@article{MTMT:32650914,
	title = {The effect of non-invasive dermal electroporation on skin barrier function and skin permeation in combination with different dermal formulations},
	url = {https://m2.mtmt.hu/api/publication/32650914},
	author = {Kis, Nikolett and Kovács, Anita and Budai-Szűcs, Mária and Erős, Gábor and Csányi, Erzsébet and Berkó, Szilvia},
	doi = {10.1016/j.jddst.2022.103161},
	journal-iso = {J DRUG DELIV SCI TEC},
	journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY},
	volume = {69},
	unique-id = {32650914},
	issn = {1773-2247},
	year = {2022},
	eissn = {2588-8943},
	orcid-numbers = {Kovács, Anita/0000-0001-5593-1329; Budai-Szűcs, Mária/0000-0001-5187-5702; Csányi, Erzsébet/0000-0002-3010-1959; Berkó, Szilvia/0000-0002-3842-8876}
}

@article{MTMT:31338257,
	title = {A Randomized Controlled Trial with a Medical Device Containing Sodium Hyaluronate and Nicotinic Acid to Increase the Efficacy of Ultraviolet Phototherapy in Psoriasis},
	url = {https://m2.mtmt.hu/api/publication/31338257},
	author = {Bende, Balázs and Kui, Róbert and Németh, Annamária and Borsos, Mariann and Tóbiás, Zoltán and Erős, Gábor and Kemény, Lajos and Baltás, Eszter},
	doi = {10.1007/s13555-020-00385-9},
	journal-iso = {DERMATOLOGY THER},
	journal = {DERMATOLOGY AND THERAPY},
	volume = {10},
	unique-id = {31338257},
	issn = {2193-8210},
	abstract = {The dry and scaly skin of psoriatic patients decreases the efficacy of ultraviolet B (UVB) phototherapy. Different agents are used to facilitate the transmission of light, but most of these preparations are cosmetically unfavorable. We have tested a novel preparation containing sodium hyaluronate and nicotinic acid (UV Fotogel®; Pernix Ltd.) with the double aim to improve the efficacy of UVB phototherapy and assess the cosmetic acceptability of the preparation.Ninety patients with plaque psoriasis were enrolled in the study, of whom 44 received narrow-band UVB (NB-UVB) phototherapy. Prior to phototherapy, one side of the patient's body was treated with UV Fotogel while the other side served as a control. The other 46 patients used the preparation at their homes before regular sunbathing. The Local Psoriasis Severity Index (L-PSI), cosmetic acceptability and tolerability were recorded. The median values with the 25th and 75th percentiles (25p and 75p, respectively) were determined for the UV Fotogel-treated and control sites and then compared.The sides of the body to which UV Fotogel was applied prior to NB-UVB phototherapy had a significantly lower median L-PSI score than the non-treated control sides at the end of the treatment (1.0 [25p-75p: 0.0-2.0] vs. 2.0 [1.0-3.0], respectively). The application of UV Fotogel prior to sunbathing also led to a significant decrease in L-PSI score. There was a significant reduction in the median L-PSI score of patients at the final visit compared to baseline (2.5 [25p-75p: 1.5-3.5] vs. 6.0 [6.0-7.0], respectively). Use of the preparation was not accompanied by considerable adverse effects, and the patients found it cosmetically acceptable. Application of UV Fotogel prior to sunbathing was well tolerated by the patients, and the cosmetic acceptability was also good.UV Fotogel is potentially a useful device for enhancement of the efficacy of phototherapy in patients with psoriasis.},
	keywords = {psoriasis; phototherapy; Ultraviolet B; Optical cleaning},
	year = {2020},
	eissn = {2190-9172},
	pages = {651-662},
	orcid-numbers = {Kui, Róbert/0000-0002-9448-4573; Kemény, Lajos/0000-0002-2119-9501; Baltás, Eszter/0000-0003-0357-7393}
}

@article{MTMT:30634855,
	title = {Reconstruction of Alar-Perialar Defects with a Combined Subcutaneous and Cutaneous Pedicled Rotation-Advancement Nasolabial Flap},
	url = {https://m2.mtmt.hu/api/publication/30634855},
	author = {Mohos, Gábor and Kocsis, Ádám László and Erős, Gábor and Korponyai, Csilla and Varga, Ákos and Bende, Balázs and Varga, János},
	doi = {10.1080/08941939.2018.1538397},
	journal-iso = {J INVEST SURG},
	journal = {JOURNAL OF INVESTIGATIVE SURGERY},
	volume = {33},
	unique-id = {30634855},
	issn = {0894-1939},
	abstract = {During the reconstruction of alar defects involving the upper lip, reconstructive surgeons face the need for various thicknesses of tissues crucial to preserving the facial sulcus which is important for a cosmetically acceptable result. Our aim was to reconstruct the deep perialar and thinner lateral nasal alar defect in a single step procedure with a suitable flap which is reliable, has appropriate blood supply and provides an esthetically good result.Extended alar defect was reconstructed with a combined flap in 10 cases. During the procedure, a subcutaneous pedicle was created and the proximal part of the flap was rotated into the defect as a rotational flap. The procedure and the follow-up have been photo-documented in all cases. Furthermore, the perfusion of the flaps was monitored by means of laser Doppler flowmetry. Postoperative complications were evaluated with a semi-quantitative score and the patients completed a patient satisfaction questionnaire, too.An optimal esthetic result was obtained in all cases after the operation. The lateral nasal alar part of the defect was reconstructed with the thinner proximal part of the flap while the deeper perialar region involving the upper lip was covered with the thicker distal part. The flaps have shown sufficient blood flow after the operation. There was no significant pin cushioning or "trap-door" effect in any case. Mild erythema and edema was found in few cases. The patients were satisfied with the cosmetic result of the intervention.The flap is suitable for the reconstruction of alar defects involving the perialar region. It has the advantage of covering the deeper perialar and the thinner alar defects, whilst eliminating the pin cushioning effect of the conventional subcutaneous island pedicle flaps.},
	keywords = {skin defect; combined flap; cutaneous pedicle flap; perialar reconstruction; subcutaneous pedicle flap},
	year = {2020},
	eissn = {1521-0553},
	pages = {666-672}
}

@article{MTMT:30746292,
	title = {Efficacy and safety of long pulse 1064 and 2940 nm lasers in noninvasive lipolysis and skin tightening},
	url = {https://m2.mtmt.hu/api/publication/30746292},
	author = {Vas, Krisztina and Besenyi, Zsuzsanna and Urbán, Szabolcs and Badawi, Ashraf Mohamed and Pávics, László and Erős, Gábor and Kemény, Lajos},
	doi = {10.1002/jbio.201900083},
	journal-iso = {J BIOPHOTONICS},
	journal = {JOURNAL OF BIOPHOTONICS},
	volume = {12},
	unique-id = {30746292},
	issn = {1864-063X},
	abstract = {Noninvasive body shaping is becoming a growing demand. The aim of this study was to investigate the efficacy and safety of the combined treatments of 1064 nm Nd:YAG and 2940 nm Er:YAG in noninvasive lipolysis and skin tightening. Ten females were enrolled, and all women's side of the waist or the lower part of the abdomen were treated. In the first step, the 1064 nm Nd:YAG was used. As a second step, the 2940 nm Er:YAG laser was applied. Each woman was treated four times, once every 2 weeks. The effects were determined by comparative photo documentation, waist circumference measurement, two-dimensional B-mode ultrasonography and low-dose native computer tomography (CT), whereas body fat was monitored with bioelectric impedance. The tissue firmness was measured by ultrasound shear wave elastography. Combined laser treatment significantly reduced waist circumference and total body fat. Ultrasonography has revealed that the treatment considerably decreased fat thickness and improved skin stiffness in the treated region. Subcutaneous fat volume, measured by low-dose CT, displayed a moderate decrease in the waist region. The combined 1064 nm Nd:YAG and 2940 nm Er:YAG laser treatment results in the reduction of fat tissue and tightens the skin as confirmed by objective measurements.},
	keywords = {Nd:YAG laser; Er:YAG laser; fat reduction; skin stiffness},
	year = {2019},
	eissn = {1864-0648},
	orcid-numbers = {Besenyi, Zsuzsanna/0000-0001-9115-9620; Urbán, Szabolcs/0000-0001-5463-6811; Pávics, László/0000-0002-7319-1667; Kemény, Lajos/0000-0002-2119-9501}
}

@article{MTMT:30729349,
	title = {A nyiroködéma és a vénás lábszárfekélyek kóreredetének és kezelési lehetőségeinek legújabb vonatkozásai},
	url = {https://m2.mtmt.hu/api/publication/30729349},
	author = {Szolnoky, Győző and Erős, Gábor and Degovics, Döníz and Németh, István Balázs and Kui, Róbert and Paschali, Ekaterine and Vasas, Judit and Korom, Eszter and Varga, Mónika and Kemény, Lajos},
	doi = {10.7188/bvsz.2019.95.2.6},
	journal-iso = {BVSZ},
	journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE},
	volume = {95},
	unique-id = {30729349},
	issn = {0006-7768},
	year = {2019},
	eissn = {2064-261X},
	pages = {65-68},
	orcid-numbers = {Szolnoky, Győző/0000-0002-5391-4426; Kemény, Lajos/0000-0002-2119-9501}
}

@article{MTMT:30680175,
	title = {Protective effects of glycerol and xylitol in keratinocytes exposed to hyperosmotic stress},
	url = {https://m2.mtmt.hu/api/publication/30680175},
	author = {Szél, Edit and Danis, Judit and Sőrés, Evelin and Tóth, Dániel and Korponyai, Csilla and Degovics, Döníz and Prorok, János and Acsai, Károly and Dikstein, Shabtay and Kemény, Lajos and Erős, Gábor},
	doi = {10.2147/CCID.S197946},
	journal-iso = {CLIN COSMET INV DERM},
	journal = {CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY},
	volume = {12},
	unique-id = {30680175},
	issn = {1178-7015},
	year = {2019},
	eissn = {1178-7015},
	pages = {323-331},
	orcid-numbers = {Szél, Edit/0000-0001-9102-5542; Danis, Judit/0000-0002-0270-5309; Degovics, Döníz/0000-0001-8568-2992; Prorok, János/0000-0001-8419-8859; Dikstein, Shabtay/0000-0003-0261-464X; Kemény, Lajos/0000-0002-2119-9501}
}

@article{MTMT:30411986,
	title = {A novel target for the promotion of dermal wound healing. Ryanodine receptors.},
	url = {https://m2.mtmt.hu/api/publication/30411986},
	author = {Degovics, Döníz and Hartmann, Petra and Németh, István Balázs and Árva-Nagy, Noémi and Kaszonyi, Enikő and Szél, Edit and Strifler, Gerda and Bende, Balázs and Krenács, László and Kemény, Lajos and Erős, Gábor},
	doi = {10.1016/j.taap.2019.01.021},
	journal-iso = {TOXICOL APPL PHARM},
	journal = {TOXICOLOGY AND APPLIED PHARMACOLOGY},
	volume = {366},
	unique-id = {30411986},
	issn = {0041-008X},
	abstract = {Ryanodine receptors have an important role in the regulation of intracellular calcium levels in the nervous system and muscle. It has been described that ryanodine receptors influence keratinocyte differentiation and barrier homeostasis. Our goal was to examine the role of ryanodine receptors in the healing of full-thickness dermal wounds by means of in vitro and in vivo methods. The effect of ryanodine receptors on wound healing, microcirculation and inflammation was assessed in an in vivo mouse wound healing model, using skin fold chambers in the dorsal region, and in HaCaT cell scratch wound assay in vitro. SKH-1 mice were subjected to sterile saline (n = 36) or ryanodine receptor agonist 4-chloro-m-cresol (0.5 mM) (n = 42) or ryanodine receptor antagonist dantrolene (100 μM) (n = 42). Application of ryanodine receptor agonist 4-chloro-m-cresol did not influence the studied parameters significantly, whereas ryanodine receptor antagonist dantrolene accelerated the wound closure. Inhibition of the calcium channel also increased the vessel diameters in the wound edges during the process of healing and increased the blood flow in the capillaries at all times of measurement. Furthermore, application of dantrolene decreased xanthine-oxidoreductase activity during the inflammatory phase of wound healing. Inhibition of ryanodine receptor-mediated effects positively influence wound healing. Thus, dantrolene may be of therapeutic potential in the treatment of wounds.},
	keywords = {Wound healing; calcium channel; RYANODINE RECEPTOR; Skin fold chamber},
	year = {2019},
	eissn = {1096-0333},
	pages = {17-24},
	orcid-numbers = {Hartmann, Petra/0000-0002-4746-9792; Szél, Edit/0000-0001-9102-5542; Kemény, Lajos/0000-0002-2119-9501}
}

@article{MTMT:3347287,
	title = {A Possible Technique for the Complex Reconstruction of Exposed Breast Implant: Applicability and Microcirculation of the Capsule Flap},
	url = {https://m2.mtmt.hu/api/publication/3347287},
	author = {Varga, János and Mohos, Gábor and Varga, Ákos and Erős, Gábor and Bende, Balázs and Németh, István Balázs and Kocsis, Ádám László},
	doi = {10.1080/08941939.2018.1442532},
	journal-iso = {J INVEST SURG},
	journal = {JOURNAL OF INVESTIGATIVE SURGERY},
	volume = {32},
	unique-id = {3347287},
	issn = {0894-1939},
	abstract = {AIM OF THE STUDY: Immediate breast reconstruction is often applied after mastectomy. However, inappropriate surgical technique, postoperative radiotherapy and infection may lead to tissue necrosis and implant protrusion. Traditional therapies frequently fail. However, previous data suggested that capsule flaps may be appropriate for the salvage of implants. Our goal was to investigate the usefulness of capsuloplasty in patients with exposed breast implant and to monitor the blood supply of capsule flaps during the operation. MATERIALS AND METHODS: Capsuloplasty was performed in 19 patients with exposed implant. After removal of necrotic tissue, capsulotomy was performed, the planned flap was dissected free, the implant was covered with the flap and the wound was then closed. During operation, the blood flow of the flap was determined by means of laser Doppler flowmetry. Moreover, tissue samples were taken for histology and immunostaining for CD34. RESULTS: The postoperative follow-up showed that capsule flaps survived in each case: no complications were found. The blood flow of the flaps did not change significantly during the intervention as compared with the baseline values. The histology and the immunohistochemistry revealed considerable vascularization and angiogenesis in the flap. CONCLUSIONS: Capsule flaps seem to be appropriate for the salvage of exposed implants and for enhancement of implant cover in the case of thin and injured tissue.},
	year = {2019},
	eissn = {1521-0553},
	pages = {530-535}
}

@article{MTMT:3394721,
	title = {Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis},
	url = {https://m2.mtmt.hu/api/publication/3394721},
	author = {Hartmann, Petra and Butt, Edina and Feher, A and Szilágyi, Ágnes and Jász, Dávid Kurszán and Balázs, Boglárka and Bakonyi, Mónika and Berkó, Szilvia and Erős, Gábor and Boros, Mihály and Horváth, Gyöngyi and Varga, Endre and Csányi, Erzsébet},
	doi = {10.2147/DDDT.S161703},
	journal-iso = {DRUG DES DEV THER},
	journal = {DRUG DESIGN DEVELOPMENT AND THERAPY},
	volume = {12},
	unique-id = {3394721},
	issn = {1177-8881},
	abstract = {Purpose: Since electroporation (EP) can increase the permeability of biological membranes, we hypothesized that it offers an opportunity to enhance the transdermal delivery of drugs for intra-articular indications. Our aim was to compare the anti-inflammatory and analgesic efficacy of EP-combined topical administration of diclofenac sodium hydrogel (50 mg mL(-1) in 230 microL volume) with that of an equivalent dose of oral (75 mg kg(-1)) and simple topical administration. Methods: Arthritis was induced with the injection of 2% lambda-carrageenan and 4% kaolin into the right knee joints of male Sprague Dawley rats. EP was applied for 8 min with 900 V high-voltage pulses for 5 ms followed by a 20 ms break. Drug penetration into the synovial fluid and plasma was detected by high-performance liquid chromatography. Leukocyte-endothelial interactions were visualized by intravital videomicroscopy on the internal surface of the synovium. Inflammation-induced thermal and mechanical hyperalgesia reactions, knee joint edema, and inflammatory enzyme activities were assessed at 24 and 48 h after arthritis induction. Results: EP significantly increased the plasma level of diclofenac as compared with the topical controls 10 min after the 2% lambda-carrageenan and 4% kaolin injection. Increased leukocyte-endothelial interactions were accompanied by joint inflammation, which was significantly reduced by oral and EP diclofenac (by 45% and by 30%, respectively) and only slightly ameliorated by simple topical diclofenac treatment (by 18%). The arthritis-related secondary hyperalgesic reactions were significantly ameliorated by oral and EP-enhanced topical diclofenac treatments. The knee cross-section area (which increased by 35%) was also reduced with both approaches. However, simple topical application did not influence the development of joint edema and secondary hyperalgesia. Conclusion: The study provides evidence for the first time of the potent anti-inflammatory and analgesic effects of EP-enhanced topical diclofenac during arthritis. The therapeutic benefit provided by EP is comparable with that of oral diclofenac; EP is a useful alternative to conventional routes of administration.},
	year = {2018},
	pages = {1917-1930},
	orcid-numbers = {Hartmann, Petra/0000-0002-4746-9792; Jász, Dávid Kurszán/0000-0003-3700-5668; Bakonyi, Mónika/0000-0001-7845-7754; Berkó, Szilvia/0000-0002-3842-8876; Boros, Mihály/0000-0003-1410-1999; Horváth, Gyöngyi/0000-0002-6025-4577; Csányi, Erzsébet/0000-0002-3010-1959}
}

@article{MTMT:3300272,
	title = {Application of quality by design principles in the development and evaluation of semisolid drug carrier systems for the transdermal delivery of lidocaine},
	url = {https://m2.mtmt.hu/api/publication/3300272},
	author = {Bakonyi, Mónika and Berkó, Szilvia and Kovács, Anita and Budai-Szűcs, Mária and Kis, Nikolett and Erős, Gábor and Pannonhalminé Csóka, Ildikó and Csányi, Erzsébet},
	doi = {10.1016/j.jddst.2017.12.001},
	journal-iso = {J DRUG DELIV SCI TEC},
	journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY},
	volume = {44},
	unique-id = {3300272},
	issn = {1773-2247},
	year = {2018},
	eissn = {2588-8943},
	pages = {136-145},
	orcid-numbers = {Bakonyi, Mónika/0000-0001-7845-7754; Berkó, Szilvia/0000-0002-3842-8876; Kovács, Anita/0000-0001-5593-1329; Budai-Szűcs, Mária/0000-0001-5187-5702; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Csányi, Erzsébet/0000-0002-3010-1959}
}