TY - JOUR AU - Danis, Judit AU - Kelemen, Evelyn AU - Bozó, Renáta AU - Konczné Gubán, Barbara AU - Csörgő Sándorné Bata, Zsuzsanna AU - Kemény, Lajos AU - Széll, Márta TI - A tünetmentes állapot fenntartásáért felelős szerkezeti és immunológiai aspektusok azonosítása a pikkelysömörös nem léziós bőrben JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 15 PY - 2023 IS - 3 SP - 73 EP - 79 PG - 7 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34405846 ID - 34405846 N1 - HCEMM-USZ Skin Research Group, SZTE LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kun-Varga, Anikó AU - Konczné Gubán, Barbara AU - Miklós, Vanda AU - Parvaneh, Shahram AU - Guba, Melinda AU - Szűcs, Diána AU - Monostori, Tamás AU - Varga, János AU - Varga, Ákos AU - Rázga, Zsolt AU - Csörgő Sándorné Bata, Zsuzsanna AU - Kemény, Lajos AU - Megyeri, Klára AU - Veréb, Zoltán TI - Herpes Simplex Virus Infection Alters the Immunological Properties of Adipose-Tissue-Derived Mesenchymal-Stem Cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 15 PG - 26 SN - 1661-6596 DO - 10.3390/ijms241511989 UR - https://m2.mtmt.hu/api/publication/34085614 ID - 34085614 N1 - HCEMM-SZTE Skin Research Group, University of Szeged, Hungary, TKP2021-EGA-28 AB - The proper functioning of mesenchymal stem cells (MSCs) is of paramount importance for the homeostasis of the body. Inflammation and infection can alter the function of MSCs, which can also affect the regenerative potential and immunological status of tissues. It is not known whether human herpes simplex viruses 1 and 2 (HSV1 and HSV2), well-known human pathogens that can cause lifelong infections, can induce changes in MSCs. In non-healing ulcers, HSV infection is known to affect deeper tissue layers. In addition, HSV infection can recur after initially successful cell therapies. Our aim was to study the response of adipose-derived MSCs (ADMSCs) to HSV infection in vitro. After confirming the phenotype and differentiation capacity of the isolated cells, we infected the cells in vitro with HSV1-KOS, HSV1-532 and HSV2 virus strains. Twenty-four hours after infection, we examined the gene expression of the cells via RNA-seq and RT-PCR; detected secreted cytokines via protein array; and determined autophagy via Western blot, transmission electron microscopy (TEM) and fluorescence microscopy. Infection with different HSV strains resulted in different gene-expression patterns. In addition to the activation of pathways characteristic of viral infections, distinct non-immunological pathways (autophagy, tissue regeneration and differentiation) were also activated according to analyses with QIAGEN Ingenuity Pathway Analysis, Kyoto Encyclopedia of Genes and Genome and Genome Ontology Enrichment. Viral infections increased autophagy, as confirmed via TEM image analysis, and also increased levels of the microtubule-associated protein light chain 3 (LC3B) II protein. We identified significantly altered accumulation for 16 cytokines involved in tissue regeneration and inflammation. Our studies demonstrated that HSV infection can alter the viability and immunological status of ADMSCs, which may have implications for ADMSC-based cell therapies. Alterations in autophagy can affect numerous processes in MSCs, including the inhibition of tissue regeneration as well as pathological differentiation. LA - English DB - MTMT ER - TY - JOUR AU - Konczné Gubán, Barbara AU - Flink, Lili Borbála AU - Bozó, Renáta AU - Danis, Judit AU - Rázga, Zsolt AU - Koncz, Balázs AU - Széll, Márta AU - Kemény, Lajos AU - Csörgő Sándorné Bata, Zsuzsanna TI - Abnormal type VII collagen expression in non-lesional psoriatic skin JF - JOURNAL OF INVESTIGATIVE DERMATOLOGY J2 - J INVEST DERMATOL VL - 142 PY - 2022 IS - Suppl. 12 SP - S244 EP - S244 PG - 1 SN - 0022-202X DO - 10.1016/j.jid.2022.09.386 UR - https://m2.mtmt.hu/api/publication/33261227 ID - 33261227 LA - English DB - MTMT ER - TY - JOUR AU - Konczné Gubán, Barbara AU - Flink, Lili Borbála AU - Bozó, Renáta AU - Danis, Judit AU - Rázga, Zsolt AU - Koncz, Balázs AU - Széll, Márta AU - Kemény, Lajos AU - Csörgő Sándorné Bata, Zsuzsanna TI - Abnormal type VII collagen expression in non-lesional psoriatic skin JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 98 PY - 2022 IS - 4 SP - 190 EP - 190 PG - 1 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/33190130 ID - 33190130 LA - English DB - MTMT ER - TY - JOUR AU - Bozó, Renáta AU - Flink, Lili Borbála AU - Belső, Nóra AU - Konczné Gubán, Barbara AU - Széll, Márta AU - Kemény, Lajos AU - Csörgő Sándorné Bata, Zsuzsanna TI - Could basement membrane alterations, resembling micro-wounds at the dermo-epidermal junction in psoriatic non-lesional skin, make the skin susceptible to lesion formation? JF - EXPERIMENTAL DERMATOLOGY J2 - EXP DERMATOL VL - 30 PY - 2021 IS - 6 SP - 765 EP - 772 PG - 8 SN - 0906-6705 DO - 10.1111/exd.14267 UR - https://m2.mtmt.hu/api/publication/31798342 ID - 31798342 N1 - HCEMM-SZTE Skin Research Group, Szeged, Hungary. AB - Current data suggest that tissue microenvironment control immune functions. Therefore, understanding the tissue environment in which immune activation occurs will enhance our capability to interfere with abnormal immune pathology. Here, we argue that studying the constitutively abnormal functions of clinically uninvolved psoriatic skin in patients with plaque type psoriasis is very important to better understand psoriasis pathobiology, because non-lesional skin provides the tissue environment in which the psoriatic lesion develops. A key question in psoriasis is what initiates the abnormal, uncontrolled immune activation in the first place and the answer may lie in the skin. In light of this concept, we summarize abnormalities at the dermal-epidermal junction region which shows a special "nonhealing-like" micro-wound phenotype in the psoriatic non-lesional skin that may act as a crucial susceptibility factor in the development of the disease. LA - English DB - MTMT ER - TY - JOUR AU - Brunner, Szilvia AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Szabó, Zoltán Imre AU - Reisz, Zita AU - Konczné Gubán, Barbara AU - Szijártó, András Lajos AU - Michael, Brand AU - Stefan, Hans AU - Leonhard, Karsch AU - Elisabeth, Lessmann AU - Jörg, Pawelke AU - Michael, Schürer AU - Elke, Beyreuther AU - Hideghéty, Katalin TI - Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 40 PY - 2020 IS - 11 SP - 6123 EP - 6135 PG - 13 SN - 0250-7005 DO - 10.21873/anticanres.14633 UR - https://m2.mtmt.hu/api/publication/31655754 ID - 31655754 N1 - ELI-ALPS, ELI-HU Non-Profit Ltd., Szeged, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Department of Clinical Neuropathology, King’s College Hospital, London, United Kingdom Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany Helmholtz-Zentrum Dresden–Rossendorf, Dresden, Germany National Center for Tumor Diseases (NCT), Dresden, Germany Department of Oncotherapy, University of Szeged, Szeged, Hungary Export Date: 11 February 2022 CODEN: ANTRD Correspondence Address: Brunner, S.; ELI-ALPS, Wolfgang Sandner Str. 3., Hungary; email: Szilvia.Brunner@elialps.hu LA - English DB - MTMT ER - TY - JOUR AU - Bozó, Renáta AU - Szél, Edit AU - Danis, Judit AU - Konczné Gubán, Barbara AU - Csörgő Sándorné Bata, Zsuzsanna AU - Szabó, Kornélia Ágnes AU - Kemény, Lajos AU - Groma, Gergely TI - Cartilage Oligomeric Matrix Protein Negatively Influences Keratinocyte Proliferation Via α5β1-Integrin. Potential Relevance of Altered Cartilage Oligomeric Matrix Protein Expression in Psoriasis TS - Potential Relevance of Altered Cartilage Oligomeric Matrix Protein Expression in Psoriasis JF - JOURNAL OF INVESTIGATIVE DERMATOLOGY J2 - J INVEST DERMATOL VL - 140 PY - 2020 IS - 9 SP - 1733 EP - 1742.e7 PG - 10 SN - 0022-202X DO - 10.1016/j.jid.2019.12.037 UR - https://m2.mtmt.hu/api/publication/31180746 ID - 31180746 N1 - HCEMM-USZ Skin Research Group, Szeged LA - English DB - MTMT ER - TY - JOUR AU - Bozó, Renáta AU - Szél, Edit AU - Danis, Judit AU - Konczné Gubán, Barbara AU - Szabó, Kornélia Ágnes AU - Bata-Csörgő, Zsuzsanna AU - Kemény, Lajos TI - A porc oligomer mátrix fehérje (COMP) potenciális szerepe a pikkelysömörös tünetmentes bőrben JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 95 PY - 2019 IS - 6 SP - 271 EP - 271 PG - 1 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/31068156 ID - 31068156 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bozó, Renáta AU - Szél, Edit AU - Danis, Judit AU - Konczné Gubán, Barbara AU - Csörgő Sándorné Bata, Zsuzsanna AU - Szabó, Kornélia Ágnes AU - Kemény, Lajos AU - Groma, Gergely TI - Cartilage oligomeric matrix protein (COMP) negatively influences keratinocyte proliferation via α5β1-integrin: Potential relevance of eltered COMP expression in psoriasis JF - JOURNAL OF INVESTIGATIVE DERMATOLOGY J2 - J INVEST DERMATOL VL - 139 PY - 2019 IS - 9 SP - S285 EP - S285 SN - 0022-202X DO - 10.1016/j.jid.2019.07.412 UR - https://m2.mtmt.hu/api/publication/30879468 ID - 30879468 LA - English DB - MTMT ER - TY - JOUR AU - Belső, Nóra AU - Konczné Gubán, Barbara AU - Manczinger, Máté AU - Kormos, Bernadett AU - Bebes, Attila AU - Németh, István Balázs AU - Veréb, Zoltán AU - Széll, Márta AU - Kemény, Lajos AU - Csörgő Sándorné Bata, Zsuzsanna TI - Differential role of D cyclins in the regulation of cell cycle by influencing Ki67 expression in HaCaT cells JF - EXPERIMENTAL CELL RESEARCH J2 - EXP CELL RES VL - 374 PY - 2019 IS - 2 SP - 290 EP - 303 PG - 14 SN - 0014-4827 DO - 10.1016/j.yexcr.2018.11.030 UR - https://m2.mtmt.hu/api/publication/30401772 ID - 30401772 LA - English DB - MTMT ER -