TY - JOUR AU - Bérczi, Bálint AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Tóth, Barbara AU - Csupor, Dezső AU - Németh, Balázs AU - Lukács, Anita AU - Czumbel, László Márk AU - Kerémi, Beáta AU - Kiss, István AU - Szabó, Andrea AU - Varga, Gábor AU - Gerber, Gábor AU - Gyöngyi, Zoltán TI - Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 13 PY - 2024 IS - 6 PG - 20 SN - 2077-0383 DO - 10.3390/jcm13061818 UR - https://m2.mtmt.hu/api/publication/34760472 ID - 34760472 N1 - Journal Article; Review AB - Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia. LA - English DB - MTMT ER - TY - JOUR AU - Jávor, Péter János AU - Hanák, Lilla AU - Hegyi, Péter AU - Csonka, Endre AU - Butt, Edina AU - Horváth, Tamara AU - Góg, István AU - Lukács, Anita AU - Soós, Alexandra AU - Rumbus, Zoltán AU - Pákai, Eszter AU - Toldi, János AU - Hartmann, Petra TI - Predictive value of tachycardia for mortality in trauma-related haemorrhagic shock: a systematic review and meta-regression JF - BMJ OPEN J2 - BMJ OPEN VL - 12 PY - 2022 IS - 10 PG - 8 SN - 2044-6055 DO - 10.1136/bmjopen-2021-059271 UR - https://m2.mtmt.hu/api/publication/33192543 ID - 33192543 AB - Objectives Heart rate (HR) is one of the physiological variables in the early assessment of trauma-related haemorrhagic shock, according to Advanced Trauma Life Support (ATLS). However, its efficiency as predictor of mortality is contradicted by several studies. Furthermore, the linear association between HR and the severity of shock and blood loss presented by ATLS is doubtful. This systematic review aims to update current knowledge on the role of HR in the initial haemodynamic assessment of patients who had a trauma. Design This study is a systematic review and meta-regression that follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Data sources EMBASE, MEDLINE, CENTRAL and Web of Science databases were systematically searched through on 1 September 2020. Eligibility criteria Papers providing early HR and mortality data on bleeding patients who had a trauma were included. Patient cohorts were considered haemorrhagic if the inclusion criteria of the studies contained transfusion and/or positive focused assessment with sonography for trauma and/or postinjury haemodynamical instability and/or abdominal gunshot injury. Studies on burns, traumatic spinal or brain injuries were excluded. Papers published before January 2010 were not considered. Data extraction and synthesis Data extraction and risk of bias were assessed by two independent investigators. The association between HR and mortality of patients who had a trauma was assessed using meta-regression analysis. As subgroup analysis, meta-regression was performed on patients who received blood products. Results From a total of 2017 papers, 19 studies met our eligibility criteria. Our primary meta-regression did not find a significant relation (p=0.847) between HR and mortality in patients who had a trauma with haemorrhage. Our subgroup analysis included 10 studies, and it could not reveal a linear association between HR and mortality rate. Conclusions In accordance with the literature demonstrating the multiphasic response of HR to bleeding, our study presents the lack of linear association between postinjury HR and mortality. Modifying the pattern of HR derangements in the ATLS shock classification may result in a more precise teaching tool for young clinicians. LA - English DB - MTMT ER - TY - JOUR AU - Eitmann, Szimonetta AU - Mátrai, Péter AU - Németh, Dávid AU - Hegyi, Péter AU - Lukács, Anita AU - Bérczi, Bálint AU - Czumbel, László Márk AU - Kiss, István AU - Gyöngyi, Zoltán AU - Varga, Gábor AU - Balaskó, Márta AU - Pétervári, Erika TI - Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis JF - PAEDIATRIC AND PERINATAL EPIDEMIOLOGY J2 - PAEDIATR PERINAT EP VL - 36 PY - 2022 IS - 2 SP - 276 EP - 287 PG - 12 SN - 0269-5022 DO - 10.1111/ppe.12859 UR - https://m2.mtmt.hu/api/publication/32604750 ID - 32604750 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary Cited By :8 Export Date: 10 October 2023 CODEN: PPEPE Correspondence Address: Pétervári, E.; Institute for Translational Medicine, Hungary; email: erika.petervari@aok.pte.hu AB - Maternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.This systematic review and meta-analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.PubMed, EMBASE, Clinicaltrials.gov, CENTRAL.Human studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.Random-effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.After selection, 17 observational studies (140,517 mother-offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m2 , 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m2 , 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m2 gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m2 , 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m2 , 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).Independent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension. LA - English DB - MTMT ER - TY - JOUR AU - Lukács, Anita AU - Szabó, Andrea AU - Horváth, Edina AU - Máté, Zsuzsanna AU - Erdős, Csaba AU - Molnár, Regina AU - Paulik, Edit TI - Students in danger: Binge drinking behaviour and associated factors in Hungary JF - ZDRAVSTVENO VARSTVO J2 - ZDRAV VARST VL - 60 PY - 2021 IS - 4 SP - 244 EP - 252 PG - 9 SN - 0351-0026 DO - 10.2478/sjph-2021-0033 UR - https://m2.mtmt.hu/api/publication/32465041 ID - 32465041 LA - English DB - MTMT ER - TY - JOUR AU - Czumbel, László Márk AU - Farkasdi, Sándor AU - Gede, Noémi AU - Mikó, Alexandra AU - Csupor, Dezső AU - Lukács, Anita AU - Gaál, Valéria AU - Kiss, Szabolcs AU - Hegyi, Péter AU - Varga, Gábor TI - Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation : A Meta-Analysis JF - FRONTIERS IN SURGERY J2 - FRONT SURG VL - 8 PY - 2021 PG - 16 SN - 2296-875X DO - 10.3389/fsurg.2021.681028 UR - https://m2.mtmt.hu/api/publication/32155156 ID - 32155156 N1 - Department of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Ophthalmology, Medical School, University of Pécs, Pécs, Hungary Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary Cited By :11 Export Date: 19 December 2023 Correspondence Address: Varga, G.; Department of Oral Biology, Hungary; email: varga.gabor@dent.semmelweis-univ.hu AB - Introduction: The lips and the mouth play an indispensable role in vocalization, mastication and face aesthetics. Various noxious factors may alter and destruct the original structure, and appearance of the lips and the anatomical area surrounding the mouth. The application of hyaluronic acid (HA) may serve as a safe method for lip regeneration. Although a number of studies exist for HA effectiveness and safety, its beneficial effect is not well-established. Aim: The present meta-analysis and systematic review was performed to investigate the effectiveness of HA on lip augmentation. We also investigated the types and nature of adverse effects (AEs) of HA application. Methods: We reported our meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol registration: CRD42018102899. We performed the systematic literature search in CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case series and case reports were included. The untransformed proportion (random-effects, DerSimonian-Laird method) of responder rate to HA injection was calculated. For treatment related AEs descriptive statistics were used. Results: The systematic literature search yielded 32 eligible records for descriptive statistics and 10 records for quantitative synthesis. The results indicated that the overall estimate of responders (percentage of subjects with increased lip fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85-0.96) 2 months after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66-0.82) and 46% (ES = 0.46, 95% CI:0.28-0.65) after 6 and 12 months, respectively. We included 1,496 participants for estimating the event rates of AEs. The most frequent treatment-related AEs were tenderness (88.8%), injection site swelling (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), herpes labialis (0.6%) and angioedema (0.3%). Conclusion: Our meta-analysis revealed that lip augmentation with injectable HA is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. Moreover, we found that most AEs of HA treatment were mild or moderate, but a small number of serious adverse effects were also found. In conclusion, further well-designed RCTs are still needed to make the presently available evidence stronger. LA - English DB - MTMT ER - TY - JOUR AU - Takács, István AU - Urkon, Melinda AU - Kiss, Tivadar AU - Horváth, Edina AU - Laczkó-Zöld, Eszter AU - Zomborszki, Zoltán Péter AU - Lukács, Anita AU - Oszlánczi, Gábor AU - Csupor, Dezső AU - Szabó, Andrea TI - The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats JF - SCIENTIA PHARMACEUTICA J2 - SCI PHARM VL - 89 PY - 2021 IS - 3 PG - 9 SN - 0036-8709 DO - 10.3390/scipharm89030039 UR - https://m2.mtmt.hu/api/publication/32151210 ID - 32151210 LA - English DB - MTMT ER - TY - JOUR AU - Lukács, Anita AU - Máté, Zsuzsanna AU - Borbásné Farkas, Kornélia AU - Mikó, Alexandra AU - Tenk, Judit AU - Hegyi, Péter AU - Németh, Balázs AU - Czumbel, László Márk AU - Wuttapon, Sadaeng AU - Kiss, István AU - Gyöngyi, Zoltán AU - Varga, Gábor AU - Rumbus, Zoltán AU - Szabó, Andrea TI - The quadrivalent HPV vaccine is protective against genital warts: a meta-analysis JF - BMC PUBLIC HEALTH J2 - BMC PUBLIC HEALTH VL - 20 PY - 2020 IS - 1 PG - 16 SN - 1471-2458 DO - 10.1186/s12889-020-08753-y UR - https://m2.mtmt.hu/api/publication/31328720 ID - 31328720 AB - The quadrivalent human papillomavirus (HPV) vaccine has been assumed to give protection against genital warts (GW) as well as cervical cancer. Our main question was whether HPV vaccine has any effects on the prevention of GW reported in randomised controlled clinical trials (RCTs) and time-trend analyses.This meta-analysis was performed according to the PRISMA guidelines using the PICO format. We searched in three electronic databases (PubMed, Embase, Cochrane Trials), and assessed heterogeneity using the Q-test and I-squared statistics, meta-regression was also performed. Odds ratios (OR) and their confidence intervals (CI) were calculated. The sensitivity was tested by leave-one-out method. We evaluated the presence of publication bias using the funnel plot graph and the Copas selection model. The strength of evidence was assessed using the GRADE approach.Eight RCTs (per-protocol populations) and eight time-trend ecological studies were included in this meta-analysis. A significant reduction (pooled OR = 0.03, 95% CI: 0.01-0.09; I-squared = 53.6%) of GW in young women was recorded in RCTs, and in time-trend analyses both in young women (pooled OR = 0.36, CI 95% = 0.26-0.51; I-squared = 98.2%), and in young men (pooled OR = 0.69, 95% CI = 0.61-0.78; I-squared = 92.7%). In subgroup analysis, a significant reduction of the number of GW events was observed especially in women under 21 years (pooled OR = 0.33, 95% CI = 0.17-0.63). Leave-one-out analysis showed that similar results could be obtained after excluding one study, meta-regression did not show significant difference.Prophylactic, quadrivalent HPV vaccination can prevent GW in healthy women and men, therefore, it should be included in routine immunization programme. LA - English DB - MTMT ER - TY - JOUR AU - Czumbel, László Márk AU - Gaál, V AU - Lujber, L AU - Hegyi, Péter AU - Varga, Gábor AU - Farkasdi, Sándor AU - Gede, N AU - Mikó, A AU - Csupor, Dezső AU - Lukács, Anita AU - Kanaan, Reem AU - Egyed, Z AU - Sepp, Róbert TI - Efficacy of Hyaluronic Acid Dermal Fillers for Lip Augmentation: Meta-analysis JF - JOURNAL OF DENTAL RESEARCH J2 - J DENT RES VL - 98 PY - 2019 IS - B SN - 0022-0345 UR - https://m2.mtmt.hu/api/publication/31323456 ID - 31323456 LA - English DB - MTMT ER - TY - JOUR AU - Vezér, Tünde AU - Müller, Anna AU - Lukács, Anita AU - Borsányi, Fruzsina AU - D., Kis Nóra AU - Halápi, Bernadett AU - Katona, Csilla AU - Paulik, Edit TI - Influenza vakcinációs magatartás és befolyásoló tényezőinek vizsgálata a Szegedi Tudományegyetemen JF - EGÉSZSÉGTUDOMÁNY J2 - EGÉSZSÉGTUDOMÁNY VL - 63 PY - 2019 IS - 3-4 SP - 3 EP - 31 PG - 29 SN - 0013-2268 DO - 10.29179/EgTud.2019.3-4.3-31 UR - https://m2.mtmt.hu/api/publication/31289687 ID - 31289687 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lukács, Anita AU - Horváth, Edina AU - Máté, Zsuzsanna AU - Szabó, Andrea AU - Virág, Katalin AU - Papp, Magor Csongor AU - Sándor, János AU - Ádány, Róza AU - Paulik, Edit TI - Abdominal obesity increases metabolic risk factors in non-obese adults: a Hungarian cross-sectional study JF - BMC PUBLIC HEALTH J2 - BMC PUBLIC HEALTH VL - 19 PY - 2019 IS - 1 PG - 8 SN - 1471-2458 DO - 10.1186/s12889-019-7839-1 UR - https://m2.mtmt.hu/api/publication/30921933 ID - 30921933 LA - English DB - MTMT ER -