@article{MTMT:34523817, title = {Tumour regression predicts better response to interferon therapy in melanoma patients. a retrospective single centre study.}, url = {https://m2.mtmt.hu/api/publication/34523817}, author = {Mezőlaki, Noémi and Baltás, Eszter and Ócsai, Henriette and Varga, Anita and Korom, Irma and Varga, Erika and Németh, István Balázs and Kis, Erika and Varga, János and Kocsis, Ádám László and Gyulai, Rolland Péter and Bukva, Mátyás and Kemény, Lajos and Oláh, Judit Magdolna}, doi = {10.1097/CMR.0000000000000935}, journal-iso = {MELANOMA RES}, journal = {MELANOMA RESEARCH}, volume = {34}, unique-id = {34523817}, issn = {0960-8931}, abstract = {We hypothesise that regression may have an impact on the effectiveness of adjuvant IFN therapy, based on its role in the host immune response. Our purpose is to investigate regression and ulceration as prognostic factors in case of interferon-alpha (IFN)-treated melanoma patients. We followed 357 IFN-treated melanoma patients retrospectively, investigating progression-free survival (PFS) and overall survival (OS) depending on the presence of ulceration and regression. A Kaplan-Meier analysis was performed, and we used a Cox regression analysis to relate risk factors. The survival function of the Cox regression was used to measure the effect of regression and ulceration on PFS and OS depending on the Breslow thickness (T1-T4) of the primary tumour. Regression was significantly positively related to PFS ( P = 0.0018, HR = 0.352) and OS ( P = 0.0112, HR = 0.380), while ulceration showed a negative effect (PFS: P = 0.0001, HR = 2.629; OS: P = 0.0003, HR = 2.388). They influence survival independently. The most favourable outcome was measured in the regressed/non-ulcerated group, whereas the worse was in the non-regressed/ulcerated one. Of risk factors, Breslow thickness is the most significant predictor. The efficacy of regression is regardless of Breslow thickness, though the more favourable the impact of regression was in the thicker primary lesions. Our results indicate that regression is associated with a more favourable outcome for IFN-treated melanoma patients, whereas ulceration shows an inverse relation. Further studies are needed to analyse the survival benefit of regression in relation to innovative immune checkpoint inhibitors.}, year = {2024}, eissn = {1473-5636}, pages = {54-62}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Gyulai, Rolland Péter/0000-0002-3286-8846; Bukva, Mátyás/0000-0002-5225-0285; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:34509121, title = {Survival Benefit of Stereotactic Radiotherapy in the Complex Management of Metastatic Melanoma}, url = {https://m2.mtmt.hu/api/publication/34509121}, author = {Kelemen, Gyöngyi and Együd, Zsófia and Dobi, Ágnes and Varga, Linda and Kószó, Renáta Lilla and Borzási, Emőke and Paczona, Viktor Róbert and Végváry, Zoltán and Borzák, Ferenc and Fodor, Emese and Ócsai, Henriette and Baltás, Eszter and Oláh, Judit Magdolna and Hideghéty, Katalin}, doi = {10.21873/anticanres.16803}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {44}, unique-id = {34509121}, issn = {0250-7005}, year = {2024}, eissn = {1791-7530}, pages = {205-212}, orcid-numbers = {Varga, Linda/0000-0003-4116-9497; Kószó, Renáta Lilla/0000-0002-1958-7839; Fodor, Emese/0009-0008-6961-6731; Baltás, Eszter/0000-0003-0357-7393; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:34513904, title = {Immun-kapcsolt polymyositis és thrombotikus komplikációk adjuváns pembrolizumab kezelés kapcsán}, url = {https://m2.mtmt.hu/api/publication/34513904}, author = {Ónodi-Nagy, Katinka and Csányi, Ildikó and Ócsai, Henriette and Belső, Nóra and Kemény, Lajos and Gyulai, Rolland Péter and Oláh, Judit Magdolna and Csörgő Sándorné Bata, Zsuzsanna and Baltás, Eszter}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {34513904}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {438}, orcid-numbers = {Csányi, Ildikó/0000-0002-0766-5289; Kemény, Lajos/0000-0002-2119-9501; Gyulai, Rolland Péter/0000-0002-3286-8846; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Baltás, Eszter/0000-0003-0357-7393} } @article{MTMT:34513890, title = {Sarcoid-like reakciók előfordulása metasztatikus melanoma miatt immunterápiával kezelt betegnél}, url = {https://m2.mtmt.hu/api/publication/34513890}, author = {Hánis, Csilla and Csányi, Ildikó and Ócsai, Henriette and Németh, István Balázs and Bende, Balázs and Besenyei, Zsuzsanna and Hideghéty, Katalin and Kemény, Lajos and Gyulai, Rolland Péter and Oláh, Judit Magdolna and Baltás, Eszter}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {34513890}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {438}, orcid-numbers = {Csányi, Ildikó/0000-0002-0766-5289; Hideghéty, Katalin/0000-0001-7080-2365; Kemény, Lajos/0000-0002-2119-9501; Gyulai, Rolland Péter/0000-0002-3286-8846; Baltás, Eszter/0000-0003-0357-7393} } @article{MTMT:34513594, title = {Metasztatikus melanomás betegek kórlefolyása az immunterápia leállítását követően: egycentrumos retrospektív vizsgálat}, url = {https://m2.mtmt.hu/api/publication/34513594}, author = {Csányi, Ildikó and Hánis, Csilla and Ócsai, Henriette and Kemény, Lajos and Gyulai, Rolland Péter and Oláh, Judit Magdolna and Baltás, Eszter}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {34513594}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {424}, orcid-numbers = {Csányi, Ildikó/0000-0002-0766-5289; Kemény, Lajos/0000-0002-2119-9501; Gyulai, Rolland Péter/0000-0002-3286-8846; Baltás, Eszter/0000-0003-0357-7393} } @{MTMT:34426094, title = {Impact of neoadjuvant FLOT treatment of advanced gastric and gastroesophageal junction cancer following surgical therapy}, url = {https://m2.mtmt.hu/api/publication/34426094}, author = {Paszt, Attila and Simonka, Zsolt and Budai, Krisztina and Horváth, Zoltán and Erdos, Marton and Vas, Márton Árpád and Ottlakán, Aurél and Nyári, Tibor András and Szepes, Zoltán and Uhercsák, Gabriella and Maráz, Anikó and Torday, László and Tiszlavicz, László and Oláh, Judit Magdolna and Lázár, György ifj}, booktitle = {Surgical and Oncological Updates in the Management of Gastric Cancer: the Role of Neoadjuvant Therapy and Minimally Invasive Surgery}, unique-id = {34426094}, year = {2023}, pages = {56-68}, orcid-numbers = {Paszt, Attila/0000-0002-1637-8652; Simonka, Zsolt/0000-0002-3490-226X; Horváth, Zoltán/0000-0002-9790-4975; Ottlakán, Aurél/0000-0002-7743-7775; Nyári, Tibor András/0000-0001-8900-6641; Szepes, Zoltán/0000-0002-9466-8719; Maráz, Anikó/0000-0002-2018-8413; Torday, László/0000-0002-2911-5499; Tiszlavicz, László/0000-0003-1134-6587; Lázár, György ifj/0000-0001-7155-2978} } @article{MTMT:34340896, title = {Immunszupprimált betegek multiplex bőrdaganatainak elektrokemoterápiás kezelése [Electrochemotherapy for multiple cutaneous tumors in immunosuppressed patients]}, url = {https://m2.mtmt.hu/api/publication/34340896}, author = {Rózsa, Petra and Ágoston, Dóra and Szederkényi, Edit and Ócsai, Henriette and Baltás, Eszter and Vass, Gábor and Kemény, Lajos and Oláh, Judit Magdolna and Kis, Erika}, doi = {10.1556/650.2023.32852}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {164}, unique-id = {34340896}, issn = {0030-6002}, abstract = {Introduction: The risk of cutaneous malignancies is significantly higher in immunosuppressed patients compared to the general population. These high-risk skin tumors tend to be aggressive, multiplex, rapidly growing lesions. It is common to see local recurrence after surgical excision. Multiplex tumors are difficult to treat, especially in the head/ neck region.Objective: Amongst the standard treatment options, electrochemotherapy can be a suitable option. Our aim was to evaluate the efficacy of electrochemotherapy in immunocompromised patients.Method: In 9 immunosuppressed patients, 118 (average: 13, n = 5-27) non-melanoma skin tumors were treated with electrochemotherapy with intravenous administration of bleomycin, according to the ESOPE criteria.Results: The median follow-up was 15 months. 6 months after the treatment, the objective response rate was 96%. We observed complete response in 88%, partial response in 8% and progressive disease in 2% of the treated lesions. In 2%, the response was not evaluable.Conclusion: In immunocompromised patients, electrochemotherapy is an effective and safe therapeutic option for non-melanoma skin tumors. In order to provide more ideal management for this special sub-group, prevention, multidisciplinary approach and optimized immunosuppressive therapy is essential.}, keywords = {ELECTROCHEMOTHERAPY; immunosuppressed patients; non-melanoma skin tumors}, year = {2023}, eissn = {1788-6120}, pages = {1462-1468}, orcid-numbers = {Szederkényi, Edit/0000-0002-3583-6874; Baltás, Eszter/0000-0003-0357-7393; Vass, Gábor/0000-0003-0787-8679; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:34093322, title = {Prostate-specific membrane antigen-based imaging for stereotactic irradiation of low-volume progressive prostate cancer: a single-center experience}, url = {https://m2.mtmt.hu/api/publication/34093322}, author = {Varga, Linda and Besenyi, Zsuzsanna and Paczona, Viktor Róbert and Farkas, István and Urbán, Szabolcs and Sipka, Gábor and Pávics, László and Varga, Zoltán and Fodor, Emese and Hideghéty, Katalin and Oláh, Judit Magdolna and Bajory, Zoltán and Maráz, Anikó}, doi = {10.3389/fonc.2023.1166665}, journal-iso = {FRONT ONCOL}, journal = {FRONTIERS IN ONCOLOGY}, volume = {13}, unique-id = {34093322}, issn = {2234-943X}, year = {2023}, eissn = {2234-943X}, orcid-numbers = {Varga, Linda/0000-0003-4116-9497; Besenyi, Zsuzsanna/0000-0001-9115-9620; Farkas, István/0000-0002-0270-7101; Urbán, Szabolcs/0000-0001-5463-6811; Sipka, Gábor/0000-0002-1259-0576; Pávics, László/0000-0002-7319-1667; Varga, Zoltán/0000-0001-8537-6282; Fodor, Emese/0009-0008-6961-6731; Hideghéty, Katalin/0000-0001-7080-2365; Bajory, Zoltán/0000-0003-3835-2549; Maráz, Anikó/0000-0002-2018-8413} } @article{MTMT:34035935, title = {Whole-Exome Sequencing Identified Two Novel Pathogenic Mutations in the PTCH1 Gene in BCNS}, url = {https://m2.mtmt.hu/api/publication/34035935}, author = {Pál, Margit and Vetró, Éva and Nagy, Nikoletta and Nagy, Dóra and Ferdinandyné Horváth, Emese and Bokor, Barbara Anna and Varga, Anita and Seres, László and Oláh, Judit Magdolna and Piffkó, József and Széll, Márta}, doi = {10.3390/cimb45070336}, journal-iso = {CURR ISSUES MOL BIOL}, journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY}, volume = {45}, unique-id = {34035935}, issn = {1467-3037}, abstract = {Basal cell nevus syndrome (BCNS, OMIM 109400) is a familial cancer syndrome characterized by the development of numerous basal cell cancers and various other developmental abnormalities, including epidermal cysts of the skin, calcified dural folds, keratocysts of the jaw, palmar and plantar pits, ovarian fibromas, medulloblastomas, lymphomesenteric cysts, and fetal rhabdomyomas. BCNS shows autosomal dominant inheritance and is caused by mutations in the patched 1 (PTCH1) gene and the suppressor of the fused homolog (SUFU) gene. In a few cases, variants of patched 2 (PTCH2) have been found in patients who met the criteria for BCNS. In an investigation of 11 Hungarian families who fulfilled the diagnostic criteria for BCNS, whole-exome sequencing (WES) and multiplex ligation-dependent probe amplification (MLPA) identified two novel pathogenic variants (c.2994C>A; p.Cys998Ter and c.814_818del; p.Asn272SerfsTer11), one recently identified variant (c.1737_1745del p.Val580_Val582del), and three recurrent disease-causing variants of the PTCH1 gene with a diagnosis rate of 63.6%. Disease-causing variants were not found for the SUFU and PTCH2 genes. These applied methods could not fully elucidate the genetic background of all the BCNS cases that we investigated. To uncover the missing heritability of BCNS, whole-genome sequencing or an epigenetic approach might be considered in the future.}, year = {2023}, eissn = {1467-3045}, pages = {5293-5304}, orcid-numbers = {Nagy, Nikoletta/0000-0001-8576-7953; Piffkó, József/0000-0001-7119-2685; Széll, Márta/0000-0002-0730-714X} } @article{MTMT:33929072, title = {Gyermekbőrgyógyászati kutatások a szegedi Bőrgyógyászati és Allergológiai Klinikán 2004-2023 között [Paediatric dermatological research at the Department of Dermatology and Allergology of the University of Szeged between 2004-2023]}, url = {https://m2.mtmt.hu/api/publication/33929072}, author = {Csoma, Zsanett and Ábrahám, Rita and Meszes, Angéla and Dalmády, Szandra and Tajti, Zsanett and Széll, Márta and Tálosi, Gyula and Szabó, Miklós and Orvos, Hajnalka and Oláh, Judit Magdolna and Tóth-Molnár, Edit}, doi = {10.7188/bvsz.2023.99.2.8}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33929072}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {133-138}, orcid-numbers = {Csoma, Zsanett/0000-0003-0376-9061; Meszes, Angéla/0000-0001-5386-3836; Dalmády, Szandra/0000-0001-7362-5640; Széll, Márta/0000-0002-0730-714X; Orvos, Hajnalka/0000-0001-9400-865X; Tóth-Molnár, Edit/0000-0001-7989-1616} }