@article{MTMT:34177727, title = {Abnormal basement membrane results in increased keratinocyte-derived periostin expression in psoriasis similar to wound healing}, url = {https://m2.mtmt.hu/api/publication/34177727}, author = {Flink, Lili Borbála and Ghaffarinia, Ameneh and Papp, Benjamin Tamás and Varga, Ákos and Vigh, András István and Vidács, Dániel László and Kui, Róbert and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna and Bozó, Renáta}, doi = {10.1038/s41598-023-43396-0}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34177727}, issn = {2045-2322}, abstract = {The psoriatic skin resembles wound healing, and it shows abnormalities at the basement membrane (BM), also in the non-lesional skin. Fibroblast-derived dermal periostin has well-known functions in wound healing and Th2-mediated diseases, such as atopic dermatitis. Here we show that serum periostin level was elevated in psoriatic patients, remarkably in the systemically treated ones. Obvious periostin positivity was detected in basal keratinocytes of the non-lesional, lesional, and previously-lesional psoriatic vs. healthy skin. Ex vivo skin models were generated to examine how different skin injuries affect periostin expression during wound healing. Our newly developed cultured salt-split model demonstrated that BM-injury induced periostin expression in basal keratinocytes, and periostin levels in the supernatant were also increased upon healing. In wound healing models, β1-integrin expression was similarly induced. β1-integrin blocking caused reduced periostin expression in in vitro scratch assay, indicating that β1-integrin can mediate periostin production. In contrast to atopic dermatitis, psoriatic basal keratinocytes are in an activated state and show a stable wound healing-like phenotype with the overexpression of periostin. This abnormal BM-induced wound healing as a potential compensatory mechanism can be initiated already in the non-lesional skin present in the lesion and keratinocytes can remain activated in the healed skin.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Kui, Róbert/0000-0002-9448-4573; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Bozó, Renáta/0000-0003-4242-2474} } @article{MTMT:33929292, title = {A nyiroködéma, a zsírödéma és a vénás lábszárfekélyek kezelési lehetőségeinek legújabb vonatkozásai [Recent aspects of lymphedema, lipedema and venous leg ulcer-related therapeutic modalities]}, url = {https://m2.mtmt.hu/api/publication/33929292}, author = {Szolnoky, Győző and Degovics, Döníz and Kui, Róbert and Vasas, Judit and Varga, Mónika and Varga, Enikő and Korom, Eszter}, doi = {10.7188/bvsz.2023.99.2.11}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33929292}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {150-154}, orcid-numbers = {Szolnoky, Győző/0000-0002-5391-4426} } @article{MTMT:33929120, title = {A psoriasis vulgaris kezelésének fejlődése az elmúlt húsz évben [Advances in the treatment of psoriasis in the past twenty years]}, url = {https://m2.mtmt.hu/api/publication/33929120}, author = {Kui, Róbert and Kovács, Réka and Nagy, Géza Róbert and Baltás, Eszter}, doi = {10.7188/bvsz.2023.99.2.9}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33929120}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {139-143}, orcid-numbers = {Nagy, Géza Róbert/0000-0002-3876-0422; Baltás, Eszter/0000-0003-0357-7393} } @article{MTMT:33297424, title = {Proaktív stratégia a psoriasis helyi kezelésében - szakértői állásfoglalás}, url = {https://m2.mtmt.hu/api/publication/33297424}, author = {Kui, Róbert and Kemény, Lajos and Gyulai, Rolland Péter and Szegedi, Andrea and Holló, Péter and Wikonkál, Norbert}, doi = {10.7188/bvsz.2022.98.5.6}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {98}, unique-id = {33297424}, issn = {0006-7768}, year = {2022}, eissn = {2064-261X}, pages = {283-286}, orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Gyulai, Rolland Péter/0000-0002-3286-8846; Holló, Péter/0000-0002-0744-8989; Wikonkál, Norbert/0000-0003-4949-8711} } @article{MTMT:33190202, title = {A diabetes nem fertőzéses bőrtünetei, diagnosztika és terápia}, url = {https://m2.mtmt.hu/api/publication/33190202}, author = {Kui, Róbert}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {98}, unique-id = {33190202}, issn = {0006-7768}, year = {2022}, eissn = {2064-261X}, pages = {173-173} } @misc{MTMT:32475993, title = {A helyileg alkalmazható készítmények és a fényterápia helye a psoriasis modern kezelésében}, url = {https://m2.mtmt.hu/api/publication/32475993}, author = {Kui, Róbert}, unique-id = {32475993}, year = {2021} } @article{MTMT:31821611, title = {Vénás lábszárfekély sikeres kezelése vérlemezkében gazdag fibrin segítségével}, url = {https://m2.mtmt.hu/api/publication/31821611}, author = {Kui, Róbert and Vasas, Judit and Szolnoky, Győző and Kemény, Lajos}, doi = {10.7188/bvsz.2020.96.6.1}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {96}, unique-id = {31821611}, issn = {0006-7768}, year = {2020}, eissn = {2064-261X}, pages = {303-306}, orcid-numbers = {Szolnoky, Győző/0000-0002-5391-4426; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:31338257, title = {A Randomized Controlled Trial with a Medical Device Containing Sodium Hyaluronate and Nicotinic Acid to Increase the Efficacy of Ultraviolet Phototherapy in Psoriasis}, url = {https://m2.mtmt.hu/api/publication/31338257}, author = {Bende, Balázs and Kui, Róbert and Németh, Annamária and Borsos, Mariann and Tóbiás, Zoltán and Erős, Gábor and Kemény, Lajos and Baltás, Eszter}, doi = {10.1007/s13555-020-00385-9}, journal-iso = {DERMATOLOGY THER}, journal = {DERMATOLOGY AND THERAPY}, volume = {10}, unique-id = {31338257}, issn = {2193-8210}, abstract = {The dry and scaly skin of psoriatic patients decreases the efficacy of ultraviolet B (UVB) phototherapy. Different agents are used to facilitate the transmission of light, but most of these preparations are cosmetically unfavorable. We have tested a novel preparation containing sodium hyaluronate and nicotinic acid (UV Fotogel®; Pernix Ltd.) with the double aim to improve the efficacy of UVB phototherapy and assess the cosmetic acceptability of the preparation.Ninety patients with plaque psoriasis were enrolled in the study, of whom 44 received narrow-band UVB (NB-UVB) phototherapy. Prior to phototherapy, one side of the patient's body was treated with UV Fotogel while the other side served as a control. The other 46 patients used the preparation at their homes before regular sunbathing. The Local Psoriasis Severity Index (L-PSI), cosmetic acceptability and tolerability were recorded. The median values with the 25th and 75th percentiles (25p and 75p, respectively) were determined for the UV Fotogel-treated and control sites and then compared.The sides of the body to which UV Fotogel was applied prior to NB-UVB phototherapy had a significantly lower median L-PSI score than the non-treated control sides at the end of the treatment (1.0 [25p-75p: 0.0-2.0] vs. 2.0 [1.0-3.0], respectively). The application of UV Fotogel prior to sunbathing also led to a significant decrease in L-PSI score. There was a significant reduction in the median L-PSI score of patients at the final visit compared to baseline (2.5 [25p-75p: 1.5-3.5] vs. 6.0 [6.0-7.0], respectively). Use of the preparation was not accompanied by considerable adverse effects, and the patients found it cosmetically acceptable. Application of UV Fotogel prior to sunbathing was well tolerated by the patients, and the cosmetic acceptability was also good.UV Fotogel is potentially a useful device for enhancement of the efficacy of phototherapy in patients with psoriasis.}, keywords = {psoriasis; phototherapy; Ultraviolet B; Optical cleaning}, year = {2020}, eissn = {2190-9172}, pages = {651-662}, orcid-numbers = {Kui, Róbert/0000-0002-9448-4573; Kemény, Lajos/0000-0002-2119-9501; Baltás, Eszter/0000-0003-0357-7393} } @article{MTMT:30729349, title = {A nyiroködéma és a vénás lábszárfekélyek kóreredetének és kezelési lehetőségeinek legújabb vonatkozásai}, url = {https://m2.mtmt.hu/api/publication/30729349}, author = {Szolnoky, Győző and Erős, Gábor and Degovics, Döníz and Németh, István Balázs and Kui, Róbert and Paschali, Ekaterine and Vasas, Judit and Korom, Eszter and Varga, Mónika and Kemény, Lajos}, doi = {10.7188/bvsz.2019.95.2.6}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {95}, unique-id = {30729349}, issn = {0006-7768}, year = {2019}, eissn = {2064-261X}, pages = {65-68}, orcid-numbers = {Szolnoky, Győző/0000-0002-5391-4426; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:30729346, title = {Új terápiás lehetőségek a gyulladásos bőrbetegségek kezelésében}, url = {https://m2.mtmt.hu/api/publication/30729346}, author = {Kui, Róbert and Paschali, Ekaterine and Kovács, Réka and Gaál, Magdolna and Baltás, Eszter and Kemény, Lajos}, doi = {10.7188/bvsz.2019.95.2.5}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {95}, unique-id = {30729346}, issn = {0006-7768}, year = {2019}, eissn = {2064-261X}, pages = {60-64}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Kemény, Lajos/0000-0002-2119-9501} }