TY - JOUR AU - Hánis, Csilla AU - Csányi, Ildikó AU - Ócsai, Henriette AU - Németh, István Balázs AU - Bende, Balázs AU - Besenyei, Zsuzsanna AU - Hideghéty, Katalin AU - Kemény, Lajos AU - Gyulai, Rolland Péter AU - Oláh, Judit Magdolna AU - Baltás, Eszter TI - Sarcoid-like reakciók előfordulása metasztatikus melanoma miatt immunterápiával kezelt betegnél JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 99 PY - 2023 IS - 6 SP - 438 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/34513890 ID - 34513890 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szűcs, Diána AU - Miklós, Vanda AU - Monostori, Tamás AU - Guba, Melinda AU - Kun-Varga, Anikó AU - Póliska, Szilárd AU - Kis, Erika AU - Bende, Balázs AU - Kemény, Lajos AU - Veréb, Zoltán TI - Effect of inflammatory microenvironment on the regenerative capacity of adipose-derived mesenchymal stem cells JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 15 PY - 2023 IS - 3 SP - 35 EP - 35 PG - 1 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34405844 ID - 34405844 N1 - HCEMM-SZTE Skin Research Group, University of Szeged LA - English DB - MTMT ER - TY - JOUR AU - Monostori, Tamás AU - Szűcs, Diána AU - Miklós, Vanda AU - Bende, Balázs AU - Kemény, Lajos AU - Veréb, Zoltán TI - SVF cell therapy for the treatment of non-healing limb ulcers JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 15 PY - 2023 IS - 3 SP - 27 EP - 28 PG - 2 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34405831 ID - 34405831 N1 - HCEMM-USZ Skin Research Group, Szeged LA - English DB - MTMT ER - TY - JOUR AU - Szűcs, Diána AU - Miklós, Vanda AU - Monostori, Tamás AU - Guba, Melinda AU - Kun-Varga, Anikó AU - Póliska, Szilárd AU - Kis, Erika AU - Bende, Balázs AU - Kemény, Lajos AU - Veréb, Zoltán TI - Effect of Inflammatory Microenvironment on the Regenerative Capacity of Adipose-Derived Mesenchymal Stem Cells JF - CELLS J2 - CELLS-BASEL VL - 12 PY - 2023 IS - 15 PG - 19 SN - 2073-4409 DO - 10.3390/cells12151966 UR - https://m2.mtmt.hu/api/publication/34085618 ID - 34085618 N1 - HCEMM-USZ Skin Research Group, University of Szeged, Hungary, TKP2021-EGA-28 AB - Adipose-derived mesenchymal stem cells are increasingly being used in regenerative medicine as cell therapy targets, including in the treatment of burns and ulcers. The regenerative potential of AD-MSCs and some of their immunological properties are known from in vitro studies; however, in clinical applications, cells are used in non-ideal conditions and can behave differently in inflammatory environments, affecting the efficacy and outcome of therapy. Our aim was to investigate and map the pathways that the inflammatory microenvironment can induce in these cells. High-throughput gene expression assays were performed on AD-MSCs activated with LPS and TNFα. Analysis of RNA-Seq data showed that control, LPS-treated and TNFα-treated samples exhibited distinct gene expression patterns. LPS treatment increased the expression of 926 genes and decreased the expression of 770 genes involved in cell division, DNA repair, the cell cycle, and several metabolic processes. TNFα treatment increased the expression of 174 genes and decreased the expression of 383 genes, which are related to cell division, the immune response, cell proliferation, and differentiation. We also map the biological pathways by further investigating the most altered genes using the Gene Ontology and KEGG databases. Secreted cytokines, which are important in the immunological response, were also examined at the protein level, and a functional assay was performed to assess wound healing. Activated AD-MSC increased the secretion of IL-6, IL-8 and CXCL-10, and also the closure of wounds. AD-MSCs presented accelerated wound healing under inflammation conditions, suggesting that we could use this cell in clinical application. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Ákos AU - Bende, Balázs AU - Baltás, Eszter AU - Németh, István Balázs AU - Varga, Erika AU - Vass, Gábor AU - Kis, Erika AU - Oláh, Judit Magdolna AU - Varga, János AU - Kocsis, Ádám László TI - Az SZTE Bőrgyógyászati és Allergológiai Klinikán a melanoma malignum sebészi kezelésében történt változások az elmúlt évtizedben [Changes in the surgical treatment of melanoma malignum at the Department of Dermatology and Allergology University of Szeged over the last decade] JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 99 PY - 2023 IS - 2 SP - 122 EP - 124 PG - 3 SN - 0006-7768 DO - 10.7188/bvsz.2023.99.2.6 UR - https://m2.mtmt.hu/api/publication/33928935 ID - 33928935 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bende, Balázs AU - Lovászi, Borbála AU - Szűcs, Diána AU - Monostori, Tamás AU - Kun-Varga, Anikó AU - Parvaneh, Shahram AU - Göblös, Anikó AU - Veréb, Zoltán TI - Innovatív eljárások a sebgyógyításban JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 99 PY - 2023 IS - 2 SP - 103 EP - 107 PG - 5 SN - 0006-7768 DO - 10.7188/bvsz.2023.99.2.3 UR - https://m2.mtmt.hu/api/publication/33928610 ID - 33928610 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dvorácskó, Szabolcs AU - Körmöczi, Tímea AU - Sija, Éva AU - Bende, Balázs AU - Weiczner, Roland AU - Varga, Tibor AU - Ilisz, István AU - Institóris, László AU - Kereszty, Éva Margit AU - Tömböly, Csaba AU - Berkecz, Róbert TI - Focusing on the 5F-MDMB-PICA, 4F-MDMB-BICA synthetic cannabinoids and their primary metabolites in analytical and pharmacological aspects JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J2 - TOXICOL APPL PHARM VL - 470 PY - 2023 PG - 10 SN - 0041-008X DO - 10.1016/j.taap.2023.116548 UR - https://m2.mtmt.hu/api/publication/33831570 ID - 33831570 N1 - TKP2021-EGA LA - English DB - MTMT ER - TY - JOUR AU - Lázár, Péter AU - Tóth-Molnár, Edit AU - Bende, Balázs AU - Vass, Gábor AU - Baltás, Eszter AU - Paczona, Róbert AU - Varga, Erika AU - Piffkó, József AU - Kemény, Lajos AU - Oláh, Judit Magdolna AU - Kis, Erika TI - Challenges in the complex management of neglected cutaneous melanomas in the head and neck area: a single center experience JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 5 PG - 11 SN - 2077-0383 DO - 10.3390/jcm12051910 UR - https://m2.mtmt.hu/api/publication/33680226 ID - 33680226 AB - Familiar controversies in the management of head and neck melanomas are more remarkable in locally advanced cases, and they represent a treatment challenge both surgically and oncologically. In our retrospective study, patients with surgically treated primary malignant melanoma of the head and neck region larger than 3 cm in diameter were included. Five patients met our inclusion criteria. In all cases, wide excision and immediate reconstruction were performed without sentinel lymph node biopsy. The defect on the scalp was covered by a split skin graft, with local flaps chosen for reconstruction on the face on an individual basis. After a 2–6 year follow-up, a good oncological, functional, and esthetic result was achieved. Our results show that in the case of large, locally advanced melanomas, surgical treatment still plays a crucial role that can provide long-term local control and support the effect of systemic treatment. LA - English DB - MTMT ER - TY - JOUR AU - Bende, Balázs AU - Degovics, Döníz AU - Varga, János AU - Varga, Ákos AU - Kocsis, Ádám László AU - Kis, Erika AU - Guba, Melinda AU - Szűcs, Diána AU - Monostori, Tamás AU - Kemény, Lajos AU - Veréb, Zoltán TI - SVF cell therapy for the treatment of non-healing limb ulcers JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 98 PY - 2022 IS - 4 SP - 179 EP - 180 PG - 2 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/33190247 ID - 33190247 N1 - HCEMM-USZ Skin Research Group LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bende, Balázs AU - Kui, Róbert AU - Németh, Annamária AU - Borsos, Mariann AU - Tóbiás, Zoltán AU - Erős, Gábor AU - Kemény, Lajos AU - Baltás, Eszter TI - A Randomized Controlled Trial with a Medical Device Containing Sodium Hyaluronate and Nicotinic Acid to Increase the Efficacy of Ultraviolet Phototherapy in Psoriasis JF - DERMATOLOGY AND THERAPY J2 - DERMATOLOGY THER VL - 10 PY - 2020 IS - 4 SP - 651 EP - 662 PG - 12 SN - 2193-8210 DO - 10.1007/s13555-020-00385-9 UR - https://m2.mtmt.hu/api/publication/31338257 ID - 31338257 N1 - HCEMM SZTE Skin Research Group, Szeged AB - The dry and scaly skin of psoriatic patients decreases the efficacy of ultraviolet B (UVB) phototherapy. Different agents are used to facilitate the transmission of light, but most of these preparations are cosmetically unfavorable. We have tested a novel preparation containing sodium hyaluronate and nicotinic acid (UV Fotogel®; Pernix Ltd.) with the double aim to improve the efficacy of UVB phototherapy and assess the cosmetic acceptability of the preparation.Ninety patients with plaque psoriasis were enrolled in the study, of whom 44 received narrow-band UVB (NB-UVB) phototherapy. Prior to phototherapy, one side of the patient's body was treated with UV Fotogel while the other side served as a control. The other 46 patients used the preparation at their homes before regular sunbathing. The Local Psoriasis Severity Index (L-PSI), cosmetic acceptability and tolerability were recorded. The median values with the 25th and 75th percentiles (25p and 75p, respectively) were determined for the UV Fotogel-treated and control sites and then compared.The sides of the body to which UV Fotogel was applied prior to NB-UVB phototherapy had a significantly lower median L-PSI score than the non-treated control sides at the end of the treatment (1.0 [25p-75p: 0.0-2.0] vs. 2.0 [1.0-3.0], respectively). The application of UV Fotogel prior to sunbathing also led to a significant decrease in L-PSI score. There was a significant reduction in the median L-PSI score of patients at the final visit compared to baseline (2.5 [25p-75p: 1.5-3.5] vs. 6.0 [6.0-7.0], respectively). Use of the preparation was not accompanied by considerable adverse effects, and the patients found it cosmetically acceptable. Application of UV Fotogel prior to sunbathing was well tolerated by the patients, and the cosmetic acceptability was also good.UV Fotogel is potentially a useful device for enhancement of the efficacy of phototherapy in patients with psoriasis. LA - English DB - MTMT ER -