@article{MTMT:34513890, title = {Sarcoid-like reakciók előfordulása metasztatikus melanoma miatt immunterápiával kezelt betegnél}, url = {https://m2.mtmt.hu/api/publication/34513890}, author = {Hánis, Csilla and Csányi, Ildikó and Ócsai, Henriette and Németh, István Balázs and Bende, Balázs and Besenyei, Zsuzsanna and Hideghéty, Katalin and Kemény, Lajos and Gyulai, Rolland Péter and Oláh, Judit Magdolna and Baltás, Eszter}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {34513890}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {438}, orcid-numbers = {Csányi, Ildikó/0000-0002-0766-5289; Hideghéty, Katalin/0000-0001-7080-2365; Kemény, Lajos/0000-0002-2119-9501; Gyulai, Rolland Péter/0000-0002-3286-8846; Baltás, Eszter/0000-0003-0357-7393} } @article{MTMT:34405844, title = {Effect of inflammatory microenvironment on the regenerative capacity of adipose-derived mesenchymal stem cells}, url = {https://m2.mtmt.hu/api/publication/34405844}, author = {Szűcs, Diána and Miklós, Vanda and Monostori, Tamás and Guba, Melinda and Kun-Varga, Anikó and Póliska, Szilárd and Kis, Erika and Bende, Balázs and Kemény, Lajos and Veréb, Zoltán}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {15}, unique-id = {34405844}, issn = {2061-0203}, year = {2023}, pages = {35-35}, orcid-numbers = {Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:34405831, title = {SVF cell therapy for the treatment of non-healing limb ulcers}, url = {https://m2.mtmt.hu/api/publication/34405831}, author = {Monostori, Tamás and Szűcs, Diána and Miklós, Vanda and Bende, Balázs and Kemény, Lajos and Veréb, Zoltán}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {15}, unique-id = {34405831}, issn = {2061-0203}, year = {2023}, pages = {27-28}, orcid-numbers = {Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:34085618, title = {Effect of Inflammatory Microenvironment on the Regenerative Capacity of Adipose-Derived Mesenchymal Stem Cells}, url = {https://m2.mtmt.hu/api/publication/34085618}, author = {Szűcs, Diána and Miklós, Vanda and Monostori, Tamás and Guba, Melinda and Kun-Varga, Anikó and Póliska, Szilárd and Kis, Erika and Bende, Balázs and Kemény, Lajos and Veréb, Zoltán}, doi = {10.3390/cells12151966}, journal-iso = {CELLS-BASEL}, journal = {CELLS}, volume = {12}, unique-id = {34085618}, abstract = {Adipose-derived mesenchymal stem cells are increasingly being used in regenerative medicine as cell therapy targets, including in the treatment of burns and ulcers. The regenerative potential of AD-MSCs and some of their immunological properties are known from in vitro studies; however, in clinical applications, cells are used in non-ideal conditions and can behave differently in inflammatory environments, affecting the efficacy and outcome of therapy. Our aim was to investigate and map the pathways that the inflammatory microenvironment can induce in these cells. High-throughput gene expression assays were performed on AD-MSCs activated with LPS and TNFα. Analysis of RNA-Seq data showed that control, LPS-treated and TNFα-treated samples exhibited distinct gene expression patterns. LPS treatment increased the expression of 926 genes and decreased the expression of 770 genes involved in cell division, DNA repair, the cell cycle, and several metabolic processes. TNFα treatment increased the expression of 174 genes and decreased the expression of 383 genes, which are related to cell division, the immune response, cell proliferation, and differentiation. We also map the biological pathways by further investigating the most altered genes using the Gene Ontology and KEGG databases. Secreted cytokines, which are important in the immunological response, were also examined at the protein level, and a functional assay was performed to assess wound healing. Activated AD-MSC increased the secretion of IL-6, IL-8 and CXCL-10, and also the closure of wounds. AD-MSCs presented accelerated wound healing under inflammation conditions, suggesting that we could use this cell in clinical application.}, year = {2023}, eissn = {2073-4409}, orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:33928935, title = {Az SZTE Bőrgyógyászati és Allergológiai Klinikán a melanoma malignum sebészi kezelésében történt változások az elmúlt évtizedben [Changes in the surgical treatment of melanoma malignum at the Department of Dermatology and Allergology University of Szeged over the last decade]}, url = {https://m2.mtmt.hu/api/publication/33928935}, author = {Varga, Ákos and Bende, Balázs and Baltás, Eszter and Németh, István Balázs and Varga, Erika and Vass, Gábor and Kis, Erika and Oláh, Judit Magdolna and Varga, János and Kocsis, Ádám László}, doi = {10.7188/bvsz.2023.99.2.6}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33928935}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {122-124}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Vass, Gábor/0000-0003-0787-8679} } @article{MTMT:33928610, title = {Innovatív eljárások a sebgyógyításban}, url = {https://m2.mtmt.hu/api/publication/33928610}, author = {Bende, Balázs and Lovászi, Borbála and Szűcs, Diána and Monostori, Tamás and Kun-Varga, Anikó and Parvaneh, Shahram and Göblös, Anikó and Veréb, Zoltán}, doi = {10.7188/bvsz.2023.99.2.3}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33928610}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {103-107}, orcid-numbers = {Göblös, Anikó/0000-0001-7229-8940; Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:33831570, title = {Focusing on the 5F-MDMB-PICA, 4F-MDMB-BICA synthetic cannabinoids and their primary metabolites in analytical and pharmacological aspects}, url = {https://m2.mtmt.hu/api/publication/33831570}, author = {Dvorácskó, Szabolcs and Körmöczi, Tímea and Sija, Éva and Bende, Balázs and Weiczner, Roland and Varga, Tibor and Ilisz, István and Institóris, László and Kereszty, Éva Margit and Tömböly, Csaba and Berkecz, Róbert}, doi = {10.1016/j.taap.2023.116548}, journal-iso = {TOXICOL APPL PHARM}, journal = {TOXICOLOGY AND APPLIED PHARMACOLOGY}, volume = {470}, unique-id = {33831570}, issn = {0041-008X}, year = {2023}, eissn = {1096-0333}, orcid-numbers = {Körmöczi, Tímea/0000-0002-0973-2473; Weiczner, Roland/0000-0002-5990-2661; Ilisz, István/0000-0001-8282-457X; Kereszty, Éva Margit/0000-0001-7196-6150; Berkecz, Róbert/0000-0002-9076-2177} } @article{MTMT:33680226, title = {Challenges in the complex management of neglected cutaneous melanomas in the head and neck area: a single center experience}, url = {https://m2.mtmt.hu/api/publication/33680226}, author = {Lázár, Péter and Tóth-Molnár, Edit and Bende, Balázs and Vass, Gábor and Baltás, Eszter and Paczona, Róbert and Varga, Erika and Piffkó, József and Kemény, Lajos and Oláh, Judit Magdolna and Kis, Erika}, doi = {10.3390/jcm12051910}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {12}, unique-id = {33680226}, abstract = {Familiar controversies in the management of head and neck melanomas are more remarkable in locally advanced cases, and they represent a treatment challenge both surgically and oncologically. In our retrospective study, patients with surgically treated primary malignant melanoma of the head and neck region larger than 3 cm in diameter were included. Five patients met our inclusion criteria. In all cases, wide excision and immediate reconstruction were performed without sentinel lymph node biopsy. The defect on the scalp was covered by a split skin graft, with local flaps chosen for reconstruction on the face on an individual basis. After a 2–6 year follow-up, a good oncological, functional, and esthetic result was achieved. Our results show that in the case of large, locally advanced melanomas, surgical treatment still plays a crucial role that can provide long-term local control and support the effect of systemic treatment.}, year = {2023}, eissn = {2077-0383}, orcid-numbers = {Tóth-Molnár, Edit/0000-0001-7989-1616; Vass, Gábor/0000-0003-0787-8679; Baltás, Eszter/0000-0003-0357-7393; Piffkó, József/0000-0001-7119-2685; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:33190247, title = {SVF cell therapy for the treatment of non-healing limb ulcers}, url = {https://m2.mtmt.hu/api/publication/33190247}, author = {Bende, Balázs and Degovics, Döníz and Varga, János and Varga, Ákos and Kocsis, Ádám László and Kis, Erika and Guba, Melinda and Szűcs, Diána and Monostori, Tamás and Kemény, Lajos and Veréb, Zoltán}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {98}, unique-id = {33190247}, issn = {0006-7768}, year = {2022}, eissn = {2064-261X}, pages = {179-180}, orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:31338257, title = {A Randomized Controlled Trial with a Medical Device Containing Sodium Hyaluronate and Nicotinic Acid to Increase the Efficacy of Ultraviolet Phototherapy in Psoriasis}, url = {https://m2.mtmt.hu/api/publication/31338257}, author = {Bende, Balázs and Kui, Róbert and Németh, Annamária and Borsos, Mariann and Tóbiás, Zoltán and Erős, Gábor and Kemény, Lajos and Baltás, Eszter}, doi = {10.1007/s13555-020-00385-9}, journal-iso = {DERMATOLOGY THER}, journal = {DERMATOLOGY AND THERAPY}, volume = {10}, unique-id = {31338257}, issn = {2193-8210}, abstract = {The dry and scaly skin of psoriatic patients decreases the efficacy of ultraviolet B (UVB) phototherapy. Different agents are used to facilitate the transmission of light, but most of these preparations are cosmetically unfavorable. We have tested a novel preparation containing sodium hyaluronate and nicotinic acid (UV Fotogel®; Pernix Ltd.) with the double aim to improve the efficacy of UVB phototherapy and assess the cosmetic acceptability of the preparation.Ninety patients with plaque psoriasis were enrolled in the study, of whom 44 received narrow-band UVB (NB-UVB) phototherapy. Prior to phototherapy, one side of the patient's body was treated with UV Fotogel while the other side served as a control. The other 46 patients used the preparation at their homes before regular sunbathing. The Local Psoriasis Severity Index (L-PSI), cosmetic acceptability and tolerability were recorded. The median values with the 25th and 75th percentiles (25p and 75p, respectively) were determined for the UV Fotogel-treated and control sites and then compared.The sides of the body to which UV Fotogel was applied prior to NB-UVB phototherapy had a significantly lower median L-PSI score than the non-treated control sides at the end of the treatment (1.0 [25p-75p: 0.0-2.0] vs. 2.0 [1.0-3.0], respectively). The application of UV Fotogel prior to sunbathing also led to a significant decrease in L-PSI score. There was a significant reduction in the median L-PSI score of patients at the final visit compared to baseline (2.5 [25p-75p: 1.5-3.5] vs. 6.0 [6.0-7.0], respectively). Use of the preparation was not accompanied by considerable adverse effects, and the patients found it cosmetically acceptable. Application of UV Fotogel prior to sunbathing was well tolerated by the patients, and the cosmetic acceptability was also good.UV Fotogel is potentially a useful device for enhancement of the efficacy of phototherapy in patients with psoriasis.}, keywords = {psoriasis; phototherapy; Ultraviolet B; Optical cleaning}, year = {2020}, eissn = {2190-9172}, pages = {651-662}, orcid-numbers = {Kui, Róbert/0000-0002-9448-4573; Kemény, Lajos/0000-0002-2119-9501; Baltás, Eszter/0000-0003-0357-7393} }