@article{MTMT:33644822,
	title = {HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex},
	url = {https://m2.mtmt.hu/api/publication/33644822},
	author = {Szegedi, Viktor and Bakos , Emőke and Furdan, Szabina and H. Kovács, Bálint Barna and Varga, Dániel and Erdélyi, Miklós and Barzó, Pál and Szűcs, Attila and Tamás, Gábor and Lamsa, Karri},
	doi = {10.1371/journal.pbio.3002001},
	journal-iso = {PLOS BIOL},
	journal = {PLOS BIOLOGY},
	volume = {21},
	unique-id = {33644822},
	issn = {1544-9173},
	abstract = {Accumulating evidence indicates that there are substantial species differences in the properties of mammalian neurons, yet theories on circuit activity and information processing in the human brain are based heavily on results obtained from rodents and other experimental animals. This knowledge gap may be particularly important for understanding the neocortex, the brain area responsible for the most complex neuronal operations and showing the greatest evolutionary divergence. Here, we examined differences in the electrophysiological properties of human and mouse fast-spiking GABAergic basket cells, among the most abundant inhibitory interneurons in cortex. Analyses of membrane potential responses to current input, pharmacologically isolated somatic leak currents, isolated soma outside-out patch recordings, and immunohistochemical staining revealed that human neocortical basket cells abundantly express hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel isoforms HCN1 and HCN2 at the cell soma membrane, whereas these channels are sparse at the rodent basket cell soma membrane. Antagonist experiments showed that HCN channels in human neurons contribute to the resting membrane potential and cell excitability at the cell soma, accelerate somatic membrane potential kinetics, and shorten the lag between excitatory postsynaptic potentials and action potential generation. These effects are important because the soma of human fast-spiking neurons without HCN channels exhibit low persistent ion leak and slow membrane potential kinetics, compared with mouse fast-spiking neurons. HCN channels speed up human cell membrane potential kinetics and help attain an input–output rate close to that of rodent cells. Computational modeling demonstrated that HCN channel activity at the human fast-spiking cell soma membrane is sufficient to accelerate the input–output function as observed in cell recordings. Thus, human and mouse fast-spiking neurons exhibit functionally significant differences in ion channel composition at the cell soma membrane to set the speed and fidelity of their input–output function. These HCN channels ensure fast electrical reactivity of fast-spiking cells in human neocortex.},
	year = {2023},
	eissn = {1545-7885},
	orcid-numbers = {Szegedi, Viktor/0000-0003-4191-379X; Varga, Dániel/0000-0003-0391-5057; Erdélyi, Miklós/0000-0002-9501-5752; Barzó, Pál/0000-0001-8717-748X; Szűcs, Attila/0000-0001-9733-4135; Tamás, Gábor/0000-0002-7905-6001; Lamsa, Karri/0000-0002-4609-1337}
}

@article{MTMT:31341681,
	title = {Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc [Alzheimer risk factors age and female sex induce cortical A beta aggregation by raising extracellular zinc]},
	url = {https://m2.mtmt.hu/api/publication/31341681},
	author = {Datki, Zsolt László and Oláh, Zita and Jánosi-Mózes, Emese and Szegedi, Viktor and Kálmán, János and Hunya, Ákos and Fülöp, Lívia and Tamano, Haruna and Takeda, Atsushi and Adlard, Paul A. and Bush, Ashley I.},
	doi = {10.1038/s41380-020-0800-y},
	journal-iso = {MOL PSYCHIATR},
	journal = {MOLECULAR PSYCHIATRY},
	volume = {25},
	unique-id = {31341681},
	issn = {1359-4184},
	abstract = {Aging and female sex are the major risk factors for Alzheimer's disease and its associated brain amyloid-beta (A beta) neuropathology, but the mechanisms mediating these risk factors remain uncertain. Evidence indicates that A beta aggregation by Zn(2+)released from glutamatergic neurons contributes to amyloid neuropathology, so we tested whether aging and sex adversely influences this neurophysiology. Using acute hippocampal slices, we found that extracellular Zn2+-elevation induced by high K(+)stimulation was significantly greater with older (65 weeks vs 10 weeks old) rats, and was exaggerated in females. This was driven by slower reuptake of extracellular Zn2+, which could be recapitulated by mitochondrial intoxication. Zn2+:A beta aggregates were toxic to the slices, but A beta alone was not. Accordingly, high K(+)caused synthetic human A beta added to the slices to form soluble oligomers as detected by bis-ANS, attaching to neurons and inducing toxicity, with older slices being more vulnerable. Age-dependent energy failure impairing Zn(2+)reuptake, and a higher maximal capacity for Zn(2+)release by females, could contribute to age and sex being major risk factors for Alzheimer's disease.},
	year = {2020},
	eissn = {1476-5578},
	pages = {2728-2741},
	orcid-numbers = {Datki, Zsolt László/0000-0002-2537-4741; Oláh, Zita/0000-0002-6372-532X; Jánosi-Mózes, Emese/0000-0003-1532-289X; Szegedi, Viktor/0000-0003-4191-379X; Kálmán, János/0000-0001-5319-5639; Hunya, Ákos/0000-0002-4547-9284; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:31127691,
	title = {Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex},
	url = {https://m2.mtmt.hu/api/publication/31127691},
	author = {Szegedi, Viktor and Paizs, Melinda and Baka, Judith and Barzó, Pál and Molnár, Gábor and Tamás, Gábor and Lamsa, Karri},
	doi = {10.7554/eLife.51691},
	journal-iso = {ELIFE},
	journal = {ELIFE},
	volume = {9},
	unique-id = {31127691},
	issn = {2050-084X},
	abstract = {Inhibitory autapses are self-innervating synaptic connections in GABAergic interneurons in the brain. Autapses in neocortical layers have not been systematically investigated, and their function in different mammalian species and specific interneuron types is poorly known. We investigated GABAergic parvalbumin-expressing basket cells (pvBCs) in layer 2/3 (L2/3) in human neocortical tissue resected in deep-brain surgery, and in mice as control. Most pvBCs showed robust GABAAR-mediated self-innervation in both species, but autapses were rare in nonfast-spiking GABAergic interneurons. Light- and electron microscopy analyses revealed pvBC axons innervating their own soma and proximal dendrites. GABAergic self-inhibition conductance was similar in human and mouse pvBCs and comparable to that of synapses from pvBCs to other L2/3 neurons. Autaptic conductance prolonged somatic inhibition in pvBCs after a spike and inhibited repetitive firing. Perisomatic autaptic inhibition is common in both human and mouse pvBCs of supragranular neocortex, where they efficiently control discharge of the pvBCs.},
	year = {2020},
	eissn = {2050-084X},
	orcid-numbers = {Szegedi, Viktor/0000-0003-4191-379X; Baka, Judith/0000-0002-8803-0217; Barzó, Pál/0000-0001-8717-748X; Tamás, Gábor/0000-0002-7905-6001; Lamsa, Karri/0000-0002-4609-1337}
}

@CONFERENCE{MTMT:30445707,
	title = {Modelling Alzheimer's Disease with 3D Engineered Neuronal Tissue Derived from Induced Pluripotent Stem Cells. Poster at 16th Annual Conference of the Hungarian Neuroscience Society, Hungarian Academy of Sciences Debrecen, Magyarország 17-18 January 2019},
	url = {https://m2.mtmt.hu/api/publication/30445707},
	author = {Berki, D and Bellák, Tamás and Kobolák, Julianna and Téglási, A and Szegedi, Viktor and Lo Giudice, Maria and Bock, István and Molnár, Kinga and László, L and Dinnyés, András},
	booktitle = {16th Annual Conference of the Hungarian Neuroscience Society, Hungarian Academy of Sciences, Debrecen},
	unique-id = {30445707},
	year = {2019},
	orcid-numbers = {Kobolák, Julianna/0000-0002-0986-9517; Szegedi, Viktor/0000-0003-4191-379X; Molnár, Kinga/0000-0002-7196-5331}
}

@misc{MTMT:30876984,
	title = {3D Engineered Neural Tissue from Induced Pluripotent Stem Cells as a Tool for Modelling Diseases, Testing Drugs or Neurotoxicity. Poster at EU-ToxRisk General Assembly Egmond aan Zee, The Netherlands 19-23 February 2018},
	url = {https://m2.mtmt.hu/api/publication/30876984},
	author = {Kobolák, Julianna and Ochalek, Anna and Chandrasekaran, Abinaya and Bellák, Tamás and Téglási, A and Molnár, K and Schmidt, B and Szegedi, Viktor and Bock, István and László, L and Dinnyés, András},
	unique-id = {30876984},
	year = {2018},
	orcid-numbers = {Kobolák, Julianna/0000-0002-0986-9517; Szegedi, Viktor/0000-0003-4191-379X}
}

@article{MTMT:3344638,
	title = {Plasma phospholipid profiling of a mouse model of anxiety disorder by hydrophilic interaction liquid chromatography coupled to high-resolution mass spectrometry},
	url = {https://m2.mtmt.hu/api/publication/3344638},
	author = {Berkecz, Róbert and Körmöczi, Tímea and Tömösi, Ferenc and Szegedi, Viktor and Horváth, János and Nóra, Kovács and Janáky, Tamás},
	doi = {10.1002/bmc.4202},
	journal-iso = {BIOMED CHROMATOGR},
	journal = {BIOMEDICAL CHROMATOGRAPHY},
	volume = {32},
	unique-id = {3344638},
	issn = {0269-3879},
	year = {2018},
	eissn = {1099-0801},
	orcid-numbers = {Berkecz, Róbert/0000-0002-9076-2177; Körmöczi, Tímea/0000-0002-0973-2473; Tömösi, Ferenc/0000-0002-6657-5777; Szegedi, Viktor/0000-0003-4191-379X; Janáky, Tamás/0000-0002-6466-8283}
}

@article{MTMT:3292067,
	title = {Comprehensive phospholipid and sphingomyelin profiling of different brain regions in mouse model of anxiety disorder using online two-dimensional (HILIC/RP)-LC/MS method},
	url = {https://m2.mtmt.hu/api/publication/3292067},
	author = {Berkecz, Róbert and Tömösi, Ferenc and Körmöczi, Tímea and Szegedi, Viktor and Horváth, János and Janáky, Tamás},
	doi = {10.1016/j.jpba.2017.10.043},
	journal-iso = {J PHARMACEUT BIOMED ANAL},
	journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
	volume = {149},
	unique-id = {3292067},
	issn = {0731-7085},
	abstract = {A novel online system including two-dimensional liquid chromatography coupled to high-resolution mass spectrometry (2D-LC/MS) was developed and applied for comprehensive phospholipid (PL) and sphingomyelin (SM) profiling of dorsal hippocampus (DHPC), ventral (VHPC) and prefrontal cortex (PFC) brain regions in a mouse model of anxiety disorder. In the first dimension, lipid classes were distinguished by hydrophilic interaction liquid chromatography (HILIC), while the second dimensional separation of individual PL and SM species was achieved by reversed-phase (RP) chromatography. For the enrichment of lipid species in diluted HILIC effluent, two RP trapping columns were used separately. The developed fully-automated 2D method allowed the quantitative analysis of over 150 endogenous PL and SM species in mouse brain regions within 40min. The developed method was applied in a pilot study, which aimed to find alteration of PL and SM composition in a mouse model of anxiety disorder. In the case of 37 PL and SM species, significant differences were observed between high anxiety-related behavior (AX) and low anxiety-related behavior (nAX) mice. In mice having elevated anxiety, the most typical trend was the downregulation of PL species, in particular, in VHPC.},
	year = {2018},
	eissn = {1873-264X},
	pages = {308-317},
	orcid-numbers = {Berkecz, Róbert/0000-0002-9076-2177; Tömösi, Ferenc/0000-0002-6657-5777; Körmöczi, Tímea/0000-0002-0973-2473; Szegedi, Viktor/0000-0003-4191-379X; Janáky, Tamás/0000-0002-6466-8283}
}

@{MTMT:33699144,
	title = {Small peptide inhibitors of ß-amyloid toxicity},
	url = {https://m2.mtmt.hu/api/publication/33699144},
	author = {Fülöp, Lívia and Penke, Botond and Zarándi, Márta and Bozsó, Zsolt and Virók, Dezső and Janáky, Tamás and Verdier, Yann and Datki, Zsolt László and Szegedi, Viktor and Busa-Fekete, Róbert and Soós, Katalin and Kasza, Ágnes and Kocsor, András and Borbély, Emőke},
	unique-id = {33699144},
	year = {2017},
	orcid-numbers = {Fülöp, Lívia/0000-0002-8010-0129; Penke, Botond/0000-0003-0938-0567; Zarándi, Márta/0000-0002-2136-2946; Bozsó, Zsolt/0000-0002-5713-3096; Janáky, Tamás/0000-0002-6466-8283; Datki, Zsolt László/0000-0002-2537-4741; Szegedi, Viktor/0000-0003-4191-379X}
}

@{MTMT:3316518,
	title = {Three-dimensional Engineered Neural Tissues (ENTs) in Modelling Neurological Diseases. Lecture at First Annual Meeting, COST Action CA16119 CellFit, “In vitro 3D total cell guidance and fitness”},
	url = {https://m2.mtmt.hu/api/publication/3316518},
	author = {Táncos, Zs and Bellák, Tamás and Téglási, A and Ochalek, A and Chandrasekaran, A and Szegedi, Viktor and Kobolák, Julianna and Dinnyés, András},
	booktitle = {In vitro 3-D Total Cell Guidance and Fitness},
	unique-id = {3316518},
	year = {2017},
	pages = {88-88},
	orcid-numbers = {Szegedi, Viktor/0000-0003-4191-379X; Kobolák, Julianna/0000-0002-0986-9517}
}

@article{MTMT:3310819,
	title = {Studies for improving a rat model of Alzheimer's disease: ICV administration of well-characterized β-amyloid 1-42 oligomers induce dysfunction in spatial memory},
	url = {https://m2.mtmt.hu/api/publication/3310819},
	author = {Kasza, Ágnes and Penke, Botond and Frank, Z and Bozsó, Zsolt and Szegedi, Viktor and Hunya, Ákos and Nemeth, K and Kozma, Gábor and Fülöp, Lívia},
	doi = {10.3390/molecules22112007},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {22},
	unique-id = {3310819},
	issn = {1420-3049},
	year = {2017},
	eissn = {1420-3049},
	orcid-numbers = {Penke, Botond/0000-0003-0938-0567; Bozsó, Zsolt/0000-0002-5713-3096; Szegedi, Viktor/0000-0003-4191-379X; Hunya, Ákos/0000-0002-4547-9284; Kozma, Gábor/0000-0003-2033-0720; Fülöp, Lívia/0000-0002-8010-0129}
}