TY - JOUR AU - Pallós, Péter AU - Gajdács, Márió AU - Zsoldiné Urbán, Edit AU - Szabados, Yvett AU - Szalai, Klaudia AU - Hevesi, Lívia AU - Horváth, Anna AU - Kuklis, Anna AU - Morjaria, Devina AU - Iffat, Wajiha AU - Hetta, Helal F. AU - Piredda, Nicola AU - Donadu, Matthew Gavino TI - Characterization of antibiotic and disinfectant susceptibility in biofilm-forming Acinetobacter baumannii: A focus on environmental isolates JF - EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY J2 - EUR J MICROBIOL IMMU PY - 2024 SN - 2062-509X DO - 10.1556/1886.2024.00014 UR - https://m2.mtmt.hu/api/publication/34721811 ID - 34721811 N1 - Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66., Szeged, 6720, Hungary Department of Medical Microbiology and Immunology, University of Pécs Medical School, Szigeti út 12, Pécs, 7624, Hungary Department of Pharmaceutics, Dow College of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Dow University of Health Sciences, OJHA Campus, Karachi, Pakistan Department of Natural Products and Alternative Medicine, Division of Microbiology and Immunology, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt Radiology Unit, Giovanni Paolo II Hospital, ASL Gallura, Olbia, 07026, Italy Hospital Pharmacy, Giovanni Paolo II Hospital, ASL Gallura, Olbia, 07026, Italy Department of Medicine, Surgery and Pharmacy, Scuola di Specializzazione in Farmacia Ospedaliera, University of Sassari, Sassari, 07100, Italy Export Date: 19 April 2024 Correspondence Address: Gajdács, M.; Department of Oral Biology and Experimental Dental Research, Tisza Lajos krt. 64-66., Hungary; email: mariopharma92@gmail.com Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, ÚNKP-23-1-SZTE-146 Funding text 1: A.K. was supported by the New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research Development and Innovation Fund (ÚNKP-23-1-SZTE-146). The authors are thankful for the support of the Study Group for Dental Research Methodology and Health Sciences, University of Szeged. AB - The clinical role of Acinetobacter baumannii has been highlighted in numerous infectious syndromes with a high mortality rate, due to the high prevalence of multidrug-resistant (MDR) isolates. The treatment and eradication of this pathogen is hindered by biofilm-formation, providing protection from noxious environmental factors and antimicrobials. The aim of this study was to assess the antibiotic susceptibility, antiseptic susceptibility and biofilm-forming capacity using phenotypic methods in environmental A. baumannii isolates. One hundred and fourteen ( n = 114) isolates were collected, originating from various environmental sources and geographical regions. Antimicrobial susceptibility testing was carried out using the disk diffusion method, while antiseptic susceptibility was performed using the agar dilution method. Determination of biofilm-forming capacity was carried out using a microtiter-plate based method. Resistance in environmental A. baumannii isolates were highest for ciprofloxacin (64.03%, n = 73), levofloxacin (62.18%, n = 71) and trimethoprim-sulfamethoxazole (61.40%, n = 70), while lowest for colistin (1.75%, n = 2). Efflux pump overexpression was seen in 48.25% of isolates ( n = 55), 49.12% ( n = 56) were classified as MDR. 6.14% ( n = 7), 9.65% ( n = 11), 24.65% ( n = 28) and 59.65% ( n = 68) of isolates were non-biofilm producers, weak, medium, and strong biofilm producers, respectively. No significant differences were observed between non-MDR vs. MDR isolates regarding their distribution of biofilm-producers ( P = 0.655). The MIC ranges for the tested antiseptics were as follows: benzalkonium chloride 16–128 μg mL −1 , chlorhexidine digluconate 4–128 μg mL −1 , formaldehyde 64–256 μg mL −1 and triclosan 2–16 μg mL −1 , respectively. The conscientious use of antiseptics, together with periodic surveillance, is essential to curb the spread of these bacteria, and to maintain current infection prevention capabilities. LA - English DB - MTMT ER - TY - GEN AU - Zsoldiné Urbán, Edit TI - Tendenciák a bakteriológiai körvizsgálatok eredményességében PY - 2024 UR - https://m2.mtmt.hu/api/publication/34574175 ID - 34574175 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bede, Olga AU - Sólyom, Enikő AU - Kosaras, Éva AU - Demeter, Botond AU - Vass, Klára AU - Adonyi, Mária AU - Székely, Györgyi AU - Terhes, Gabriella AU - Zsoldiné Urbán, Edit TI - A nem tuberculosis Mycobacterium abscessus complex jelentősége cystás fibrosisban JF - MUCOVISCIDOSIS HUNGARICA J2 - MUCOVISCIDOSIS HUNGARICA VL - 9 PY - 2023 IS - 2 SP - 681 EP - 695 PG - 15 SN - 2416-0695 UR - https://m2.mtmt.hu/api/publication/34542009 ID - 34542009 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Zsoldiné Urbán, Edit AU - Péter, Pallós AU - Adrienn, Márta AU - Matusovits, Danica AU - Kárpáti, Krisztina AU - Basem, Battah AU - Helal, F. Hetta AU - Ameer, Khusro AU - Dani, Dordevic AU - Ivan, Kushkevych TI - Phenotypic characteristics of environmental Pseudomonas aeruginosa: an in vitro study on epidemiological aspects JF - ACTA BIOLOGICA SZEGEDIENSIS J2 - ACTA BIOL SZEGED VL - 67 PY - 2023 IS - 1 SP - 35 EP - 44 PG - 10 SN - 1588-385X DO - 10.14232/abs.2023.1.35-44 UR - https://m2.mtmt.hu/api/publication/34500066 ID - 34500066 LA - English DB - MTMT ER - TY - JOUR AU - Polgár, Beáta AU - Zsoldiné Urbán, Edit TI - Új in vitro modell a hosszantartó Pseudomonas aeruginosa fertőzés vizsgálatára cystás fibrosisos betegek hörgőhámjában JF - MUCOVISCIDOSIS HUNGARICA J2 - MUCOVISCIDOSIS HUNGARICA VL - 9 PY - 2023 IS - 2 SP - 699 EP - 702 PG - 4 SN - 2416-0695 UR - https://m2.mtmt.hu/api/publication/34498282 ID - 34498282 LA - Hungarian DB - MTMT ER - TY - GEN AU - Zsoldiné Urbán, Edit TI - Fókuszban a bakteriális vaginosis – aktuális szakirodalmi kitekintés PY - 2023 UR - https://m2.mtmt.hu/api/publication/34498240 ID - 34498240 LA - Hungarian DB - MTMT ER - TY - GEN AU - Schneider-Patkó, Brigitta AU - Kovács, Krisztina AU - Zsoldiné Urbán, Edit AU - Lutz, Zsolt AU - Nyul, Adrienn AU - Fenyvesi, Hajnalka AU - Csontos, Csaba AU - Rauth, Erika AU - Sonnevend, Ágnes TI - Multirezisztens kórokozók szűrése egy egyetemi kórház központi intenzív osztályán PY - 2023 UR - https://m2.mtmt.hu/api/publication/34498239 ID - 34498239 LA - Hungarian DB - MTMT ER - TY - GEN AU - Meszéna, Réka AU - Schneider-Patkó, Brigitta AU - Halda-Kiss, Bernadett AU - Kovács, Krisztina AU - Zsoldiné Urbán, Edit AU - Lutz, Zsolt AU - Nyul, Adrienn AU - Fenyvesi, Hajnalka AU - Urbán, Péter AU - Gyenesei, Attila AU - Tóth, Ákos AU - Pál, Tibor AU - Sonnevend, Ágnes TI - NDM-5 termelő Escherichia coli ST361 megjelenése és terjedése Baranya vármegyében. PY - 2023 UR - https://m2.mtmt.hu/api/publication/34498236 ID - 34498236 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kövér, Zsanett AU - Bán, Ágnes AU - Gajdács, Márió AU - Polgár, Beáta AU - Zsoldiné Urbán, Edit TI - Role of Actinomyces spp. and related organisms in the development of medication-related osteonecrosis of the jaw (MRONJ): Clinical evidence based on a case series JF - EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY J2 - EUR J MICROBIOL IMMU VL - 13 PY - 2023 IS - 4 SP - 125 EP - 134 PG - 10 SN - 2062-509X DO - 10.1556/1886.2023.00041 UR - https://m2.mtmt.hu/api/publication/34413255 ID - 34413255 N1 - Department of Dentistry, Oral and Maxillofacial Surgery, Medical School, University of Pécs, Tüzér u. 1, Pécs, 7623, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64-66., Szeged, 6725, Hungary Department of Medical Microbiology and Immunology, Clinical Center, University of Pécs, Szigeti út 12., Pécs, 7624, Hungary Export Date: 3 January 2024 Correspondence Address: Urbán, E.; Department of Medical Microbiology and Immunology, Hungary; email: urban.edit@pte.hu AB - Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common consequence of antiresorptive treatment, which often leads to the development of necrotic exposed bone surfaces with inflammatory processes affecting the jawbone. Although the development of MRONJ is often associated with the inflammatory response or infections caused by the colonizing members of the oral microbiota, the exact pathogenesis of MRONJ is still not fully understood. In the present paper, we aimed to provide additional, microbiological culture-supported evidence, supporting the "infection hypothesis" that Actinomyces spp. and related organisms may play an important pathogenic role in the development of MRONJ and the resulting bone necrosis. In our case series, all patients presented with similar underlying conditions and anamnestic data, and have received antiresorptive medications (bisphosphonates or a RANK ligand (RANKL) inhibitor) to prevent the occurrence or progression of bone metastases, secondary to prostate cancer. Nevertheless, a few years into antiresorptive drug therapy, varying stages of MRONJ was identified in the mentioned patients. In all three cases, quantitative microbiological culture of the necrotic bone samples yielded a complex microbiota, dominated by Actinomyces and Schaalia spp. with high colony counts. Additionally, our followed-up case series document the treatment of these patients with a combination of surgical intervention and long-term antibiotic therapy, where favourable clinical responses were seen is all cases. If the "infection hypothesis" is valid, it may have significant consequences in the preventative and therapeutic strategies associated with this disease. LA - English DB - MTMT ER - TY - JOUR AU - Zsoldiné Urbán, Edit TI - A cystás fibrózisban szenvedő gyermekek indukált köpetmintavétellel nyert tüdőbiopsziája JF - MUCOVISCIDOSIS HUNGARICA J2 - MUCOVISCIDOSIS HUNGARICA VL - 9 PY - 2023 IS - 1 SP - 647 EP - 651 PG - 5 SN - 2416-0695 UR - https://m2.mtmt.hu/api/publication/34126238 ID - 34126238 LA - Hungarian DB - MTMT ER -