@article{MTMT:34110644,
	title = {Targeting Melanoma-Associated Fibroblasts (MAFs) with Activated γδ (Vδ2) T Cells: An In Vitro Cytotoxicity Model},
	url = {https://m2.mtmt.hu/api/publication/34110644},
	author = {Hajdara, Anna and Cakir, Ugur and Molnár-Érsek, Barbara and Silló, Pálma and Széky, Balázs and Barna, Gábor and Faqi, Shaaban and Gyöngy, Miklós and Kárpáti, Sarolta and Németh, Krisztián and Mayer, Balázs},
	doi = {10.3390/ijms241612893},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34110644},
	issn = {1661-6596},
	abstract = {The tumor microenvironment (TME) has gained considerable scientific attention by playing a role in immunosuppression and tumorigenesis. Besides tumor cells, TME is composed of various other cell types, including cancer-associated fibroblasts (CAFs or MAFs when referring to melanoma-derived CAFs) and tumor-infiltrating lymphocytes (TILs), a subpopulation of which is labeled as γδ T cells. Since the current anti-cancer therapies using γδ T cells in various cancers have exhibited mixed treatment responses, to better understand the γδ T cell biology in melanoma, our research group aimed to investigate whether activated γδ T cells are capable of killing MAFs. To answer this question, we set up an in vitro platform using freshly isolated Vδ2-type γδ T cells and cultured MAFs that were biobanked from our melanoma patients. This study proved that the addition of zoledronic acid (1–2.5 µM) to the γδ T cells was necessary to drive MAFs into apoptosis. The MAF cytotoxicity of γδ T cells was further enhanced by using the stimulatory clone 20.1 of anti-BTN3A1 antibody but was reduced when anti-TCR γδ or anti-BTN2A1 antibodies were used. Since the administration of zoledronic acid is safe and tolerable in humans, our results provide further data for future clinical studies on the treatment of melanoma.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Cakir, Ugur/0000-0001-8270-1430; Molnár-Érsek, Barbara/0000-0001-8627-9601; Silló, Pálma/0000-0002-6940-8368; Barna, Gábor/0000-0003-1960-5061; Kárpáti, Sarolta/0000-0002-8472-0712; Mayer, Balázs/0000-0003-3577-3823}
}

@mastersthesis{MTMT:34056982,
	title = {ISOLATION, CHARACTERIZATION AND FUNCTIONAL EXAMINATION OF MELANOMA ASSOCIATED FIBROBLASTS},
	url = {https://m2.mtmt.hu/api/publication/34056982},
	author = {Silló, Pálma},
	doi = {10.14753/SE.2022.2713},
	unique-id = {34056982},
	year = {2022},
	orcid-numbers = {Silló, Pálma/0000-0002-6940-8368}
}

@article{MTMT:32799889,
	title = {Szemészeti érintettséggel járó paraneoplasiás pemphigoid},
	url = {https://m2.mtmt.hu/api/publication/32799889},
	author = {Fodor, Eszter and Silló, Pálma and Lukács, Andrea and Kárpáti, Sarolta and Nagy, Zoltán Zsolt and Füst, Ágnes},
	doi = {10.1556/650.2022.32441},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {163},
	unique-id = {32799889},
	issn = {0030-6002},
	year = {2022},
	eissn = {1788-6120},
	pages = {720-725},
	orcid-numbers = {Fodor, Eszter/0000-0002-5789-571X; Silló, Pálma/0000-0002-6940-8368; Kárpáti, Sarolta/0000-0002-8472-0712; Nagy, Zoltán Zsolt/0000-0002-7330-0464; Füst, Ágnes/0000-0002-5725-4461}
}

@article{MTMT:32529964,
	title = {Mesenchymal-Stromal Cell-like Melanoma-Associated Fibroblasts Increase IL-10 Production by Macrophages in a Cyclooxygenase/Indoleamine 2,3-Dioxygenase-Dependent Manner},
	url = {https://m2.mtmt.hu/api/publication/32529964},
	author = {Cakir, Ugur and Hajdara, Anna and Széky, Balázs and Mayer, Balázs and Kárpáti, Sarolta and Mezey, Éva and Silló, Pálma and Szakács, Gergely and Füredi, András and Pós, Zoltán and Molnár-Érsek, Barbara and Sárdy, Miklós and Németh, Krisztián},
	doi = {10.3390/cancers13246173},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {13},
	unique-id = {32529964},
	year = {2021},
	eissn = {2072-6694},
	orcid-numbers = {Cakir, Ugur/0000-0001-8270-1430; Mayer, Balázs/0000-0003-3577-3823; Kárpáti, Sarolta/0000-0002-8472-0712; Mezey, Éva/0000-0002-5907-4691; Silló, Pálma/0000-0002-6940-8368; Szakács, Gergely/0000-0002-9311-7827; Füredi, András/0000-0002-7883-9901; Pós, Zoltán/0000-0002-2574-7616; Molnár-Érsek, Barbara/0000-0001-8627-9601; Sárdy, Miklós/0000-0003-4306-5093}
}

@article{MTMT:31270012,
	title = {Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity},
	url = {https://m2.mtmt.hu/api/publication/31270012},
	author = {Molnár-Érsek, Barbara and Silló, Pálma and Cakir, Ugur and Molnár, Viktor and Bencsik, András and Mayer, Balázs and Mezey, Eva and Kárpáti, Sarolta and Pós, Zoltán and Németh, Krisztián},
	doi = {10.1007/s00018-020-03517-8},
	journal-iso = {CELL MOL LIFE SCI},
	journal = {CELLULAR AND MOLECULAR LIFE SCIENCES},
	volume = {78},
	unique-id = {31270012},
	issn = {1420-682X},
	year = {2021},
	eissn = {1420-9071},
	pages = {661-673},
	orcid-numbers = {Molnár-Érsek, Barbara/0000-0001-8627-9601; Silló, Pálma/0000-0002-6940-8368; Cakir, Ugur/0000-0001-8270-1430; Molnár, Viktor/0000-0002-4156-9987; Bencsik, András/0000-0002-7859-3286; Mayer, Balázs/0000-0003-3577-3823; Kárpáti, Sarolta/0000-0002-8472-0712; Pós, Zoltán/0000-0002-2574-7616}
}

@article{MTMT:30433090,
	title = {Soluble mediators released by human melanoma-associated fibroblasts interfere with cytotoxic T cell response},
	url = {https://m2.mtmt.hu/api/publication/30433090},
	author = {Molnár-Érsek, Barbara and Silló, Pálma and Bencsik, András and Németh, Krisztián and Pós, Zoltán},
	doi = {10.1136/esmoopen-2018-EACR25.908},
	journal-iso = {ESMO OPEN},
	journal = {ESMO OPEN},
	volume = {3},
	unique-id = {30433090},
	issn = {2059-7029},
	year = {2018},
	eissn = {2059-7029},
	pages = {A384-A385},
	orcid-numbers = {Molnár-Érsek, Barbara/0000-0001-8627-9601; Silló, Pálma/0000-0002-6940-8368; Pós, Zoltán/0000-0002-2574-7616}
}

@article{MTMT:30336199,
	title = {Skin-homing CD8+ T cells preferentially express GPI-anchored peptidase inhibitor 16, an inhibitor of cathepsin K.},
	url = {https://m2.mtmt.hu/api/publication/30336199},
	author = {Lupsa, Nikolett and Molnár-Érsek, Barbara and Horváth, Andor and Bencsik, András and Lajkó, Eszter and Silló, Pálma and Oszvald, Ádám and Wiener, Zoltán and Reményi, Péter and Mikala, Gábor and Masszi, Tamás and Buzás, Edit Irén and Pós, Zoltán},
	doi = {10.1002/eji.201847552},
	journal-iso = {EUR J IMMUNOL},
	journal = {EUROPEAN JOURNAL OF IMMUNOLOGY},
	volume = {48},
	unique-id = {30336199},
	issn = {0014-2980},
	abstract = {This study sought to identify novel CD8+ T cell homing markers by studying acute graft versus host disease (aGvHD), typically involving increased T cell homing to the skin and gut. FACS-sorted skin-homing (CD8β+ /CLA+ ), gut-homing (CD8β+ /integrinβ7+ ), and reference (CD8β+ /CLA- /integrinβ7- ) T cells were compared in patients affected by cutaneous and/or gastrointestinal aGVHD. Microarray analysis, qPCR, and flow cytometry revealed increased expression of peptidase inhibitor 16 (PI16) in skin-homing CD8+ T cells. Robust association of PI16 with skin homing was confirmed in all types of aGvHD and in healthy controls, too. PI16 was not observed on CLA+ leukocytes other than T cells. Induction of PI16 expression on skin-homing T cells occurred independently of vitamin D3. Among skin-homing T cells, PI16 expression was most pronounced in memory-like CD45RO+ /CD127+ /CD25+ /CD69- /granzyme B- cells. PI16 was confined to the plasma membrane, was GPI-anchored, and was lost upon restimulation of memory CD8+ T cells. Loss of PI16 occurred by downregulation of PI16 transcription, and not by Phospholipase C (PLC)- or Angiotensin-converting enzyme (ACE)-mediated shedding, or by protein recycling. Inhibitor screening and pull-down experiments confirmed that PI16 inhibits cathepsin K, but may not bind to other skin proteases. These data link PI16 to skin-homing CD8+ T cells, and raise the possibility that PI16 may regulate cutaneous cathepsin K.},
	keywords = {SKIN; GVHD; homing; CD8+ T cell; PI16},
	year = {2018},
	eissn = {1521-4141},
	pages = {1944-1957},
	orcid-numbers = {Lupsa, Nikolett/0000-0003-1968-0619; Molnár-Érsek, Barbara/0000-0001-8627-9601; Bencsik, András/0000-0002-7859-3286; Lajkó, Eszter/0000-0002-4796-4646; Silló, Pálma/0000-0002-6940-8368; Oszvald, Ádám/0000-0002-1931-7345; Wiener, Zoltán/0000-0001-7056-4926; Reményi, Péter/0000-0003-3581-113X; Masszi, Tamás/0000-0003-2322-9863; Buzás, Edit Irén/0000-0002-3744-206X; Pós, Zoltán/0000-0002-2574-7616}
}

@article{MTMT:30477796,
	title = {Nanomechanical properties of collagen VII anchoring fibrils in recessive dystrophic epidermolysis bullosa patients},
	url = {https://m2.mtmt.hu/api/publication/30477796},
	author = {Mayer, Balázs and Silló, Pálma and Mazán, Mercédesz and Haluszka, Dóra and Kellermayer, Miklós and Kárpáti, Sarolta},
	doi = {10.1016/j.jid.2017.07.203},
	journal-iso = {J INVEST DERMATOL},
	journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
	volume = {137},
	unique-id = {30477796},
	issn = {0022-202X},
	year = {2017},
	eissn = {1523-1747},
	pages = {S228-S228},
	orcid-numbers = {Mayer, Balázs/0000-0003-3577-3823; Silló, Pálma/0000-0002-6940-8368; Haluszka, Dóra/0000-0003-3760-2016; Kellermayer, Miklós/0000-0002-5553-6553; Kárpáti, Sarolta/0000-0002-8472-0712}
}

@misc{MTMT:30433156,
	title = {CANCER ASSOCIATED FIBROBLAST-DERIVED SOLUBLE FACTORS SHAPE THE IMMUNOLOGICAL LANDSCAPE OF MALIGNANT MELANOMA},
	url = {https://m2.mtmt.hu/api/publication/30433156},
	author = {Molnár-Érsek, Barbara and Silló, Pálma and Bencsik, András and Pós, Zoltán and Németh, Krisztián},
	unique-id = {30433156},
	year = {2017},
	orcid-numbers = {Molnár-Érsek, Barbara/0000-0001-8627-9601; Silló, Pálma/0000-0002-6940-8368; Pós, Zoltán/0000-0002-2574-7616}
}

@misc{MTMT:30433127,
	title = {Regulation of the cytotoxic immune response by the presence of normal and melanoma-associated fibroblasts},
	url = {https://m2.mtmt.hu/api/publication/30433127},
	author = {Molnár-Érsek, Barbara and Silló, Pálma and Bencsik, András and Pós, Zoltán and Németh, Krisztián},
	unique-id = {30433127},
	year = {2017},
	orcid-numbers = {Molnár-Érsek, Barbara/0000-0001-8627-9601; Silló, Pálma/0000-0002-6940-8368; Pós, Zoltán/0000-0002-2574-7616}
}