for experimental validation. We found that indeed nascent chains of Sgs1 form EDTA-resistant RNP condensates, assemblysomes by definition. Moreover, upon exposure to UV, SGS1 mRNA shifted from assemblysomes to polysomes, suggesting that external stimuli are regulators of assemblysome dynamics. We extended our studies to human cell lines. The BLM helicase, ortholog of yeast Sgs1, was identified upon sequencing assemblysome-associated RNAs from the MCF7 human breast cancer cell line, and mRNAs encoding DNA repair proteins were overall enriched. Using the radiation-resistant A549 cell line, we observed by transmission electron microscopy that 1,6-hexanediol, an agent known to disrupt phase-separated condensates, depletes ring ribosome structures compatible with assemblysomes from the cytoplasm of cells and makes the cells more sensitive to X-ray treatment. Taken together these findings suggest that assemblysomes may be a component of the DNA damage response from yeast to human.},
	year = {2023},
	eissn = {1469-9001},
	pages = {1557-1574},
	orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Igaz, Nóra/0000-0003-1580-4397; Rázga, Zsolt/0000-0003-4717-8482; Nagy, Gábor/0000-0001-5464-1135; Zsindely, Nóra/0000-0002-6189-3100; Bodai, László/0000-0001-8411-626X; Erdélyi, Miklós/0000-0002-9501-5752; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Boros, Imre Miklós/0000-0001-8504-9687}
}

@article{MTMT:33634274,
	title = {Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy},
	url = {https://m2.mtmt.hu/api/publication/33634274},
	author = {Nagy, Ferenc István and Adamecz, Dóra Izabella and Baji, Ádám and Kiricsi, Ágnes and Huliák, Ildikó and Rónavári, Andrea and Kónya, Zoltán and Nagyné Frank, Éva and Gopisetty, Mohana Krishna and Csontné Kiricsi, Mónika},
	doi = {10.3390/pharmaceutics15020584},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33634274},
	issn = {1999-4923},
	abstract = {Multidrug resistance (MDR) is a serious hurdle to successful cancer therapy. Here, we examined the efficiency of novel semi-synthetic dihydrotestosterone derivatives, more specifically androstano-arylpyrimidines in inhibiting the efflux activity of ATP-binding cassette (ABC) transporters and sensitizing inherently MDR colon cancer cells to various chemotherapy drugs. Using the Rhodamine123 accumulation assay, we evaluated the efflux activity of cancer cells following treatments with androstano-arylpyrimidines. We found that acetylated compounds were capable of attenuating the membrane efflux of inherently MDR cells; however, deacetylated counterparts were ineffective. To delineate the possible molecular mechanisms underlying these unique activities of androstano-arylpyrimidines, the degree of apoptosis induction was assessed by AnnexinV-based assays, both upon the individual as well as by steroid and chemotherapy agent combination treatments. Five dihydrotestosterone derivatives applied in combination with Doxorubicin or Epirubicin triggered massive apoptosis in MDR cells, and these combinations were more efficient than chemotherapy drugs together with Verapamil. Furthermore, our results revealed that androstano-arylpyrimidines induced significant endoplasmic reticulum stress (ER stress) but did not notably modulate ABC transporter expression. Therefore, ER stress triggered by acetylated androstano-arylpyrimidines is probably involved in the mechanism of efflux pump inhibition and drug sensitization which can be targeted in future drug developments to defeat inherently multidrug-resistant cancer.},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Adamecz, Dóra Izabella/0000-0002-1883-9600; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Nagyné Frank, Éva/0000-0002-1332-0551; Gopisetty, Mohana Krishna/0000-0002-4310-3478; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:33632436,
	title = {Multi-round recycling of green waste for the production of iron nanoparticles: synthesis, characterization, and prospects in remediation},
	url = {https://m2.mtmt.hu/api/publication/33632436},
	author = {Rónavári, Andrea and Balázs, Margit and Szilágyi, Árpád and Molnár, Csaba and Kotormán, Márta and Ilisz, István and Csontné Kiricsi, Mónika and Kónya, Zoltán},
	doi = {10.1186/s11671-023-03784-x},
	journal-iso = {DISCOVER NANO},
	journal = {DISCOVER NANO},
	volume = {18},
	unique-id = {33632436},
	abstract = {Due to the widespread applications of metal nanoparticles (NPs), green synthesis strategies have recently advanced, e.g., methods that utilize extracts made from different plant wastes. A particularly innovative approach to reducing large amounts of available household/agricultural green wastes is their application in nanoparticle generation. Regarding this, the aim of our work was to examine the possibility of upgrading green nanoparticle syntheses from an innovative economic and environmental point of view, namely by investigating the multiple recyclabilities of green tea (GT), coffee arabica (CA), and Virginia creeper ( Parthenocissus quinquefolia ) (VC) waste residues for iron nanoparticle (FeNPs) synthesis. The plant extracts obtained by each extraction round were analyzed individually to determine the amount of main components anticipated to be involved in NPs synthesis. The synthesized FeNPs were characterized by X-ray powder diffraction and transmission electron microscopy. The activity of the generated FeNPs in degrading chlorinated volatile organic compounds (VOC) and thus their future applicability for remediation purposes were also assessed. We have found that VC and especially GT residues could be reutilized in multiple extraction rounds; however, only the first extract of CA was suitable for FeNPs’ generation. All of the obtained FeNPs could degrade VOC with efficiencies GT1-Fe 91.0%, GT2-Fe 83.2%, GT3-Fe 68.5%; CA1-Fe 76.2%; VC1-Fe 88.2%, VC2-Fe 79.7%, respectively, where the number (as in GT3) marked the extraction round. These results indicate that the adequately selected green waste material can be reutilized in multiple rounds for nanoparticle synthesis, thus offering a clean, sustainable, straightforward alternative to chemical methods.},
	year = {2023},
	eissn = {2731-9229},
	orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Szilágyi, Árpád/0000-0002-3276-1934; Molnár, Csaba/0000-0002-6124-1209; Ilisz, István/0000-0001-8282-457X; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Kónya, Zoltán/0000-0002-9406-8596}
}

@article{MTMT:33416616,
	title = {Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities},
	url = {https://m2.mtmt.hu/api/publication/33416616},
	author = {Petrasheuskaya, Tatsiana and Kovács, Ferenc and Igaz, Nóra and Rónavári, Andrea and Hajdu, Bálint and Nagyné Bereczki, Laura and May, Nóra Veronika and Spengler, Gabriella and Gyurcsik, Béla and Csontné Kiricsi, Mónika and Nagyné Frank, Éva and Enyedy, Éva Anna},
	doi = {10.3390/molecules28010054},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {33416616},
	issn = {1420-3049},
	abstract = {A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Gyurcsik, Béla/0000-0003-1894-7414; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128}
}