TY - CONF AU - Várkonyi, Ákos AU - Kupai, Krisztina AU - Várkonyi, Tamás AU - Tokodi, Margaréta ED - Fritz, P TI - A fel nem ismert hypoglykaemia gyakoriságának vizsgálata a sport szerepének tükrében T2 - IV. Leisure Tudományos Konferencia PB - Közép-Kelet-Európai Rekreációs Társaság C1 - Budapest SN - 9786156637185 PY - 2024 SP - 18 EP - 19 PG - 2 UR - https://m2.mtmt.hu/api/publication/34395722 ID - 34395722 LA - Hungarian DB - MTMT ER - TY - GEN AU - Kupai, Krisztina AU - Németh, T AU - Hausinger, Péter AU - Pósa, Anikó AU - Barzó, P AU - Valkusz, Zsuzsanna TI - Dezmopresszin szerepe sinus petrosus inferiorok szelektív katéterezése Cushing kórban: endokrinológiai és idegsebészeti kooperáció PY - 2023 UR - https://m2.mtmt.hu/api/publication/34132116 ID - 34132116 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Matusovits, Danica AU - Murlasits, Zsolt AU - Kupai, Krisztina AU - Baráth, Zoltán Lajos AU - Hsu, Linkang AU - Osváth, Péter AU - Szűcs, Miklós AU - Priksz, Dániel AU - Juhász, Béla AU - Radák, Zsolt AU - Várkonyi, Tamás AU - Pávó, Imre AU - Pósa, Anikó TI - Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium: Its Heme-Oxygenase Mediated Role in Cardiovascular Research JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 5 PG - 13 SN - 2076-3921 DO - 10.3390/antiox12051129 UR - https://m2.mtmt.hu/api/publication/33856409 ID - 33856409 N1 - Megosztott első szerzőség AB - (1) Background: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration and significantly reduces the occurrence of restenosis and target lesion revascularization. However, the cellular effects of paclitaxel in the myocardium are not well understood; (2) Methods: Wistar rats were divided into four groups: control (CTRL), isoproterenol (ISO) treated (1 mg/kg) and two groups treated with paclitaxel (PAC), which was administrated (10 mg/kg/day) for 5 days by gavage/per os alone or in combination (ISO + PAC) 3 weeks after ISO treatment. Ventricular tissue was harvested 24 h later for measurements of heme oxygenase (HO-1), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), NF-κB, TNF-α and myeloperoxidase (MPO); (3) Results: HO-1 protein concentration, HO-1 activity, SOD protein concentration and total glutathione significantly decreased in response to ISO treatment. When PAC was administered in conjunction with ISO, HO-1, SOD concentration and total glutathione were not different from control levels. MPO activity, NF-κB concentration and TNF-α protein concentration were significantly increased in the ISO-only group, while the levels of these molecules were restored when PAC was co-administered; (4) Conclusions: Oral administration of PAC can maintain the expression of important antioxidants, anti-inflammatory molecules, HO-1, SOD and GSH, and suppress the production of TNF-α, MPO and NF-κB, which are involved in myocardial damage. The principal component of this cellular defense seems to be the expression of HO-1. LA - English DB - MTMT ER - TY - JOUR AU - Bordács, Barbara Anikó AU - Kupai, Krisztina AU - Valkusz, Zsuzsanna AU - Jost, K AU - Várkonyi, Ákos AU - Nyiraty, Szabolcs AU - Lengyel, Csaba Attila AU - Kempler, Péter AU - Várkonyi, Tamás TI - A komplex metabolikus állapot lehetséges szerepének vizsgálata az autonóm idegrendszeri működészavar kialakulásában 1-es típusú diabéteszben [Assessment of the role of the complex metabolic control in the development of autonomic dysfunction in type 1 diabetic patients] JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 31 PY - 2023 IS - Suppl 1 SP - 6 EP - 7 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/33805049 ID - 33805049 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Murlasits, Zsolt AU - Kupai, Krisztina AU - Kneffel, Zsuzsanna TI - Role of physical activity and cardiorespiratory fitness in metabolically healthy obesity: a narrative review JF - BMJ OPEN SPORT & EXCERCISE MEDICINE J2 - BMJ OPEN SPORT EXCERC MED VL - 8 PY - 2022 IS - 4 PG - 7 SN - 2055-7647 DO - 10.1136/bmjsem-2022-001458 UR - https://m2.mtmt.hu/api/publication/33316600 ID - 33316600 N1 - Accepted November 23, 2022 First published December 5, 2022. Online issue publication December 05, 2022 AB - Obesity has been associated with a multitude of metabolic disorders, often clustering with risk factors of cardiovascular disease and type 2 diabetes mellitus, hypertension, dyslipidaemia. Overall, obesity is a worldwide, growing health concern. However, a subgroup of obese individuals with a low burden of metabolic abnormalities have been identified and described as metabolically healthy obese (MHO). Whether the MHO phenotype is protective against obesity-related metabolic disorders in the long-term is presently unclear, and current research examining the potential transition has yielded inconsistent results. In this current narrative review, we aim to provide insights on the role of physical activity (PA) and cardiorespiratory fitness (CRF) in MHO. Lifestyle factors such as PA and CRF may influence the MHO phenotype. Limited studies have characterised energy expenditure and CRF in MHO and metabolically unhealthy obese. However, higher levels of PA, less sedentary behaviour and higher CRF have been observed in MHO individuals. Considering the multiple benefits of PA, it is high time to advocate this lifestyle change beyond its influence on energy balance in a weight loss programme to improve cardiovascular and metabolic risk factors irrespective of body weight and fat mass changes. Improved CRF via increased PA, especially exercise participation, while avoiding weight gain is not only a realistic goal, but should be the primary intervention for MHO populations to prevent the transition to an abnormal metabolic state. LA - English DB - MTMT ER - TY - GEN AU - Török, Szilvia AU - Almási, Nikoletta AU - Baráth, D AU - Pósa, Anikó AU - Kupai, Krisztina AU - Varga, Csaba TI - Anti-inflammatory effect of hydrogen sulfide is mediated via the activation of Prdx6 in TNBS-induced rat colitis PY - 2022 UR - https://m2.mtmt.hu/api/publication/33116012 ID - 33116012 LA - English DB - MTMT ER - TY - GEN AU - Almási, Nikoletta AU - Török, Szilvia AU - Al-Awar, Amin AU - Veszelka, Médea AU - Baráth, D AU - Pósa, Anikó AU - Kupai, Krisztina AU - Varga, Csaba TI - The protective effect of voluntary exercise is mediated by the inhibition of NETosis and upregulation of Prdx6 in TNBS-induced rat colitis PY - 2022 UR - https://m2.mtmt.hu/api/publication/33116005 ID - 33116005 LA - English DB - MTMT ER - TY - JOUR AU - Kupai, Krisztina AU - Török, Szilvia AU - Várkonyi, Ákos AU - Csonka, Á AU - Almási, Nikoletta AU - Várkonyi, Tamás AU - Lengyel, Csaba Attila AU - Valkusz, Zsuzsanna AU - Pósa, Anikó AU - Varga, Csaba TI - Fehérjék poszttranszlációs módosításának szerepe 1-es típusú diabetes mellitusban [ Role of post-translational modifications of proteins in experimental type 1 diabetes] JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 30 PY - 2022 IS - Suppl. 2 SP - 62 EP - 63 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/33089323 ID - 33089323 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Várkonyi, Tamás AU - Nyiraty, Szabolcs AU - Tóth, Bettina AU - Pesei, F AU - Kupai, Krisztina AU - Vágvölgyi, Anna AU - Orosz, Andrea AU - Lengyel, Csaba Attila AU - Kempler, Péter TI - Autonomic and sensory neuropathy in typee 1 diabetic patients with different disease durations JF - DIABETES STOFFWECHSEL UND HERZ J2 - DIABETES STOFFWECH H VL - 31 PY - 2022 SP - 245 EP - 245 PG - 1 SN - 1861-7603 UR - https://m2.mtmt.hu/api/publication/33075619 ID - 33075619 LA - English DB - MTMT ER - TY - JOUR AU - Kupai, Krisztina AU - Várkonyi, Tamás AU - Török, Szilvia AU - Gáti, Viktória AU - Czimmerer, Zsolt AU - Puskás, László AU - Szebeni, Gábor TI - Recent Progress in the Diagnosis and Management of Type 2 Diabetes Mellitus in the Era of COVID-19 and Single Cell Multi-Omics Technologies JF - LIFE-BASEL J2 - LIFE-BASEL VL - 12 PY - 2022 IS - 8 SN - 2075-1729 DO - 10.3390/life12081205 UR - https://m2.mtmt.hu/api/publication/33056290 ID - 33056290 N1 - Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFI), Hungary [2020-1.1.6-JOVO-2021-00003, 2018-1.3.1-VKE-2018-00024]; Janos Bolyai Postdoctoral Research Scholarship of the Hungarian Academy of Sciences [BO/00683/21/5, BO/00582/22/8]; New National Excellence Program of the Ministry of Human Capacities [UNKP-21-5-SZTE-597] Funding text: This research was funded by the 2020-1.1.6-JOVO-2021-00003, and 2018-1.3.1-VKE-201800024 grants from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the Janos Bolyai Postdoctoral Research Scholarship of the Hungarian Academy of Sciences (BO/00683/21/5 for K.K. and BO/00582/22/8 for G.J.S.) and was also supported by the UNKP-21-5-SZTE-597 (K.K.) New National Excellence Program of the Ministry of Human Capacities. AB - Type 2 diabetes mellitus (T2DM) is one of the world’s leading causes of death and life-threatening conditions. Therefore, we review the complex vicious circle of causes responsible for T2DM and risk factors such as the western diet, obesity, genetic predisposition, environmental factors, and SARS-CoV-2 infection. The prevalence and economic burden of T2DM on societal and healthcare systems are dissected. Recent progress on the diagnosis and clinical management of T2DM, including both non-pharmacological and latest pharmacological treatment regimens, are summarized. The treatment of T2DM is becoming more complex as new medications are approved. This review is focused on the non-insulin treatments of T2DM to reach optimal therapy beyond glycemic management. We review experimental and clinical findings of SARS-CoV-2 risks that are attributable to T2DM patients. Finally, we shed light on the recent single-cell-based technologies and multi-omics approaches that have reached breakthroughs in the understanding of the pathomechanism of T2DM. LA - English DB - MTMT ER -