@article{MTMT:32496864, title = {β-galactosidase Containing Innovative Drug Delivery System}, url = {https://m2.mtmt.hu/api/publication/32496864}, author = {Király, Márton and Sántha, Konrád and Kállai-Szabó, Barnabás and Kállai-Szabó, Nikolett and Antal, István and Ludányi, Krisztina}, doi = {10.33892/aph.2021.91.253-254}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {91}, unique-id = {32496864}, issn = {0001-6659}, year = {2021}, eissn = {1587-1495}, pages = {253-254}, orcid-numbers = {Király, Márton/0000-0002-9792-663X; Sántha, Konrád/0000-0002-1483-5784; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Antal, István/0000-0002-5434-201X; Ludányi, Krisztina/0000-0002-2380-9529} } @article{MTMT:31793659, title = {Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies}, url = {https://m2.mtmt.hu/api/publication/31793659}, author = {Sántha, Konrád and Kállai-Szabó, Nikolett and Fülöp, Viktor and Jakab, Géza and Gordon, Péter and Kállai-Szabó, Barnabás and Bertalanné Balogh, Emese and Antal, István}, doi = {10.1208/s12249-020-01902-x}, journal-iso = {AAPS PHARMSCITECH}, journal = {AAPS PHARMSCITECH}, volume = {22}, unique-id = {31793659}, issn = {1530-9932}, abstract = {Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets.}, year = {2021}, eissn = {1530-9932}, orcid-numbers = {Sántha, Konrád/0000-0002-1483-5784; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Fülöp, Viktor/0000-0002-6046-1955; Jakab, Géza/0000-0002-8103-774X; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Bertalanné Balogh, Emese/0000-0002-1127-3923; Antal, István/0000-0002-5434-201X} } @article{MTMT:3161341, title = {Physicochemical analysis in the evaluation of reconstituted dry emulsion tablets}, url = {https://m2.mtmt.hu/api/publication/3161341}, author = {Niczinger, Noémi and Kállai-Szabó, Barnabás and Lengyel, Miléna and Gordon, P and Klebovich, Imre and Antal, István}, doi = {10.1016/j.jpba.2016.11.031}, journal-iso = {J PHARMACEUT BIOMED ANAL}, journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS}, volume = {134}, unique-id = {3161341}, issn = {0731-7085}, abstract = {The aim of this study was to characterize the formation of emulsions by droplet size analysis and turbidimetry during reconstitution from a solid dosage form, namely from dry emulsion systems, which carry an oil phase for poorly soluble active ingredients. For the dry emulsion systems tablets were prepared either from oil-in-water systems using a freeze-drying process or through direct compression containing the same oil and excipients. The ratios of oil to emulgents and oil to xanthan gum were equal in both methods. In the preparation methods applied, mannitol, erythritol and lactose were used as excipients and mannitol was found to be the most effective excipient based on droplet size reconstitution, turbidimetry and physical properties. Quality control involved testing the physical properties of tablets and characterizing the reconstituted emulsions. © 2016 Elsevier B.V.}, keywords = {turbidimetry; olive oil; Contact angle; scanning microscopy; laser diffraction; Required HLB}, year = {2017}, eissn = {1873-264X}, pages = {86-93}, orcid-numbers = {Niczinger, Noémi/0000-0002-2076-0643; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Lengyel, Miléna/0000-0001-8865-054X; Klebovich, Imre/0000-0003-1672-5172; Antal, István/0000-0002-5434-201X} } @article{MTMT:3077675, title = {Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion}, url = {https://m2.mtmt.hu/api/publication/3077675}, author = {Démuth, Balázs and Farkas, Attila and Balogh, Attila and Bartosiewicz, Karolina and Kállai-Szabó, Barnabás and Bertels, Johny and Vigh, Tamás and Mensch, Jurgen and Verreck, Geert and Van, Assche Ivo and Marosi, György and Nagy, Zsombor Kristóf}, doi = {10.1016/j.xphs.2016.04.032}, journal-iso = {J PHARM SCI}, journal = {JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {105}, unique-id = {3077675}, issn = {0022-3549}, keywords = {CRYSTALLIZATION; DISSOLUTION; raman spectroscopy; amorphous; Nanotechnology; Oral drug delivery; Solid dispersion; Chemical stability; tableting}, year = {2016}, eissn = {1520-6017}, pages = {2982-2988}, orcid-numbers = {Farkas, Attila/0000-0002-8877-2587; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Marosi, György/0000-0002-4774-2023} } @article{MTMT:3072406, title = {Assessment of distribution of pellets in tablets by non-destructive microfocus X-ray imaging and image analysis technique}, url = {https://m2.mtmt.hu/api/publication/3072406}, author = {Csobán, Zsombor and Kállai-Szabó, Barnabás and Kállai-Szabó, Nikolett and Takács, Tamara and Hurtony, Tamás József and Gordon, Péter and Zelkó, Romána and Antal, István}, doi = {10.1016/j.powtec.2016.05.067}, journal-iso = {POWDER TECHNOL}, journal = {POWDER TECHNOLOGY}, volume = {301}, unique-id = {3072406}, issn = {0032-5910}, year = {2016}, eissn = {1873-328X}, pages = {228-233}, orcid-numbers = {Csobán, Zsombor/0000-0002-9376-5701; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Zelkó, Romána/0000-0002-5419-9137; Antal, István/0000-0002-5434-201X} } @article{MTMT:3026953, title = {Improvement of mechanical properties of pellet containing tablets by thermal treatment}, url = {https://m2.mtmt.hu/api/publication/3026953}, author = {Csobán, Zsombor and Kállai-Szabó, Barnabás and Kállai-Szabó, Nikolett and Sebe, István and Gordon, Péter and Antal, István}, doi = {10.1016/j.ijpharm.2015.10.040}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {496}, unique-id = {3026953}, issn = {0378-5173}, abstract = {Batches of partially spray-dried lactose tablets with three different initial tensile strength (similar to 20 N, similar to 35 N, similar to 50 N) were made. Changes along a 24 h long thermal treatment at 100 degrees C in tensile strength, friability, individual mass, water content, disintegration time, average free volume and wetting properties were evaluated. Caffeine containing gastroresistant pellets were gained by drug layering and filmcoating of inert microcrystalline cellulose pellet cores in fluid bed equipment. Shape, size, mechanical properties, drug content and dissolution profile of the coated pellets were determined. Batches of pellet containing tablets with three different pellet-filler ratios were compressed where partially spray-dried lactose was used as a filler-binder material. Characteristics of pellet containing tablets were evaluated before and after a 24 h long thermal treatment at 100 degrees C. Results shown that the poor initial mechanical properties (friability, tensile strength) were improved by thermal exposure while there were no remarkable alterations in drug release profiles. (C) 2015 Elsevier B.V. All rights reserved.}, year = {2015}, eissn = {1873-3476}, pages = {489-496}, orcid-numbers = {Csobán, Zsombor/0000-0002-9376-5701; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Sebe, István/0000-0003-0752-781X; Antal, István/0000-0002-5434-201X} } @{MTMT:2962055, title = {Gyógyszerészeti és orvosi alkalmazású kontakt szálhúzó berendezés és eljárás polimer alapú, hatóanyag-tartalmú lapkák előállítására}, url = {https://m2.mtmt.hu/api/publication/2962055}, author = {Sebe, István and Zelkó, Romána and Kállai-Szabó, Barnabás}, unique-id = {2962055}, year = {2015}, orcid-numbers = {Sebe, István/0000-0003-0752-781X; Zelkó, Romána/0000-0002-5419-9137; Kállai-Szabó, Barnabás/0000-0001-6259-4818} } @article{MTMT:2941106, title = {EFFECT OF STORAGE TEMPERATURE ON THE STABILITY OF TOTAL PARENTERAL NUTRITION ADMIXTURES PREPARED FOR INFANTS}, url = {https://m2.mtmt.hu/api/publication/2941106}, author = {Turmezeiné Horváth, Judit and Jávorszky, Eszter and Szabó, Eszter and Dredán, Judit and Kállai-Szabó, Barnabás and Zelkó, Romána}, journal-iso = {ACTA POL PHARM}, journal = {ACTA POLONIAE PHARMACEUTICA: DRUG RESEARCH}, volume = {72}, unique-id = {2941106}, issn = {0001-6837}, year = {2015}, eissn = {2353-5288}, pages = {843-849}, orcid-numbers = {Turmezeiné Horváth, Judit/0000-0002-1745-1081; Jávorszky, Eszter/0000-0002-7834-8854; Szabó, Eszter/0000-0003-4054-5032; Dredán, Judit/0000-0001-5278-8053; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Zelkó, Romána/0000-0002-5419-9137} } @article{MTMT:2930272, title = {Incorporating small molecules or biologics into nanofibres for optimized drug release: A review}, url = {https://m2.mtmt.hu/api/publication/2930272}, author = {Sebe, István and Szabó, Péter and Kállai-Szabó, Barnabás and Zelkó, Romána}, doi = {10.1016/j.ijpharm.2015.08.054}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {494}, unique-id = {2930272}, issn = {0378-5173}, year = {2015}, eissn = {1873-3476}, pages = {516-530}, orcid-numbers = {Sebe, István/0000-0003-0752-781X; Szabó, Péter/0000-0002-6791-1226; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Zelkó, Romána/0000-0002-5419-9137} } @article{MTMT:2923067, title = {Tracking of crystalline-amorphous transition of carvedilol in rotary spun microfibers and their formulation to orodispersible tablets for in vitro dissolution enhancement}, url = {https://m2.mtmt.hu/api/publication/2923067}, author = {Szabó, Péter and Sebe, István and Stiedl, B and Kállai-Szabó, Barnabás and Zelkó, Romána}, doi = {10.1016/j.jpba.2015.07.042}, journal-iso = {J PHARMACEUT BIOMED ANAL}, journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS}, volume = {115}, unique-id = {2923067}, issn = {0731-7085}, abstract = {Physicochemical characterization of microfibers including powder X-ray diffraction, differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, and positron annihilation spectroscopy were used to track the crystalline-amorphous transition of carvedilol during formulation and stability testing. The applied methods unanimously indicated the amorphous transition of carvedilol in the course of rotary spinning, furthermore a supramolecular ordering of chains of polymer matrix was revealed out by positron annihilation spectroscopy. The accelerated stability study (40 +/- 2 degrees C/75 +/- 5% RH, for 4 weeks) indicated a large stress tolerance capacity of fibers, since only a partial crystallization of the active compound was observable at the last sampling point. To demonstrate possible utilization of microfibers, orodispersible tablets containing 10 mg of carvedilol were successfully prepared by direct compression applying common tableting excipients. All of the investigated tablet parameters (hardness, friability, in vitro disintegration time) complied with the pharmacopoeial requirements. The performed dissolution (pH 1.0 and 6.8) study indicated that the drug dissolution from the microfiber based formula was rapid, complete and independent from the pH of the applied media, while the dissolution from the control tablets, containing crystalline carvedilol was incomplete and was strongly influenced by the pH of the applied media. (C) 2015 Elsevier B.V. All rights reserved.}, keywords = {Release; HEART-FAILURE; NANOFIBERS; POLYMER; Solubility; FTIR; BIOAVAILABILITY; Differential scanning calorimetry (DSC); Chemistry, Analytical; SOLID LIPID NANOPARTICLES; HOT-MELT EXTRUSION; X-ray diffractometry (XRD); Positron annihilation spectroscopy (PALS); Rotary-spun microfiber; PHARMACEUTICAL APPLICATIONS}, year = {2015}, eissn = {1873-264X}, pages = {359-367}, orcid-numbers = {Szabó, Péter/0000-0002-6791-1226; Sebe, István/0000-0003-0752-781X; Kállai-Szabó, Barnabás/0000-0001-6259-4818; Zelkó, Romána/0000-0002-5419-9137} }