@article{MTMT:35211531,
	title = {Study of phenanthrenes from their unique mass spectrometric behavior through quantum chemical calculations to liquid chromatographic quantitation},
	url = {https://m2.mtmt.hu/api/publication/35211531},
	author = {Körmöczi, Tímea and Barta, Anita and Bogár, Ferenc and Ali, Zahraa and Bús, Csaba and Hohmann, Judit and Domoki, Ferenc and Ilisz, István and Weiczner, Roland and Vasas, Andrea and Berkecz, Róbert},
	doi = {10.1016/j.talanta.2024.126799},
	journal-iso = {TALANTA},
	journal = {TALANTA},
	volume = {281},
	unique-id = {35211531},
	issn = {0039-9140},
	year = {2025},
	eissn = {1873-3573},
	orcid-numbers = {Körmöczi, Tímea/0000-0002-0973-2473; Bogár, Ferenc/0000-0002-0611-1452; Bús, Csaba/0000-0002-4515-8317; Hohmann, Judit/0000-0002-2887-6392; Domoki, Ferenc/0000-0002-5581-2167; Ilisz, István/0000-0001-8282-457X; Weiczner, Roland/0000-0002-5990-2661; Vasas, Andrea/0000-0002-1818-7702; Berkecz, Róbert/0000-0002-9076-2177}
}

@article{MTMT:35321478,
	title = {Euphane and Tirucallane Triterpenes with Trypanocidal Activity from Euphorbia desmondii},
	url = {https://m2.mtmt.hu/api/publication/35321478},
	author = {Saidu, Muhammad Bello and Krstić, Gordana and Barta, Anita and Hunyadi, Attila and Berkecz, Róbert and Gallah, Umar Shehu and Cholke, Kaushavi and Gertsch, Jürg and Rédei, Dóra and Hohmann, Judit},
	doi = {10.1021/acs.jnatprod.4c00730},
	journal-iso = {J NAT PROD},
	journal = {JOURNAL OF NATURAL PRODUCTS},
	unique-id = {35321478},
	issn = {0163-3864},
	year = {2024},
	eissn = {1520-6025},
	orcid-numbers = {Krstić, Gordana/0000-0001-6945-6178; Hunyadi, Attila/0000-0003-0074-3472; Berkecz, Róbert/0000-0002-9076-2177; Gertsch, Jürg/0000-0003-0978-1555; Rédei, Dóra/0000-0002-5013-247X; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:35201147,
	title = {Synthesis of Tumor Selective Indole and 8-Hydroxyquinoline Skeleton Containing Di-, or Triarylmethanes with Improved Cytotoxic Activity},
	url = {https://m2.mtmt.hu/api/publication/35201147},
	author = {Hegedűs, Dóra and Szemerédi, Nikoletta and Petrinca, Krisztina and Berkecz, Róbert and Spengler, Gabriella and Szatmári, István},
	doi = {10.3390/molecules29174176},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {29},
	unique-id = {35201147},
	issn = {1420-3049},
	abstract = {The reaction between glycine-type aminonaphthol derivatives substituted with 2- or 1-naphthol and indole or 7-azaindole has been tested. Starting from 2-naphthol as a precursor, the reaction led to the formation of ring-closed products, while in the case of a 1-naphthol-type precursor, the desired biaryl ester was isolated. The synthesis of a bifunctional precursor starting from 5-chloro-8-hydroxyquinoline, morpholine, and ethyl glyoxylate via modified Mannich reaction is reported. The formed Mannich base 10 was subjected to give bioconjugates with indole and 7-azaindole. The effect of the aldehyde component and the amine part of the Mannich base on the synthetic pathway was also investigated. In favor of having a preliminary overview of the structure-activity relationships, the derivatives have been tested on cancer and normal cell lines. In the case of bioconjugate 16, as the most powerful scaffold in the series bearing indole and a 5-chloro-8-hydroxyquinoline skeleton, a potent toxic activity against the resistant Colo320 colon adenocarcinoma cell line was observed. Furthermore, this derivative was selective towards cancer cell lines showing no toxicity on non-tumor fibroblast cells.},
	year = {2024},
	eissn = {1420-3049},
	orcid-numbers = {Berkecz, Róbert/0000-0002-9076-2177; Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229}
}

@CONFERENCE{MTMT:35182009,
	title = {Determination of Ex Vivo Pharmacokinetics of Diclofenac and its Main Phase I and II Metabolites by New Targeted UHPLC-MS/MS Method},
	url = {https://m2.mtmt.hu/api/publication/35182009},
	author = {Berkecz, Róbert and Samavati, Reza and Kovács, O and Weiczner, Roland and Ilisz, István and Gáspár, Róbert},
	booktitle = {Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024},
	unique-id = {35182009},
	year = {2024},
	pages = {215-215},
	orcid-numbers = {Berkecz, Róbert/0000-0002-9076-2177; Weiczner, Roland/0000-0002-5990-2661; Ilisz, István/0000-0001-8282-457X; Gáspár, Róbert/0000-0002-1571-7579}
}

@article{MTMT:35166968,
	title = {Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity},
	url = {https://m2.mtmt.hu/api/publication/35166968},
	author = {Barta, Anita and Salusso, Agostina and Kúsz, Norbert and Berkecz, Róbert and Schlauer, Jan and Purger, Dragica and Hohmann, Judit and Carpinella, Maria Cecilia and Vasas, Andrea},
	doi = {10.1021/acs.jnatprod.4c00577},
	journal-iso = {J NAT PROD},
	journal = {JOURNAL OF NATURAL PRODUCTS},
	volume = {87},
	unique-id = {35166968},
	issn = {0163-3864},
	year = {2024},
	eissn = {1520-6025},
	pages = {2068-2080},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Purger, Dragica/0000-0003-2480-0777; Hohmann, Judit/0000-0002-2887-6392; Carpinella, Maria Cecilia/0000-0001-5553-1851; Vasas, Andrea/0000-0002-1818-7702}
}

@article{MTMT:35156158,
	title = {Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant},
	url = {https://m2.mtmt.hu/api/publication/35156158},
	author = {Dávid, Csilla Zsuzsanna and Kúsz, Norbert and Agbadua, Orinamhe Godwin and Berkecz, Róbert and Kincses, Annamária and Spengler, Gabriella and Hunyadi, Attila and Hohmann, Judit and Vasas, Andrea},
	doi = {10.3390/molecules29143427},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {29},
	unique-id = {35156158},
	issn = {1420-3049},
	abstract = {Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points of view. The present study focused on the isolation, structure determination, and pharmacological investigation of constituents from Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, and phenylpropanoids, were identified from the methanol extract of the plant. Five of these compounds, namely, carexines A–E, are previously undescribed natural products. All compounds were isolated for the first time from C. praecox. The ACE-inhibitory activity of seven stilbenoid compounds was tested, and (–)-hopeaphenol proved to be the most active (IC50 7.7 ± 0.9 μM). The enzyme–kinetic studies revealed a mixed-type inhibition; therefore, domain-specific studies were also conducted. The in silico docking of (–)-hopeaphenol to the ACE affirmed some favorable interactions. In addition, the antiproliferative and antibacterial effects of some compounds were also evaluated.},
	year = {2024},
	eissn = {1420-3049},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702}
}

@CONFERENCE{MTMT:35150785,
	title = {French paradox},
	url = {https://m2.mtmt.hu/api/publication/35150785},
	author = {Agbadua, Orinamhe Godwin and Kúsz, Norbert and Berkecz, Róbert and Marton, András and Karancsi, Tamás and Gáti, Tamás and Tóth, Gábor and Balogh, György Tibor and Huber, Robin and Marcourt, Laurence and Wolfender, Jean-Luc and Queiroz, Emerson Ferreira and Hunyadi, Attila},
	booktitle = {5th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrpharmacognosy.2024.a3},
	unique-id = {35150785},
	year = {2024},
	pages = {8-9},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Balogh, György Tibor/0000-0001-8273-1760; Huber, Robin/0000-0001-9164-6584; Marcourt, Laurence/0000-0002-9614-1099; Wolfender, Jean-Luc/0000-0002-0125-952X; Queiroz, Emerson Ferreira/0000-0001-9567-1664; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:35131233,
	title = {Ortho-quinone methide driven synthesis of kynurenic acid lactams},
	url = {https://m2.mtmt.hu/api/publication/35131233},
	author = {Sárik, Julián Robin and Hetényi, Anasztázia and Berkecz, Róbert and Szatmári, István and Lőrinczi, Bálint},
	doi = {10.1039/D4RA04341C},
	journal-iso = {RSC ADV},
	journal = {RSC ADVANCES},
	volume = {14},
	unique-id = {35131233},
	issn = {2046-2069},
	abstract = {Lactam formation of different KYNA amides and Mannich bases mediated by ortho -quinone methide has been investigated.},
	year = {2024},
	eissn = {2046-2069},
	pages = {22123-22131},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Berkecz, Róbert/0000-0002-9076-2177; Szatmári, István/0000-0002-8571-5229; Lőrinczi, Bálint/0000-0001-7773-0034}
}

@article{MTMT:35089776,
	title = {New Members of the Centrapalus Coumarin and Pauciflorin Series from Centrapalus pauciflorus},
	url = {https://m2.mtmt.hu/api/publication/35089776},
	author = {Saidu, Muhammad Bello and Krstić, Gordana and Bombicz, Petra and De, Sourav and Barta, Anita and Ali, Hazhmat and Zupkó, István and Berkecz, Róbert and Gallah, Umar Shehu and Rédei, Dóra and Hohmann, Judit},
	doi = {10.3390/pharmaceutics16070907},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {35089776},
	issn = {1999-4923},
	abstract = {Monoterpene and 5-methylcoumarin- or 5-methylchromone-coupled meroterpenoids occurring mainly in the Asteraceae species proved to have high potency against protozoans, worms, and various tumor cells, which make them interesting targets for searching for new bioactive compounds. The African plant Centrapalus pauciflorus was applied in traditional medicine for healing chest pain and stomach aches. Three new meroterpenoids named centrapalus coumarin N (2), pauciflorins P (3), and Q (4), and the already known cyclohoehnelia coumarin (1), were isolated from the chloroform extract of C. pauciflorus, together with centrapalus coumarin O (5), which was obtained for the first time from a natural source. The structures were established from HRESIMS, 1D (1H NMR, 13C NMR JMOD) and 2D NMR (HSQC, HMBC, 1H-1H COSY, NOESY) spectroscopies, and the absolute stereochemistry of 5 was determined by single-crystal X-ray diffraction. Compounds 1, 2, and 5 are hybrid molecules of 5-methylcoumarin–monoterpene origin. Centrapalus coumarin N is the first example of meroterpenoids, where a monoterpene is fused with a coumarin and an acetophenone unit. Pauciflorins P and Q are dimeric meroterpenoid isomers. Centrapalus coumarins N and O were tested for antiproliferative activity against human adherent breast (MCF-7, MDA-MB-231), cervical (HeLa, SiHa), and ovarian (A2780) cancer cell lines, and were additionally included to obtain data concerning cancer selectivity. Both compounds exhibited moderate (IC50 > 10 µM) but selective activity against A2780 cells.},
	year = {2024},
	eissn = {1999-4923},
	orcid-numbers = {Krstić, Gordana/0000-0001-6945-6178; Bombicz, Petra/0000-0002-5509-1515; De, Sourav/0000-0003-3014-8084; Zupkó, István/0000-0003-3243-5300; Berkecz, Róbert/0000-0002-9076-2177; Rédei, Dóra/0000-0002-5013-247X; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:35078258,
	title = {Preparation of dearomatized p‐coumaric acid derivatives as DNA damage response inhibitors with potent in vitro antitumor effect},
	url = {https://m2.mtmt.hu/api/publication/35078258},
	author = {Fási, Laura and Gonda, Tímea and Crul-Tóth, Noémi and Vass, Máté and Gyovai, András and Nagy, Viktória and Ocsovszki, Imre and Zupkó, István and Kúsz, Norbert and Nové, Márta and Spengler, Gabriella and Berkecz, Róbert and Wang, Hui-Chun and Chang, Fang-Rong and Hunyadi, Attila},
	doi = {10.1002/cmdc.202300675},
	journal-iso = {CHEMMEDCHEM},
	journal = {CHEMMEDCHEM},
	unique-id = {35078258},
	issn = {1860-7179},
	abstract = {Our research group previously identified graviquinone (1) as a promising antitumor metabolite that is formed in situ when the antioxidant methyl caffeate scavenges free radicals. Furthermore, it exerted a DNA damaging effect on cancer cells and a DNA protective effect on normal keratinocytes. To expand and explore chemical space around qraviquinone, in the current work we synthesized 9 new alkyl‐substituted derivatives and tested their in vitro antitumor potential. All new compounds bypassed ABCB1‐mediated multidrug resistance and showed highly different cell line specificity compared with 1. All compounds were more potent in MDA‐MB‐231 than on MCF‐7 cells. The n‐butyl‐substituted derivatives 2 and 8 modulated the cell cycle and inhibited the ATR‐mediated phosphorylation of checkpoint kinase‐1 in MCF‐7 cells. As a significant expansion of our previous findings, our results highlight the potential antitumor value of alkyl‐substituted graviquinone derivatives.},
	year = {2024},
	eissn = {1860-7187},
	orcid-numbers = {Gyovai, András/0000-0003-2316-2160; Ocsovszki, Imre/0000-0003-1290-996X; Zupkó, István/0000-0003-3243-5300; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Berkecz, Róbert/0000-0002-9076-2177; Hunyadi, Attila/0000-0003-0074-3472}
}