TY - JOUR AU - Király, Márton AU - Sántha, Konrád AU - Kállai-Szabó, Barnabás AU - Kállai-Szabó, Nikolett AU - Antal, István AU - Ludányi, Krisztina TI - β-galactosidase Containing Innovative Drug Delivery System JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 253 EP - 254 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.253-254 UR - https://m2.mtmt.hu/api/publication/32496864 ID - 32496864 N1 - Poster-45 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Sántha, Konrád AU - Kállai-Szabó, Nikolett AU - Fülöp, Viktor AU - Jakab, Géza AU - Gordon, Péter AU - Kállai-Szabó, Barnabás AU - Bertalanné Balogh, Emese AU - Antal, István TI - Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 22 PY - 2021 IS - 1 PG - 10 SN - 1530-9932 DO - 10.1208/s12249-020-01902-x UR - https://m2.mtmt.hu/api/publication/31793659 ID - 31793659 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, 1111, Hungary ViteCer Ltd., Ipartelepi Str. 8/b, Cegléd, 2700, Hungary Cited By :3 Export Date: 23 September 2022 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Str. 7, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu AB - Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets. LA - English DB - MTMT ER - TY - JOUR AU - Niczinger, Noémi AU - Kállai-Szabó, Barnabás AU - Lengyel, Miléna AU - Gordon, P AU - Klebovich, Imre AU - Antal, István TI - Physicochemical analysis in the evaluation of reconstituted dry emulsion tablets JF - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS J2 - J PHARMACEUT BIOMED ANAL VL - 134 PY - 2017 SP - 86 EP - 93 PG - 8 SN - 0731-7085 DO - 10.1016/j.jpba.2016.11.031 UR - https://m2.mtmt.hu/api/publication/3161341 ID - 3161341 N1 - Department of Pharmaceutics, Semmelweis University, 7 Hőgyes Endre Str., Budapest, H-1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, 18 Egry J. Str., Budapest, H-1111, Hungary Cited By :5 Export Date: 27 March 2024 CODEN: JPBAD Correspondence Address: Antal, I.; Department of Pharmaceutics, 7 Hőgyes Endre Str., Hungary; email: antal.istvan@pharma.semmelweis-univ.hu Chemicals/CAS: erythritol, 149-32-6, 7541-59-5; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; mannitol, 69-65-8, 87-78-5; xanthan, 11138-66-2; Emulsions; Excipients; Polysaccharides, Bacterial; Tablets; xanthan gum AB - The aim of this study was to characterize the formation of emulsions by droplet size analysis and turbidimetry during reconstitution from a solid dosage form, namely from dry emulsion systems, which carry an oil phase for poorly soluble active ingredients. For the dry emulsion systems tablets were prepared either from oil-in-water systems using a freeze-drying process or through direct compression containing the same oil and excipients. The ratios of oil to emulgents and oil to xanthan gum were equal in both methods. In the preparation methods applied, mannitol, erythritol and lactose were used as excipients and mannitol was found to be the most effective excipient based on droplet size reconstitution, turbidimetry and physical properties. Quality control involved testing the physical properties of tablets and characterizing the reconstituted emulsions. © 2016 Elsevier B.V. LA - English DB - MTMT ER - TY - JOUR AU - Démuth, Balázs AU - Farkas, Attila AU - Balogh, Attila AU - Bartosiewicz, Karolina AU - Kállai-Szabó, Barnabás AU - Bertels, Johny AU - Vigh, Tamás AU - Mensch, Jurgen AU - Verreck, Geert AU - Van, Assche Ivo AU - Marosi, György AU - Nagy, Zsombor Kristóf TI - Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion JF - JOURNAL OF PHARMACEUTICAL SCIENCES J2 - J PHARM SCI VL - 105 PY - 2016 IS - 9 SP - 2982 EP - 2988 PG - 7 SN - 0022-3549 DO - 10.1016/j.xphs.2016.04.032 UR - https://m2.mtmt.hu/api/publication/3077675 ID - 3077675 N1 - Összes idézések száma a WoS-ban: 0 Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1111, Hungary Department of Pharmaceutics, Semmelweis University, Budapest, 1091, Hungary Drug Product Development, Janssen R&D, Beerse, 2340, Belgium Cited By :15 Export Date: 9 September 2020 CODEN: JPMSA Correspondence Address: Marosi, G.Hungary; email: gmarosi@mail.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; magnesium stearate, 557-04-0; stearic acid, 57-11-4, 646-29-7; Antifungal Agents; Excipients; Itraconazole; Lubricants; stearic acid; Stearic Acids; Tablets Manufacturers: Johnson and Johnson, Belgium Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1111, Hungary Department of Pharmaceutics, Semmelweis University, Budapest, 1091, Hungary Drug Product Development, Janssen R&D, Beerse, 2340, Belgium Cited By :18 Export Date: 18 March 2021 CODEN: JPMSA Correspondence Address: Marosi, G.Hungary; email: gmarosi@mail.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; magnesium stearate, 557-04-0; stearic acid, 57-11-4, 646-29-7; Antifungal Agents; Excipients; Itraconazole; Lubricants; stearic acid; Stearic Acids; Tablets Manufacturers: Johnson and Johnson, Belgium Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 Funding details: Hungarian Scientific Research Fund, OTKA, K112644, PD108975 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: This work was financially supported by the New Széchenyi Development Plan (TÁMOP-4.2.1/B-09/1/KMR-2010-0002), OTKA research fund (grant numbers K112644 and PD108975 ), MedInProt Synergy Program, and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1111, Hungary Department of Pharmaceutics, Semmelweis University, Budapest, 1091, Hungary Drug Product Development, Janssen R&D, Beerse, 2340, Belgium Cited By :18 Export Date: 23 April 2021 CODEN: JPMSA Correspondence Address: Marosi, G.Hungary; email: gmarosi@mail.bme.hu Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1111, Hungary Department of Pharmaceutics, Semmelweis University, Budapest, 1091, Hungary Drug Product Development, Janssen R&D, Beerse, 2340, Belgium Cited By :18 Export Date: 26 April 2021 CODEN: JPMSA Correspondence Address: Marosi, G.Hungary; email: gmarosi@mail.bme.hu Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1111, Hungary Department of Pharmaceutics, Semmelweis University, Budapest, 1091, Hungary Drug Product Development, Janssen R&D, Beerse, 2340, Belgium Cited By :20 Export Date: 7 September 2021 CODEN: JPMSA Correspondence Address: Marosi, G.Hungary; email: gmarosi@mail.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; magnesium stearate, 557-04-0; stearic acid, 57-11-4, 646-29-7; Antifungal Agents; Excipients; Itraconazole; Lubricants; stearic acid; Stearic Acids; Tablets Manufacturers: Johnson and Johnson, Belgium Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 Funding details: Hungarian Scientific Research Fund, OTKA, K112644, PD108975 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: This work was financially supported by the New Széchenyi Development Plan (TÁMOP-4.2.1/B-09/1/KMR-2010-0002), OTKA research fund (grant numbers K112644 and PD108975 ), MedInProt Synergy Program, and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, 1111, Hungary Department of Pharmaceutics, Semmelweis University, Budapest, 1091, Hungary Drug Product Development, Janssen R&D, Beerse, 2340, Belgium Cited By :20 Export Date: 8 September 2021 CODEN: JPMSA Correspondence Address: Marosi, G.Hungary; email: gmarosi@mail.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; magnesium stearate, 557-04-0; stearic acid, 57-11-4, 646-29-7; Antifungal Agents; Excipients; Itraconazole; Lubricants; stearic acid; Stearic Acids; Tablets Manufacturers: Johnson and Johnson, Belgium Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 Funding details: Hungarian Scientific Research Fund, OTKA, K112644, PD108975 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: This work was financially supported by the New Széchenyi Development Plan (TÁMOP-4.2.1/B-09/1/KMR-2010-0002), OTKA research fund (grant numbers K112644 and PD108975 ), MedInProt Synergy Program, and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Csobán, Zsombor AU - Kállai-Szabó, Barnabás AU - Kállai-Szabó, Nikolett AU - Takács, Tamara AU - Hurtony, Tamás József AU - Gordon, Péter AU - Zelkó, Romána AU - Antal, István TI - Assessment of distribution of pellets in tablets by non-destructive microfocus X-ray imaging and image analysis technique JF - POWDER TECHNOLOGY J2 - POWDER TECHNOL VL - 301 PY - 2016 SP - 228 EP - 233 PG - 6 SN - 0032-5910 DO - 10.1016/j.powtec.2016.05.067 UR - https://m2.mtmt.hu/api/publication/3072406 ID - 3072406 LA - English DB - MTMT ER - TY - JOUR AU - Csobán, Zsombor AU - Kállai-Szabó, Barnabás AU - Kállai-Szabó, Nikolett AU - Sebe, István AU - Gordon, Péter AU - Antal, István TI - Improvement of mechanical properties of pellet containing tablets by thermal treatment JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 496 PY - 2015 IS - 2 SP - 489 EP - 496 PG - 8 SN - 0378-5173 DO - 10.1016/j.ijpharm.2015.10.040 UR - https://m2.mtmt.hu/api/publication/3026953 ID - 3026953 AB - Batches of partially spray-dried lactose tablets with three different initial tensile strength (similar to 20 N, similar to 35 N, similar to 50 N) were made. Changes along a 24 h long thermal treatment at 100 degrees C in tensile strength, friability, individual mass, water content, disintegration time, average free volume and wetting properties were evaluated. Caffeine containing gastroresistant pellets were gained by drug layering and filmcoating of inert microcrystalline cellulose pellet cores in fluid bed equipment. Shape, size, mechanical properties, drug content and dissolution profile of the coated pellets were determined. Batches of pellet containing tablets with three different pellet-filler ratios were compressed where partially spray-dried lactose was used as a filler-binder material. Characteristics of pellet containing tablets were evaluated before and after a 24 h long thermal treatment at 100 degrees C. Results shown that the poor initial mechanical properties (friability, tensile strength) were improved by thermal exposure while there were no remarkable alterations in drug release profiles. (C) 2015 Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - PAT AU - Sebe, István AU - Zelkó, Romána AU - Kállai-Szabó, Barnabás TI - Gyógyszerészeti és orvosi alkalmazású kontakt szálhúzó berendezés és eljárás polimer alapú, hatóanyag-tartalmú lapkák előállítására PY - 2015 UR - https://m2.mtmt.hu/api/publication/2962055 ID - 2962055 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Turmezeiné Horváth, Judit AU - Jávorszky, Eszter AU - Szabó, Eszter AU - Dredán, Judit AU - Kállai-Szabó, Barnabás AU - Zelkó, Romána TI - EFFECT OF STORAGE TEMPERATURE ON THE STABILITY OF TOTAL PARENTERAL NUTRITION ADMIXTURES PREPARED FOR INFANTS JF - ACTA POLONIAE PHARMACEUTICA: DRUG RESEARCH J2 - ACTA POL PHARM VL - 72 PY - 2015 IS - 5 SP - 843 EP - 849 PG - 7 SN - 0001-6837 UR - https://m2.mtmt.hu/api/publication/2941106 ID - 2941106 LA - English DB - MTMT ER - TY - JOUR AU - Sebe, István AU - Szabó, Péter AU - Kállai-Szabó, Barnabás AU - Zelkó, Romána TI - Incorporating small molecules or biologics into nanofibres for optimized drug release: A review JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 494 PY - 2015 IS - 1 SP - 516 EP - 530 PG - 15 SN - 0378-5173 DO - 10.1016/j.ijpharm.2015.08.054 UR - https://m2.mtmt.hu/api/publication/2930272 ID - 2930272 N1 - \n University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hogyes Endre Str. 7-9, Budapest, H-1092, Hungary \n Gedeon Richter Plc., Gyömroi Str. 19-21, Formulation RandD, Budapest, H-1103, Hungary \n Department of Pharmaceutics, Semmelweis University, Hogyes Endre Str. 9, Budapest, H-1092, Hungary \n Cited By :36 \n Export Date: 20 November 2018 \n CODEN: IJPHD \n Correspondence Address: Zelkó, R.; University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hogyes Endre Str. 7-9, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Péter AU - Sebe, István AU - Stiedl, B AU - Kállai-Szabó, Barnabás AU - Zelkó, Romána TI - Tracking of crystalline-amorphous transition of carvedilol in rotary spun microfibers and their formulation to orodispersible tablets for in vitro dissolution enhancement JF - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS J2 - J PHARMACEUT BIOMED ANAL VL - 115 PY - 2015 SP - 359 EP - 367 PG - 9 SN - 0731-7085 DO - 10.1016/j.jpba.2015.07.042 UR - https://m2.mtmt.hu/api/publication/2923067 ID - 2923067 N1 - Gedeon Richter Plc., Formulation R andD, Gyömroi Str. 19-21, Budapest, H-1103, Hungary University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hogyes Endre Str. 7-9, Budapest, H-1092, Hungary Department of Pharmaceutics, Semmelweis University, Hogyes Endre Str. 7, Budapest, H-1092, Hungary Cited By :15 Export Date: 11 May 2022 CODEN: JPBAD Correspondence Address: Zelkó, R.; University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hogyes Endre Str. 7-9, Hungary AB - Physicochemical characterization of microfibers including powder X-ray diffraction, differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, and positron annihilation spectroscopy were used to track the crystalline-amorphous transition of carvedilol during formulation and stability testing. The applied methods unanimously indicated the amorphous transition of carvedilol in the course of rotary spinning, furthermore a supramolecular ordering of chains of polymer matrix was revealed out by positron annihilation spectroscopy. The accelerated stability study (40 +/- 2 degrees C/75 +/- 5% RH, for 4 weeks) indicated a large stress tolerance capacity of fibers, since only a partial crystallization of the active compound was observable at the last sampling point. To demonstrate possible utilization of microfibers, orodispersible tablets containing 10 mg of carvedilol were successfully prepared by direct compression applying common tableting excipients. All of the investigated tablet parameters (hardness, friability, in vitro disintegration time) complied with the pharmacopoeial requirements. The performed dissolution (pH 1.0 and 6.8) study indicated that the drug dissolution from the microfiber based formula was rapid, complete and independent from the pH of the applied media, while the dissolution from the control tablets, containing crystalline carvedilol was incomplete and was strongly influenced by the pH of the applied media. (C) 2015 Elsevier B.V. All rights reserved. LA - English DB - MTMT ER -