TY - JOUR AU - Bahar, Muhammad Akbar AU - Kusuma, Ikhwan Yuda AU - Visnyovszki, Ádám AU - Matuz, Mária AU - Benkő, Ria AU - Ferenci, Tamás AU - Szabó, Bálint Gergely AU - Hajdú, Edit AU - Pető, Zoltán AU - Csupor, Dezső TI - Favipiravir does not improve viral clearance in mild to moderate COVID-19 – a systematic review and meta-analysis of randomized controlled trials JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 9 PG - 15 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e29808 UR - https://m2.mtmt.hu/api/publication/34796471 ID - 34796471 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Matuz, Mária AU - Benkő, Ria AU - Pető, Zoltán AU - Hajdú, Edit TI - Correlation between Stenotrophomonas maltophilia incidence and systemic antibiotic use: A 10-year retrospective, observational study in Hungary JF - EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY J2 - EUR J MICROBIOL IMMU PY - 2024 SN - 2062-509X DO - 10.1556/1886.2024.00022 UR - https://m2.mtmt.hu/api/publication/34721808 ID - 34721808 N1 - Export Date: 12 April 2024 Correspondence Address: Gajdács, M.; Department of Oral Biology and Experimental Dental Research, Tisza Lajos krt. 64-66, Hungary; email: mariopharma92@gmail.com Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: The authors are thankful for the support of the Study Group for Dental Research Methodology and Health Sciences, University of Szeged. Part of the study was presented at the 31st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. AB - Extensive use of carbapenems may lead to selection pressure for Stenotrophomonas maltophilia (SM) in hospital environments. The aim of our study was to assess the possible association between systemic antibiotic use and the incidence of SM. A retrospective, observational study was carried out in a tertiary-care hospital in Hungary, between January 1st 2010 and December 31st 2019. Incidence-density for SM and SM resistant to trimethoprim-sulfamethoxazole (SXT) was standardized for 1000 patient-days, while systemic antibiotic use was expressed as defined daily doses (DDDs) per 100 patient-days. Mean incidence density for SM infections was 0.42/1000 patient-days; 11.08% were were resistant to SXT, the mean incidence density for SXT-resistant SM was 0.047/1000 patient-days. Consumption rate for colistin, glycopeptides and carbapenems increased by 258.82, 278.94 and 372.72% from 2010 to 2019, respectively. Strong and significant positive correlations were observed with the consumption of carbapenems (r: 0.8759; P < 0.001 and r: 0.8968; P < 0.001), SXT (r: 0.7552; P = 0.011 and r: 0.7004; P = 0.024), and glycopeptides (r: 0.7542; P = 0.012 and r: 0.8138; P < 0.001) with SM and SXT-resistant SM incidence-density/1000 patient-days, respectively. Implementation of institutional carbapenem-sparing strategies are critical in preserving these life-saving drugs, and may affect the microbial spectrum of infections in clinical settings. LA - English DB - MTMT ER - TY - JOUR AU - Hites, Maya AU - Massonnaud, Clément R AU - Jamard, Simon AU - Goehringer, François AU - Danion, François AU - Reignier, Jean AU - de Castro, Nathalie AU - Garot, Denis AU - Lapique, Eva Larranaga AU - Lacombe, Karine AU - Tolsma, Violaine AU - Faure, Emmanuel AU - Malvy, Denis AU - Staub, Thérèse AU - Courjon, Johan AU - Cazenave-Roblot, France AU - Riise, Anne Ma Dyrhol AU - Leturnier, Paul AU - Martin-Blondel, Guillaume AU - Roger, Claire AU - Akinosoglou, Karolina AU - Moing, Vincent Le AU - Piroth, Lionel AU - Sellier, Pierre AU - Lescure, Xavier AU - Trøseid, Marius AU - Clevenbergh, Philippe AU - Dalgard, Olav AU - Gallien, Sébastien AU - Gousseff, Marie AU - Loubet, Paul AU - Vardon-Bounes, Fanny AU - Visée, Clotilde AU - Belkhir, Leila AU - Botelho-Nevers, Élisabeth AU - Cabié, André AU - Kotanidou, Anastasia AU - Lanternier, Fanny AU - Rouveix-Nordon, Elisabeth AU - Silva, Susana AU - Thiery, Guillaume AU - Poignard, Pascal AU - Carcelain, Guislaine AU - Diallo, Alpha AU - Mercier, Noémie AU - Terzic, Vida AU - Bouscambert-Duchamp, Maude AU - Gaymard, Alexandre AU - Trabaud, Mary-Anne AU - Destras, Grégory AU - Josset, Laurence AU - Belhadi, Drifa AU - Billard, Nicolas AU - Guedj, Jérémie AU - Han, Thi-Hong-Lien AU - Couffin-Cadiergues, Sandrine AU - Dechanet, Aline AU - Delmas, Christelle AU - Esperou, Hélène AU - Fougerou-Leurent, Claire AU - Mestre, Soizic Le AU - Métois, Anabelle AU - Noret, Marion AU - Bally, Isabelle AU - Dergan-Dylon, Sebastián AU - Tubiana, Sarah AU - Kalif, Ouifiya AU - Bergaud, Nathalie AU - Leveau, Benjamin AU - Eustace, Joe AU - Greil, Richard AU - Hajdú, Edit AU - Halanova, Monika AU - Paiva, Jose-Artur AU - Piekarska, Anna AU - Baño, Jesus Rodriguez AU - Tonby, Kristian AU - Trojánek, Milan AU - Tsiodras, Sotirios AU - Unal, Serhat AU - Burdet, Charles AU - Costagliola, Dominique AU - Yazdanpanah, Yazdan AU - Peiffer-Smadja, Nathan AU - Mentré, France AU - Ader, Florence TI - Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy). a phase 3, randomized, double-blind, placebo-controlled trial. TS - a phase 3, randomized, double-blind, placebo-controlled trial. JF - JOURNAL OF INFECTION J2 - J INFECTION VL - 88 PY - 2024 IS - 3 PG - 7 SN - 0163-4453 DO - 10.1016/j.jinf.2024.106120 UR - https://m2.mtmt.hu/api/publication/34657209 ID - 34657209 LA - English DB - MTMT ER - TY - JOUR AU - Ruzsa, Roxána AU - Benkő, Ria AU - Hambalek, Helga AU - Papfalvi, Erika Piroska AU - Csupor, Dezső AU - Nacsa, Róbert AU - Csatordai, Márta AU - Soós, Gyöngyvér AU - Hajdú, Edit AU - Matuz, Mária TI - Hospital Antibiotic Consumption before and during the COVID-19 Pandemic in Hungary JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 13 PY - 2024 IS - 1 PG - 11 SN - 2079-6382 DO - 10.3390/antibiotics13010102 UR - https://m2.mtmt.hu/api/publication/34532941 ID - 34532941 N1 - Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, 6725, Hungary University Pharmacy Albert Szent-Györgyi Health Center, University of Szeged, Szeged, 6725, Hungary Department of Emergency Medicine, Albert Szent-Györgyi Health Center, University of Szeged, Szeged, 6725, Hungary Institute of Translational Medicine, Medical School, University of Pécs, Pécs, 7624, Hungary Department of Internal Medicine Infectiology Unit, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, 6725, Hungary Export Date: 6 February 2024 Correspondence Address: Ruzsa, R.; Institute of Clinical Pharmacy, Hungary; email: roxana.ruzsa@med.u-szeged.hu Correspondence Address: Matuz, M.; Institute of Clinical Pharmacy, Hungary; email: matuz.maria@szte.hu AB - The aim of this study was to assess antibiotic use in the Hungarian hospital care sector during and before the pandemic. Aggregated systemic antibiotic (ATC: J01) utilisation data were obtained for the 2010–2021 period. Classifications and calculations were performed according to the WHO ATC/DDD index and expressed as DDD per 1000 inhabitants and per day (DID), DDD per 100 patient-days (DHPD) and DDD/discharge. A linear regression (trend analysis) was performed for the pre-COVID years (2010–2019) and a prediction interval was set up to assess whether the pandemic years’ observed utilisation fit in. Antibiotic utilisation was constant in DID before and during the pandemic (2019: 1.16; 2020: 1.21), while we observed a substantial increase in antibiotic use when expressed in DDD per 100 patient-days (2019: 23.3, 2020: 32.2) or DDD/discharge (2019: 1.83, 2020: 2.45). The observed utilisation level of penicillin combinations; first-, third- and fourth-generation cephalosporins; carbapenems; glycopeptides; nitroimidazoles and macrolides exceeded the predicted utilisation values in both pandemic years. Before the pandemic, co-amoxiclav headed the top list of antibiotic use, while during the pandemic, ceftriaxone became the most widely used antibiotic. Azithromycin moved up substantially on the top list of antibiotic use, with a 397% increase (2019: 0.45; 2020: 2.24 DHPD) in use. In summary, the pandemic had a major impact on the scale and pattern of hospital antibiotic use in Hungary. LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Benkő, Ria AU - Matuz, Mária AU - Bodó, Gabriella AU - Pető, Zoltán AU - Hajdú, Edit TI - Stenotrophomonas maltophilia epidemiológiája és az antibiotikum-fogyasztás közötti összefüggések: 10-éves korrelációs vizsgálat T2 - XV. Fiatal Higiénikusok Fóruma: Program és összefoglalók PB - Magyar Higiénikusok Társasága PY - 2023 SP - 12 EP - 12 PG - 1 UR - https://m2.mtmt.hu/api/publication/34500723 ID - 34500723 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ruzsa, Roxána AU - Benkő, Ria AU - Hambalek, Helga AU - Csupor, Dezső AU - Csatordai, Márta AU - Soós, Gyöngyvér AU - Papfalvi, Erika Piroska AU - Kusuma, Ikhwan Yuda AU - Hajdú, Edit AU - Matuz, Mária TI - Kórházi antibiotikum alkalmazás kórházakban: volt COVID hatás hazánkban? [Hospital care antibiotic use in hungary: was there a COVID effect?] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 93 PY - 2023 IS - S1 SP - S69 EP - S70 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/34398415 ID - 34398415 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hambalek, Helga AU - Varga, Erika AU - Csoma, Zsanett AU - Szolnoky, Győző AU - Szadai, Leticia AU - Honfi, Vivien AU - Soós, Gyöngyvér AU - Hajdú, Edit AU - Matuz, Mária AU - Benkő, Ria TI - Súlyos disszeminált acanthamoeba fertőzés: esettanulmány a klinikai gyógyszerész szemével [Severe disseminated acanthamoeba infection: case study from a clinical pharmacist viewpoint] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 93 PY - 2023 IS - Suppl 1 SP - S48 EP - S49 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/34398369 ID - 34398369 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hambalek, Helga AU - Matuz, Mária AU - Ruzsa, Roxána AU - Engi, Zsófia AU - Csupor, Dezső AU - Doró, Péter AU - Soós, Gyöngyvér AU - Visnyovszki, Ádám AU - Hajdú, Edit AU - Benkő, Ria TI - Ambuláns antibiotikum alkalmazás: volt – e a pandémiának hatása? [Ambulatory care antibiotic use in Hungary: was there a pandemic effect?] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 93 PY - 2023 IS - Suppl 1 SP - S47 EP - S48 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/34398357 ID - 34398357 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Benkő, Ria AU - Papfalvi, Erika Piroska AU - Nacsa, Róbert AU - Matuz, Mária AU - Ruzsa, Roxána AU - Hambalek, Helga AU - Hajdú, Edit AU - Pető, Zoltán AU - Erdélyi, Péter AU - Soós, Gyöngyvér TI - Antibiotikum stewardship a sürgősségi osztályon [Antibiotic stewardship in the emergency department] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 93 PY - 2023 IS - S1 SP - S34 EP - S35 PG - 2 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/34392952 ID - 34392952 LA - Hungarian DB - MTMT ER - TY - CONF AU - Dudás, Gábor AU - Orosz, László AU - Matuz, Mária AU - Benkő, Ria AU - Hajdú, Edit AU - Visnyovszki, Ádám TI - Retrospektív 5 éves vizsgálat: a húgyúti szepszist okozó multirezisztens baktériumok előfordulása és trendje T2 - A Magyar Infektológiai és Klinikai Mikrobiológiai Társaság 50. kongresszusa PY - 2023 SP - 53 EP - 53 PG - 1 UR - https://m2.mtmt.hu/api/publication/34194554 ID - 34194554 LA - Hungarian DB - MTMT ER -