TY - JOUR AU - Tóth, Barbara AU - Horváth, Attila AU - Jójártné Laczkovich, Orsolya AU - Biró, Dalma AU - Matuz, Mária AU - Csupor, Dezső TI - Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED PY - 2024 SN - 0032-0943 DO - 10.1055/a-2283-8147 UR - https://m2.mtmt.hu/api/publication/34728728 ID - 34728728 N1 - Funding Agency and Grant Number: Ministry of Innovation and Technology of Hungary [TKP2021-EGA, TKP2021-EGA-32]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund Funding text: This work was supported by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme; project No. TKP2021-EGA-32 has been implemented with the support provided. AB - Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy. LA - English DB - MTMT ER - TY - CHAP AU - Szalai, Boglárka AU - Jójártné Laczkovich, Orsolya AU - Budai-Szűcs, Mária ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Evaluation of combined thermoresponsive ophthalmic gels T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 22 EP - 22 PG - 1 UR - https://m2.mtmt.hu/api/publication/34561726 ID - 34561726 LA - English DB - MTMT ER - TY - JOUR AU - Saker, Ranim AU - Jójártné Laczkovich, Orsolya AU - Regdon, Géza (ifj.) AU - Takács, Tamás AU - Szenti, Imre AU - Bózsity-Faragó, Noémi AU - Zupkó, István AU - Sovány, Tamás TI - Surface Modification of Titanate Nanotubes with a Carboxylic Arm for Further Functionalization Intended to Pharmaceutical Applications JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 12 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics15122780 UR - https://m2.mtmt.hu/api/publication/34443794 ID - 34443794 AB - Nanotechnology is playing a significant role in modern life with tremendous potential and promising results in almost every domain, especially the pharmaceutical one. The impressive performance of nanomaterials is shaping the future of science and revolutionizing the traditional concepts of industry and research. Titanate nanotubes (TNTs) are one of these novel entities that became an appropriate choice to apply in several platforms due to their remarkable properties such as preparation simplicity, high stability, good biocompatibility, affordability and low toxicity. Surface modification of these nanotubes is also promoting their superior characters and contributing more to the enhancement of their performance. In this research work, an attempt was made to functionalize the surface of titanate nanotubes with carboxylic groups to increase their surface reactivity and widen the possibility of bonding different molecules that could not be bonded directly. Three carboxylic acids were investigated (trichloroacetic acid, citric acid and acrylic acid), and the prepared composites were examined using FT-IR and Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS). The toxicity of these functionalized TNTs was also investigated using adherent cancer cell lines and fibroblasts to determine their safety profile and to draw the basic lines for their intended future application. Based on the experimental results, acrylic acid could be the suitable choice for permanent surface modification with multiple carboxylic groups due to its possibility to be polymerized, thus presenting the opportunity to link additional molecules of interest such as polyethylene glycol (PEG) and/or other molecules at the same time. LA - English DB - MTMT ER - TY - JOUR AU - Szalai, Boglárka AU - Jójártné Laczkovich, Orsolya AU - Budai-Szűcs, Mária TI - In situ gelling mucoadhesive eye drops: evaluation of physicochemical properties, in vitro dissolution and transcorneal permeability JF - MACEDONIAN PHARMACEUTICAL BULLETIN J2 - MACED PHARMA BULL VL - 69 PY - 2023 IS - 03 SP - 47 EP - 48 PG - 2 SN - 1409-8695 DO - 10.33320/maced.pharm.bull.2023.69.03.023 UR - https://m2.mtmt.hu/api/publication/34128937 ID - 34128937 LA - English DB - MTMT ER - TY - CHAP AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Jójártné Laczkovich, Orsolya AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Formulation of buccal films in Parkinson’s disease T2 - V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2023 SP - 34 EP - 34 PG - 1 DO - 10.14232/syrptbrs.2023.34 UR - https://m2.mtmt.hu/api/publication/34046049 ID - 34046049 LA - English DB - MTMT ER - TY - CHAP AU - Kanti, S P Yamini AU - Jójártné Laczkovich, Orsolya AU - Pannonhalminé Csóka, Ildikó ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Antimicrobial film-coated catheters for intravesical drug delivery: factors affecting and future opportunities applying the quality by design concepts T2 - V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2023 SP - 35 EP - 35 PG - 1 DO - 10.14232/syrptbrs.2023.35 UR - https://m2.mtmt.hu/api/publication/34012928 ID - 34012928 LA - English DB - MTMT ER - TY - JOUR AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Jójártné Laczkovich, Orsolya AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin TI - Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 187 PY - 2023 PG - 12 SN - 0928-0987 DO - 10.1016/j.ejps.2023.106491 UR - https://m2.mtmt.hu/api/publication/34008857 ID - 34008857 N1 - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720, Szeged, Hungary Department of Pharmaceutical Technology, University of Debrecen, Nagyerdei krt. 98., H-4032, Debrecen, Hungary Export Date: 1 August 2023 CODEN: EPSCE Correspondence Address: Regdon, G.; Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u. 6., H-6720, Hungary; email: geza.regdon@pharm.u-szeged.hu Chemicals/CAS: pramipexole, 104632-26-0, 104632-25-9, 191217-81-9; Drug Carriers; Pramipexole Funding details: 5991 Funding details: Richter Gedeon Talentum Alapítvány, 100822 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, ÚNKP-21-3 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The publication was funded by The University of Szeged Open Access Fund (FundRef, Grant No. 5991). This research work was supported by Richter Gedeon Talentum Foundation to help me participate in the PhD program (Grant No. 100822 ). This work was also supported by the New National Excellence Program of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Fund (Grant No. ÚNKP-21-3 ). LA - English DB - MTMT ER - TY - CHAP AU - Szalai, Boglárka AU - Jójártné Laczkovich, Orsolya AU - Budai-Szűcs, Mária ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Design and optimization of in situ > gelling mucoadhesive eye drops containing dexamethasone T2 - V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2023 SP - 26 EP - 26 PG - 1 DO - 10.14232/syrptbrs.2023.26 UR - https://m2.mtmt.hu/api/publication/33634469 ID - 33634469 LA - English DB - MTMT ER - TY - CONF AU - Szalai, Boglárka AU - Budai-Szűcs, Mária AU - Jójártné Laczkovich, Orsolya TI - Design and optimization of in situ gelling eye drops containing dexamethasone-cyclodextrin complex T2 - Figon & EUFEPS European Medicines Day PY - 2022 SP - 63 EP - 64 PG - 2 UR - https://m2.mtmt.hu/api/publication/33604632 ID - 33604632 LA - English DB - MTMT ER - TY - CONF AU - Szalai, Boglárka AU - Budai-Szűcs, Mária AU - Jójártné Laczkovich, Orsolya TI - In situ gélesedő, mukoadhezív szemcseppek vizsgálata és optimalizálása T2 - Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2022: A Magyar Gyógyszerésztudományi Társaság Gyógyszeripari Szervezetének és Gyógyszertechnológiai Szakosztályának Konferenciája PY - 2022 SP - 64 UR - https://m2.mtmt.hu/api/publication/33604409 ID - 33604409 LA - Hungarian DB - MTMT ER -