@article{MTMT:34760472, title = {Aromatase Inhibitors and Plasma Lipid Changes in Postmenopausal Women with Breast Cancer: A Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/34760472}, author = {Bérczi, Bálint and Borbásné Farkas, Kornélia and Hegyi, Péter and Tóth, Barbara and Csupor, Dezső and Németh, Balázs and Lukács, Anita and Czumbel, László Márk and Kerémi, Beáta and Kiss, István and Szabó, Andrea and Varga, Gábor and Gerber, Gábor and Gyöngyi, Zoltán}, doi = {10.3390/jcm13061818}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {13}, unique-id = {34760472}, abstract = {Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points. Results: We identified 15 studies, including 1708 patients. Studies using anastrozole (ANA), exemestane (EXE), letrozole (LET), and tamoxifen (TMX) were involved. Subgroup analyses revealed that 3- and 12-month administrations of LET and EXE lead to negative changes in lipid profiles that tend to alter the lipid profile undesirably, unlike ANA and TMX. Conclusions: Our results suggest that, despite statistically significant results, EXE and LET may not be sufficient to cause severe dyslipidemia in patients without cardiovascular comorbidities according to the AHA/ACC Guideline on the Management of Blood Cholesterol. However, the results may raise the question of monitoring the effects of AIs in patients, especially those with pre-existing cardiovascular risk factors such as dyslipidemia.}, year = {2024}, eissn = {2077-0383}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Tóth, Barbara/0000-0002-6086-8819; Csupor, Dezső/0000-0002-4088-3333; Németh, Balázs/0000-0002-4914-9872; Lukács, Anita/0000-0002-0746-8920; Czumbel, László Márk/0000-0002-5915-0383; Kerémi, Beáta/0000-0003-4000-9440; Szabó, Andrea/0000-0003-4949-9431; Varga, Gábor/0000-0002-5506-8198; Gerber, Gábor/0000-0003-0256-2608; Gyöngyi, Zoltán/0000-0001-9330-9119} } @article{MTMT:33192543, title = {Predictive value of tachycardia for mortality in trauma-related haemorrhagic shock: a systematic review and meta-regression}, url = {https://m2.mtmt.hu/api/publication/33192543}, author = {Jávor, Péter János and Hanák, Lilla and Hegyi, Péter and Csonka, Endre and Butt, Edina and Horváth, Tamara and Góg, István and Lukács, Anita and Soós, Alexandra and Rumbus, Zoltán and Pákai, Eszter and Toldi, János and Hartmann, Petra}, doi = {10.1136/bmjopen-2021-059271}, journal-iso = {BMJ OPEN}, journal = {BMJ OPEN}, volume = {12}, unique-id = {33192543}, issn = {2044-6055}, abstract = {Objectives Heart rate (HR) is one of the physiological variables in the early assessment of trauma-related haemorrhagic shock, according to Advanced Trauma Life Support (ATLS). However, its efficiency as predictor of mortality is contradicted by several studies. Furthermore, the linear association between HR and the severity of shock and blood loss presented by ATLS is doubtful. This systematic review aims to update current knowledge on the role of HR in the initial haemodynamic assessment of patients who had a trauma. Design This study is a systematic review and meta-regression that follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Data sources EMBASE, MEDLINE, CENTRAL and Web of Science databases were systematically searched through on 1 September 2020. Eligibility criteria Papers providing early HR and mortality data on bleeding patients who had a trauma were included. Patient cohorts were considered haemorrhagic if the inclusion criteria of the studies contained transfusion and/or positive focused assessment with sonography for trauma and/or postinjury haemodynamical instability and/or abdominal gunshot injury. Studies on burns, traumatic spinal or brain injuries were excluded. Papers published before January 2010 were not considered. Data extraction and synthesis Data extraction and risk of bias were assessed by two independent investigators. The association between HR and mortality of patients who had a trauma was assessed using meta-regression analysis. As subgroup analysis, meta-regression was performed on patients who received blood products. Results From a total of 2017 papers, 19 studies met our eligibility criteria. Our primary meta-regression did not find a significant relation (p=0.847) between HR and mortality in patients who had a trauma with haemorrhage. Our subgroup analysis included 10 studies, and it could not reveal a linear association between HR and mortality rate. Conclusions In accordance with the literature demonstrating the multiphasic response of HR to bleeding, our study presents the lack of linear association between postinjury HR and mortality. Modifying the pattern of HR derangements in the ATLS shock classification may result in a more precise teaching tool for young clinicians.}, year = {2022}, eissn = {2044-6055}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Horváth, Tamara/0000-0003-4437-9924; Lukács, Anita/0000-0002-0746-8920; Hartmann, Petra/0000-0002-4746-9792} } @article{MTMT:32604750, title = {Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/32604750}, author = {Eitmann, Szimonetta and Mátrai, Péter and Németh, Dávid and Hegyi, Péter and Lukács, Anita and Bérczi, Bálint and Czumbel, László Márk and Kiss, István and Gyöngyi, Zoltán and Varga, Gábor and Balaskó, Márta and Pétervári, Erika}, doi = {10.1111/ppe.12859}, journal-iso = {PAEDIATR PERINAT EP}, journal = {PAEDIATRIC AND PERINATAL EPIDEMIOLOGY}, volume = {36}, unique-id = {32604750}, issn = {0269-5022}, abstract = {Maternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.This systematic review and meta-analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.PubMed, EMBASE, Clinicaltrials.gov, CENTRAL.Human studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.Random-effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.After selection, 17 observational studies (140,517 mother-offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m2 , 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m2 , 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m2 gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m2 , 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m2 , 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).Independent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension.}, keywords = {Blood Pressure; HYPERTENSION; maternal obesity; developmental programming; gestational weight gain}, year = {2022}, eissn = {1365-3016}, pages = {276-287}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Lukács, Anita/0000-0002-0746-8920; Czumbel, László Márk/0000-0002-5915-0383; Gyöngyi, Zoltán/0000-0001-9330-9119; Varga, Gábor/0000-0002-5506-8198; Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:32465041, title = {Students in danger: Binge drinking behaviour and associated factors in Hungary}, url = {https://m2.mtmt.hu/api/publication/32465041}, author = {Lukács, Anita and Szabó, Andrea and Horváth, Edina and Máté, Zsuzsanna and Erdős, Csaba and Molnár, Regina and Paulik, Edit}, doi = {10.2478/sjph-2021-0033}, journal-iso = {ZDRAV VARST}, journal = {ZDRAVSTVENO VARSTVO}, volume = {60}, unique-id = {32465041}, issn = {0351-0026}, year = {2021}, eissn = {1854-2476}, pages = {244-252}, orcid-numbers = {Lukács, Anita/0000-0002-0746-8920; Máté, Zsuzsanna/0000-0003-0446-5422; Paulik, Edit/0000-0002-3446-4327} } @article{MTMT:32155156, title = {Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation : A Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/32155156}, author = {Czumbel, László Márk and Farkasdi, Sándor and Gede, Noémi and Mikó, Alexandra and Csupor, Dezső and Lukács, Anita and Gaál, Valéria and Kiss, Szabolcs and Hegyi, Péter and Varga, Gábor}, doi = {10.3389/fsurg.2021.681028}, journal-iso = {FRONT SURG}, journal = {FRONTIERS IN SURGERY}, volume = {8}, unique-id = {32155156}, abstract = {Introduction: The lips and the mouth play an indispensable role in vocalization, mastication and face aesthetics. Various noxious factors may alter and destruct the original structure, and appearance of the lips and the anatomical area surrounding the mouth. The application of hyaluronic acid (HA) may serve as a safe method for lip regeneration. Although a number of studies exist for HA effectiveness and safety, its beneficial effect is not well-established. Aim: The present meta-analysis and systematic review was performed to investigate the effectiveness of HA on lip augmentation. We also investigated the types and nature of adverse effects (AEs) of HA application. Methods: We reported our meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol registration: CRD42018102899. We performed the systematic literature search in CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case series and case reports were included. The untransformed proportion (random-effects, DerSimonian-Laird method) of responder rate to HA injection was calculated. For treatment related AEs descriptive statistics were used. Results: The systematic literature search yielded 32 eligible records for descriptive statistics and 10 records for quantitative synthesis. The results indicated that the overall estimate of responders (percentage of subjects with increased lip fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85-0.96) 2 months after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66-0.82) and 46% (ES = 0.46, 95% CI:0.28-0.65) after 6 and 12 months, respectively. We included 1,496 participants for estimating the event rates of AEs. The most frequent treatment-related AEs were tenderness (88.8%), injection site swelling (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), herpes labialis (0.6%) and angioedema (0.3%). Conclusion: Our meta-analysis revealed that lip augmentation with injectable HA is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. Moreover, we found that most AEs of HA treatment were mild or moderate, but a small number of serious adverse effects were also found. In conclusion, further well-designed RCTs are still needed to make the presently available evidence stronger.}, keywords = {Hyaluronic Acid; Adverse effects; Effectiveness; Dermal filler; lip augmentation}, year = {2021}, eissn = {2296-875X}, orcid-numbers = {Czumbel, László Márk/0000-0002-5915-0383; Farkasdi, Sándor/0000-0001-7531-8046; Csupor, Dezső/0000-0002-4088-3333; Lukács, Anita/0000-0002-0746-8920; Hegyi, Péter/0000-0003-0399-7259; Varga, Gábor/0000-0002-5506-8198} } @article{MTMT:32151210, title = {The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats}, url = {https://m2.mtmt.hu/api/publication/32151210}, author = {Takács, István and Urkon, Melinda and Kiss, Tivadar and Horváth, Edina and Laczkó-Zöld, Eszter and Zomborszki, Zoltán Péter and Lukács, Anita and Oszlánczi, Gábor and Csupor, Dezső and Szabó, Andrea}, doi = {10.3390/scipharm89030039}, journal-iso = {SCI PHARM}, journal = {SCIENTIA PHARMACEUTICA}, volume = {89}, unique-id = {32151210}, issn = {0036-8709}, year = {2021}, eissn = {2218-0532}, orcid-numbers = {Kiss, Tivadar/0000-0003-3538-377X; Zomborszki, Zoltán Péter/0000-0002-7412-9793; Lukács, Anita/0000-0002-0746-8920; Oszlánczi, Gábor/0000-0002-7849-8318; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:31328720, title = {The quadrivalent HPV vaccine is protective against genital warts: a meta-analysis}, url = {https://m2.mtmt.hu/api/publication/31328720}, author = {Lukács, Anita and Máté, Zsuzsanna and Borbásné Farkas, Kornélia and Mikó, Alexandra and Tenk, Judit and Hegyi, Péter and Németh, Balázs and Czumbel, László Márk and Wuttapon, Sadaeng and Kiss, István and Gyöngyi, Zoltán and Varga, Gábor and Rumbus, Zoltán and Szabó, Andrea}, doi = {10.1186/s12889-020-08753-y}, journal-iso = {BMC PUBLIC HEALTH}, journal = {BMC PUBLIC HEALTH}, volume = {20}, unique-id = {31328720}, issn = {1471-2458}, abstract = {The quadrivalent human papillomavirus (HPV) vaccine has been assumed to give protection against genital warts (GW) as well as cervical cancer. Our main question was whether HPV vaccine has any effects on the prevention of GW reported in randomised controlled clinical trials (RCTs) and time-trend analyses.This meta-analysis was performed according to the PRISMA guidelines using the PICO format. We searched in three electronic databases (PubMed, Embase, Cochrane Trials), and assessed heterogeneity using the Q-test and I-squared statistics, meta-regression was also performed. Odds ratios (OR) and their confidence intervals (CI) were calculated. The sensitivity was tested by leave-one-out method. We evaluated the presence of publication bias using the funnel plot graph and the Copas selection model. The strength of evidence was assessed using the GRADE approach.Eight RCTs (per-protocol populations) and eight time-trend ecological studies were included in this meta-analysis. A significant reduction (pooled OR = 0.03, 95% CI: 0.01-0.09; I-squared = 53.6%) of GW in young women was recorded in RCTs, and in time-trend analyses both in young women (pooled OR = 0.36, CI 95% = 0.26-0.51; I-squared = 98.2%), and in young men (pooled OR = 0.69, 95% CI = 0.61-0.78; I-squared = 92.7%). In subgroup analysis, a significant reduction of the number of GW events was observed especially in women under 21 years (pooled OR = 0.33, 95% CI = 0.17-0.63). Leave-one-out analysis showed that similar results could be obtained after excluding one study, meta-regression did not show significant difference.Prophylactic, quadrivalent HPV vaccination can prevent GW in healthy women and men, therefore, it should be included in routine immunization programme.}, keywords = {PREVENTION; vaccination; human papillomavirus; Genital wart}, year = {2020}, eissn = {1471-2458}, orcid-numbers = {Lukács, Anita/0000-0002-0746-8920; Máté, Zsuzsanna/0000-0003-0446-5422; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Németh, Balázs/0000-0002-4914-9872; Czumbel, László Márk/0000-0002-5915-0383; Wuttapon, Sadaeng/0000-0003-1052-3051; Gyöngyi, Zoltán/0000-0001-9330-9119; Varga, Gábor/0000-0002-5506-8198} } @article{MTMT:31323456, title = {Efficacy of Hyaluronic Acid Dermal Fillers for Lip Augmentation: Meta-analysis}, url = {https://m2.mtmt.hu/api/publication/31323456}, author = {Czumbel, László Márk and Gaál, V and Lujber, L and Hegyi, Péter and Varga, Gábor and Farkasdi, Sándor and Gede, N and Mikó, A and Csupor, Dezső and Lukács, Anita and Kanaan, Reem and Egyed, Z and Sepp, Róbert}, journal-iso = {J DENT RES}, journal = {JOURNAL OF DENTAL RESEARCH}, volume = {98}, unique-id = {31323456}, issn = {0022-0345}, year = {2019}, eissn = {1544-0591}, orcid-numbers = {Czumbel, László Márk/0000-0002-5915-0383; Hegyi, Péter/0000-0003-0399-7259; Varga, Gábor/0000-0002-5506-8198; Farkasdi, Sándor/0000-0001-7531-8046; Csupor, Dezső/0000-0002-4088-3333; Lukács, Anita/0000-0002-0746-8920; Sepp, Róbert/0000-0003-4964-1661} } @article{MTMT:31289687, title = {Influenza vakcinációs magatartás és befolyásoló tényezőinek vizsgálata a Szegedi Tudományegyetemen}, url = {https://m2.mtmt.hu/api/publication/31289687}, author = {Vezér, Tünde and Müller, Anna and Lukács, Anita and Borsányi, Fruzsina and D., Kis Nóra and Halápi, Bernadett and Katona, Csilla and Paulik, Edit}, doi = {10.29179/EgTud.2019.3-4.3-31}, journal-iso = {EGÉSZSÉGTUDOMÁNY}, journal = {EGÉSZSÉGTUDOMÁNY}, volume = {63}, unique-id = {31289687}, issn = {0013-2268}, year = {2019}, pages = {3-31}, orcid-numbers = {Lukács, Anita/0000-0002-0746-8920; Paulik, Edit/0000-0002-3446-4327} } @article{MTMT:30921933, title = {Abdominal obesity increases metabolic risk factors in non-obese adults: a Hungarian cross-sectional study}, url = {https://m2.mtmt.hu/api/publication/30921933}, author = {Lukács, Anita and Horváth, Edina and Máté, Zsuzsanna and Szabó, Andrea and Virág, Katalin and Papp, Magor Csongor and Sándor, János and Ádány, Róza and Paulik, Edit}, doi = {10.1186/s12889-019-7839-1}, journal-iso = {BMC PUBLIC HEALTH}, journal = {BMC PUBLIC HEALTH}, volume = {19}, unique-id = {30921933}, issn = {1471-2458}, year = {2019}, eissn = {1471-2458}, orcid-numbers = {Lukács, Anita/0000-0002-0746-8920; Máté, Zsuzsanna/0000-0003-0446-5422; Virág, Katalin/0000-0003-2129-6405; Paulik, Edit/0000-0002-3446-4327} }