TY - JOUR AU - Visnovitz, Tamás AU - Lenzinger, Dorina AU - Koncz, Anna AU - Vizi, Péter Márk AU - Bárkai, Tünde AU - Visnovitzné Dr Vukman, Krisztina AU - Galinsoga, Alicia AU - Németh, Krisztina AU - Fletcher, Kelsey Aine AU - Komlósi, Zsolt AU - Cserép, Csaba AU - Dénes, Ádám AU - Lőrincz, Péter AU - Valcz, Gábor AU - Buzás, Edit Irén TI - A “torn bag mechanism” of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) JF - ELIFE J2 - ELIFE VL - 13 PY - 2025 PG - 19 SN - 2050-084X DO - 10.7554/eLife.95828.3 UR - https://m2.mtmt.hu/api/publication/34720930 ID - 34720930 AB - Recent studies showed an unexpected complexity of extracellular vesicle (EV) biogenesis pathways. We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc. Here, we tested whether this large EV type is unique to colorectal cancer cells. We found that all cell types we studied (including different cell lines and cells in their original tissue environment) released multivesicular large EVs (MV-lEVs). We also demonstrated that upon spontaneous rupture of the limiting membrane of the MV-lEVs, their intraluminal vesicles (ILVs) escaped to the extracellular environment by a ‘torn bag mechanism’. We proved that the MV-lEVs were released by ectocytosis of amphisomes (hence, we termed them amphiectosomes). Both ILVs of amphiectosomes and small EVs separated from conditioned media were either exclusively CD63 or LC3B positive. According to our model, upon fusion of multivesicular bodies with autophagosomes, fragments of the autophagosomal inner membrane curl up to form LC3B positive ILVs of amphisomes, while CD63 positive small EVs are of multivesicular body origin. Our data suggest a novel common release mechanism for small EVs, distinct from the exocytosis of multivesicular bodies or amphisomes, as well as the small ectosome release pathway. LA - English DB - MTMT ER - TY - JOUR AU - György, Bernadett AU - Szatmári, Réka AU - Ditrói, Tamás AU - Torma, Ferenc Gergely AU - Pálóczi, Krisztina AU - Balbisi, Mirjam AU - Visnovitz, Tamás AU - Koltai, Erika AU - Nagy, Péter AU - Buzás, Edit Irén AU - Horvath, Steve AU - Radák, Zsolt TI - The protein cargo of extracellular vesicles correlates with the epigenetic aging clock of exercise sensitive DNAmFitAge JF - BIOGERONTOLOGY J2 - BIOGERONTOLOGY VL - 26 PY - 2025 IS - 1 PG - 17 SN - 1389-5729 DO - 10.1007/s10522-024-10177-9 UR - https://m2.mtmt.hu/api/publication/35675779 ID - 35675779 N1 - Research Centre for Molecular Exercise Science, Hungarian University of Sport Science, Alkotás U. 42-48, Budapest, 1123, Hungary Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Ráth György U. 7-9, Budapest, 1122, Hungary Laki Kálmán Doctoral School, University of Debrecen, Nagyerdei Krt. 98, Debrecen, 4032, Hungary Chemistry Coordinating Institute, University of Debrecen, Egyetem Tér 1, Debrecen, 4032, Hungary Department of Genetics, Cell and Immunobiology, Semmelweis University, Üllői Út 26, Budapest, 1085, Hungary Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary Department of Plant Physiology and Molecular Plant Biology, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/C, Budapest, 1117, Hungary Department of Anatomy and Histology, HUN-REN–UVMB Laboratory of Redox Biology Research Group, University of Veterinary Medicine, István Utca 2, Budapest, 1078, Hungary HUN-REN-SU Translational Extracellular Vesicle Research Group, Budapest, Hungary HCEMM-SU Extracellular Vesicle Research Group, Budapest, Hungary Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, 90095, CA, United States San Diego Institute of Science, Altos Labs, San Diego, 92121, CA, United States Faculty of Sport Sciences, Waseda University, Tokorozawa, 2-579-15, Japan Export Date: 19 March 2025; Cited By: 0; Correspondence Address: Z. Radák; Research Centre for Molecular Exercise Science, Hungarian University of Sport Science, Budapest, Alkotás U. 42-48, 1123, Hungary; email: radak.zsolt@tf.hu; CODEN: BIOGC AB - Extracellular vesicles (EVs) are implicated in inter-organ communication, which becomes particularly relevant during aging and exercise. DNA methylation-based aging clocks reflect lifestyle and environmental factors, while regular exercise is known to induce adaptive responses, including epigenetic adaptations. Twenty individuals with High-fitness (aged 57.7 ± 9.8 years) and twenty Medium–Low-fitness (aged 57.5 ± 9.7 years) subjects provided blood samples. EVs were isolated from the samples using a size exclusion chromatography (SEC)-based method, and their protein content was analyzed by mass spectrometry (MS). Acceleration of the biological age estimator DNAmFitAge (AgeAccelFit) was associated with the protein cargo of EVs, whereas PhenoAge and GrimAge acceleration did not show a significant relationship. This finding suggests that the epigenetic aging-modulating role of exercise may involve inter-organ communication via EVs. Set Enrichment Analysis was performed to identify enriched Gene Ontology (GO) terms for sets of proteins that were either correlated with AgeAccelFit or detected exclusively in individuals with high levels of aerobic fitness. The protein cargo of EVs further suggests that inter-organ communication influences inflammation, the immune system, cellular repair, adhesion, metabolism and coagulation. Our findings help to understand the preventive role of exercise, which could be mediated in part by EVs. LA - English DB - MTMT ER - TY - JOUR AU - Bató, Csaba AU - Szabó, Ildikó AU - Yousef, M. AU - Lenzinger, Dorina AU - Grébecz, Fülöp Károly AU - Visnovitz, Tamás AU - Bősze, Szilvia AU - Bánóczi, Zoltán AU - Mező, Gábor TI - 1-Pyrene Carboxylic Acid: An Internalization Enhancer for Short Oligoarginines JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 26 PY - 2025 IS - 5 PG - 16 SN - 1661-6596 DO - 10.3390/ijms26052202 UR - https://m2.mtmt.hu/api/publication/35801901 ID - 35801901 N1 - Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/A, Budapest, 1117, Hungary Hevesy György PhD School of Chemistry, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/A, Budapest, 1117, Hungary HUN-REN-ELTE Research Group of Peptide Chemistry, Budapest, 1117, Hungary MTA-TTK Lendület “Momentum” Peptide-Based Vaccines Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary Ecole Super Biotechnol Strasbourg ESBS, CNRS, UMR 7242, Biotechnol & Cellular Signalling, University Strasbourg, Illkirch Graffenstaden, F-67400, France Department of Genetics, Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary Department of Plant Physiology and Molecular Plant Biology, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/c, Budapest, 1117, Hungary Export Date: 28 March 2025; Cited By: 0; Correspondence Address: Z. Bánóczi; Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, ELTE Eötvös Loránd University, Budapest, Pázmány Péter Sétány 1/A, 1117, Hungary; email: zoltan.banoczi@ttk.elte.hu; G. Mező; Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, ELTE Eötvös Loránd University, Budapest, Pázmány Péter Sétány 1/A, 1117, Hungary; email: gabor.mezo@ttk.elte.hu AB - Getting through the cell membrane is challenging, and transporting a therapeutic agent while entering the cell is even more complicated. Cell-penetrating peptides (CPPs) are valuable tools for solving this problem, although they have drawbacks. In this work, the synthesis and investigation of efficient CPPs are described. We used an aromatic group, 1-pyrene carboxylic acid (PCA), to enhance internalization. We designed oligoarginines to investigate the effect of PCA in different positions at the N-terminus or in the side chain. Our novel peptide derivatives showed remarkable internalization on tumor cell lines, and more than one endocytic pathway plays a role in their internalization mechanism. With this modification, there is an opportunity to design short oligoarginines that can rival well-known CPPs like octaarginine in internalization. LA - English DB - MTMT ER - TY - JOUR AU - Veres-Székely, Apor AU - Szász, Csenge AU - Pap, Domonkos AU - Bokrossy, Péter AU - Lenzinger, Dorina AU - Visnovitz, Tamás AU - Mihály, Judith AU - Pálmai, Marcell AU - Varga, Zoltán AU - Őrfi, László AU - Szabó, Attila AU - Vannay, Ádám AU - Szebeni, Beáta TI - Improvement in Transient Agarose Spot (TAS) Cell Migration Assay: Microplate-Based Detection and Evaluation JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 26 PY - 2025 IS - 12 PG - 13 SN - 1661-6596 DO - 10.3390/ijms26125584 UR - https://m2.mtmt.hu/api/publication/36188672 ID - 36188672 AB - Collective cell migration is crucial in various biological processes, including tumor progression and metastasis. The widely used scratch assay (wound healing assay) has limitations in throughput, reproducibility, and data analysis. To overcome these challenges, we previously developed the Transient Agarose Spot (TAS) assay, which enhanced assay precision and reproducibility. In this study, we present an improved microplate-based TAS assay. By using a microplate reader, we automated data acquisition, enabling the detection of cell migration in a 96-well plate format with greater throughput and accuracy. The new method applies Hoechst staining to label viable cells, providing a stable signal for kinetic analysis without compromising cell viability. We validated this approach with fluorophore-expressing cancer cells and demonstrated its ability to monitor dose-dependent effects of fetal bovine serum on cell migration. Additionally, we applied the microplate-based TAS assay to assess the anti-migratory effects of kinase inhibitors and mesenchymal stem cell-derived extracellular vesicles (EVs) on lung cancer cells. The assay accurately quantified migration inhibition and revealed the concentration-dependent effects of EVs, highlighting their potential as therapeutic agents. This microplate-based TAS assay provides a scalable, efficient, and cost-effective platform for high-throughput screening of cell migration and drug discovery, offering a robust alternative to traditional microscopy-based methods. LA - English DB - MTMT ER - TY - JOUR AU - György, Bernadett AU - Pálóczi, Krisztina AU - Balbisi, Mirjam AU - Turiák, Lilla AU - Drahos, László AU - Visnovitz, Tamás AU - Koltai, Erika AU - Radák, Zsolt TI - Effect of the 35 nm and 70 nm Size Exclusion Chromatography (SEC) Column and Plasma Storage Time on Separated Extracellular Vesicles JF - CURRENT ISSUES IN MOLECULAR BIOLOGY J2 - CURR ISSUES MOL BIOL VL - 46 PY - 2024 IS - 5 SP - 4337 EP - 4357 PG - 21 SN - 1467-3037 DO - 10.3390/cimb46050264 UR - https://m2.mtmt.hu/api/publication/34850199 ID - 34850199 N1 - Research Centre for Molecular Exercise Science, Hungarian University of Sport Science, Alkotás u. 42-48, Budapest, 1123, Hungary Department of Genetics, Cell and Immunobiology, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary Research Centre for Natural Sciences, Institute of Organic Chemistry, Magyar Tudósok Körútja 2, Budapest, 1117, Hungary Department of Plant Physiology and Molecular Plant Biology, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest, 1117, Hungary Faculty of Sport Sciences, Waseda University, Tokorozawa 2-579-15, Japan Export Date: 17 June 2024 CODEN: CMBIF Correspondence Address: Radák, Z.; Research Centre for Molecular Exercise Science, Alkotás u. 42-48, Hungary; email: radak.zsolt@tf.hu AB - The technical difficulty of separating extracellular vesicles (EVs) from plasma proteins in human blood presents a significant hurdle in EV research, particularly during nano ultra-high-performance liquid chromatography–tandem mass spectrometric (UHPLC-MS/MS) analysis, where detecting “vesicular” proteins among abundant plasma proteins is challenging. Standardisation is a pressing issue in EV research, prompting collaborative global efforts to address it. While the MISEV guidelines offer valuable recommendations, unanswered questions remain, particularly regarding sample storage. We compared size exclusion chromatography (SEC) columns with pore sizes of 35 nm and 70 nm to identify fractions with minimal contaminating proteins and the highest concentration of small EVs (sEVs). Following column selection, we explored potential differences in the quality and quantity of sEVs isolated from platelet-free plasma (PFP) after long-term storage at −80 °C (>2.5 years) compared to freshly drawn blood. Our methodologically rigorous study indicates that prolonged storage, under correct storage and processing conditions, does not compromise sEV quality. Both columns effectively isolated vesicles, with the 70 nm column exhibiting a higher abundance of “vesicular” proteins. We propose a relatively rapid and moderately efficient protocol for obtaining a comparatively pure sEV fraction from plasma, facilitating sEV processing in clinical trials. LA - English DB - MTMT ER - TY - JOUR AU - Balassa, Kinga AU - Balassa, György AU - Almási, Asztéria AU - Visnovitz, Tamás AU - Rudnóy, Szabolcs TI - Detection of exogenous siRNA inside sweet corn bundle sheath cells and the RNAi dynamics in the early stage of Maize dwarf mosaic virus infection. JF - PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS J2 - PHYSIOL MOL BIOL PLANTS VL - 30 PY - 2024 IS - 8 SP - 1265 EP - 1276 PG - 12 SN - 0971-5894 DO - 10.1007/s12298-024-01500-2 UR - https://m2.mtmt.hu/api/publication/35164265 ID - 35164265 LA - English DB - MTMT ER - TY - CONF AU - Zelenyánszki, Helga AU - Klencsár, Zoltán AU - Visnovitz, Tamás AU - Kolbert, Zsuzsanna AU - Solti, Ádám TI - Nitric oxide accumulates under iron deficiency in chloroplasts T2 - 9th Plant Nitric Oxide International Meeting (PNO9) C1 - New Delhi PY - 2024 SP - 7 EP - 7 PG - 1 UR - https://m2.mtmt.hu/api/publication/35172786 ID - 35172786 AB - Iron (Fe) is an essential cofactor of multiple enzymes, but to avoid its hazardous effects on oxidative stress, signalling of the Fe status, especially in plant cells organelles is essential, although hardly known. Since 80–90% of Fe in the mesophyll cells is targeted to the chloroplasts to operate the photosynthetic apparatus, the control over plastidial Fe status has prime importance. Sensing the cytoplasmic Fe is based on hemerythrin motif-containing E3 ubiquitin ligases that are negative regulators of Fe deficiency responses. Indeed, no mechanisms are described that monitor the Fe status of the organelles. In vitro chloroplast Fe uptake (Solti et al., 2012; Müller et al. 2019) and ferric chelate reductase enzyme studies (Solti et al. 2014; Sági-Kazár et al. 2021) suggests that Fe in the chloroplasts has a feedback regulatory effect on the affinity of the plastidial Fe acquisition machinery. Nitric oxide (NO) is long known to regulate Fe uptake of roots, but also generated in chloroplasts under increasing Fe availability. It is involved in post translation modification of proteins that directly affect the function of those. Since the synthesis and accumulation of NO in chloroplasts has not been confirmed so far, we aimed here to detect and quantify NO in response to altered Fe nutrition chloroplasts. Sugar beet (Beta vulgaris cv. Orbis) model was grown on Fe(III)-EDTA source. Fe deficiency (Fe-def) was achieved with a complete depletion of Fe in the four-leaf stage. Mesophyll cell protoplasts and chloroplasts were isolated. Abundance of the NO signal in the protoplast population and the subcellular NO locations in the protoplasts were analysed applying DAF-FM diacetate in fluorescence activated cell sorting and confocal microscopy, respectively. The proportion of DAF-FM positive protoplasts significantly increased under iron deficiency, together with a higher apparent DAF-FM signal intensity in the protoplasts. Applying BioXol membrane staining of the chloroplast envelopes, chloroplast stroma origin of the DAF-FM signal was approved. DAF-FM signal of isolated chloroplasts was analysed by epifluorescent microscope, also indicating an increased ratio and pixel density of DAF-FM positive chloroplasts under Fe-def compared to the control. Electron paramagnetic resonance (EPR) spectroscopy based semiquantitative NO determination, applying N-methyl-D-glucamine dithiocarbamate spin trap and 150 K environment indicated a concentration of NO in the Fe-def chloroplasts around the lower detection limit, that of attomol NO chloroplast-1 dimension. NO in the control chloroplasts remained below the detection limit. Tyr nitration pattern detected by anti-nitro-Tyr immunoblotting of total chloroplast protein showed no significant changes in the Tyr nitration status indicating that nitrosative stress level has not increased significantly. This work was supported by the grant financed by the National Research, Development and Innovation Office, Hungary (NKFIH K-135607). Á.S. was also supported by the Bolyai János Research Scholarship of the Hungarian Academy of Sciences (BO/00113/23/8). References Müller et al. (2019) Planta 249:751. Sági-Kazár et al. (2021) Front Plant Sci 12:748. Solti et al. (2014) New Phytol 202:920. Solti et al. (2012) Plant Physiol Biochem 52:91 LA - English DB - MTMT ER - TY - JOUR AU - Nochta-Kazsoki, Adrienn Katalin AU - Németh, Krisztina AU - Visnovitz, Tamás AU - Lenzinger, Dorina AU - Buzás, Edit Irén AU - Zelkó, Romána TI - Formulation and characterization of nanofibrous scaffolds incorporating extracellular vesicles loaded with curcumin JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-024-79277-3 UR - https://m2.mtmt.hu/api/publication/35526600 ID - 35526600 N1 - Adrienn Kazsoki and Krisztina Németh authors contributed equally LA - English DB - MTMT ER - TY - JOUR AU - Visnovitz, Tamás TI - Extracellular Vesicles: Biology and Therapeutic Applications JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 23 PG - 4 SN - 1661-6596 DO - 10.3390/ijms252313034 UR - https://m2.mtmt.hu/api/publication/35620321 ID - 35620321 N1 - Export Date: 2 January 2025 Correspondence Address: Visnovitz, T.; Department of Genetics, Nagyvárad tér 4, Hungary; email: visnovitz.tamas@semmelweis.hu AB - Extracellular vesicles (EVs) are phospholipid-bilayer-limited particles in the extracellular space, without self-replicating capabilities [...] LA - English DB - MTMT ER - TY - JOUR AU - Welsh, Joshua A AU - Goberdhan, Deborah C I AU - O'Driscoll, Lorraine AU - Buzás, Edit Irén AU - Blenkiron, Cherie AU - Bussolati, Benedetta AU - Cai, Houjian AU - Di Vizio, Dolores AU - Driedonks, Tom A P AU - Erdbrügger, Uta AU - Falcon-Perez, Juan M AU - Fu, Qing-Ling AU - Hill, Andrew F AU - Lenassi, Metka AU - Lim, Sai Kiang AU - Mahoney, Mỹ G AU - Mohanty, Sujata AU - Möller, Andreas AU - Nieuwland, Rienk AU - Ochiya, Takahiro AU - Sahoo, Susmita AU - Torrecilhas, Ana C AU - Zheng, Lei AU - Zijlstra, Andries AU - Abuelreich, Sarah AU - Bagabas, Reem AU - Bergese, Paolo AU - Bridges, Esther M AU - Brucale, Marco AU - Burger, Dylan AU - Carney, Randy P AU - Cocucci, Emanuele AU - Crescitelli, Rossella AU - Hanser, Edveena AU - Harris, Adrian L AU - Haughey, Norman J AU - Hendrix, An AU - Ivanov, Alexander R AU - Jovanovic-Talisman, Tijana AU - Kruh-Garcia, Nicole A AU - Ku'ulei-Lyn Faustino, Vroniqa AU - Kyburz, Diego AU - Lässer, Cecilia AU - Lennon, Kathleen M AU - Lötvall, Jan AU - Maddox, Adam L AU - Martens-Uzunova, Elena S AU - Mizenko, Rachel R AU - Newman, Lauren A AU - Ridolfi, Andrea AU - Rohde, Eva AU - Rojalin, Tatu AU - Rowland, Andrew AU - Saftics, Andras AU - Sandau, Ursula S AU - Saugstad, Julie A AU - Shekari, Faezeh AU - Swift, Simon AU - Ter-Ovanesyan, Dmitry AU - Tosar, Juan P AU - Useckaite, Zivile AU - Valle, Francesco AU - Varga, Zoltán AU - van der Pol, Edwin AU - van Herwijnen, Martijn J C AU - Wauben, Marca H M AU - Wehman, Ann M AU - Williams, Sarah AU - Zendrini, Andrea AU - Zimmerman, Alan J AU - Théry, Clotilde AU - Witwer, Kenneth W ED - Abuelreich, Sarah / Collaborator ED - Ahmad, Samar / Collaborator ED - Ahmed, Dina Ak / Collaborator ED - Ahmed, Sarah H / Collaborator ED - Aikawa, Elena / Collaborator ED - Akbar, Naveed / Collaborator ED - Akiyoshi, Kazunari / Collaborator ED - Al-Adra, David P / Collaborator ED - Al-Masawa, Maimonah E / Collaborator ED - Albanese, Manuel / Collaborator ED - Alberro, Ainhoa / Collaborator ED - Alcaraz, María José / Collaborator ED - Alexander-Brett, Jen / Collaborator ED - Alexander, Kimberley L / Collaborator ED - Ali, Nilufar / Collaborator ED - Alibhai, Faisal J / Collaborator ED - Allelein, Susann / Collaborator ED - Allenby, Mark C / Collaborator ED - Almeida, Fausto / Collaborator ED - Almousa, Sameh W / Collaborator ED - Altan-Bonnet, Nihal / Collaborator ED - Altei, Wanessa F / Collaborator ED - Alvarez-Llamas, Gloria / Collaborator ED - Alvarez, Cora L / Collaborator ED - An, Hyo Jung / Collaborator ED - Anand, Krishnan / Collaborator ED - Anderson, Johnathon D / Collaborator ED - Andriantsitohaina, Ramaroson / Collaborator ED - Ansari, Khairul I / Collaborator ED - Anselmo, Achille / Collaborator ED - Antoniou, Anna / Collaborator ED - Aqil, Farrukh / Collaborator ED - Arab, Tanina / Collaborator ED - Archer, Fabienne / Collaborator ED - Arif, Syrine / Collaborator ED - Armstrong, David A / Collaborator ED - Arntz, Onno J / Collaborator ED - Arsène, Pierre / Collaborator ED - Arteaga-Blanco, Luis / Collaborator ED - Asokan, Nandini / Collaborator ED - Aspelin, Trude / Collaborator ED - Atkin-Smith, Georgia K / Collaborator ED - Aubert, Dimitri / Collaborator ED - Ayyar, Kanchana K / Collaborator ED - Azlan, Maryam / Collaborator ED - Azoidis, Ioannis / Collaborator ED - Bécot, Anaïs / Collaborator ED - Bach, Jean-Marie / Collaborator ED - Bachurski, Daniel / Collaborator ED - Bae, Seoyoon / Collaborator ED - Bagabas, Reem / Collaborator ED - Baj-Krzyworzeka, Monika / Collaborator ED - Balaj, Leonora / Collaborator ED - Balbi, Carolina / Collaborator ED - van Balkom, Bas Wm / Collaborator ED - Ballal, Abhijna R / Collaborator ED - Bano, Afsareen / Collaborator ED - Banzet, Sébastien / Collaborator ED - Bare, Yonis / Collaborator ED - Barile, Lucio / Collaborator ED - Barman, Bahnisikha / Collaborator ED - Barranco, Isabel / Collaborator ED - Barreca, Valeria / Collaborator ED - Bart, Geneviève / Collaborator ED - Barteneva, Natasha S / Collaborator ED - Basso, Manuela / Collaborator ED - Batish, Mona / Collaborator ED - Bauer, Natalie R / Collaborator ED - Baxter, Amy A / Collaborator ED - Bazié, Wilfried W / Collaborator ED - Bazzan, Erica / Collaborator ED - Beaumont, Joel Ej / Collaborator ED - Bebawy, Mary / Collaborator ED - Bebelman, Maarten P / Collaborator ED - Bedina-Zavec, Apolonija / Collaborator ED - Beetler, Danielle J / Collaborator ED - Beke-Somfai, Tamás / Collaborator ED - Belleannée, Clémence / Collaborator ED - Benedikter, Birke J / Collaborator ED - Benediktsdóttir, Berglind E / Collaborator ED - Berardi, Anna C / Collaborator ED - Bergamelli, Mathilde / Collaborator ED - Bergese, Paolo / Collaborator ED - Bertolini, Irene / Collaborator ED - Bhattacharyya, Asima / Collaborator ED - Bhattacharyya, Suvendra N / Collaborator ED - Biller, Steven J / Collaborator ED - Billottet, Clotilde / Collaborator ED - Bissler, John J / Collaborator ED - Blanc-Brude, Olivier / Collaborator ED - Blenkiron, Cherie / Collaborator ED - Blijdorp, Charles J / Collaborator ED - Bobis-Wozowicz, Sylwia / Collaborator ED - Bodart-Santos, Victor / Collaborator ED - Bodnár, Bernadett Réka / Collaborator ED - Boilard, Eric / Collaborator ED - Boireau, Wilfrid / Collaborator ED - Bokun, Vladimir / Collaborator ED - Bollard, Stephanie M / Collaborator ED - Bollini, Sveva / Collaborator ED - Bongiovanni, Antonella / Collaborator ED - Bongiovanni, Laura / Collaborator ED - Bonifay, Amandine / Collaborator ED - Boppart, Marni D / Collaborator ED - Borràs, Francesc E / Collaborator ED - Bosch, Steffi / Collaborator ED - Boselli, Daniela / Collaborator ED - Bottini, Massimo / Collaborator ED - Bouffard, Jeff / Collaborator ED - Boulanger, Chantal M / Collaborator ED - Boutros, Paul C / Collaborator ED - Boyadjian, Oscar / Collaborator ED - Boysen, Anders T / Collaborator ED - Bozkurt, Batuhan T / Collaborator ED - Bramich, Kyle P / Collaborator ED - Braun, Fabian / Collaborator ED - Bravo-Miana, Rocío Del Carmen / Collaborator ED - Breakefield, Xandra O / Collaborator ED - Brenna, Santra / Collaborator ED - Brennan, Kieran / Collaborator ED - Brennan, Meadhbh Á / Collaborator ED - Breyne, Koen / Collaborator ED - Bridges, Esther M / Collaborator ED - Brigstock, David R / Collaborator ED - Brisson, Alain R / Collaborator ED - Brodie, Chaya / Collaborator ED - Brucale, Marco / Collaborator ED - Bruno, Katelyn A / Collaborator ED - Bucci, Cecilia / Collaborator ED - Buch, Shilpa / Collaborator ED - Buck, Amy H / Collaborator ED - Bukva, Mátyás / Collaborator ED - Bulte, Jeff Wm / Collaborator ED - Buratta, Sandra / Collaborator ED - Burger, Dylan / Collaborator ED - Burgy, Olivier / Collaborator ED - Burnier, Julia V / Collaborator ED - Burrows, Kaiping / Collaborator ED - Busatto, Sara / Collaborator ED - Bussolati, Benedetta / Collaborator ED - Buzás, Edit Irén / Collaborator ED - Buzás, Krisztina / Collaborator ED - Byrd, J Brian / Collaborator ED - Cáceres-Verschae, Albano / Collaborator ED - Cai, Houjian / Collaborator ED - Caires, Hugo R / Collaborator ED - Campos-Silva, Carmen / Collaborator ED - Camussi, Giovanni / Collaborator ED - de Candia, Paola / Collaborator ED - Carceller, Carmen / Collaborator ED - Fernandez-Becerra, Carmen / Collaborator ED - Carney, Randy P / Collaborator ED - Murillo Carrasco, Alexis G / Collaborator ED - Carter, David Rf / Collaborator ED - Cavallaro, Sara / Collaborator ED - Cavallero, Serena / Collaborator ED - Cavallero, Sophie / Collaborator ED - Cerda-Troncoso, Cristóbal / Collaborator ED - Chahwan, Richard / Collaborator ED - Chalupská, Renata / Collaborator ED - Chamley, Lawrence W / Collaborator ED - Chandra, Partha K / Collaborator ED - Chang, Wen-Wei / Collaborator ED - Charest, Al / Collaborator ED - Chen, Chihchen / Collaborator ED - Chen, Hao / Collaborator ED - Chen, Qiang / Collaborator ED - Chen, Shuai / Collaborator ED - Chen, Siyu / Collaborator ED - Chen, Yunxi / Collaborator ED - Cheng, Lesley / Collaborator ED - Chernyshev, Vasiliy S / Collaborator ED - Chetty, Venkatesh Kumar / Collaborator ED - Chitti, Sai V / Collaborator ED - Cho, Ssang-Goo / Collaborator ED - Cho, Yoon-Kyoung / Collaborator ED - Choi, Byeong Hyeon / Collaborator ED - Chutipongtanate, Somchai / Collaborator ED - Cicardi, Maria Elena / Collaborator ED - Cifuentes-Rius, Anna / Collaborator ED - Ciullo, Alessandra / Collaborator ED - Clayton, Aled / Collaborator ED - Cleary, Jacob A / Collaborator ED - Cocozza, Federico / Collaborator ED - Cocucci, Emanuele / Collaborator ED - Coffey, Robert J / Collaborator ED - Collino, Federica / Collaborator ED - Colombo, Federico / Collaborator ED - Colosetti, Pascal / Collaborator ED - Compañ-Bertomeu, Alvaro / Collaborator ED - Constanzo, Julie / Collaborator ED - Corbeil, Denis / Collaborator ED - Cordeiro-da-Silva, Anabela / Collaborator ED - Costa, Júlia / Collaborator ED - Couch, Yvonne / Collaborator ED - Courageux, Yvan / Collaborator ED - Coutant, Kelly / Collaborator ED - Coyle, Beth / Collaborator ED - Crescitelli, Rossella / Collaborator ED - Cretich, Marina / Collaborator ED - Cronemberger-Andrade, André / Collaborator ED - Crossland, Rachel E / Collaborator ED - Cucher, Marcela A / Collaborator ED - Czystowska-Kuzmicz, Malgorzata / Collaborator ED - D'Acunzo, Pasquale / Collaborator ED - D'Agnano, Igea / Collaborator ED - D'Agostino, Vito G / Collaborator ED - D'Angelo, Gisela / Collaborator ED - D'Arrigo, Daniele / Collaborator ED - D'Souza-Schorey, Crislyn / Collaborator ED - Dagur, Raghubendra S / Collaborator ED - Danielson, Kirsty M / Collaborator ED - Das, Saumya / Collaborator ED - Dauphin, Thibaud / Collaborator ED - Davidson, Sean M / Collaborator ED - Davies, Owen G / Collaborator ED - Davies, Rebecca L / Collaborator ED - Davis, Chelsea N / Collaborator ED - Deep, Gagan / Collaborator ED - Degosserie, Jonathan / Collaborator ED - Van Delen, Mats / Collaborator ED - Deliwala, Vatsal / Collaborator ED - Dellar, Elizabeth R / Collaborator ED - Deun, Jan Van / Collaborator ED - Dev, Apurba / Collaborator ED - Deville, Sarah / Collaborator ED - Devitt, Andrew / Collaborator ED - Dhondt, Bert / Collaborator ED - Dieterich, Lothar C / Collaborator ED - Dittmer, Dirk P / Collaborator ED - Dobosh, Brian / Collaborator ED - Dobra, Gabriella / Collaborator ED - Dogra, Navneet / Collaborator ED - Dohi, Eisuke / Collaborator ED - Dolo, Vincenza / Collaborator ED - Domashevich, Timothy V / Collaborator ED - Dominici, Massimo / Collaborator ED - Dong, Liang / Collaborator ED - Doré, Etienne / Collaborator ED - Dragovic, Rebecca A / Collaborator ED - Driedonks, Tom Ap / Collaborator ED - Drittanti, Lila / Collaborator ED - Droste, Marvin / Collaborator ED - Duan, Wei / Collaborator ED - Durmaz, Esmahan / Collaborator ED - Dutta, Suman / Collaborator ED - Eguchi, Takanori / Collaborator ED - Eichenberger, Ramon M / Collaborator ED - Eitan, Erez / Collaborator ED - Ekström, Karin / Collaborator ED - El Andaloussi, Samir / Collaborator ED - Eldh, Maria / Collaborator ED - Elie-Caille, Celine / Collaborator ED - Enciso-Martinez, Agustin / Collaborator ED - Erdbrügger, Uta / Collaborator ED - Esmaeili, Rezvan / Collaborator ED - Ettelaie, Camille / Collaborator ED - Försönits, András / Collaborator ED - Fabbri, Muller / Collaborator ED - Falasca, Marco / Collaborator ED - Falcon-Perez, Juan M / Collaborator ED - Fan, Hongkuan / Collaborator ED - Fatima, Farah / Collaborator ED - Faustino, Vroniqa Ku'ulei-Lyn / Collaborator ED - Fazeli, Alireza / Collaborator ED - Fernández-Rhodes, María / Collaborator ED - Fernandez-Prada, Christopher / Collaborator ED - Ferraro, Mariola J / Collaborator ED - Ferreira, Joao N / Collaborator ED - Ferreira, Rafaela F / Collaborator ED - Figueroa-Hall, Leandra K / Collaborator ED - Figueroa-Valdés, Aliosha I / Collaborator ED - Fioretti, Paolo V / Collaborator ED - Flenady, Sabine / Collaborator ED - Flores-Bellver, Miguel / Collaborator ED - Fok, Ellis K / Collaborator ED - Fonseka, Pamali / Collaborator ED - Forbes, Karen / Collaborator ED - Ford, Verity J / Collaborator ED - Fornaguera, Cristina / Collaborator ED - Forte, Dorian / Collaborator ED - Forte, Stefano / Collaborator ED - Fortunato, Orazio / Collaborator ED - Franklin, Jeffrey L / Collaborator ED - Freitas, Daniela / Collaborator ED - Frelet-Barrand, Annie / Collaborator ED - Fu, Qing-Ling / Collaborator ED - Fujita, Yu / Collaborator ED - Gärtner, Kathrin / Collaborator ED - Görgens, André / Collaborator ED - Gabriel, Áurea M / Collaborator ED - Gabrielli, Martina / Collaborator ED - Gabrielsson, Susanne / Collaborator ED - Galinsoga, Alicia / Collaborator ED - Galisova, Andrea / Collaborator ED - Gamage, Teena Kjb / Collaborator ED - Gao, Yingtang / Collaborator ED - Garcia-Contreras, Marta / Collaborator ED - Garcia Garcia, M Madhy / Collaborator ED - Garcia, Maria Noé / Collaborator ED - Gargiulo, Ernesto / Collaborator ED - Gee, Margaret M Mc / Collaborator ED - Genard, Géraldine C / Collaborator ED - Geraci, Fabiana / Collaborator ED - Ghanam, Jamal / Collaborator ED - Ghatak, Subhadip / Collaborator ED - Ghavami, Mahlegha / Collaborator ED - Ghebosu, Raluca E / Collaborator ED - Gho, Yong Song / Collaborator ED - Ghosal, Sayam / Collaborator ED - Giamas, Georgios / Collaborator ED - Giebel, Bernd / Collaborator ED - Gilbert, Caroline / Collaborator ED - Gimona, Mario / Collaborator ED - Girão, Henrique / Collaborator ED - Giusti, Ilaria / Collaborator ED - Gizzie, Evan A / Collaborator ED - Glamočlija, Sofija / Collaborator ED - Glass, Sarah E / Collaborator ED - Gobbo, Jessica / Collaborator ED - Goberdhan, Deborah Ci / Collaborator ED - Godbole, Nihar / Collaborator ED - Goetz, Jacky G / Collaborator ED - Gololobova, Olesia / Collaborator ED - Gomez-Florit, Manuel / Collaborator ED - Pendiuk Goncalves, Jenifer / Collaborator ED - González-King Garibotti, Hernán / Collaborator ED - Gorgun, Cansu / Collaborator ED - Gori, Alessandro / Collaborator ED - Gorska, Sabina / Collaborator ED - Graner, Michael W / Collaborator ED - Grau, Georges E / Collaborator ED - Grech, Laura / Collaborator ED - Greening, David W / Collaborator ED - Groß, Rüdiger M / Collaborator ED - Gross, Julia C / Collaborator ED - Gruber, Jens / Collaborator ED - Gualerzi, Alice / Collaborator ED - Guanzon, Dominic / Collaborator ED - Gudbergsson, Johann M / Collaborator ED - Guerin, Coralie L / Collaborator ED - Guerra, Flora / Collaborator ED - Guillén, Maria I / Collaborator ED - Gujar, Vikramsingh / Collaborator ED - Guo, Wei / Collaborator ED - Gupta, Veer Bala / Collaborator ED - Gupta, Vivek Kumar / Collaborator ED - Gustafson, Dakota / Collaborator ED - Gyukity-Sebestyén, Edina / Collaborator ED - Hölker, Patrick / Collaborator ED - Hade, Mangesh D / Collaborator ED - Hagey, Daniel W / Collaborator ED - Han, Chungmin / Collaborator ED - Han, Pingping / Collaborator ED - Hanayama, Rikinari / Collaborator ED - Handberg, Aase / Collaborator ED - Hanser, Edveena / Collaborator ED - Harada, Masako / Collaborator ED - Harmati, Mária / Collaborator ED - Harris, Adrian L / Collaborator ED - Harrison, Paul / Collaborator ED - Harrison, Rane A / Collaborator ED - Haughey, Norman J / Collaborator ED - Haynes, Paul A / Collaborator ED - He, Mei / Collaborator ED - Hegyesi, Hargita / Collaborator ED - Hendrix, An / Collaborator ED - van Herwijnen, Martijn Jc / Collaborator ED - Hill, Andrew F / Collaborator ED - Hisey, Colin L / Collaborator ED - Hochberg, Fred H / Collaborator ED - Nolte-'t Hoen, Esther Nm / Collaborator ED - Holcar, Marija / Collaborator ED - Holder, Beth / Collaborator ED - Holnthoner, Wolfgang / Collaborator ED - Holthofer, Harry / Collaborator ED - Hooper, D Craig / Collaborator ED - Hosseini-Beheshti, Elham / Collaborator ED - Hosseinkhani, Baharak / Collaborator ED - Howard, Jane / Collaborator ED - Howe, Kathryn L / Collaborator ED - Hoyle, Nicholas R / Collaborator ED - Hrdy, Jiri / Collaborator ED - Hu, Guoku / Collaborator ED - Huang, Yiyao / Collaborator ED - Huber, Veronica / Collaborator ED - Hudoklin, Samo / Collaborator ED - Hufnagel, Antonia / Collaborator ED - Hulett, Mark D / Collaborator ED - Hunt, Stuart / Collaborator ED - Hyenne, Vincent / Collaborator ED - Di Ianni, Emilio / Collaborator ED - Iannotta, Dalila / Collaborator ED - Ibrahim, Ahmed Ge / Collaborator ED - Ibrahim, Sherif A / Collaborator ED - Ikezu, Seiko / Collaborator ED - Ikezu, Tsuneya / Collaborator ED - Im, Hyungsoon / Collaborator ED - Inal, Jameel M / Collaborator ED - Inic-Kanada, Aleksandra / Collaborator ED - Inngjerdingen, Marit / Collaborator ED - Inoshima, Yasuo / Collaborator ED - Ivanov, Alexander R / Collaborator ED - Ivanova, Alena / Collaborator ED - Izquierdo, Elena / Collaborator ED - Møller Jørgensen, Malene / Collaborator ED - Jackson, Hannah K / Collaborator ED - Jacobsen, Soren / Collaborator ED - Jadue, Fernanda / Collaborator ED - Javeed, Naureen / Collaborator ED - Jay, Steven M / Collaborator ED - Jayachandran, Muthuvel / Collaborator ED - Jayasinghe, Migara K / Collaborator ED - Jenster, Guido / Collaborator ED - Jeppesen, Dennis K / Collaborator ED - Jerónimo, Carmen / Collaborator ED - Jiang, Linglei / Collaborator ED - Jin, Jing / Collaborator ED - Jingushi, Kentaro / Collaborator ED - Jo, Dong-Gyu / Collaborator ED - Joerger-Messerli, Marianne S / Collaborator ED - Jones, Jennifer C / Collaborator ED - Jones, Melissa K / Collaborator ED - de Jong, Olivier G / Collaborator ED - Jovanovic-Talisman, Tijana / Collaborator ED - Jr, Anthony W Ferrante / Collaborator ED - Coleman, Leon G / Collaborator ED - Juncker, David / Collaborator ED - Jung, Stephanie / Collaborator ED - Jurek, Benjamin / Collaborator ED - Jurga, Marcin / Collaborator ED - Justilien, Verline / Collaborator ED - Kabani, Mehdi / Collaborator ED - Kalluri, Raghu / Collaborator ED - Kamali-Moghaddam, Masood / Collaborator ED - Kanada, Masamitsu / Collaborator ED - Kang, Taeyoung / Collaborator ED - Kano, Shin-Ichi / Collaborator ED - Kaparakis-Liaskos, Maria / Collaborator ED - Karnas, Elżbieta / Collaborator ED - Karoichan, Antoine / Collaborator ED - Kashanchi, Fatah / Collaborator ED - Assar Kashani, Sara / Collaborator ED - Kashyap, Namita N / Collaborator ED - Katsur, Miroslava / Collaborator ED - Kau-Strebinger, Silvio / Collaborator ED - Kauffman, Amy C / Collaborator ED - Kaur, Sukhbir / Collaborator ED - Kehoe, Oksana / Collaborator ED - Kelwick, Richard Jr / Collaborator ED - Nasiri Kenari, Amirmohammad / Collaborator ED - Kestecher, Brachyahu Meir / Collaborator ED - Keulers, Tom G / Collaborator ED - Van Keuren-Jensen, Kendall R / Collaborator ED - Khalaj, Kasra / Collaborator ED - Khamari, Delaram / Collaborator ED - Khanabdali, Ramin / Collaborator ED - Khomyakova, Elena / Collaborator ED - Khoo, Amanda / Collaborator ED - Kim, Daniel H / Collaborator ED - Kim, Dongin / Collaborator ED - Kim, Han Sang / Collaborator ED - Kim, In-San / Collaborator ED - Kim, Soo / Collaborator ED - Kim, Yohan / Collaborator ED - Kima, Peter E / Collaborator ED - Kislinger, Thomas / Collaborator ED - Klingeborn, Mikael / Collaborator ED - Knight, Rob / Collaborator ED - Komuro, Hiroaki / Collaborator ED - Koncz, Anna / Collaborator ED - Konstantinou, Timothea / Collaborator ED - van der Koog, Luke / Collaborator ED - Kooijmans, Sander Aa / Collaborator ED - Kornek, Miroslaw T / Collaborator ED - Kosanović, Maja / Collaborator ED - Kostallari, Enis / Collaborator ED - Koukoulis, Tiana F / Collaborator ED - Kourembanas, Stella / Collaborator ED - Krämer-Albers, Eva-Maria / Collaborator ED - Kralj-Iglic, Veronika / Collaborator ED - Krasemann, Susanne / Collaborator ED - Krasnodembskaya, Anna D / Collaborator ED - Krawczynska, Natalia J / Collaborator ED - Kreft, Mateja E / Collaborator ED - Kruh-Garcia, Nicole A / Collaborator ED - Kuehn, Meta J / Collaborator ED - Kuipers, Marije E / Collaborator ED - Kulaj, Konxhe / Collaborator ED - Kuligowski, Julia / Collaborator ED - Kumagai, Yumi / Collaborator ED - Kumar, Ashish / Collaborator ED - Kumar, Saroj / Collaborator ED - Kumar, Sharad / Collaborator ED - Kumari, Meena / Collaborator ED - Kundrotas, Gabrielis / Collaborator ED - Kurochkin, Igor V / Collaborator ED - Kuroda, Masahiko / Collaborator ED - Kurzawa-Akanbi, Marzena / Collaborator ED - Kweskin, Sasha J / Collaborator ED - Kyburz, Diego / Collaborator ED - Lázaro-Ibáñez, Elisa / Collaborator ED - Lässer, Cecilia / Collaborator ED - Lötvall, Jan / Collaborator ED - Lőrincz, Márton Ákos / Collaborator ED - Lai, Andrew / Collaborator ED - Lai, Charles P / Collaborator ED - Laitinen, Saara / Collaborator ED - Landreville, Solange / Collaborator ED - Lange, Sigrun / Collaborator ED - Langevin, Scott M / Collaborator ED - Langlois, Marc-André / Collaborator ED - Languino, Lucia R / Collaborator ED - Lannigan, Joanne / Collaborator ED - Lark, Daniel S / Collaborator ED - Larregina, Adriana T / Collaborator ED - Laurent, Louise C / Collaborator ED - Laurin, David / Collaborator ED - Lavieu, Gregory / Collaborator ED - Lawson, Charlotte / Collaborator ED - Le Lay, Soazig / Collaborator ED - Leandro, Kevin / Collaborator ED - Ledreux, Aurélie / Collaborator ED - Lee, Changjin / Collaborator ED - Lee, Dong-Sup / Collaborator ED - Lee, Hakho / Collaborator ED - Lee, Heon-Jin / Collaborator ED - Lee, Sun Young / Collaborator ED - Lee, Tae Ryong / Collaborator ED - Lee, Wai-Leng / Collaborator ED - Lefterov, Iliya / Collaborator ED - Lei, Xinhua / Collaborator ED - Leivo, Janne / Collaborator ED - Lemaire, Quentin / Collaborator ED - Paes Leme, Adriana F / Collaborator ED - Lemon, Stanley M / Collaborator ED - Lenassi, Metka / Collaborator ED - Lennon, Kathleen M / Collaborator ED - Lenzini, Stephen / Collaborator ED - Leor, Jonathan / Collaborator ED - Levy, Efrat / Collaborator ED - Li, Bo / Collaborator ED - Li, Guoping / Collaborator ED - Li, Jiao Jiao / Collaborator ED - Li, Qiubai / Collaborator ED - Li, Xinlei / Collaborator ED - Liang, Xiuming / Collaborator ED - Lim, Rebecca / Collaborator ED - Lim, Sai Kiang / Collaborator ED - Limongi, Tania / Collaborator ED - Linē, Aija / Collaborator ED - Pincela Lins, Paula / Collaborator ED - Lippens, Lien / Collaborator ED - Liu, Guanshu / Collaborator ED - Llorente, Alicia / Collaborator ED - Longjohn, Modeline N / Collaborator ED - van de Loo, Fons Aj / Collaborator ED - Lorenowicz, Magdalena J / Collaborator ED - Lorico, Aurelio / Collaborator ED - Loudig, Olivier / Collaborator ED - Loyer, Xavier / Collaborator ED - Lozano-Andrés, Estefanía / Collaborator ED - Lu, Biao / Collaborator ED - Lu, Quan / Collaborator ED - Lubart, Quentin / Collaborator ED - Lucien, Fabrice / Collaborator ED - Lunavat, Taral R / Collaborator ED - Ermann Lundberg, Ludwig / Collaborator ED - Lundy, David J / Collaborator ED - Luoto, Jens C / Collaborator ED - Lyden, David C / Collaborator ED - Möller, Andreas / Collaborator ED - Müller, Janis A / Collaborator ED - MacPhee, Daniel J / Collaborator ED - Maddox, Adam L / Collaborator ED - Madec, Elise / Collaborator ED - Magaña, Setty M / Collaborator ED - Mahairaki, Vasiliki / Collaborator ED - Mahoney, Mỹ G / Collaborator ED - Malhi, Harmeet / Collaborator ED - Malnou, Cécile E / Collaborator ED - Mamand, Doste R / Collaborator ED - Man, Kenny / Collaborator ED - Manno, Mauro / Collaborator ED - Mantel, Pierre-Yves / Collaborator ED - Marangon, Tecla / Collaborator ED - Marbán, Eduardo / Collaborator ED - Marcilla, Antonio / Collaborator ED - Maremanda, Krishna P / Collaborator ED - Margolis, Leonid / Collaborator ED - Mariñas-Pardo, Luis / Collaborator ED - Marić, Ivica / Collaborator ED - Sánchez Martín, Silvia / Collaborator ED - Martínez-Martínez, Eduardo / Collaborator ED - Martel, Catherine / Collaborator ED - Martens-Uzunova, Elena S / Collaborator ED - Martin-Duque, Pilar / Collaborator ED - Martin-Jaular, Lorena / Collaborator ED - Martinez-Murillo, Paola A / Collaborator ED - Martinez-Pacheco, Sarai / Collaborator ED - Martins-Marques, Tania / Collaborator ED - Mary, Benjamin / Collaborator ED - Marzan, Akbar L / Collaborator ED - Matamoros-Angles, Andreu / Collaborator ED - Mathivanan, Suresh / Collaborator ED - Matsuzaki, Juntaro / Collaborator ED - Mayan, Maria D / Collaborator ED - Mazzeo, Carla / Collaborator ED - Mbengue, Mariama / Collaborator ED - McCann, Mark J / Collaborator ED - McIlvenna, Luke C / Collaborator ED - McVey, Mark J / Collaborator ED - Meisner-Kober, Nicole / Collaborator ED - Mellergaard, Maiken / Collaborator ED - Melli, Giorgia / Collaborator ED - Menck, Kerstin / Collaborator ED - Menjivar, Nico G / Collaborator ED - Menon, Ramkumar / Collaborator ED - Mentkowski, Kyle I / Collaborator ED - Miklavcic, John J / Collaborator ED - Miklosi, Andras G / Collaborator ED - Milutinovic, Bojana / Collaborator ED - Minciacchi, Valentina R / Collaborator ED - Mirzaei, Mehdi / Collaborator ED - Mishra, Shalini / Collaborator ED - Mitchell, Megan I / Collaborator ED - Mizenko, Rachel R / Collaborator ED - Mladenović, Danilo / Collaborator ED - Mohamadi, Eqbal / Collaborator ED - Mohanty, Sujata / Collaborator ED - Momen-Heravi, Fatemeh / Collaborator ED - Mondal, Sujan K / Collaborator ED - Monguió-Tortajada, Marta / Collaborator ED - Moon, Jisook / Collaborator ED - Morandi, Mattia I / Collaborator ED - Moreau, Violaine / Collaborator ED - Retana Moreira, Lissette / Collaborator ED - Morelli, Adrian E / Collaborator ED - Mori, Marcelo A / Collaborator ED - Morimoto, Masahiro / Collaborator ED - Mosser, Mathilde / Collaborator ED - Motaung, Thabiso E / Collaborator ED - Moussay, Etienne / Collaborator ED - Mugoni, Vera / Collaborator ED - Mullier, Francois / Collaborator ED - Muraca, Maurizio / Collaborator ED - Murugesan, Saravanakumar / Collaborator ED - Musante, Luca / Collaborator ED - Musicò, Angelo / Collaborator ED - Németh, Afrodité / Collaborator ED - Németh, Krisztina / Collaborator ED - Nadeau, Amélie / Collaborator ED - Nam, Gi-Hoon / Collaborator ED - Naora, Honami / Collaborator ED - Natoli, Riccardo / Collaborator ED - Nawaz, Muhammad / Collaborator ED - Nazarenko, Irina / Collaborator ED - Ndukaife, Justus C / Collaborator ED - Nedeva, Christina / Collaborator ED - Nejsum, Peter / Collaborator ED - Nelissen, Inge / Collaborator ED - Neri, Christian / Collaborator ED - Neri, Tommaso / Collaborator ED - Neviani, Paolo / Collaborator ED - Newman, Lauren A / Collaborator ED - Ng, Chiew Yong / Collaborator ED - van Niel, Guillaume / Collaborator ED - Nieuwland, Rienk / Collaborator ED - Nikiforova, Nadezhda / Collaborator ED - Nimrichter, Leonardo / Collaborator ED - Nitin, Chitranshi / Collaborator ED - Njock, Makon-Sébastien / Collaborator ED - Noël, Daniele / Collaborator ED - Noghero, Alessio / Collaborator ED - Nolan, John P / Collaborator ED - Noppen, Sam / Collaborator ED - Noren Hooten, Nicole / Collaborator ED - Novaes, Antonio da Silva / Collaborator ED - O'Driscoll, Lorraine / Collaborator ED - O'Loghlen, Ana / Collaborator ED - Ochiya, Takahiro / Collaborator ED - Oesterreicher, Johannes / Collaborator ED - Oh, Seung W / Collaborator ED - Oláh, Attila / Collaborator ED - Olivier, Martin / Collaborator ED - Olofsson Bagge, Roger / Collaborator ED - Ong, Siew Ling / Collaborator ED - Ortiz, Angelica / Collaborator ED - Ortiz, Luis A / Collaborator ED - Østergaard, Ole / Collaborator ED - Osorio, Omar A / Collaborator ED - Osteikoetxea, Xabier / Collaborator ED - Ostrowski, Matias / Collaborator ED - Otaegui, David / Collaborator ED - Otahal, Alexander / Collaborator ED - Ozawa, Patricia M M / Collaborator ED - Ozkocak, Dilara C / Collaborator ED - Pálóczi, Krisztina / Collaborator ED - Pérez-González, Rocío / Collaborator ED - Pachane, Bianca C / Collaborator ED - Padinharayil, Hafiza / Collaborator ED - Paget, Daan / Collaborator ED - Paggetti, Jerome / Collaborator ED - Loreto Palacio, Paola C / Collaborator ED - Pallasch, Christian P / Collaborator ED - Palmulli, Roberta / Collaborator ED - Pang, Bairen / Collaborator ED - Paniushkina, Liliia / Collaborator ED - Pantazi, Paschalia / Collaborator ED - Paolini, Lucia / Collaborator ED - Papademetrio, Daniela L / Collaborator ED - Parisse, Pietro / Collaborator ED - Park, Dong Jun / Collaborator ED - Park, Juhee / Collaborator ED - Park, Young-Gyun / Collaborator ED - Patton, James G / Collaborator ED - Peake, Nicholas J / Collaborator ED - Pegtel, D Michiel / Collaborator ED - Peinado, Héctor / Collaborator ED - Pereira de Almeida, Luis / Collaborator ED - Perut, Francesca / Collaborator ED - Pfaffl, Michael W / Collaborator ED - Pfeiffer, Annika / Collaborator ED - Phan, Thanh Kha / Collaborator ED - Phinney, Donald G / Collaborator ED - Phylactou, Leonidas A / Collaborator ED - Picciolini, Silvia / Collaborator ED - Pietrowska, Monika / Collaborator ED - Piffoux, Max / Collaborator ED - Pinheiro, Cláudio / Collaborator ED - Pink, Ryan C / Collaborator ED - Pleet, Michelle L / Collaborator ED - Pocsfalvi, Gabriella / Collaborator ED - Poh, Qi Hui / Collaborator ED - van der Pol, Edwin / Collaborator ED - Poojary, Ganesha / Collaborator ED - Poon, Ivan Kh / Collaborator ED - Poppa, Giuseppina / Collaborator ED - Del Portillo, Hernando A / Collaborator ED - Pospichalova, Vendula / Collaborator ED - Potter, Shirley / Collaborator ED - Powell, Bonita H / Collaborator ED - Powis, Simon J / Collaborator ED - Prada, Ilaria / Collaborator ED - Prasadam, Indira / Collaborator ED - Preußer, Christian / Collaborator ED - Pua, Heather H / Collaborator ED - Pucci, Ferdinando / Collaborator ED - Puhm, Florian / Collaborator ED - Puig, Berta / Collaborator ED - Pulliam, Lynn / Collaborator ED - Purnianto, Adityas / Collaborator ED - Puutio, Johanna Mm / Collaborator ED - Quilang, Rachel C / Collaborator ED - Rabbani, Piul S / Collaborator ED - Rackov, Gorjana / Collaborator ED - Radeghieri, Annalisa / Collaborator ED - Radu, Claudia M / Collaborator ED - Raffai, Robert L / Collaborator ED - Raghav, Alok / Collaborator ED - Rahbari, Mohammad / Collaborator ED - Rahman, Md Matiur / Collaborator ED - Rahman, Md Mostafizur / Collaborator ED - Rai, Alex J / Collaborator ED - Raimondo, Stefania / Collaborator ED - Raju, Sneha / Collaborator ED - Rak, Janusz / Collaborator ED - Ramaswamy, Lausonia / Collaborator ED - Ramirez-Ricardo, Javier / Collaborator ED - Ramirez, Marcel I / Collaborator ED - Rani, Shikha / Collaborator ED - Raposo, Graca / Collaborator ED - Rather, Hilal A / Collaborator ED - Razim, Agnieszka / Collaborator ED - Reale, Antonia / Collaborator ED - Reategui, Eduardo / Collaborator ED - Reddel, Caroline J / Collaborator ED - Reddy, Shivakumar K / Collaborator ED - Redenti, Stephen / Collaborator ED - Reed, Samantha L / Collaborator ED - Regev-Rudzki, Neta / Collaborator ED - Reiners, Katrin S / Collaborator ED - Resnik, Nataša / Collaborator ED - Rice, Gregory E / Collaborator ED - Ricklefs, Franz L / Collaborator ED - Ridolfi, Andrea / Collaborator ED - Rilla, Kirsi / Collaborator ED - Rimmer, Michael P / Collaborator ED - Roballo, Kelly Cs / Collaborator ED - Robbins, Paul D / Collaborator ED - Roberts, David D / Collaborator ED - Roca, Jordi / Collaborator ED - Rodal, Avital A / Collaborator ED - Rodrigues-Junior, Dorival M / Collaborator ED - Rodrigues, Marcio L / Collaborator ED - Roefs, Marieke T / Collaborator ED - Rogers, Russell G / Collaborator ED - Rohde, Eva / Collaborator ED - Rojalin, Tatu / Collaborator ED - Romani, Rita / Collaborator ED - Romano, Miriam / Collaborator ED - Rome, Sophie / Collaborator ED - Romih, Rok / Collaborator ED - Romolo, Anna / Collaborator ED - De Rossi, Tatiane / Collaborator ED - Rouschop, Kasper M / Collaborator ED - Routenberg, David A / Collaborator ED - Roux, Quentin / Collaborator ED - Rowland, Andrew / Collaborator ED - van Royen, Martin E / Collaborator ED - Rozo, Annaïg J / Collaborator ED - Rufino-Ramos, David / Collaborator ED - Rughetti, Aurelia / Collaborator ED - Russell, Ashley E / Collaborator ED - Rutter, Stephanie F / Collaborator ED - Rysmakhanov, Myltykbay S / Collaborator ED - Sánchez, Catherine A / Collaborator ED - Sadovsky, Yoel / Collaborator ED - Safavi-Sohi, Reihaneh / Collaborator ED - Saftics, Andras / Collaborator ED - Sagar, Ram / Collaborator ED - Sahoo, Susmita / Collaborator ED - Saidu, Nathaniel Eb / Collaborator ED - Saint-Pol, Julien / Collaborator ED - Salas-Huenuleo, Edison / Collaborator ED - Salazar-Puerta, Ana I / Collaborator ED - Saleem, Ayesha / Collaborator ED - Salekdeh, Ghasem Hosseini / Collaborator ED - Salomon, Carlos / Collaborator ED - Salviano-Silva, Amanda / Collaborator ED - Salybekov, Amankeldi A / Collaborator ED - Samuels, Mark / Collaborator ED - Sandau, Ursula S / Collaborator ED - Santavanond, Jascinta P / Collaborator ED - Santoro, Jessie / Collaborator ED - Santos, Mark / Collaborator ED - Sanwlani, Rahul / Collaborator ED - Saugstad, Julie A / Collaborator ED - Saul, Meike J / Collaborator ED - Schøyen, Tine Hiorth / Collaborator ED - Schabussova, Irma / Collaborator ED - Scharrig, Emilia / Collaborator ED - Schekman, Randy / Collaborator ED - Schiavi-Tritz, Jessica / Collaborator ED - Schiffelers, Raymond M / Collaborator ED - Schmid, Anna M / Collaborator ED - Schneider, Raphael / Collaborator ED - Schneider, Stefan / Collaborator ED - Schoeberlein, Andreina / Collaborator ED - Schorey, Jeffrey S / Collaborator ED - Seo, Naohiro / Collaborator ED - Seras-Franzoso, Joaquin / Collaborator ED - Shahi, Sanjay / Collaborator ED - Shatnyeva, Olga / Collaborator ED - Shea, Deanna F / Collaborator ED - Shekari, Faezeh / Collaborator ED - Shelke, Ganesh V / Collaborator ED - Shetty, Ashok K / Collaborator ED - Shiba, Kiyotaka / Collaborator ED - Shiju, Thomas Michael / Collaborator ED - Shrivastava, Surya / Collaborator ED - Shukla, Sachin / Collaborator ED - Siljander, Pia R-M / Collaborator ED - Silva, Andreia M / Collaborator ED - Singh, Ajay P / Collaborator ED - Singh, Sangeeta / Collaborator ED - Skliar, Mikhail / Collaborator ED - Skog, Johan / Collaborator ED - Sluijter, Joost Pg / Collaborator ED - Snyder, Orman L / Collaborator ED - Soekmadji, Carolina / Collaborator ED - Somaida, Ahmed / Collaborator ED - Somiya, Masaharu / Collaborator ED - Soroczyńska, Karolina / Collaborator ED - Sotillo, Javier / Collaborator ED - Souza-Fonseca-Guimaraes, Fernando / Collaborator ED - Spada, Sheila / Collaborator ED - Spiers, Harry Vm / Collaborator ED - Spitzberg, Joshua D / Collaborator ED - Srivastava, Akhil / Collaborator ED - Srivastava, Amit K / Collaborator ED - Stępień, Ewa Ł / Collaborator ED - St-Denis-Bissonnette, Frederic / Collaborator ED - Stahl, Philip D / Collaborator ED - Stam, Janine / Collaborator ED - Stambouli, Oumaima / Collaborator ED - Stanton, Bruce A / Collaborator ED - Stassen, Frank Rm / Collaborator ED - Staufer, Oskar / Collaborator ED - Steiner, Loïc / Collaborator ED - Stepanova, Ganna / Collaborator ED - Stoka, Veronika / Collaborator ED - Stoorvogel, Willem / Collaborator ED - Pogge von Strandmann, Elke / Collaborator ED - Strunk, Dirk / Collaborator ED - Stylli, Stanley S / Collaborator ED - Su, Huaqi / Collaborator ED - Subramanian, Subbaya / Collaborator ED - Sui, Bingdong / Collaborator ED - Sukreet, Sonal / Collaborator ED - Sulaiman, Elias / Collaborator ED - Sung, Bong Hwan / Collaborator ED - Sunkara, Vijaya / Collaborator ED - Suo, Zucai / Collaborator ED - Svenningsen, Per / Collaborator ED - 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Torrecilhas, Ana C / Collaborator ED - Tosar, Juan P / Collaborator ED - Trinidad, Camille V / Collaborator ED - Tritten, Lucienne / Collaborator ED - Trivedi, Rucha / Collaborator ED - Troyer, Zach / Collaborator ED - Tsamchoe, Migmar / Collaborator ED - Tscherrig, Vera / Collaborator ED - Tsering, Thupten / Collaborator ED - Turkova, Kristyna / Collaborator ED - Tutanov, Oleg S / Collaborator ED - Ueda, Koji / Collaborator ED - Upadhya, Dinesh / Collaborator ED - Urabe, Fumihiko / Collaborator ED - Urbanelli, Lorena / Collaborator ED - Urzì, Ornella / Collaborator ED - Useckaite, Zivile / Collaborator ED - Vacchi, Elena / Collaborator ED - Vader, Pieter / Collaborator ED - Vago, Riccardo / Collaborator ED - Valadi, Hadi / Collaborator ED - Valkonen, Sami / Collaborator ED - Valle, Francesco / Collaborator ED - Varas-Godoy, Manuel / Collaborator ED - Varga, Zoltán / Collaborator ED - Varga, Zoltan / Collaborator ED - Vasconcelos, M Helena / Collaborator ED - Vechetti, Ivan J / Collaborator ED - Veiga, Sara I / Collaborator ED - Vella, Laura J / Collaborator ED - Velot, Émilie / Collaborator ED - Verweij, Frederik J / Collaborator ED - Vestad, Beate / Collaborator ED - Vinay, Ludovic / Collaborator ED - Viola, Margarida / Collaborator ED - Visnovitz, Tamás / Collaborator ED - Vizio, Dolores Di / Collaborator ED - Vreeland, Wyatt N / Collaborator ED - Visnovitzné Dr Vukman, Krisztina / Collaborator ED - Wade, Philippa K / Collaborator ED - van de Wakker, Simonides I / Collaborator ED - Walther, Lucas / Collaborator ED - Wang, Tong / Collaborator ED - Wang, Xiaoqin / Collaborator ED - Watson, Dionysios C / Collaborator ED - Wauben, Marca Hm / Collaborator ED - Weaver, Alissa M / Collaborator ED - Webber, Jason P / Collaborator ED - Weber, Viktoria / Collaborator ED - Wehman, Ann M / Collaborator ED - Weiss, Luisa / Collaborator ED - Weiss, Mark L / Collaborator ED - Weiss, René / Collaborator ED - Weissleder, Ralph / Collaborator ED - Welsh, Joshua A / Collaborator ED - Wen, Yi / Collaborator ED - de Wever, Olivier / Collaborator ED - Wheelock, Asa M / Collaborator ED - White, Katherine E / Collaborator ED - Whitehead, Bradley / Collaborator ED - Whiteside, Theresa L / Collaborator ED - Whitley, Joseph / Collaborator ED - Wiener, Zoltán / Collaborator ED - van Wijnen, Andre J / Collaborator ED - Wiklander, Oscar Pb / Collaborator ED - Williams, Sarah / Collaborator ED - Winston, Charisse N / Collaborator ED - Witwer, Kenneth W / Collaborator ED - Wolf, Martin / Collaborator ED - Wolfram, Joy / Collaborator ED - Wu, Liang / Collaborator ED - Wu, Yunjie / Collaborator ED - Wysmołek, Magdalena E / Collaborator ED - Xander, Patricia / Collaborator ED - Xavier, Cristina Pr / Collaborator ED - Xiao, Yu / Collaborator ED - Xu, Rong / Collaborator ED - Yáñez-Mó, María / Collaborator ED - Yamamoto, Tomofumi / Collaborator ED - Yamamoto, Yuki / Collaborator ED - Yamamoto, Yusuke / Collaborator ED - Yan, Xiaomei / Collaborator ED - Yang, Lifang / Collaborator ED - Yang, Yongkang / Collaborator ED - Yarani, Reza / Collaborator ED - Yea, Kyungmoo / Collaborator ED - Yedigaryan, Laura / Collaborator ED - Yenuganti, Vengala Rao / Collaborator ED - Yerneni, Saigopalakrishna S / Collaborator ED - Yeung, Vincent / Collaborator ED - Yildizhan, Yagmur / Collaborator ED - Yin, Hang / Collaborator ED - Yokoi, Akira / Collaborator ED - Yoshioka, Yusuke / Collaborator ED - You, Yang / Collaborator ED - Yuan, Ling-Qing / Collaborator ED - Tassi Yunga, Samuel / Collaborator ED - Zakeri, Amin / Collaborator ED - Zani, Augusto / Collaborator ED - Zanoni, Michele / Collaborator ED - Zappulli, Valentina / Collaborator ED - Zarovni, Natasa / Collaborator ED - Zarubova, Jana / Collaborator ED - Zempleni, Janos / Collaborator ED - Žėkas, Vytautas / Collaborator ED - Zendrini, Andrea / Collaborator ED - Zhang, Hao / Collaborator ED - Zhang, Qin / Collaborator ED - Zhao, Zheng / Collaborator ED - Zheng, Lei / Collaborator ED - Zhou, Yinghong / Collaborator ED - Zickler, Antje M / Collaborator ED - Zijlstra, Andries / Collaborator ED - Zimmerman, Alan J / Collaborator ED - Zimmermann, Pascale / Collaborator ED - Zivkovic, Angela M / Collaborator ED - Zocco, Davide / Collaborator ED - Zuba-Surma, Ewa K / Collaborator ED - Zubair, Haseeb / Collaborator TI - Minimal information for studies of extracellular vesicles (MISEV2023). From basic to advanced approaches TS - From basic to advanced approaches JF - JOURNAL OF EXTRACELLULAR VESICLES J2 - J EXTRACELLULAR VESICL VL - 13 PY - 2024 IS - 2 PG - 84 SN - 2001-3078 DO - 10.1002/jev2.12404 UR - https://m2.mtmt.hu/api/publication/36216221 ID - 36216221 AB - Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly. LA - English DB - MTMT ER -