@article{MTMT:34728728, title = {Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials}, url = {https://m2.mtmt.hu/api/publication/34728728}, author = {Tóth, Barbara and Horváth, Attila and Jójártné Laczkovich, Orsolya and Biró, Dalma and Matuz, Mária and Csupor, Dezső}, doi = {10.1055/a-2283-8147}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, unique-id = {34728728}, issn = {0032-0943}, abstract = {Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.}, year = {2024}, eissn = {1439-0221}, orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333} } @{MTMT:34561726, title = {Evaluation of combined thermoresponsive ophthalmic gels}, url = {https://m2.mtmt.hu/api/publication/34561726}, author = {Szalai, Boglárka and Jójártné Laczkovich, Orsolya and Budai-Szűcs, Mária}, booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, unique-id = {34561726}, year = {2024}, pages = {22-22}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} } @article{MTMT:34443794, title = {Surface Modification of Titanate Nanotubes with a Carboxylic Arm for Further Functionalization Intended to Pharmaceutical Applications}, url = {https://m2.mtmt.hu/api/publication/34443794}, author = {Saker, Ranim and Jójártné Laczkovich, Orsolya and Regdon, Géza (ifj.) and Takács, Tamás and Szenti, Imre and Bózsity-Faragó, Noémi and Zupkó, István and Sovány, Tamás}, doi = {10.3390/pharmaceutics15122780}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {15}, unique-id = {34443794}, issn = {1999-4923}, abstract = {Nanotechnology is playing a significant role in modern life with tremendous potential and promising results in almost every domain, especially the pharmaceutical one. The impressive performance of nanomaterials is shaping the future of science and revolutionizing the traditional concepts of industry and research. Titanate nanotubes (TNTs) are one of these novel entities that became an appropriate choice to apply in several platforms due to their remarkable properties such as preparation simplicity, high stability, good biocompatibility, affordability and low toxicity. Surface modification of these nanotubes is also promoting their superior characters and contributing more to the enhancement of their performance. In this research work, an attempt was made to functionalize the surface of titanate nanotubes with carboxylic groups to increase their surface reactivity and widen the possibility of bonding different molecules that could not be bonded directly. Three carboxylic acids were investigated (trichloroacetic acid, citric acid and acrylic acid), and the prepared composites were examined using FT-IR and Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS). The toxicity of these functionalized TNTs was also investigated using adherent cancer cell lines and fibroblasts to determine their safety profile and to draw the basic lines for their intended future application. Based on the experimental results, acrylic acid could be the suitable choice for permanent surface modification with multiple carboxylic groups due to its possibility to be polymerized, thus presenting the opportunity to link additional molecules of interest such as polyethylene glycol (PEG) and/or other molecules at the same time.}, year = {2023}, eissn = {1999-4923}, orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Zupkó, István/0000-0003-3243-5300; Sovány, Tamás/0000-0003-3392-7788} } @article{MTMT:34128937, title = {In situ gelling mucoadhesive eye drops: evaluation of physicochemical properties, in vitro dissolution and transcorneal permeability}, url = {https://m2.mtmt.hu/api/publication/34128937}, author = {Szalai, Boglárka and Jójártné Laczkovich, Orsolya and Budai-Szűcs, Mária}, doi = {10.33320/maced.pharm.bull.2023.69.03.023}, journal-iso = {MACED PHARMA BULL}, journal = {MACEDONIAN PHARMACEUTICAL BULLETIN}, volume = {69}, unique-id = {34128937}, issn = {1409-8695}, year = {2023}, eissn = {1857-8969}, pages = {47-48}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} } @{MTMT:34046049, title = {Formulation of buccal films in Parkinson’s disease}, url = {https://m2.mtmt.hu/api/publication/34046049}, author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Jójártné Laczkovich, Orsolya and Nemes, Dániel and Bácskay, Ildikó and Kristó, Katalin}, booktitle = {V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2023.34}, unique-id = {34046049}, year = {2023}, pages = {34-34}, orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540; Bácskay, Ildikó/0000-0001-8663-2890} } @{MTMT:34012928, title = {Antimicrobial film-coated catheters for intravesical drug delivery: factors affecting and future opportunities applying the quality by design concepts}, url = {https://m2.mtmt.hu/api/publication/34012928}, author = {Kanti, S P Yamini and Jójártné Laczkovich, Orsolya and Pannonhalminé Csóka, Ildikó}, booktitle = {V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2023.35}, unique-id = {34012928}, year = {2023}, pages = {35-35}, orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:34008857, title = {Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease}, url = {https://m2.mtmt.hu/api/publication/34008857}, author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Jójártné Laczkovich, Orsolya and Nemes, Dániel and Bácskay, Ildikó and Kristó, Katalin}, doi = {10.1016/j.ejps.2023.106491}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {187}, unique-id = {34008857}, issn = {0928-0987}, year = {2023}, eissn = {1879-0720}, orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540} } @{MTMT:33634469, title = {Design and optimization of in situ > gelling mucoadhesive eye drops containing dexamethasone}, url = {https://m2.mtmt.hu/api/publication/33634469}, author = {Szalai, Boglárka and Jójártné Laczkovich, Orsolya and Budai-Szűcs, Mária}, booktitle = {V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2023.26}, unique-id = {33634469}, year = {2023}, pages = {26-26}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} } @CONFERENCE{MTMT:33604632, title = {Design and optimization of in situ gelling eye drops containing dexamethasone-cyclodextrin complex}, url = {https://m2.mtmt.hu/api/publication/33604632}, author = {Szalai, Boglárka and Budai-Szűcs, Mária and Jójártné Laczkovich, Orsolya}, booktitle = {Figon & EUFEPS European Medicines Day}, unique-id = {33604632}, year = {2022}, pages = {63-64}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} } @CONFERENCE{MTMT:33604409, title = {In situ gélesedő, mukoadhezív szemcseppek vizsgálata és optimalizálása}, url = {https://m2.mtmt.hu/api/publication/33604409}, author = {Szalai, Boglárka and Budai-Szűcs, Mária and Jójártné Laczkovich, Orsolya}, booktitle = {Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2022: A Magyar Gyógyszerésztudományi Társaság Gyógyszeripari Szervezetének és Gyógyszertechnológiai Szakosztályának Konferenciája}, unique-id = {33604409}, year = {2022}, pages = {64}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702} }